Throughout the year many patients have asked us about the differences between Botox and Dysport. So, we decided to give this weeks newsletter reader, a little education about Botox, Dysport and another neuromodulator called Xeomin.
Botox is the gold standard in the neurotoxin market. Neurotoxins block nerve impulses thereby preventing movement of facial muscles. Originally approved by the FDA in 2002, Botox has had ample time to gather 80% of the market share in the neurotoxin market. Botox has other uses away from the paralysis of facial muscles. Botox can be used to raise the eyebrows or the corners of the mouth, for treatment of "smoker's lines" around the mouth, wrinkles in the chin and neck area as well as for excessive sweating (hyperhidrosis) under the arms. Botox was the only neurotoxin available from 2002- 2009. In 2009, the FDA approved Dysport and eventually Xeomin in 2012
What are the advantages, disadvantages of the three products? To begin, all three products treat all of the same areas and all last approximately 3-4 months depending on factors such as activity level, the number of units injected and the area treated. Studies that have been performed show that there was no evidence that one neurotoxin outlasted the others in terms of duration. What studies have found is that Dysport typically has a faster onset (1-2 days) versus Botox and Xeomin (3-5) days. So if you had an event this upcoming weekend then we would recommend going with Dysport.
The one advantage that Botox has over Dysport and Xeomin is that Botox has built a name that comes across to consumers as a trusted brand. If someone mentions Botox, the vast majority of people know what you are talking about. Both Dysport and Xeomin are described in "Botox" terms. Dysport has been called "the new Botox" and Xeomin has been called "the naked Botox" (absence of carrier proteins).
Another distinction between Botox, Dysport and Xeomin that can confuse patients is the units in which the product is administered. Both Botox and Xeomin are mixed at 1:1 ratio
(all three are typically reconstituted with normal saline), so one unit of Botox is the equivalent of one unit of Xeomin. Dysport on the other hand is a little different. Dysport is mixed at 2.5:1 ratio. So if you were to receive 20 units of Botox or Xeomin, the equivalent dosage in Dysport would be 50 units. For this reason you will notice that Dysport sells at a lower price per unit versus Botox and Xeomin.
In summary, the advantage of Botox is that it's a dependable and trusted brand. The advantage of Dysport is its ability to work faster than Botox or Xeomin. The advantage of Xeomin is that it sells at a slight discount to Botox.