April 2016 Newsletter 
Clinical Trial Working Groups
  • Trial in start-up:
    • ER+ and/or PR+ and HER2- breast cancer (Illinois)
  • Approved LOI:
    • AR+ triple negative breast cancer (Wisconsin)
  • Current concepts: 
    • HER2+ breast cancer (Penn State)
    • Triple negative breast cancer (Indiana)
  • Next call: Wednesday, April 27 
    at 4 p.m. ET / 3 p.m. CT
  • Trials in start-up:
    • Hepatocellular (Indiana)
    • Esophageal (Indiana) - see also thoracic
  • Approved LOI:
    • Gastric/GE junction adenocarcinoma (Northwestern)
  • Current concepts
    • Hepatocellular (Wisconsin)
    • Colorectal (Wisconsin) - on hold until Q1 2016
    • Pancreatic (Penn State)
    • Colorectal (Illinois)
  • Next call: Friday, April 15 
    at 3 p.m. ET / 2 p.m. CT
  • Open trial:
    • Renal cell carcinoma (Illinois)
  • Approved LOI:
    • Bladder (Penn State)
  • Current concepts:
    • Urothelial (Indiana)
    • Prostate (Rutgers)
    • Penile (Minnesota)
  • Next call: Friday, July 29 
    at 10 a.m. ET / 9 a.m. CT
  • Trial in start-up:
    • Endometrial carcinoma (Northwestern)
  • Current concept:
    • Ovarian (Rutgers)
  • Next call: Friday, April 29 
    at 2 p.m. ET / 1 p.m. CT.
  • Current concepts :
    • Lymphoma (Minnesota)
    • Peripheral T-cell lymphoma (Michigan)
  • Concepts (not yet presented):
    • Peripheral T-cell lymphoma (Michigan) -
      3 concepts
    • Cutaneous T-cell lymphoma (Michigan) -
      2 concepts
    • Lymphoid/multiple myeloma (Indiana) - see also multiple myeloma
  • Next call: Wednesday, May 18 at 11 a.m. ET / 10 a.m. CT
  • Current concepts:
    • Squamous cell carcinoma of the skin (Rutgers)
    • Uveal melanoma (Michigan)
  • Next call: TBD.
  • Current concept:
    • Lymphoma/multiple myeloma (Indiana) - see also lymphoid
  • Next call: Thursday, April 28 
    at 10 a.m. ET / 9 a.m. CT.
  • Current concepts:
    • AML (Illinois)
    • AML (Indiana)
    • MDS (Penn State)
  • Next call: Tuesday, May 24 
    at 1 p.m. ET / 12 p.m. CT
  • Next call: TBD.
  • Trial in start-up:
    • Esophageal (Indiana) -
      see also gastrointestinal
  • Approved LOI:
    • NSCLC (Illinois)
    • NCSLC (Indiana)
  • Current concepts:
    • Splice variants in lung cancer in women (Illinois)
    • HER2 expression and targeted therapy (Illinois)
    • Non-small cell lung cancer (Illinois)
    • Small cell lung cancer (Illinois)
  • Next call: Thursday, May 5 
    at 1 p.m. ET / 12 p.m. CT
 
To Discuss Protocols: Contact Jessica Roy at [email protected] or 317-634-5842, ext. 19

To Join a CTWG or Submit an LOI: Contact Anita Borek at
[email protected] or  317-634-5842, ext. 48.

Support the BTCRC
Study accrual ahead of schedule 
One year after opening to accrual, the Big Ten Cancer Research Consortium's first clinical trial, BTCRC-GU14-003, is accruing well ahead of schedule, and projected to complete enrollment later this year. Congratulations to all member sites participating in this trial.

BTCRC-GU14-003 is led by sponsor-investigator Arkadiusz Dudek, MD, PhD, of the University of Illinois Cancer Center. 
ASCO 2016 Meetings 
The Big Ten Cancer Research Consortium will host meetings for the BTCRC Foundation, Cancer Center Directors, Steering Committee, and Clinical Trial Working Groups during ASCO 2016.

All meetings listed below will be at the Holiday Inn Chicago Mart Plaza River North, 350 West Mart Center Drive, Chicago, Ill. Meetings will be on the 14th floor. Drinks and appetizers will be provided.  See map.
 
 
FRIDAY, JUNE 3  (all times CT)
    • 6 - 6:30 p.m. - BTCRC Foundation
    • 6:30 - 7:30 p.m. - Cancer Center Directors
    • 7 - 8 p.m. - Melanoma CTWG
    • 7:30 - 9:30 p.m. - Steering Committee
    • 8:30 - 9:30 p.m. - Neuro-Oncology CTWG
SATURDAY, JUNE 4
    • 7 - 8 p.m. - Gastrointestinal CTWG
    • 7 - 8 p.m. - Thoracic CTWG
    • 8:30 - 9:30 p.m.  - Breast CTWG
SUNDAY, JUNE 5
    • 7 - 8 p.m. - Genitourinary CTWG
    • 7 - 8 p.m. - Multiple Myeloma CTWG
    • 8:30 - 9:30 p.m. - Lymphoid Malignancies CTWG
    • 8:30 - 9:30 p.m. - Myeloid Malignancies CTWG
Visit the BTCRC at Booth # 25099 at McCormick Place South, Exhibit Hall A. See booth location.

Featured Member Profile
University of Michigan Comprehensive Cancer Center 

"The BTCRC is unique because it brings together these elite academic medical centers that are able to carry out the most sophisticated studies; and it allows us to coordinate multi-institutional research, which means a larger, more diverse pool of patients who might enroll in trials."

Read more in this conversation with Theodore Lawrence, MD, PhD, director of the University of Michigan Comprehensive Cancer Center, our featured member for April.

See past member features.

Across the Consortium
A game-plan is strategy in motion - the key to a winning plan is insightful strategy. The team-research culture of the Big Ten Cancer Research Consortium fosters such insight, and BTCRC member institutions are positioned to win. In this month's edition of Across the Consortium, we take note of crucial plays made possible by the members' plan to rapidly drive from ideas to new approaches to cancer treatment. Read more .
 
Want more news from  Across the Consortium?

Progress in Cancer Prevention and Health Equity 
 
While advocating for the creation of Philadelphia's first firefighting organization, Benjamin Franklin offered his now famous advice: "an ounce of prevention is worth a pound of cure." That adage continues to resonate as the fires of cancer continue ravaging the nation nearly 280 years later, posing as the second leading cause of death.

In this awareness month feature, we highlight a few examples of Big Ten investigators addressing cancer prevention and health equity, including (pictured from left) Gary Volentine, MD, of Nebraska Medicine; Sharon R. Pine, PhD, of Rutgers Cancer Institute of New Jersey; Philip Bierman, MD, of Nebraska Medicine; and (not pictured) Dorothy Hatsukami, PhD, of Masonic Cancer Center (University of Minnesota).  Read more.


Q&A: Data Processes 
In our continuing Q&A series, we address common questions related to data processes and capabilities. These questions include:
  • What electronic data capture system does BTCRC Administrative Headquarters use for clinical trials?
  • Does the EDC system allow for collection of biospecimens?
  • How are protocols developed in the EDC system?
  • How do sites gain access to the EDC system?
  • What is data validation?
  • How is data prepared for analysis?
 Read more