MethylGenetic Nutrition Analysis Newsletter Issue # 2


I am pleased to announce that we have hired, Callie Zerby, to be a full-time researcher on genetics and to improve and maintain the reports given by the software.

Callie received her Bachelor of Science in Chemistry from Wilkes University in 2014.

She is excited to be on this project, and you will find the software to continue to improve. Recent additions have been the Oxytocin genes, the Urea Cycle genes and the DNA repair genes.

Some of you have noticed that there were some changes in how the risk alleles were being reported. If you look at various sites on the web, many of them have differing values for the risk. This is an emerging field and we have to come to expect inconsistent findings as more information is obtained and researched, however, we will keep updating and we are sorry if this has caused any confusion. I can assure you there were no "mistakes" on our part, we were depending upon what was considered credible information.

At first we thought using population data would be a good source of information to keep everything consistent. Recently, all the SNPs were changed to match the major and minor alleles from the 1000 Genomes project.

However, upon further investigation we found that even though a majority of a population has a specific allele that does not mean that this allele is not the risk. After doing even more research, we found the HaploReg database run by the Broad Institute and MIT.

When searching for SNPs in this database, the database will show the reference and alternate allele. Sometimes the reference and alternate alleles will match the population data from the 1000 Genomes project, and other times it does not. Having a risk allele does not always have a negative effect of some ones health. Consequently, the information for the VDR Taq, PON1, SHBG and MAO have been changed to match the information provided from the HaploReg database. 

Again, we apologize if this was confusing, but I can assure you, we are working diligently to be on the very cutting edge of information in this growing field. Please see the table below to see which genes were changed.

Everything we hear is that genetics is medicine of the 21st Century, and we will do our best to make sure MGNA is on that cutting edge.

These new risk alleles will be in place by 5:00 pm, Tuesday, February 16. You will need to update to V116 to have the new information.

Going forward, if any changes need to be implemented, we will inform you prior to making the changes in order to avoid confusion.

Again, look for more updates and more SNPs that will be coming on a regular basis.

Be sure to check here for the messages about updates:
Thanks for your use of the MGNA software. Our goal is to always be on the cutting edge!

Gene
Position
Risk
ACAT-2
9347340
C
ACE Del 16
4343
A
ACSL1
12503643
T
ACSL1
6552828
G
AGT M235T/C4072T
699
C
AHCY-01
819147
T
AHCY-19
819171
T
CBS A13637G
2851391
C
CYP1A2 C164A
762551
A
CYP1B1 L432V
1056836
G
CYP2E1*1B G9896C
2070676
C
CYP3A4*1B
2740574
T
FOLR2 (fetal)
651933
A
GAD1
12185692
A
GAD1
2241165
T
GIF (TCN3)
558660
G
HNMT
1455164
A
HNMT
1455167
G
HNMT
993891
G
LOC553103
2631367
G
MAO A (R297R)
6323
T
MAT1
12242871
A
MAT1
2993763
A
MAT1
4934028
A
MAT1
756208
G
MTHFD1 C105T
1076991
C
NAT2 K268R
1208
A
NOS2
2274894
G
NOS2
2248814
G
NOS3
1800779
A
NOS3 D298E
1800783
T
PEMT
4244593
G
PON1
3917550
A
PON1
854566
G
PON1
2049649
G
PON1
854569
G
PON1
854555
C
PON1 Q192R
662
C
QDPR rs1031326
1031326
C
SHBG
1799941
A
SLC16A1
7169
A
SLC22A5
274549
C
SLC22A5
274550
T
SLC22A5
274551
C
TCN1
526934
A
TCN2 C766G
1801198
C
VDR Fok (blood sugar)
2228570
G
VDR Taq (methy group)
731236
G


In health,


Bob Miller, CTN

MethylGenetic Nutrition AnalysisTM  Instructional Video Link:

WEBINARS & WEBINAR REGISTRATION LINK

To watch previous webinars hosted by Bob Miller, CTN,which cover an overview of genetic SNPs, case studies, software features, a financial outline from using the MethylGenetic Nutrition AnalysisTM, upcoming seminars and much more, please click on the link below:
https://vimeo.com/user20863995/review/121427563/8b634d70bf

To register for upcoming webinars: 
https://attendee.gotowebinar.com/register/7676859820813581058