-Study characteristics: 250 of 312 eligible patients participated; 50% were women. No data on ethnicity was provided. Mean age was 60. 24hr mean BP was 137/79 mm Hg, and
Cr 1.0 mg/dL. At study onset, equal numbers of patients were on doxazosin or a CCB.
-Regardless of the dosing regimen, office BP before and after the intervention were identical.
-Top Figure: By ambulatory monitoring, there was no difference among those randomized to morning dosing of the alternate 3rd agent compared to their usual regimen.
-Bottom Figure: Those randomized to nighttime dosing experienced a marked decline in BP (vs their prestudy regimen), particularly during the overnight hours.