March 13, 2018
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Differential Diagnosis of Lower Limb Edema

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In The News
In one study, 28% of people with cancer-related lymphedema experienced cellulitis, a common complication of all types of lymphedema. In some patients, cellulitis can result in sepsis and the need for high-dependency hospital care. People with lymphedema may experience recurrent episodes of cellulitis. These can cause further damage to the lymphatic system resulting in worsening lymphedema. This, in turn, leads to an increased risk for further cellulitis. So, a vicious circle may develop. 

The aim of this study was to investigate health-related quality of life (HRQoL) in patients with diabetic foot problems and compare the HRQoL between diabetic patients with: 1) diabetic foot problems (DF), including diabetic foot ulcer (DFU) or amputation (AMPU); 2) other diabetic complications (COM), such as diabetic retinopathy (DR), end-stage renal disease (ESRD), or coronary artery disease (CAD); and 3) no diabetic complication (CON).
Patients with foot ulcers or gangrene who received the experimental drug JVS-100 did not show evidence of faster wound healing, compared with those receiving a placebo, in a study presented at the American College of Cardiology's 67th Annual Scientific Session. The study focused on patients with a condition known as critical limb ischemia, which occurs when the arteries that supply blood to the limbs (typically the legs) become stiffened or blocked. A lack of adequate blood flow to the extremities can lead to painful skin lesions or gangrene sores that persist for months or years. Read More

Chronic wounds differ from normal acute wounds, because they do not go through the normal healing process of inflammation, proliferation, and remodelling; instead they stop at the inflammation stage, and the healing process is stopped completely. It is estimated that 1-2% of the population in developed countries will experience a chronic wound during their lifetime. In the US alone, there are over six million chronic wound patients, and treatment is costing around $25 billion per year. However there has been many important breakthroughs recently in the field of treating chronic wounds.

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