December 2016 Newsletter 
Open to Accrual 
BTCRC-ESO14-012
Closed to Accrual 
Approved LOI 
BTCRC-BRE15-024
  • Adv. AR+ triple neg. breast cancer
  • Sponsor-Investigator:
    Ruth O'Regan, MD (Wisconsin)
BTCRC-BRE16-042
  • Adv. HR+ HER2- breast cancer
  • Sponsor-Investigator:
    Nancy Chan, MD (Rutgers)
BTCRC-GI15-015
  • Adv. gastric, gastroesophageal junction cancer
  • Sponsor-Investigator:
    Halla Nimeiri, MD
    (Northwestern)
BTCRC-GI16-030
  • Adv. pancreatic cancer
  • Sponsor-Investigator:
    Safi Shahda, MD (Indiana)
BTCRC-GU16-043
  • Adv. kidney cancer
  • Sponsor-Investigator:
    Ajjai Alva, MBBS (Michigan)
BTCRC-GYN15-013
  • Adv./recurrent endometrial cancer
  • Sponsor-Investigator:
    Mario Pineda, MD, PhD
    (Northwestern)
BTCRC-HEM15-028
  • Relapsed/refractory peripheral
    T-cell lymphoma
  • Sponsor-Investigator:
    Ryan Wilcox, MD, PhD (Michigan)
BTCRC-HEM16-055
  • Relapsed/refractory Hodgkin lymphoma
  • Sponsor-Investigator:
    Tycel Phillips, MD (Michigan)
BTCRC-LUN15-017
  • Non-small cell lung cancer
  • Sponsor-Investigator:
    Lawrence Feldman, MD (Illinois)
BTCRC-LUN15-025
  • Mesothelioma
  • Sponsor-Investigator:
    Arkadiusz Dudek, MD, PhD (Illinois)
BTCRC-LUN15-029
  • Adv. non-small cell lung cancer
  • Sponsor-Investigator:
    Greg Durm, MD (Indiana)
Research Development
To Discuss Protocols: Contact Jessica Roy at [email protected] or 317-634-5842, ext. 19

To Join a Clinical Trial Working Group or Submit an LOI: Contact Anita Borek at  [email protected] or  317-634-5842, ext. 48.

Support the BTCRC
Team up with the Big Ten Cancer Research Consortium. Together, we can make a big impact!

DUART study combines radiation, immunotherapy in adv. bladder cancer  
A new Big Ten Cancer Research Consortium study, led by Monika Joshi, MD, MRCP, of Penn State Cancer Institute, is now open to accrual. BTCRC-GU15-023 is a phase Ib/II study of concurrent durvalumab and radiation therapy (DUART) followed by adjuvant durvalumab in patients with urothelial cancer of the bladder. The study is open at Penn State Cancer Institute, and additional BTCRC member sites are expected to open in the near future.

Read more .
Steering Committee appoints
chair, vice chair
Members of the Big Ten Cancer Research Consortium Steering Committee recently appointed Robert Kratzke, MD, as the committee's first chair, and Ruth O'Regan, MD, as its vice chair. Each will serve a one-year term, with Dr. O'Regan serving as chair in the subsequent year.

Dr. Kratzke is associate professor in the Department of Medicine at the Masonic Cancer Center, University of Minnesota.

Dr. O'Regan is professor and division head of hematology and oncology in the Department of Medicine at the University of Wisconsin School of Medicine and Public Health.

Diversity in clinical trial participation 
Studies show that patients with low income, the elderly, racial and ethnic minorities, women, and those who live in rural areas represent the smallest percentage of clinical trial participants. Unfortunately, these groups also represent a disproportionate burden of disease. A diverse coalition of health care partners that includes the Big Ten Cancer Research Consortium launched the #BeAGift awareness campaign aimed at changing perceptions of and encouraging participation in clinical trials.

New Clinical Trial Working Groups
The Big Ten Cancer Research Consortium invites junior and senior faculty investigators, scientists, and fellows to join the following Clinical Trial Working Groups that are now being formed:
  • Immunotherapy
  • Hematopoietic Stem Cell Transplant
To join these or other Clinical Trial Working Groups, contact [email protected], or click the button below.


We're Teaming Up!
Members of the BTCRC's lymphoid, myeloid, and multiple myeloma working groups met during the ASH Annual Meeting (pictured) to discuss study concepts and trials in development.

The BTCRC's Breast Clinical Trial Working Group also met during the San Antonio Breast Cancer Research Symposium.
Member Features
University of Wisconsin Carbone Cancer Center
Get to know Natalie Callander, MD  (left) , a hematologist at the University of Wisconsin Carbone Cancer Center and member of the BTCRC's Multiple Myeloma Clinical Trial Working Group.

Vaishalee Kenkre, MD (right), an assistant professor of medicine in the division of hematology/oncology at the UW School of Medicine and Public Health, discusses a novel strategy to reduced GVHD in lymphoma transplantations. Dr. Kenkre is a member of the BTCRC's Lymphoid Malignancies Clinical Trial Working Group.

Purdue University Center for Cancer Research
Get to know Andrea L. Kasinski, PhD (left), William and Patty Miller assistant professor of biological sciences at Purdue University.

A research team in the Department of Basic Medical Sciences at the Purdue University College of Veterinary Medicine (right) has identified a link between the hepatitis B virus (HBV) and the development of liver cancer. Dr. Ourania Andrisani leads the team of graduate assistants in collaboration with researchers at INSERM in France.

Across the Consortium
Each month, Across the Consortium offers highlights from all BTCRC member institutions.