November 17 , 2017
FROM THE DIRECTOR
Dr. Stan Gerson
Stan Gerson, MD
Director, Case Comprehensive Cancer Center

Strategic Plan 2017-2023
Over the past year, the Case Comprehensive Cancer Center has undertaken a program and center-wide effort to identify our scientific initiatives for the next 6 years, and to integrate these with our research programs. This effort engaged the help of our entire membership, guided by our Executive Committee (EC), Institutional Advisory Committee, and External Advisory Committee. The resulting Strategic Plan complements the SOM strategic plan, and looks forward through 2023. It was presented to and reviewed by the NCI site visit panel and was well received.  
 
I ask you to please review the new strategic plan and provide input. It is a roadmap, but is not in concrete: we expect to nuance it over the short term and overhaul it over the long term by responding to new opportunities and discoveries. Remember, the Center will invest in these initiatives. If there is a major need that would benefit from a Cancer Center focus or investment, it is best done through advocacy for its inclusion in the strategic plan and coordination with the research programs.
 
Over the next two months, the EC will identify 2-4 coordinating leaders per new initiative who will be charged with providing depth to the initiative through working groups and presenting their plans to the EC. After which, we will announce new support efforts for these initiatives.
 
I hope you find the strategic plan helpful, and I encourage you to consider it as you move your own initiatives forward. 


MEMBER/CENTER HIGHLIGHTS
Ganes Sen, PhD
Ganes Sen
Sen Recognized with Lifetime Membership Award
Ganes C. Sen, PhD
, Case Comprehensive Cancer Center, Department of Immunology, Cleveland Clinic Lerner Research Institute, received the prestigious Honorary Lifetime Membership Award from the International Cytokine and Interferon Society at its November "Cytokines 2017" conference in Kanazawa, Japan, according to a release posted by the Lerner Research Institute. Dr. Sen was honored for his research related to the role of interferons in antiviral responses.  more>
MARK YOUR CALENDARS
Cancer Center Seminar Series
Nov 17, 2017 | Wolstein Reserch Bldg 2-136 **NOTE ROOM CHANGE**
Join us today at noon in Wolstein Research Building Room 2-136 for the Cancer Center Seminar Series to hear Derek Taylor, PhD, Associate Professor of Pharmacology,  CWRU School of Medicine and Member, Molecular Oncology Program, Case Comprehensive Cancer Center, discuss "A novel mechanism to reversibly stall ribosome-mediated protein synthesis in response to cellular stress."

The Taylor Lab is interested in the molecular interactions that regulate fundamental cellular events. A primary focus of the lab is directed at understanding ribosome-mediated regulation of protein synthesis.
Global Adolescent & Young Adult Cancer Congress
Dec 5-7, 2017 | Atlanta, GA
Teen Cancer America Building on the success of Teenage Cancer Trust's International Conference Series and the professional global networks that have developed through subsequent world-wide advances in AYA cancer services, Teen Cancer America is proud to host the 2nd Global AYA Cancer Congress. This will be the first Congress held outside of the UK, in the wonderful host city of Atlanta, Georgia.  Healthcare professionals from across the world, including oncologists, hematologists, research scientists, psychologists, nurses, social workers, youth workers, allied health professionals, advocates, and more, are invited to join this groundbreaking summit.
Call for Abstracts: 2nd Annual Cancer Disparities Symposium
The Case Comprehensive Cancer Center and Office of Cancer Disparities Research will host the " 2nd Annual Cancer Disparities Symposium: Taking it to the Streets: Where Cancer Disparities Research and Community Intersect," on  Friday, March 23, 2018
 
This event will showcase cutting-edge research, with a focus on reducing and eliminating disparities in cancer, going from bench-to-bedside-to-community and back. This important symposium will also feature two keynote addresses, including a key leader in our community, and an internationally-recognized cancer disparities researcher. We will promote the exchange of ideas and collaborative opportunities among scientists, clinicians, government, and community representatives.
 
