October 2016 Newsletter

news 
News
Congratulations to the Lerner Research Chair of the Cleveland Clinic Health System, CTSC Associate-PI, Serpil C. Erzurum, MD!

Congratulations to our Associate-PI, Serpil C. Erzurum, MD, on her promotion to The Lerner Research Chair of the Cleveland Clinic Health System. Dr. Erzurum joined the Cleveland Clinic in 1993. A practicing pulmonologist, Dr. Erzurum's scientific accomplishments have been broad and far-reaching in respiratory medicine. Using clinical and translational methods to uncover molecular pathogenesis of human lung diseases, her contributions in pulmonary research have led to diagnostic and therapeutic advances in lung diseases. We wish Dr. Erzurum well as she continues her role as CTSC Associate-PI and starts her journey as Chair of Research at the Cleveland Clinic.


Congratulations to the July 2016 CTSC Core Utilization Pilot  Award Recipients!




Katherine Dobbs, MD  
University Hospitals Case Medical Center
"Epigenetic Reprogramming of Monocytes During Malaria Infection in Children"



Christopher King, MD, PhD
Case Western Reserve University School of Medicine
"MicroRNAs as Biomarkers and Regulators of Immune Response in Human Cord Blood"



Steven Shein, MD
University Hospitals Case Medical Center
"Ipatropium in Pediatric Status Asthmaticus - A Secondary Analysis of the OPAR Database"



Jianjun Zhao, MD, PhD
Cleveland Clinic Lerner College of Medicine 
"Identification of Secreted Exosomes as Biomarker for Multiple Myeloma Progression"

Funding Opportunities - MILSTEIN MEDICAL ASIAN AMERICAN Partnership Foundation
Researchers, please note: For the following funding opportunities, collaboration must be with a colleague or school in China.

Grants are to be awarded in Geriatrics under the Irma and Paul Milstein Program for Senior Health, Dermatology, Hematology, Reproductive Medicine, and Translational Medicine/collaborations with China colleagues.

The MMAAP Foundation invites the submission of applications in the areas of Geriatrics, Dermatology, Hematology, Reproductive Medicine, and Translational Medicine which will be referred to independent expert panels in the respective fields both in China and in the US. All grant applications will be submitted in China to the Foundation's website ( www.mmaapf.org ). The Chinese expert panels will review the applications first and make recommendations for further evaluation by the US expert panels for final selection. In the case of Dermatology and Reproductive Medicine, US expert panels are the Medical Advisory Committee of American Skin Association and Jones Foundation, respectively. Awards will be made to outstanding not-for-profit, medical and scientific institutions in the United States and China to support research and training. The MMAAP Foundation will provide the sole support for these initiatives.

One Fellowship and one Project award will be provided in each of the above five areas except for geriatrics.

The mission of the Milstein Medical Asian American Partnership Foundation (MMAAP Foundation) is to improve world health by developing mutually beneficial partnerships between the United States and China, as well as greater Asia. Working with some of the premier health organizations in the world, the MMAAP Foundation will bring together and fund exchanges among the best research, medical talent, and institutions in the regions.

Please find grant application guidelines with further details at  www.mmaapf.org .

For more information on the programs view Dermatology PDF 1 and PDF 2, Geriatrics 
PDF 1 and  PDF 2 , Hematology  PDF 1 and  PDF 2 , Translational Medicine  PDF 1 and 
PDF 2

Request for Information: NIEHS Translational Research Framwork
Deadline: October 30, 2016

The Division of Extramural Research and Training at the National Institute of Environmental Health Sciences (NIEHS) recognizes the need for a translational research framework that 1) represents the full spectrum of the research our grantees conduct, 2) captures all the nuances of environmental health research, especially at the more "basic" end of the research spectrum, 3) provides a common language for describing translational research in the environmental health sciences, and 4) promotes the telling of translational research stories in progress reports and other research documents.

The Division drafted a translational research framework for environmental health sciences, and a series of examples illustrating potential uses of the framework, which are available at: http://partners.niehs.nih.gov/trf. The draft builds upon several published translational research frameworks as well as specific case studies developed from a range of projects supported by the Division.

