Our Fellows, and readership in general, form a continuum between lay people with scant scientific background to the most sophisticated scientist. If you would like to host a blog for our readers or write a white paper or newspaper article, Schedule a call with Dave Molecular Biology involves the the composition, structure and interactions of cellular molecules – such as nucleic acids and proteins – that carry out the biological processes essential for the cell’s functions and maintenance. Read more in Nature.
Check out the ethics poll at the end of this communication.
The most common way I encountered mismatch repair genes was in the context of Lynch syndrome (hereditary nonpolyposis colorectal cancer). The Amsterdam II criteria should be met before a patient or family is categorized as having Lynch Syndrome.
  • There should be at least three relatives with any Lynch syndrome-associated cancer (colorectal cancer, cancer of the endometrium, small bowel, ureter, or renal pelvis)
  • One should be a first-degree relative of the other two
  • At least two successive generations should be affected
  • At least one should be diagnosed before age 50
  • Familial adenomatous polyposis (a less common inherited disorder) should be excluded in the colorectal cancer
  • Tumors should be verified by pathological examination
Basic science like molecular genetics rapidly becomes useful clinically; keeping current is a necessity. It now appears that there may be a genetic locus predisposing to opioid dependence and that it can be screened for.
One in 20 Americans will get colorectal cancer during their lifetime and 3-5 percent of those people will have either Hereditary Nonpolyposis colon cancer or FAP, familial adenomatous polyposis. The average age of onset of colorectal cancer is 63 years with 90% occurring after age 50. BUT, the hereditary variety occurs much earlier.
A patient refuses to tell a family member they may share an inherited mismatch repair gene
you are obligated to inform the family member they may be at risk
HIPAA prevents you from telling the family member
this might be a good case to consult the ethics committee
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