CALL FOR ABSTRACTS
We invite abstracts from attendees, organized into two areas: Academic Science and Community. Abstracts must be submitted via email to [email protected] by 5 pm on January 5, 2018. Visit the event website for more information.
CASE CCC IN THE NEWS
cleveland.com - Nov 14, 2017
Case Western Reserve University researcher and  Case Comprehensive Cancer Center member  Mark Chance remembers the extreme emotion he felt the first time he saw crystal-clear, 3-D images of a protein's coating.  "It was just a beautiful moment. I was very happy," said Chance, vice dean for research at Case Western Reserve University's School of Medicine. He predicted years ago that the device responsible for the revolutionary images he's seen, a new kind of cryo-electron microscope, was going to cause seismic waves in the field of protein research.  "You could feel things were changing, and are not going back," he recalled.  The cryo-electron microscope, which so impressed Chance, won  the 2017 Nobel Prize in chemistry.  Case is getting one of its own, and it will be the first in Ohio.
Smart curve mammogram offers new, improved way of imaging breast
KDKA CBS Local.com (Pittsburgh) - Nov 10, 2017
Dr. Donna Plecha, University Hospitals Breast Imaging Specialist, Case Comprehensive Cancer Center, admits getting your breast squashed between two plates is not exactly delightful. " Some  patients  do complain of pain, pinching, and pulling of the skin when they get their mammogram," says Dr. Plecha, "And some patients, that may make them not want to come in and get their mammogram."... Three years ago, University Hospitals in Cleveland started a study of a new, improved way of imaging the breast, and KDKA's Dr. Maria Simbra went to see what it was all about. The new technique is called Smart Curve...
dotmed.com - Nov 10, 2017
Most recently, Gannon's company, which invented, patented and manufactured TempTraq®, the only wearable, Bluetooth® continuous temperature monitor, received promising clinical study results for its medical device. A University Hospitals Seidman Cancer Center (UH) study shows the wearable can detect a rise in body temperature up to 180 minutes earlier, in a majority of patient cases, than the current standard-of-care (SOC) method, allowing medical professionals the chance to intervene more quickly. 
"This temperature monitoring patch has the potential to improve clinical outcomes for patients undergoing stem cell transplant and intensive chemotherapy for hematological malignancies by identifying neutropenic fever and beginning clinical interventions sooner," said Ehsan Malek, MD, Case Comprehensive Cancer Center, UH Seidman Cancer Center. "We are looking forward to the next step in our research-implementing this temperature patch in the outpatient stem cell transplant setting."

US News & World Report - Nov 2, 2017
By Brian Bolwell, MD, chairman, Cleveland Clinic
Taussig Cancer Institute and Deputy Director, Case Comprehensive Cancer Center.   Fear and anxiety are powerful emotions, especially when a patient faces an unsettling medical diagnosis.  As a  health care  provider, I see it every day. But as a cancer clinician in particular, I am extra mindful of the thoughts and emotions that wash over newly diagnosed patients.  One of the keys to being a good physician is to have an understanding of what your patients are going through, especially what they are thinking and not saying. I find myself - with each passing year and each new patient - giving pause to reflect on how I'm communicating, how I'm heard and if I'm understood. More than how I feel, it matters how my patients feel.
FUNDING OPPORTUNITIES
Limited Submission: NSF Research Traineeship (NRT)
Internal Deadline: Nov 17, 2017; External Deadline: Dec 27, 2017
The NSF Research Traineeship (NRT) program is designed to encourage the development and implementation of bold, new, and potentially transformative models for STEM graduate education training. The NRT program seeks proposals that explore ways for graduate students in research-based master's and doctoral degree programs to develop the skills, knowledge, and competencies needed to pursue a range of STEM careers.

The program is dedicated to effective training of STEM graduate students in high priority interdisciplinary research areas, through the use of a comprehensive traineeship model that is innovative, evidence-based, and aligned with changing workforce and research needs. For FY2018, proposals are requested in any interdisciplinary research theme of national priority, with special emphasis on two high priority areas: (1) Harnessing the Data Revolution (HDR) and (2) Innovations at the Nexus of Food, Energy, and Water Systems (INFEWS). HDR is expected to continue as a priority research area for FY2019 and FY2020 competitions, along with a new priority area to be announced in 2018.
CWRU Center for Reducing Health Disparities Pilot Awards to Understand and/or Reduce Health Disparities
Deadline: Dec 15, 2017
The CWRU Center for Reducing Health Disparities is accepting applications for Pilot Awards to Understand and/or Reduce Health Disparities. These awards aim to develop investigators with a high capacity to engage in partnerships with communities to conduct high-quality health disparities research. Investigations of interest include the development, pilot testing, and/or dissemination of community-based studies to understand and/or eliminate health disparities. 

