New Products Released by BioVision: April 2012

May 2, 2012

Greetings,

We are pleased to announce the following new products released in April 2012.

Assay Kits

Product	Catalog No.	Size	Price (USD)	Description
Gamma Glutamyl Transferase (GGT) Activity Colorimetric Assay Kit	K784-100	100 assays	365	The Gamma-Glutamyl Transferase (GGT; EC 2.3.2.2) is an enzyme that transfers gamma-glutamyl functional groups. It is found in many tissues, the most notable one being the liver, and has significance in medicine as a diagnostic marker. BioVision's Gamma-Glutamyl Transferase Assay Kit provides a convenient tool for sensitive detection of the GGT in a variety of samples. The GGT in sample will recognize L-γ-Glutamyl-pNA as a specific substrate leading to proportional color development. The activity of GGT can be easily quantified colorimetrically (λ = 418 nm). This assay detects GGT activity as low as 0.5 mIU.
Gamma Glutamyl Transferase (GGT) Activity Fluorometric Assay Kit	K785-100	100 assays	365	The Gamma-Glutamyl Transferase (GGT; EC 2.3.2.2) is an enzyme that transfers gamma-glutamyl functional groups. It is found in many tissues, the most notable one being the liver, and has significance in medicine as a diagnostic marker. BioVision's Gamma-Glutamyl Transferase Assay Kit provides a convenient tool for sensitive detection of the GGT in a variety of samples. The GGT in sample will recognize L-γ-Glutamyl-AMC as a specific substrate leading to proportional fluorescence development. The activity of GGT can be easily quantified fluorometrically (Ex/Em = 365/460 nm). This assay detects GGT activity as low as 0.02 mIU in sample.
PEP Colorimetric/Fluorometric Assay Kit	K365-100	100 assays	465	Phosphoenolpyruvate (PEP) is an important intermediate in carbohydrate metabolism. Containing a high-energy phosphate bond, PEP is involved in glycolysis and gluco-neogenesis and in the shikimate pathway as well as in carbon fixation in plants. Bacteria utilize PEP in the phosphor-transferase system to acquire sugars from the environment. In the glycolytic pathway, PEP is formed from 2-phosphoglycerate by enolase and generates ATP through the action of pyruvate kinase. BioVision's PEP Assay Kit provides a convenient colorimetric and fluorometric means to measure PEP levels in various samples. In the assay, PEP is converted to ATP and pyruvate. The generated pyruvate is quantified by colorimetric (λmax = 570 nm) or fluorometric methods (Ex/Em = 535/587 nm). The assay is simple, sensitive and reliable. The detection limit is approximately 1 µM PEP in biological samples.