This Request for Information (RFI) seeks input on the draft framework from environmental health researchers from both the intramural and extramural perspectives, community partners who work on environmental health science projects, as well as health care workers, clinicians, regulators, and policy makers. We are also seeking input from those who have experience with creating translational research frameworks and analyzing research using these frameworks, including individuals involved with, for example, the National Institute of Health (NIH) Clinical Translation Science Awards (CTSA).
Feedback received will be used to further inform and finalize the framework.


HHS Takes Steps to Provide More Information About Clinical Trials to the Public

The U.S. Department of Health and Human Services announces the final rule that is being put into place concerning submitting information to ClinicalTrials.gov. The rule outlines the specific requirements for registering trials and submitting summary results information to the website. In addition to the rule, the National Institute of Health has announced a complimentary policy which effects all clinical trials funded by the NIH, including those that do not fall under the Department of Health and Human Services' rule. The goal of these procedural changes is to increase the accessibility of clinical trials information for patients, doctors, and the public. 

To read more go to the article release on the NIH website, or watch the video below.



Cleveland VA Featured in International Web-based Technology Magazine, Engadget 

Cybathlon team
The Cleveland-based team from the Advanced Platform Technology (APT) Center at the Louis Stokes Cleveland Veterans Affairs Medical Center (LSCVAMC) and Case Western Reserve University (CWRU) was featured in the magazine, Engadget, and on Cleveland.com for their research which assists individuals with spinal cord injuries to stand up and take a few small steps. The technology was modified to work with a recumbent bike giving them the opportunity to participate in the first ever Cybathlon ("Cyborg Olympics") in Zurich, Switzerland. The Cybathlon is an international competition comprised of six disciplines with the focus of disabled athletes using assistive technology to compete.

In addition to the article, the team was also featured in a 5-part video series called Superhumans on Engadget. 


Cleveland NIH StrokeNet: Clinical Research and Training Award
Application Deadline: December 1, 2016

The Cleveland StrokeNet is accepting applicants now for the 2017-2018 Clinical Research and Training Award supported by the NIH StrokeNet program (NIHStrokeNet.org).

Up to $55,000 total will be awarded for a period of one year.

The investigator must spend 50% of their effort on research during the award period.
Application Deadline: December 1, 2016


NOTICE:New NHLBI Policy: Investigator-Initiated Single-Site Clinical Trials (Phase II and beyond)
This Notice informs potential applicants of changes in NHLBI policies and procedures for the acceptance, review, and funding of investigator-initiated single-site clinical trials. The purpose of this Notice is to announce that any application requesting funding for a Phase II and beyond clinical trial (see the  NIH definition of a clinical trial) using a single site must be submitted to  PAR-16-405 Single-Site Investigator-Initiated Clinical Trials (R61/R33) or its reissue. For the purposes of this FOA, the definition of a single site clinical trial is one in which the protocol is implemented by one investigational site that conducts and coordinates the protocol. While a single site clinical trial may enroll participants from multiple locations/clinics within a geographic area, those participants will receive an intervention or undergo outcome assessments under the direction and oversight of one research team at one investigational site. 

For due dates on or after January 8, 2017, NHLBI will no longer accept applications for single-site clinical trials if submitted through the Research Project Grant (Parent R01) FOA  PA-16-160 or its reissue.


Have you read this month's CWRUSOM360?

Check out the September edition of CWRUMED360! This newsletter features an article on the CTSC's PI Mike Constan, MD, where he explains why he does Cystic Fibrosis research, why he chose to take the position as PI of the CTSC, and what his new role on the First Year Cleveland Project. Read the article here


Researchers: Pure Experts can connect you with other researchers!

In an effort to promote multi-disciplinary clinical and translational research, the Clinical and
Translational Science Collaborative of Cleveland (CTSC) is pleased to introduce Pure Experts, a directory of researcher expertise that enables collaboration among researchers.

This expertise portal is a key component of the CTSC's mission to catalyze new knowledge  and discovery to enhance and improve patient care and promote better health in the  community.

Pure allows you to:
  • Capture and structure your research data centrally
  • Identify funding, expertise and collaborative partners
  • Report on the reliable, validated data
  • Analyze the progress of your teams and departments
  • Showcase your accomplishments
For more information about Pure, please see the Pure Brochure.
 

