May 26, 2016 
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NAVBO members receive discounts on registration to IVBM 2016

Travel Awards available for NAVBO members
June 1 Deadline

Vasculata 2016
Uppsala University
University of Pennsylvania
August 15-17
Look inside the IVBM Virtual Conference Bag

Lymphatic Conference
in Chicago, IL
June 8-11, 2017

Vascular Biology 2017
Monterey, CA
October 15-19 
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Vasculata 2016 Deadlines Extended
Abstract Deadline is now July 1
Scholarship Application Deadline is June 27
Don't miss your opportunity to attend a meeting in Philadelphia, where the speakers are prominent European scientists!  Or you can travel to Sweden and see them personally.

This year we are hosting a "hybrid" Vasculata.  The lectures will be held at Uppsala University with a live stream broadcast to the University of Pennsylvania.  Each site will host workshops to further enhance the learning experience.

Philadelphia will also host a Poster Session and is accepting abstracts.  A workshop on Analysis of Mouse Cardiovascular Physiology Using High Frequency Ultrasound will be in Philadelphia and morning workshops will be held in Uppsala.

Scholarships are available
Whether you plan to attend Vasculata in Uppsala or Philadelphia, a limited number of scholarships are available to those with limited resources.  Apply for a scholarship at Deadline is June 27 .
To register, view the program, or submit an abstract go to: 
Other Society News
Seeking Nominations for Meritorious Awards 
Nominate colleagues for the NAVBO Meritorious Awards - the Earl P. Benditt Award, recognizing an individual who has made an outstanding discovery or developed a concept that has been seminal to our understanding of vascular biology or pathology and the Judah Folkman Award in Vascular Biology, which recognizes an individual who has made a significant impact on the field through his/her original research accomplishments.  For more information about the awards and the nominating process, please visit our web site at   

Regular Members - please remember to vote!
Elections close on June 1 at 5:00pm EST.  Only regular members in good standing will be able to cast a ballot.  For information on the candidates, please go to

If you have already cast your vote, Thank you! Your participation in the society's activities is most appreciated.   
Lab of the Month
The Lab of Dr. Elisabetta Dejana
This month we are highlighting the lab of Dr. Elisabetta Dejana of the University of Milan in Italy and Uppsala University in Sweden. Find out more about Dr. Dejana's lab at
View all featured laboratories at
Share Your Lessons Learned
The NAVBO Education Committee has asked some junior faculty to share their experiences during the transition from trainee to first independent post.  We hope that their accounts of challenges confronted, dilemmas dissected, and lessons learned will help smooth your career path.  If you would like to share your own experiences, please send us reflections on your transition to Assistant Professor or whatever form of solo flight you undertook.  What helped you, what held you back, what was the "if only I had known" secret you can share.  Send your piece to

See "Lessons Learned" pieces on our web site - 
Member News
Welcome our newest members:
Thanh Theresa Dinh, Stanford
Hanna Peacock, KU Leuven
Dwight Towler, UT Southwestern Medical Center

If you have news to share with your colleagues, send it to
Product Showcase
Submit your next manuscript to Thrombosis and Haemostasis - International Journal for Vascular Biology and Medicine!

The current average turnaround time from submission to first decision is only 23 days and the Impact Factor 2014 is 4.984.
The following Manuscript categories are accepted for review by the Editorial Board:

Original Articles: Coagulation and Fibrinolysis; Cellular Haemostasis and Platelets; Blood Cells, Inflammation and Infection; Endothelium and Angiogenesis; Cellular Signalling and Proteolysis; New Technologies, Diagnostic Tools and Drugs; Stroke, Systemic or Venous Thromboembolism; and Atherosclerosis and Ischaemic Disease 
Letters to the Editor (incl. Case Reports) 
T&H Images 
Trial Design Papers 
Review Articles (contact Editorial Office before Submission)
Here you can find the instructions and forms for your online submission:

Spotlight on Trainees (from May 12)
AAAS/SciLifeLab Prize for Young Scientists Now Seeking Entries
The American Association for the Advancement of Science, publisher of Science magazine, has partnered with SciLifeLab, a Swedish national center for molecular biosciences, to create the AAAS/SciLifeLab Prize for Young Scientists, in recognition of the dependence of global economic health upon a vibrant research community. Submissions are being accepted until August 1, 2016, for this year's competition, for which doctoral graduates may submit an essay based on their thesis work. Four winners, in different categories, will be selected for this international award. The grand prizewinner will receive $30,000; each of the three category winners will receive $10,000. The grand prize winning essay will be published in Science, and essays from the three category winners will be published online.
 Recent Publications by NAVBO Members

In Vivo Functional Evaluation of Tissue Engineered Vascular Grafts Fabricated Using Human Adipose-Derived Stem Cells from High-Cardiovascular Risk Populations
Tissue Engineering Part A
Many preclinical evaluations of autologous small diameter tissue-engineered vascular grafts (TEVGs) utilize cells from healthy humans or animals. However, these models hold minimal relevance for clinical translation, as the main targeted demographic is patients at high cardiovascular risk such as individuals with diabetes mellitus or the elderly.  Read more

A novel chemo-mechano-biological model of arterial tissue growth and remodelling
Journal of Biomechanics
Arterial growth and remodelling (G&R) is mediated by vascular cells in response to their chemical and mechanical environment. To date, mechanical and biochemical stimuli tend to be modelled separately, however this ignores their complex interplay.  Read more