Antibodies & Blocking Peptides

Product	Catalog No.	Size	Price (USD)	Description
Delta Opioid Receptor Antibody (Clone 95M1)	5003-100	100 µg	280	Opioid receptors are a group of G protein coupled receptors which are used by the class of substances known as opioids. The amino-acid sequence of the three opioid receptor subtypes bears ~70% homology and they have ~40% homology with somatostatin receptor SSTR1. The delta opioid receptor (δ-opioid receptor or DOR) has enkephalins as its endogenous ligands. It is distributed in various parts of the CNS as well as in some smooth muscles. It is known to mediate analgesia. These receptors have been shown to interact with beta-2 adrenergic receptors, arrestin beta 1 and GPRASP1. Delta opioid receptor agonists are considered to be potential anti-depressants.
Etk/BMX Antibody	3398-100	100 µg	245	Etk is a member of the Bruton's tyrosine kinase family. Etk is expressed in a variety of hematopoietic, epithelial and endothelial cells. It participates in multiple signal transduction pathways. Phosphorylation of tyrosine 566 by Src kinase is required for activation of Etk in vivo. In endothelial and epithelial cells, Etk is regulated by FAK through phosphorylation at tyrosine 40.
Etk/BMX Blocking Peptide	3398BP-50	50 µg	95	The peptide is used for blocking the antibody activity of Etk/BMX (Cat.# 3398-100).
Human Amyloid Beta 1-17 Antibody (Clone C4D10)	5006-100	100 µg	280	Amyloid Beta (Aβ or Abeta) is a multi-functional peptide of 36-43 amino acids, processed from the Amyloid Precursor Protein (APP). It is most commonly known to be associated with Alzheimer's disease since it is the main component of amyloid plaques found in the brains of the diseased subjects. However, it also plays a role in multiple non-disease activities including protection against metal-induced reactive oxidizing species (ROS), modification of cholesterol transport, and potential activity as a transcription factor. It is secreted by platelets into the blood serum and its levels elevate with age.
Human Amyloid Beta 18-29 Antibody (Clone A10E2)	5007-100	100 µg	280	Amyloid Beta (Aβ or Abeta) is a multi-functional peptide of 36-43 amino acids, processed from the Amyloid Precursor Protein (APP). It is most commonly known to be associated with Alzheimer's disease since it is the main component of amyloid plaques found in the brains of the diseased subjects. However, it also plays a role in multiple non-disease activities including protection against metal-induced reactive oxidizing species (ROS), modification of cholesterol transport, and potential activity as a transcription factor. It is secreted by platelets into the blood serum and its levels elevate with age.
IGF-I Antibody	5121-100	100 µg	235	IGF-I (insulin-like Growth Factor-I) is a polypeptide growth factor that stimulates the proliferation of a wide range of cell types including muscle, bone, and cartilage tissue. Rat IGF-I is a 7.69 kDa protein.
OTX1 Antibody	3918-100	100 µg	285	This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. A similar protein in mice is required for proper brain and sensory organ development and can cause epilepsy.
PHOX2B Antibody	3919-100	100 µg	285	The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic AMP-response element and serum-response element.

Recombinant Proteins

Product	Catalog No.	Size	Price (USD)	Description
Proteinase K, Recombinant	9210-100 9210-500 9210-1G 9210-10G	100 mg 500 mg 1 g 10 g	65 255 465 4200	A serine protease that displays the ability to digest native proteins, thereby inactivating enzymes such as DNase and RNase without recourse to a denaturation process. It retains its activity in presence of SDS and urea. It is inactivated by diisopropyl fluorophosphates (DFP) and phenyl methane sulfonyl fluoride (PMSF).
Proteinase K 20 mg/ml Solution	9211-5 9211-25	5 ml 25 ml	75 325	A serine protease that displays the ability to digest native proteins, thereby inactivating enzymes such as DNase and RNase without recourse to a denaturation process. It retains its activity in presence of SDS and urea. It is inactivated by diisopropyl fluorophosphates (DFP) and phenyl methane sulfonyl fluoride (PMSF).

