-250 participants had a mean age of 60. Average clinic BP was 158/88 mm Hg, 24hr mean BP 137/79 mm Hg, and
Cr 1.0 mg/dL. At study onset, equal numbers of patients were on doxazosin or a CCB.
-Regardless of the dosing regimen, office BP was identical to pre-trial readings.
-Top Figure: By ambulatory monitoring, there was no difference among those randomized to morning dosing of the alternate 3rd agent.
-Bottom Figure: Those randomized to night time dosing experienced a marked decline in BP, particularly during the overnight hours.