How can we help you with your research needs?
Request CTSC Resources with our NEW service request form

Are you looking to...
  • Locate potential collaborators
  • Match your research needs to core services
  • Receive guidance on regulatory requirements
  • Match data collection tools to study needs
  • Receive guidance on study design and data collection instruments
Submit a request to the CTSC using our new service request form to be one step closer to meeting your research needs!
 
PRCHN News  from NCATS
HHS take steps to provide more information about the clinical trials to the public
On Sept. 16, 2016, in an effort to make information about clinical trials widely available to the public, the U.S. Department of Health and Human Services (HHS) issued a final rule specifying requirements for registering and reporting summary results information to ClinicalTrials.gov.  The new rule expands the legal requirements for submitting registration and results information for certain clinical trials involving U.S. Food and Drug Administration (FDA)-regulated drug, biological and device products to ClinicalTrials.gov. At the same time, the National Institutes of Health issued a complementary policy for registering and submitting summary results information to ClinicalTrials.gov for all NIH-funded clinical trials, including those not subject to the final rule. These actions are important steps to honor our commitments to clinical trial participants to share the knowledge gained from their participation in order to achieve the greatest benefit to human health.  
Since many of you are likely to be affected by these changes, we encourage you to read the NIH news release along with related materials to learn more about these important developments.
 

NCATS Advisory Council
DCI Director Update

Dr. Petra Kaufmann gave an update on the Clinical and Translational Science Award (CTSA) Program at the Sept. 15, 2016, joint meeting of the NCATS Advisory Council and the Cures Acceleration Network (CAN) Review Board. A recorded videocast of her presentation can be viewed here (Dr. Kaufmann's presentation starts at 1:41:40).

PRCHN News  from the PRCHN 
PRCHN Seminars

Mark your calendars for these upcoming PRCHN Seminars.


10/12/16-
FM Tracks: Development and Implementation of a System to Track Farmers' Market Use
Darcy Freedman, PhD, and FM Tracks team

11/9/16-
Tobacco Use at Community Health Centers: Burden and Opportunities for Evidence-Based Cessation Strategies
Susan Flocke, PhD

You can find more information on these seminars and other PRCHN programs   here.
For more news from PRCHN check out their e-newsletter!

PRCHN's First Dissemination Day Focuses Discussion on Food Access in Cleveland

The PRCHN had it's first Research Dissemination Day on September 14th titled "Food Access and Security Among Cleveland Residents" which was co-hosted by its Network of Community Advisors (NOCA). After a work welcome from NOCA co-chairs Brandon King and Lena Grafton, the first topic presented was an overview of the diet quality of Cleveland's youth and adult populations. The presentation used data from the IMPACT and foodNEST studies which together provide a comprehensive view of the actual diet quality of Cleveland residents. Following this the PRCHN's audit of food retail was presented with the Healthy Retail Initiative which works to provide healthy food options to the areas that the audit found were lacking accessible healthy options. The implementation of the Food Policy Coalition's goal of increasing farmer's markets in Cleveland was explained and then the preliminary results of the implementation of FreshLink were discussed. The last speech was about the Produce Prescription Program, which encourages eating behavior change as a supplement to medications for hypertension patients. The panel then took the stage and facilitated a discussion among the 150+ attendees about these issues showing that food access is everyone's issue.

Read the full article here.

CDC Site Visit Includes Healthy Retail Tour

The PRCHN welcomed visitors from the Centers for Disease Control and Prevention(CDC) September 14-16. Donna Henry, Team Lead-Program Operations Team, Prevention Research Centers Program; Connie Bish, PhD, MPH, Team Lead-Evaluation and Translation Team, Applied Research and Translation Branch;  and Suzanne Hurley Zarus, Dissemination Team Lead-Applied Research and Translation Branch, joined us at Dissemination Day. They also spent time talking with PRCHN faculty and staff and learning about the depth and breadth of the high-quality community-engaged research taking place in the Center. One of the many highlights of the visit was a tour of our community with stops at Burten Bell Carr's CornUcopia for lunch, the Coit Road Farmers' Market, and Hayden Foods Plus in East Cleveland, one of the stores working with the  Healthy Retail Initiative to increase access to healthy, fresh food in low-resource neighborhoods.

