MAY 2016
Canine Insulinoma

A 7-year-old female spayed Australian Shepherd presented to the Emergency Service for weakness and collapse following a long walk.  Several episodes of weakness and tremors had been noted over the previous few weeks, always associated with exercise.

A complete blood count and serum chemistry were normal at the time of admission to the hospital other than and blood glucose of 35 mg/dl.

Abdominal ultrasound was performed.   The right lobe of the pancreas was mildly thickened and 
heteroechoic , however, a discrete mass or nodule within the pancreas was not noted.

Blood was submitted for insulin level and the patient was referred for abdominal computed tomography (CT).  Insulin level was subsequently confirmed high at 66 uU/ml.  Thoracic radiographs were normal with no evidence of pulmonary metastasis.

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Case report: August is an 11 year old female spayed Labradoodle that presented to the oncology service for consultation regarding a recently diagnosed soft tissue sarcoma. A semi-firm soft tissue mass was noted along the cranial aspect of her right distal radius and was thought to have shown moderate growth to a size of approximately 3-4 cm over the previous 4-5 months. She also had several other dermal and subcutaneous masses that were softer and previously diagnosed as lipomas. 

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The FDA has approved Entyce, Aratana Therapeutics' new appetite stimulant for dogs, expected to be available by early 2017. Entyce is an oral liquid that acts like ghrelin, the body's natural hunger hormone. Some 10 million dogs suffer from poor appetite, said Aratana CEO Steven Peter.

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CANCER AWARENESS
Cancer affects all of us, whether through a family member, a close friend, a teacher or a beloved pet. There are approximately 165 million dogs and cats at risk for cancer in the United States. This translates into nearly 4 million dogs and 4 million cats developing cancer each year. It is estimated that nearly 50%of all dogs and 32% of all cats over the age of 10 will develop cancer, making it the leading cause of death in our pets.

Look for these warning signs: 

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Golden retrievers become heroes of cancer research
They call their dogs heroes, the people who enrolled their 3,044 golden retrievers in a lifetime study aimed at finding the causes and cures of cancers that kill dogs and people.

Sixty percent of this breed will get cancer at some point in their lives. That's why the Denver-based Morris foundation picked them for the study, although research is expected to apply to all dogs, and even to people.


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Canine clues to brain tumour discovered
A study of 25 breeds of dog, published in  PLOS Genetics, has identified three genes linked with a severe type of brain tumour known as glioma.

Future investigation may yield a better understanding of the causes and potential treatments of brain tumours in dogs and humans, researchers say.

Gliomas are very severe human brain tumours that are often incurable.
The disease can also occur in dogs, and some breeds, such as the boxer and bulldog, have an increased risk.

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NEW CANINE LYMPHOMA CLINICAL TRIAL

This is a randomized trial for dogs with confirmed B-cell LSA.

Merial's B-Cell Lymphoma Vaccine, DNA, is currently undergoing clinical trials to assess its ability to prolong the post-chemotherapeutic remission time in dogs with B-cell lymphoma. The vaccine uses the same treatment concept (called xenogenic) as used in the melanoma vaccine, now the standard of care for dogs with malignant melanoma. The vaccine is designed to help stimulate the immune system to recognize and eliminate malignant B cells. The vaccine has conditional approval via the USDA and thus is deemed safe with a reasonable expectation of efficacy. Preliminary outcome data has been favorable.

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Have a safe and fun Memorial Day weekend!