Heme oxygenase-1-derived bilirubin counteracts HIV protease inhibitor-mediated endothelial cell dysfunction
Free Radical Biology and Medicine
The use of HIV protease inhibitors (PIs) has extended the duration and quality of life for HIV-positive individuals. However there is increasing concern that this antiviral therapy may promote premature cardiovascular disease by impairing endothelial cell (EC) function.  Read more

PHD2 Deficiency in Endothelial Cells and Hematopoietic Cells Induces Obliterative Vascular Remodeling and Severe Pulmonary Arterial Hypertension in Mice and Humans through HIF-2α
Background-Vascular occlusion and complex plexiform lesions are hallmarks of the pathology of severe pulmonary arterial hypertension (PAH) in patients. However, mechanisms of obliterative vascular remodeling remain elusive and hence current therapies have not targeted the fundamental disease modifying mechanisms and result in only modest improvement in morbidity and mortality.  Read more

Elevated Leukocyte Azurophilic Enzymes in Human Diabetic Ketoacidosis Plasma Degrade Cerebrovascular Endothelial Junctional Proteins
Critical Care Medicine
OBJECTIVE: Diabetic ketoacidosis in children is associated with vasogenic cerebral edema, possibly due to the release of destructive polymorphonuclear neutrophil azurophilic enzymes. Our objectives were to measure plasma azurophilic enzyme levels in children with diabetic ketoacidosis, to correlate plasma azurophilic enzyme levels with diabetic ketoacidosis severity, and to determine whether azurophilic enzymes disrupt the blood-brain barrier in vitro.  Read more

Spatiotemporal analysis of RhoA/B/C activation in primary human endothelial cells
Scientific Reports
Endothelial cells line the vasculature and are important for the regulation of blood pressure, vascular permeability, clotting and transendothelial migration of leukocytes and tumor cells. A group of proteins that that control the endothelial barrier function are the RhoGTPases.  Read more

Ligand trap for the activin type IIA receptor protects against vascular disease and renal fibrosis in mice with chronic kidney disease
Kidney International
The causes of cardiovascular mortality associated with chronic kidney disease (CKD) are partly attributed to the CKD-mineral bone disorder (CKD-MBD). The causes of the early CKD-MBD are not well known. Our discovery of Wnt (portmanteau of wingless and int) inhibitors, especially Dickkopf 1, produced during renal repair as participating in the pathogenesis of the vascular and skeletal components of the CKD-MBD implied that additional pathogenic factors are critical.  Read more

Intracellular RIG-I Signaling Regulates TLR4-independent Endothelial Inflammatory Responses to Endotoxin
Journal of Immunology
Sepsis is a systemic inflammatory response to infections associated with organ failure that is the most frequent cause of death in hospitalized patients. Exaggerated endothelial activation, altered blood flow, vascular leakage, and other disturbances synergistically contribute to sepsis-induced organ failure.  Read more

Job Postings
Job Title
Yale University School of Medicine
New Haven, CT
Postdoctoral Positions
University of Massachusetts Medical School
Worcester, MA
University of Illinois at Chicago
Chicago, IL
Clinical Assistant Professor
University of Florida
Gainesville, FL
Calendar of Events
July 17-22 Endothelial Cell Phenotypes in Health and Disease
Aug. 15-18 Vasculata 2016
Sept. 7-10 ISACB - 15th Biennial Meeting
Sept. 26-28 Perspectives in Vascular Biology
Oct. 30 - Nov. 3 19th International Vascular Biology Meeting
Nov. 13-16 American Society for Matrix Biology Biennial Meeting
Industry News (from May 12)
New role for macrophages in repair of brain vascular rupture
Fast repair of cerebrovascular ruptures that cause hemorrhagic stroke and brain microbleeds is vital for an effective therapeutic response. The dynamic cellular events involved in cerebrovascular repair remain unknown. Investigators at Southwest University in Beibei, China, using an experimental cerebrovascular rupture system in zebrafish, report that macrophages arriving at the lesion extend filopodia or lamellipodia to physically adhere to severed endothelial ends. These macrophages generate mechanical traction forces to pull the endothelial ends and facilitate their ligation, thus mediating the repair of the rupture.

Angiopoietin 2 expression in the cornea and its control of corneal neovascularization
British Journal of Ophthalmology
From the abstract: Researchers in Milan, Italy, report results of studies to define proangiogenic angiopoietin 2 (ANG2) expression and function in vascularized corneas. Corneal neovascularization (CNV) was induced in FVB mice by means of intrastromal suture placement. Corneas were whole-mounted, stained for CD31 and LYVE1 and lymphatic/blood vessels quantified. In humans and mice, ANG2 is expressed only in the epithelium, and modestly in the endothelium, of the avascular cornea. In vascularised corneas, ANG2 is expressed in the epithelium, endothelium and stroma. The authors suggest the existence of a mechanism regulating the onset of inflammation (and associated CNV) depending on injury severity.

Biomechanics of vascular mechanosensation and remodeling
Molecular Biology of the Cell

From the abstract: Endothelial cells lining the blood and lymphatic vessels experience fluid shear stress (FSS), a frictional force imposed by flowing blood. The endothelium continually senses the magnitude, pulsatility, and directionality of FSS. Sustained increases or decreases in FSS can induce vessel remodeling to maintain proper perfusion of tissue and pressure/flow relationships. This review, co-authored by NAVBO member Martin Schwartz, describes the mechanisms involved in vascular mechanotransduction mechanisms and their relevance to physiology and disease. 
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Germantown, MD 20874-2211