Second Annual HIP-Cuyahoga Community Day

For the second year in a row,  Health Improvement Partnership-Cuyahoga (HIP-Cuyahoga)  hosted a city-wide community day. At this year's event, participants heard from the Community Health Ambassadors, who have been working with the PRCHN and our  REACH  partners to improve health outcomes in their communities. Zumba, a knitting circle, a drum circle, raffles, games, and a resource fair with 30 health and community service organizations were just some of the activities. In addition, Community Day attendees had visits from the Cleveland Metroparks Nature Tracks bus, a Cleveland fire truck and Cleveland Fire Smoke House, plus the 93.1 WZAK promotions team and prize wheel. This event provided a networking opportunity for grass roots community groups, organizations and decision makers to come together to align forces.

For more information and pictures from the event visit the PRCHN website.

Urbanhealth News from the Urban Health Initiative
 
Conquering the Digital Divide

As you know, we have been
 long concerned about the potential for the digital divide toexacerbate health disparities (see  story in July 2016 CTSC newsletter).  Thanks to  efforts of our community and national partners, local low-income households should now be able to obtain home internet service for $5 or $10/month, a promise made by AT&T to federal regulators that was not being honored.  See this  recent blog piece for more details.  Why does this matter? 
 
More than 50,000 Cleveland households have neither mobile nor home internet access; an additional 17,000 Cleveland households have only mobile access to broadband.  Thus, 41% of all Cleveland households have limited or no internet access whatsoever and these households disproportionately include under-represented minorities.  The September 29 th Institute for Computational Biology symposium,  Precision Medicine for All: Ensuring Diversity in Participants and Practice underscored the scientific and ethical imperative of ensuring diverse representation in clinical and translational research. Yet clinical research increasingly relies on internet-based recruitment and data collection.   Contact us to learn more about our efforts to ensure that all local households have the access, skills and equipment needed to use the internet-and thus be able to participate in clinical research. 
 


Health Data Matters and The Cleveland Medical Hackathon

Gearing up for the  2016 Cleveland Medical Hackathon, we continue to acquire and make available new data sets through our  Health Data Matters websites.  Visitors to  hdm.livestories.com will have access to considerable data at the census tract level that enables examination of the linkages between social and environmental factors and health.  This effort reflects a robust partnership among the Urban Health Initiative, the Master of Public Health program and the Center on Urban Poverty and Community Development at the Mandel School of Applied Social Sciences.  Building on the success of the 2015 Hackathon, this year's event, Oct. 22-23, will feature some very exciting resources and prizes to support efforts of participants to create innovative solutions to problems in health care and community health.  A few spaces are still available- apply soon to ensure you can participate in the Hackathon.  Among the efforts we have underway to sustain innovations developed at the Hackathon is a new partnership with
 
With  Cleveland Codes, the Tri-C Software Developers Academy.  Participants selected for this highly competitive, tuition-free 16 week program are helping to fully build out and deploy  NEO+Natal, the 2 nd prize winner from the 2015 Hackathon.  NEO+Natal is intended to support health professionals making home visits to high risk and vulnerable pregnant women. 
 
Finally, UHI Director Amy Sheon will be giving a talk on Data Security Concerns with use of Consumer Health Technology at the 2016 Information Security Summit on October 26 th at the Global Center. For more info about the summit:   https://www.informationsecuritysummit.org/security-summit-week-2016/.

Research Research Highlights
Anant Madabhushi and Team Awarded Three New Patents 


The project to create a suite of algorithms for computer-based extraction of histological biomarkers started when preliminary research was funded by a CTSC Annual Pilot Award in 2007. The data found using the award funds set the stage for application and approval to receive slides and cases from a multi-site randomized clinical trial (ECOG 2197). Having the multi-site data allowed for the variation of color distribution and feature variance between sites to be calibrated. Since then, researchsupport from many groups has enabled the group to continue their research.

