Issue 23 | April 2018
A Message from the Lead Principal Investigator
The Pediatric Trials Network (PTN) will have a significant presence at the Pediatric Academic Societies (PAS) 2018 Meeting May 5-8 in Toronto. This annual event brings together thousands of researchers, academics, and clinical care providers united by a common mission: to improve the health and well-being of children worldwide. We always look forward to this opportunity to share our research and hear leading ideas for helping children lead healthier lives.

Our investigators will be sharing information on a variety of PTN studies involving antibiotic safety, treatment of hospital-acquired and ventilator-associated bacterial pneumonia, infant weight estimation, personal protective equipment, and the development of a data repository to aid in pediatric research.

We hope you can join us at this year’s meeting. As always, thank you—your care and enthusiasm make this essential work possible.



Danny Benjamin, MD, PhD, MPH
PTN at PAS 2018 Meeting

PTN investigators will be presenting their research May 5-8 at the PAS 2018 Meeting in Toronto. See a listing of PTN presentations below or view the online program guide on the PAS website.
Saturday, May 5
1:15 p.m. – Validation and Human Factors Evaluation of a New Device for Infant Weight Estimation
 Dr. Susan Abdel-Rahman, Children’s Mercy Kansas City (Poster)
1:15 p.m. – The Use of PPE During Pediatric Resuscitation: Which Tasks Are Most Affected? The Results of a Survey During a Simulation Trial
 Dr. Aaron Donoghue, Children’s Hospital of Philadelphia (Poster)
Sunday, May 6
11 a.m. – The Impact of Personal Protective Equipment on Performing Critical Procedures for Pediatric Patients in the Pre-Hospital Setting
 Dr. Maybelle Kou, Inova Fairfax Hospital (Platform)
3:45 p.m. – Population Pharmacokinetics of Milrinone in Infants and Children , Dr. Christoph Hornik, Duke University (Platform)

4:45 p.m. – Development of an Electronic Health Record Derived Multicenter Inpatient Pediatric Data Repository
Dr. Christoph Hornik, Duke University (Platform)
5:45 p.m. Population Pharmacokinetics and Safety of Sildenafil in Premature Infants
Dr. Daniel Gonzalez, University of North Carolina at Chapel Hill (Poster)

5:45 p.m. – Hospital-Associated and Ventilator-Acquired Bacterial Pneumonias in Infants and Children
 Dr. Jessica Ericson, Penn State Milton S. Hershey Medical Center (Poster)
Monday, May 7
2 p.m. – Antibiotic Safety and Efficacy in Infants with Complicated Intra-Abdominal Infections (cIAIs)
 Dr. Michael Smith, Duke University (Platform)
5:45 p.m. – Dosing-Safety Relationship for Acyclovir in the Treatment of Neonatal Herpes Simplex Virus Disease
 Dr. Jessica Ericson, Penn State Milton S. Hershey Medical Center (Poster)
5:45 p.m. – Impact of Personal Protective Equipment on Pediatric Cardiopulmonary Resuscitation Performance
 Dr. Aaron Donoghue, Children’s Hospital of Philadelphia (Poster)
5:45 p.m. – Weight Gain and Metabolic Syndrome in Children Exposed to Second-Generation Antipsychotic Medications
Dr. Angela Czaja, Children’s Hospital Colorado (Platform)
Tuesday, May 8
7:30 a.m. – Correlating Pulmonary Hypertension by Echocardiogram with Mortality in Premature Infants
Dr. Rachel Torok, Duke University (Platform)
You're Invited! DCRI Reception at PAS 2018

Please join us on Monday, May 7, from 7-9:30 p.m. for a reception hosted by the Duke Clinical Research Institute at the PAS 2018 Meeting. The reception will be held at the Fairmont Royal York Hotel at 100 Front St. W. in Toronto. If you plan to attend, please RSVP by emailing Debria Morton-Glenn by Friday, April 20.
First Australian sites join PTN

The PTN welcomed its first Australian sites in February. Sydney Children’s Hospitals Network and the Royal Children’s Hospital in Melbourne are now participating in PTN’s Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care (POPS) study. The sites are currently involved in the Paediatric Trials Network Australia (PTNA), a counterpart of PTN that brings together pediatric researchers from across Australia who are committed to improving child health through the facilitation of pediatric clinical trials. Read more on our website.