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Anti-aging news for the two weeks ending March 30, 2016
QualityCounts.com Newsletter of March 30, 2016

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New study shows aged garlic extract can reduce dangerous plaque buildup in arteries - Science Daily, 1/21/16 - "the participants were given either a placebo or a dose of 2,400 milligrams of Aged Garlic Extract every day. A follow-up screening conducted a year after the initial screening found those who had taken Aged Garlic Extract had slowed total plaque accumulation by 80%, reduced soft plaque and demonstrated regression (less plaque on follow-up) for low-attenuation plaque" - See aged garlic extract at Amazon.com.

Garlic could protect against hip osteoarthritis - Science Daily, 12/16/10 - "women who consume a diet high in allium vegetables, such as garlic, onions and leeks, have lower levels of hip osteoarthritis ... a compound called diallyl disulphide limits the amount of cartilage-damaging enzymes when introduced to a human cartilage cell-line in the laboratory ... While we don't yet know if eating garlic will lead to high levels of this component in the joint, these findings may point the way towards future treatments and prevention of hip osteoarthritis"  - See aged garlic extract at Amazon.com.

The effect of aged garlic extract on blood pressure and other cardiovascular risk factors in uncontrolled hypertensives: the AGE at Heart trial - Integr Blood Press Control. 2016 Jan 27;9:9-21 - "a double-blind randomized placebo-controlled trial of 12 weeks investigating the effect of daily intake of aged garlic extract (1.2 g containing 1.2 mg S-allylcysteine) or placebo on blood pressure ... Mean blood pressure was significantly reduced by 5.0±2.1 mmHg (P=0.016) systolic, and in responders by 11.5±1.9 mmHg systolic and 6.3±1.1 mmHg diastolic compared to placebo ... Aged garlic extract was highly tolerable with a high safety profile as a stand-alone or adjunctive antihypertensive treatment" - [Nutra USA] - See aged garlic extract at Amazon.com .

Garlic Lowers Blood Pressure in Hypertensive Individuals, Regulates Serum Cholesterol, and Stimulates Immunity: An Updated Meta-analysis and Review - J Nutr. 2016 Jan 13 - "Our updated meta-analysis on the effect of garlic on blood pressure, which included 20 trials with 970 participants, showed a mean ± SE decrease in systolic blood pressure (SBP) of 5.1 ± 2.2 mm Hg (P < 0.001) and a mean ± SE decrease in diastolic blood pressure (DBP) of 2.5 ± 1.6 mm Hg (P < 0.002) compared with placebo. Subgroup analysis of trials in hypertensive subjects (SBP/DBP ≥140/90 mm Hg) at baseline revealed a larger significant reduction in SBP of 8.7 ± 2.2 mm Hg (P < 0.001; n = 10) and in DBP of 6.1 ± 1.3 mm Hg (P < 0.001; n = 6). A previously published meta-analysis on the effect of garlic on blood lipids, which included 39 primary RCTs and 2300 adults treated for a minimum of 2 wk, suggested garlic to be effective in reducing total and LDL cholesterol by 10% if taken for >2 mo by individuals with slightly elevated concentrations [e.g., total cholesterol >200 mg/dL (>5.5 mmol/L)]. Garlic has immunomodulating effects by increasing macrophage activity, natural killer cells, and the production of T and B cells. Clinical trials have shown garlic to significantly reduce the number, duration, and severity of upper respiratory infections"  - See aged garlic extract at Amazon.com.

Garlic and Heart Disease - J Nutr. 2016 Jan 13 - "Garlic supplementation reduced blood pressure by 7-16 mm Hg (systolic) and 5-9 mm Hg (diastolic) (4 meta-analyses and 2 original studies). It reduced total cholesterol by 7.4-29.8 mg/dL (8 meta-analyses)" - See aged garlic extract at Amazon.com.