Now, almost 10 years later, the team was issued three patents in digital pathology and precision medicine. The first patent is for a method for predicting prostate cancer progression using tumor cell morphology and benign region graph features. The second patent is for an apparatus used to detect mitosis in breast cancer pathology images using handcrafted and convultional neural network features. The last patent describes objectively predicting disease aggressiveness using SpACCI graphs. The numbers, titles, and inventors of the patents are as follows: 
  • U.S. patent 9,424,460: "Tumor plus adjacent benign signature (TABS) for quantitative histomorphometry" Co-inventors include George Lee and Sahirzeeshan Ali.
  • U.S. patent 9,430,829: "Automatic Detection Of Mitosis Using Handcrafted And Convolutional Neural Network Features" Co-inventors include Haibo Wang and Angel Cruz Roa.
  • U.S. patent 9,430,830: "Spatially aware Cell Cluster (SpACCl) Graphs for
    Quantitative Histomorphometry"  The co-inventor is Sahirzeeshan Ali.  
Read more about their research in the daily, and in past articles covering two previous patents they were awarded and their use of NIH grant funds.

Jayme Knutson, PhD Tests Effectiveness of a New Brand of Functional Electrical Stimulation 

Jayme Knutson, PhD is a former KL2 scholar whose focus is in biomedical engineering. He is an expert in the development and clinical testing of functional electrical stimulation (FES) applications for restoring motor function after central nervous system injury. The focus of Dr. Knutson's current research is hand movement in stroke patients of which 75% lose arm and/or hand motion after stroke, and about two-thirds  of those patients retain this loss for more than 6 months past their stroke.

Dr. Knutson and colleagues have developed a new type of FES therapy called contralaterally controlled functional electrical stimulation (CCFES). In this therapy, patients wear a glove on their good hand which is connected to a device which stimulates the affected hand. By training the affected hand in this way, they hope to exercise the functions of the brain which have been damaged by the stroke. After 12 weeks, the research team conducts a test without the glove to see how much improvement the electrical stimulation therapy provided.

To learn more about Dr. Knutson's research watch this short video:


Events Events
FDA Guidance Core Lecture Series

Sessions  are held in School of Medicine  T501 from 9-10 am.

10/4/16     Dietary Supplements and Vitamans: When is FDA Regulation Necessary?
10/11/16   Emergency Use and Expanded Action IND's: Compare and Contrast Session
10/18/16   Closing and/or Transferring an IND
10/28/16*  How do you know when an IND application is required? (*in LKSD 1400)
11/3/16*   Maintaining your IND and Investigator Brochure with the FDA (*in LKSD 1400)



Seminar in Multidisciplinary Clinical and Translational Research
WRB 6136 - 12-1pm

10/10/2016 - "Image Computing and Precision Medicine"
Anant Madabhushi, PhD, F. Alex Nason Professor II and Director, Center for Computational Imaging and Personalized Diagnotics, Department of Biomedical Engineering, CWRU

11/14/2016 - "Reducing Racial/Ethnic Disparities in Smoking Cessation"
Monica Webb Hooper, PhD, Director, Office of Cancer Disparities Research, Case Comprehensive Cancer Center, Professor of Oncology, CWRU/SOM

12/12/2016 - "Genetic Risk Scores and Prostate Cancer"
Fredrick Schumacher, PhD, MPH, Associate Professor, Epidemiology and Biostatics, CWRU

For more information contact Angela Bowling at axb710@case.edu.

Data Management  Education Series

Sessions  are held in Sears Tower  T501 on Tuesdays from 9-10 am with the exception of 12/05 and 12/12 which will be held Mondays from 10-11 am.

10/25/16     Basic 1: It's a System!
11/01/16     Basic 2: Research Plan
11/08/16     Basic 3: Building a Data Management Plan
11/15/16     Basic 4: Data Entry and Quality Control (including CRF design)
11/22/16     Advanced 1: The Regulations: HIPAA For Research
11/29/16     Advanced 2: The Regulations: 21 CFR Part 11
12/05/16*   Advanced 3: Data Safety Monitoring Board
12/12/16*   Advanced 4: Study Infrastructure Template

For registration visit: 

Research @ CWRU: A boot camp for investigators
Multiple Dates

For all university faculty:
Tuesday, October 11 ~ Adelbert Hall, Toepfer Room ~ 12:00 pm - 1:30 pm
Friday, November 4 ~ Adelbert Hall, Toepfer Room ~ 10:00 am - 11:30 am

For School of Medicine faculty:
Thursday, October 13 ~ Sears Tower, Room T503 ~ 11:30 am - 1:00 pm
Tuesday, November 1 ~ Wolstein Research Building, Room 2505 ~ 12:00 pm - 1:30 pm

The Office of Research Administration welcomes all new faculty to attend this 90-minute orientation designed to help navigate the university's research grant and regulatory compliance processes and policies. Research Administration staff members will share the university's internal procedures and attendees will receive a binder of helpful information to take away from the presentation. There will be plenty of time for questions.