Technical Assistance Sessions 
A t echnical assistance session will be offered to give a brief overview of the program and offer an opportunity for potential applicants to ask relevant questions regarding the application process and the scope of the RFA. RSVP to  [email protected]

Tuesday, November 28,  5:30-6:30p
CWRU Thwing 302
AACR Scholar-in-Training Awards: Annual Meeting  
Deadline: Dec 7, 2017
American Association for Cancer Research (AACR) Scholar-in-Training Awards are highly competitive and recognize outstanding young investigators presenting meritorious proffered papers at the AACR Annual Meeting. To apply for a Scholar-in-Training Award, applicants must first submit their abstract and then complete a Scholar-in-Training Award Application.
BETRNet Pilot Project Award Program
Deadline: Jan 31, 2018
The CWRU Barrett's Esophagus Translational Research Network (BETRNet) Research Center, supported by NIH/NCI U54CA163060, announces a program to encourage innovative transdisciplinary and translational research related to Barrett's Esophagus (BE). The overall objectives of the program are: 1) to encourage innovative transdisciplinary and translational research, especially high risk/high impact research; 2) to explore emerging opportunities and to enhance productivity of the research projects in the BETRNet, and; 3) to attract new researchers, resources and technologies to conduct translational research on BE and Esophageal Adenocarcinoma (EAC).  

Limited awards of up to $40,000/year will be made to eligible applicants for one year, with the possibility of a second year of funding based on the success of the pilot. Pilot projects must have a transdisciplinary approach and translational research plan focused on BE and/or EAC in one of the focus areas defined by BETRNet.
NIH BULLETIN- Notices and Funding Opportunities
rfas 
Call for Applications/Program Announcements


Program Announcements
Exploratory/Developmental Bioengineering Research Grants (EBRG) (R21 Clinical Trial Optional)(PA-18-286)
Deadline: Standard dates apply

NCI Research Specialist (Core-based Scientist) Award (R50)(PAR-18-342)
Deadline: Jan 17, 2018
EVENTSevents
Fri, Nov 17
Cancer Center Seminar Series
Derek Taylor, PhD Member, Molecular Oncology Program, Case Comprehensive Cancer 
Associate Professor, Pharmacology, Center Case Western Reserve University
"A novel mechanism to reversibly stall ribosome-mediated protein synthesis in response to cellular stress"
12p WRB 2-136 **NOTE ROOM CHANGE**
Mon, Nov 20
Genomic Medicine Institute
Xinwen Wang, PhD Clinical Pharmacology, University of Michigan "Carboxylesterase 1 pharmacogenomics: From bench to clinic"
12p NE1-205
Tues, Nov 21
Radiation Oncology Grand Rounds
Shlomo Koyfman, MD
Associate Professor, Radiation Oncology, Cleveland Clinic "Aggressive skin squamous cell cancer of the head and neck: Changing paradigms"
8:10a Lerner B-151
Mon, Nov 27
Genomic Medicine Institute
Madhav Sankunny, PhD
Eng Lab, Genomic Medicine Institute, Cleveland Clinic
"Role of KLLN in DNA damage and apoptosis"
12p NE1-205

Cancer Center Research Chalk Talk
1p WRB 3-136
Tues, Nov 28
Cancer Biology Seminar Series
Jing Zhang, PhD Professor, Oncology, University of Wisconsin Carbone Cancer Center "Ras-driven leukemias: mechanisms and potential therapeutics"
2p NC1-202 
Thurs, Nov 30
Developmental Therapeutics Journal Club
9a R4-013

Biochemisty Seminar Series
Gerhard Wagner, PhD Professor, Biological Chemistry and Molecular Pharmacology, Harvard University
"Mechanism of translation initiation and their inhibition to control cancer"
12p Wood W428

Molecular Biology & Microbiology Seminar
Junpeng Yan
Skowronski lab, Molecular Biology & Microbiology Seminar, CWRU
"Restriction of HIV-1 infection by SAMHD1: an update"
1p SOM W203
Fri, Dec 1
Hematology & Oncology Grand Rounds
8a Wearn 137

Taussig Cancer Institute Grand Rounds
8a CA5-120

Cancer Center Seminar Series
Fredrick R. Schumacher, PhD, MPH
Member, Cancer Prevention, Control & Population Research Program, Case Comprehensive Cancer Center
Associate Professor, Population and Quantitative health Sciences, Case Western Reserve University
12p WRB 1-413

ADDITIONAL UPCOMING SYMPOSIUMS & EVENTS
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CANCER MOONSHOT FUNDING
OPPORTUNITIES

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PREVIOUSLY ANNOUNCED OPPORTUNITIES

Case Comprehensive Cancer Center 
11100 Euclid Avenue, Wearn152
Cleveland, OH 44106-5065