New Options to Dupe Demodex
Isoxazolines are a potent new class of ectoparasiticides that exhibit their anitparasitic activity through specific blockade of insect GABA- and glutamate-gated chloride channels
Fluralaner (Bravecto®, Merck Animal Heath), afoxolaner (NexGard®, Merial), and sarolaner (Simparica®, Zoetis) are oral isoxazolines approved for the prevention of fleas and ticks in dogs. Mounting clinical experience and several recent studies have illustrated the efficacy of isoxazoline parasiticides for canine demodicosis. Given their ease of use, safety, relative low cost and the potential side effects of other available treatments, many veterinarians and veterinary dermatologists are now reaching for these newer products when treating generalized demodicosis in dogs. Regardless of the selected treatment, miticidal therapy should be continued until at least two consecutive negative skin scrapings are obtained at monthly intervals. Below are brief summaries of the recently published studies.