New faculty are specifically invited, but all faculty are welcome to attend.


Diversity in Research
Multiple Dates

Thursday, October 13, 2016
1:00 - 2:30 pm
Wolstein Research Building, Room 1403

Monday, December 12, 2016
1:00 - 2:30 pm
Toepfer Room, Adelbert Hall

4 CREC

Diversity in Research explores the scientific, ethical, and legal bases for the inclusion of diverse participants in research and the recruitment and hiring of diverse research staff. Potential barriers to diversity in the research context are discussed.

This workshop meets the requirements of the CWRU Office of Inclusion, Diversity, and Equal Opportunity (OIDEO) for participation on CWRU search committees.

7th Great Lakes Nuclear Receptor Conference (GLNRC)
October 19-20, 2016

The 7th Great Lakes Nuclear Receptor 
Conference (GLNRC) will be taking place at Case Western Reserve University's Tinkham-Veale University Center. The event consists of an evening session on Wednesday, October 19th and a full day session on Thursday October 20th. It includes keynote speeches by Drs. Lorraine Gudas and Christopher Glass, and five sessions which will cover topics from nuclear receptors in cancer to nuclear receptors and metabolism. 

For more information and registration links visit the GLNRC Website.

Clinical Investigator Training Course
November 7-9, 2016

In this intensive, three-day course clinical investigators will be trained by FDA medical officers and senior scientists--along with other experts--in all aspects of clinical studies: preclinical and clinical science, statistical structure of trials, ethical requirements, and regulatory considerations. In addition, the course will help foster communication between clinical investigators and FDA and enhance investigators' understanding of FDA's role in experimental medicine.


Drug Development Boot Camp from the Harvard University Office of Technology Development
November 16-17, 2016
Boston, MA

This is an intensive course for clinical investigators who would like to gain an understanding of drug development, or improve their understanding of the drug development process.

There is a discounted fee of $2900 to 4 participants who are at least at the post-doctoral level from the CTSC and are working in a translational medicine setting! 

Researchers from other areas are welcome to participate in the Boot Camp with a registration fee of $3200. 

Click here for a Boot Camp flyer and click here for the Drug Development Boot Camp program.

Clinical Research Forum IT Roundtable
November 16-17, 2016
Chicago, Illinois

The Clinical Research Forum considers the integration of information technology (IT) and clinical research a high priority for its members. The IT Roundtable was initiated in 2005 and has continued to be one of the Forum's most engaging initiatives. 

Roundtable meetings provide a venue for academic health center leaders to share experiences and work with vendors to address key IT issues in clinical research such as the interface of clinical services and clinical research data, warehousing, data security, electronic health record platforms, and governance.


Funding Funding Opportunities

Robert Wood Johnson Foundation
Letter of Intent Deadline: October 5, 2016

The Robert Wood Johnson Foundation has announced this solicitation to encourage and support a series of projects aimed at increasing transparency and accountability throughout the research life cycle, with a special emphasis on open access, to increase the speed of the flow of information from funded research to action. RWJF wants to use these grants to help increase their understanding, and the understanding of the research community, about the potential for these approaches to accelerate the discovery process and expand access to research findings.

Up to $1.5 million has been allocated for this work, and the Foundation anticipates making six-eight individual awards for projects to be completed within 12-24 months. It is anticipated that the award will begin March 1, 2017.

Letter of Intent Deadline: October 5, 2016

For more information visit the Robert Wood Johnson website.