Biochemicals

Product	Catalog No.	Size	Price (USD)	Description
BCl-2 Inhibitor GX15-070	2040-5	5 mg	245	Cell-permeable. A small molecule pan-Bcl-2 antagonist that mimics BH3-only proteins by binding to multiple antiapoptotic Bcl-2 members. GX15-070 has been shown to overcome Bcl-2-, Bcl-xl-, Bcl-w-, and Mcl-1-mediated resistance to Bax or Bak. It potently interferes with the direct interaction between Mcl-1 and Bak in intact outer mitochondrial membrane and inhibits the association between Mcl-1 and Bak in intact cells.
CHS-828	2044-5 2044-25	5 mg 25 mg	120 475	A pyridyl cyanoguanidine derivative that displays potent antitumor activity. Also acts as an inhibitor of Nampt/visfatin, NF-kB and IkB kinase. In addition, CHS-828 induces programmed cell death and activates p53.
Erlotinib, Free Base	2048-100 2048-1000	100 mg 1 g	95 295	A free base form of the EGFR inhibitor Erlotinib Hydrochloride (Cat. No.1588-100, 1000).
Neuronal Transdifferentiation Modulators Set I	K872-3	3	175	A convenient set of three small molecule modulators for enhancing neuronal transdifferentiation. The three products are: SB-431542 (Cat. No. 1674-1), LDN193189 (Cat. No. 1995-1) and CHIR99021 (Cat. No. 1677-1).
Neuronal Transdifferentiation Modulators Set II	K873-2	2	145	A convenient set of two small molecule modulators for enhancing neuronal transdifferentiation. The two products are: SB-431542 (Cat. No. 1674-1) and CHIR99021 (Cat. No. 1677-1).
Neuronal Transdifferentiation Modulators Set III	K874-4	4	335	A convenient set of four small molecule modulators for enhancing neuronal transdifferentiation. The four products are: SB-431542 (Cat. No. 1674-1), LDN193189 (Cat. No. 1995-1), CHIR99021 (Cat. No. 1677-1) and Noggin, human recombinant (Cat. No. 4675-20)
Neuronal Transdifferentiation Modulators Set IV	K875-3	3	425	A convenient set of four small molecule modulators for enhancing neuronal transdifferentiation. The four products are: SB-431542 (Cat. No. 1674-1), LDN193189 (Cat. No. 1995-1), CHIR99021 (Cat. No. 1677-1) and Noggin, human recombinant (Cat. No. 4675-50)
RO-3306	2039-1 2039-5	1 mg 5 mg	65 255	Cell-permeable. A selective CDK 1 inhibitor (Cdk1/B1 and Cdk1/A). Arrests cell cycle at G1, S, and G2/M and induces apoptosis in embryonic stem cells. Actively enhances downstream p53 signaling to promote apoptosis in AML cell lines, and suppresses phosphorylation of p53 at Ser315 and procaspase-8 at Ser387.
RO 20-1724	2042-50 2042-250	50 mg 250 mg	65 245	Cell-permeable. A potent,selective, cAMP-specific phosphodiesterase inhibitor (PDE IV, IC₅₀ = 2 µM). Inhibits superoxide generation and platelet aggregation stimulated by arachidonic acid. Also inhibits fMLP-induced neutrophil adhesion to vascular endothelial cells.
Skyrin, Talaromyces sp.	2043-1	1 mg	225	A non-peptidic anti-diabetic agent and a receptor-selective glucagon antagonist. Also acts as an antioxidant, free radical and singlet oxygen species scavenger.
Sphingosine Kinase Inhibitor, SKI-I	2046-5 2046-25	5 mg 25 mg	95 375	Cell-permeable. SKI-I is a non-lipid pan-sphingosine kinase (SK) inhibitor that inhibits both SK1 and SK2 to suppress the production of pro-mitogenic sphingosine 1-phosphate (S1P) and promote cell death. Also induces autophagy.
Sphingosine Kinase Inhibitor, SKI-II	2047-5 2047-25	5 mg 25 mg	95 375	Cell-permeable. SKI-II is selective a non-lipid sphingosine kinase (SK) inhibitor. It displays non-ATP-competitive inhibition of human recombinant GST-SK 1 with an IC₅₀ value of 0.5 µM, with no inhibition against ERK2, PI3-kinase, or PKCα at concentrations up to 60 µM.
WST-8	2049-10 2049-30	10 mg 30 mg	95 255	A next generation tetrazolium reagent that serves as a sensitive chromogenic indicator for NADH. It is reduced by NADH at neutral pHs in the presence of 1-methoxy PMS to produce the corresponding formazan dye that absorbs at 460 nM. Useful in cell proliferation assays as a cell viability indicator.
WY-14643	2041-10 2041-50	10 mg 50 mg	65 245	Cell-permeable. A selective PPARα agonist (EC₅₀ values are 0.63, 32 and > 100 μM at PPARα, PPARγ and PPARδ respectively.
YM201636	2045-1 2045-5	1 mg 5 mg	65 255	Cell-permeable. YM-201636 is a selective inhibitor of phosphoinositide kinase (PIK) PIKfyve (IC₅₀ = 33 nM). It inhibits p110α at higher concentration (IC₅₀ = 3 µM). It reversibly impairs endosomal trafficking in NIH3T3 cells, mimicking the effect produced by depleting PIKfyve with siRNA.YM-201636 also blocks retroviral exit by budding from cells.

Thanks for your interest in our products and stay tuned for many new exciting products that are coming soon!

Sincerely,

BioVision, Inc.
Marketing Department