BASSER CENTER FOR BRCA - External Research Grant Program Announcement
Letter of Intent Deadline: October 10, 2016
Application Deadline: November 14, 2016

The Basser Center for BRCA at Penn Medicine's Abramson Cancer Center announces the Basser External Research Grant Program, which focuses on projects that have the potential to advance the care of individuals living with BRCA1 and BRCA2 mutations. Research grant applications in basic science, prevention, early detection, or targeted therapeutics and relevant to the study of BRCA1/2 will be considered.  Grants that demonstrate a potential for translation into clinical practice will be prioritized for funding.

Basser Innovation Award: Three $100,000, one-year, high-risk idea projects will be awarded. Six-month progress updates are required. A three-month notice of termination will be given if lack of progress is demonstrated. Final reports are required.

A mandatory letter of intent (LOI) is due by Monday, October 10, 2016.

The deadline for full applications is 5:00 PM (EST) on Monday, November 14, 2016.

Review and Notification: All applications will be reviewed by an External Review Committee and successful applicants will be announced in January of 2017. Funding will have a start date of July 1, 2017.

For more information visit the website.


Limited Submission Opportunities for Pilot Projects in Non-AIDS Defining Cancers

Deadlines:  October 24, 2016 and February 27, 2017

With support from a supplement to its NCI P30 grant, the Case Comprehensive Cancer Center in coordination with the CWRU/UH Center for AIDS Research (CFAR) is providing seed funding for the development of cancer research projects focusing on the interface between aging and HIV infection in Non-AIDS Defining Cancers (NADC). The goal of this RFA is to build collaborative projects in cancer biology, aging, immunology, HIV/AIDS, systems biology/informatics, geriatric oncology, geriatric epidemiology, and/or cancer survivorship that will be competitive for nationally-funded multi-PI awards.

For more information go to cancer.case.edu/members/funding/casecccfunding or contact Megan Kilbane, Assistant Dean of Oncology,  casecccpilots@case.edu.

American Heart Association
Letter of Intent Deadline: November 3, 2016

The American Heart Association is accepting letters of intent for the Collaborative Sciences Award. The required letter of intent (five pages maximum) must describe a proposed new innovative, collaborative approach to research that incorporates a novel grouping of investigators from at least two broad disciplines. The written summary must focus on the collaborative relationship, such that the scientific objectives cannot be achieved without the efforts of at least two co-principal investigators and their respective disciplines. The combination and integration of studies may be inclusive of basic, clinical, population and/or translational research.

AHA will contact the applicants who have been selected to submit a full application. Only invited applicants may submit a full application.

An application must be submitted jointly by at least two co-principal investigators of any independent faculty rank, who each hold an M.D., Ph.D., D.O., D.V.M. or equivalent post-baccalaureate terminal degree. Co-PIs must have received independent funding and be experts in their respective fields, as evidenced by relevant publications. The co-PIs may be from the same institution, or from different institutions, and they must work in different disciplines. For example, a partnership between a clinician and a basic scientist or other collaboration that would not arise otherwise (organically). The applicants should adequately convey the uniqueness of the collaboration for the benefit of the study section

Letter of Intent deadline: November 3, 2016

For more information visit the website.


CDC: Epidemiology of Zika Virus as a Sexually Transmitted Disease
Application Deadline: December 13, 2016

The purpose of this Funding Opportunity Announcement (FOA) is to address critical scientific questions necessary to bolster evidence-based responses to the ZIKA epidemic in the United States and globally. The FOA will explore the duration and infectiousness of Zika virus shedding in semen, vaginal secretions, and other body fluids, determine the risk of sexual transmission in areas both with and without local vector transmission, and evaluate factors that may facilitate sexual transmission including behavioral factors.

Application Deadline: December 13, 2016

For more information visit the Grants.Gov website.


Howard Hughes Medical Institute (HHMI)
Application Deadline: February 15, 2017

The Howard Hughes Medical Institute (HHMI) has announced the Hanna H. Gray Fellows Program. Recognizing the value of individuals from different backgrounds to move science forward, HHMI seeks to increase diversity in the biomedical research community. The Hanna H. Gray Fellows Program will recruit and retain early career scientists who are from groups underrepresented in the life sciences and who have the potential to become leaders in academic research. Through their successful careers, Hanna H. Gray Fellows will inspire the next generation of scientists from America's diverse talent pool. The Institute will select and support up to 15 Fellows in this first competition.

Fellows will receive funding ($80,000) for up to four years of their postdoctoral training and may continue to receive funding ($270,000) for up to four years during their early career years as independent faculty. The program includes opportunities for career development, including mentoring and active involvement in the HHMI scientific community.

Application Deadline: February 15, 2017

For more information visit the HHMI website.


Patient-Centered Outcomes Research Institute - Clinical Strategies for Managing and Reducing Long-Term Opioid Use for Chronic Pain
Notice of Upcoming PCORI Funding Announcement (PFA) - Re-opened

This notice encourages research institutions or consortiums of institutions with expertise in clinical comparative effectiveness research (CER)/patient-centered outcomes research (PCOR), and in clinical and epidemiological research related to chronic opioid treatment, to consider applying for this re-opened PFA. The re-issue of this targeted funding announcement reflects the significant policy importance and the crucial need for evidence regarding the comparative effectiveness of different treatment strategies for patients on long-term opioid therapy with chronic noncancer pain.

The Patient-Centered Outcomes Research Institute (PCORI) seeks to fund randomized clinical trials (RCTs) that compare two or more alternative clinical strategies for reducing/eliminating opioid use while managing pain or strategies used to limit dose escalation. The two priority research questions are:

1. Among patients with chronic noncancer pain on moderate/high-dose long-term opioid therapy, what is the comparative effectiveness of strategies for reducing/eliminating opioid use while managing pain?

2. Among patients with chronic noncancer pain on moderate/low-dose long-term opioid therapy, what are the comparative effectiveness and harms of strategies used to limit dose escalation?

The full funding announcement will be released on October 4, 2016.

For more information visit the PCORI website.

Department of Health and Human Services Funding Opportunities
Multiple Application Deadlines

NIAID Career Transition Award (K22) -  Synopsis 1
 
NIAID Career Transition Award (K22) - Synopsis 2
http://www.grants.gov/web/grants/view-opportunity.html?oppId=264808

Paul B. Beeson Emerging Leaders Career Development Award in Aging (K76)
http://www.grants.gov/web/grants/view-opportunity.html?oppId=288940
 
Core Centers for Clinical Research (CCCR) (P30)
http://www.grants.gov/web/grants/view-opportunity.html?oppId=288938

Special Funding Notices
Multiple Deadlines

BD2K Research Education Curriculum Development: Data Science Overview for Biomedical Scientists (R25)

NIH Big Data to Knowledge (BD2K) Enhancing Diversity in Biomedical Data Science (R25)

Big Data to Knowledge (BD2K) Enhancing the Efficiency and Effectiveness of Digital Curation for Biomedical Big Data (U01)
(RFA-LM-17-001)

Bench Testing Therapeutic/Indication Pairing Strategies (UH2/UH3)

Innovation Corps (I-Corps) at NIH Program for NIH and CDC Phase I Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Grantees (Admin Supp )
(PA-16-414) 

Core Clinical Centers for the Blood and Marrow Transplant Clinical Trials Network (UG1)

Limited Competition: Data Coordinating Center for the Blood and Marrow Transplant Clinical Trials Network (U24)
(RFA-HL-17-019)

Notice of Change in Key Dates for PAR-16-176 "NCI Clinical and Translational Exploratory/Developmental Studies (R21)" 
(NOT-CA-16-065)

Exploratory Clinical Trials and Studies of Natural Products in NCCIH High Priority Research Topics (R61/R33)
(PAR-16-418)

Policy on Funding Opportunity Announcement (FOA) for Clinical Trial 

Policy on Good Clinical Practice Training for NIH Awardees Involved in NIH-funded Clinical Trials

NIH Policy on the Dissemination of NIH-Funded Clinical Trial Information 

Expanding Alcohol-Focused High-Priority Translational Research for HIV/AIDS (UH2/UH3)

Basic and Translational Research on Decision Making in Aging and Alzheimer's Disease (R01)
Basic and Translational Research on Decision Making in Aging and Alzheimer's Disease (R21)
(PAR-16-449) 

NIAMS Clinical Trial Planning Grant (R34)
(PAR-16-446)

NIAMS Clinical Trial Implementation Cooperative Agreement (U01)
(PAR-16-447) 

Department of Defense Funding Opportunities


















 
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