Antioxidant and hypolipidemic potential of aged garlic extract and its constituent, s-allyl cysteine, in rats - Evid Based Complement Alternat Med. 2015;2015:328545 - "Aged garlic extract (AGE) is one of the unique preparations standardized with 100% bioavailable active ingredients found in the bloodstream. The current research was aimed at exploring the role of AGE and its chief active constituent, s-allyl cysteine (SAC) as antioxidant and hypolipidemic agent in rats ... Both AGE and SAC significantly declined elevated levels of triglyceride, total cholesterol, ALP, AST, ALT, malondialdehyde, glutathione peroxidase enzyme activity, total glutathione and oxidised glutathione in serum and inclined superoxide dismutase, catalase, ferric reducing/antioxidant power, and total sulfhydryl values in liver tissue with reduction in thiobarbituric acid reactive species. The protective effects were superior with AGE compared with SAC indicating potential implication of other active constituents apart from SAC in AGE for combating hyperlipidemic stress"  - See aged garlic extract at Amazon.com.

Garlic for hypertension: A systematic review and meta-analysis of randomized controlled trials - Phytomedicine. 2015 Mar 15 - "A total of seven randomized, placebo-controlled trials were identified. Compared with the placebo, this meta-analysis revealed a significant lowering effect of garlic on both systolic BP (WMD: -6.71 mmHg; 95% CI: -12.44 to -0.99; P = 0.02) and diastolic BP (WMD: -4.79 mmHg; 95% CI: -6.60 to -2.99; P < 0.00001). No serious adverse events were reported in any of the trials" - [ Nutra USA - See aged garlic extract at Amazon.com.

Effect of Garlic on Blood Pressure: A Meta-Analysis - J Clin Hypertens (Greenwich). 2015 Jan 5 - "Pooled analysis showed that garlic intake caused a 3.75-mm Hg reduction (95% confidence interval [CI], -5.04 to -2.45, I2 =30.7%; P<.001) in systolic BP and a 3.39-mm Hg reduction (95% CI, -4.14 to -2.65, I2 =67%; P<.001) in diastolic BP compared with controls. Meta-analysis of subgroups showed a significant reduction in systolic BP in hypertensive (-4.4 mm Hg; 95% CI, -7.37 to -1.42, I2 =0.0%; P=.004) but not normotensive patients"  - See aged garlic extract at Amazon.com.

Aged garlic extract reduces blood pressure in hypertensives: a dose-response trial - Eur J Clin Nutr. 2012 Nov 21 - "A total of 79 general practice patients with uncontrolled systolic hypertension participated in a double-blind randomised placebo-controlled dose-response trial of 12 weeks. Participants were allocated to one of three garlic groups with either of one, two or four capsules daily of aged garlic extract (240/480/960 mg containing 0.6/1.2/2.4 mg of S-allylcysteine) or placebo ... Mean systolic blood pressure was significantly reduced by 11.8+/-5.4 mm Hg in the garlic-2-capsule group over 12 weeks compared with placebo (P=0.006), and reached borderline significant reduction in the garlic-4-capsule group at 8 weeks (-7.4+/-4.1 mm Hg, P=0.07). Changes in systolic blood pressure in the garlic-1-capsule group and diastolic blood pressure were not significantly different to placebo. Tolerability, compliance and acceptability were high in all garlic groups (93%) and highest in the groups taking one or two capsules daily" - See aged garlic extract at Amazon.com.

Aged garlic extract lowers blood pressure in patients with treated but uncontrolled hypertension: a randomised controlled trial - Maturitas. 2010 Oct;67(2):144-50 - "In patients with uncontrolled hypertension (SBP ≥ 140 mmHg at baseline), systolic blood pressure was on average 10.2 +/- 4.3 mmHg (p=0.03) lower in the garlic group compared with controls over the 12-week treatment period. Changes in blood pressure between the groups were not significant in patients with SBP<140 mmHg at baseline. Aged garlic extract was generally well tolerated and acceptability of trial treatment was high (92%)"  - See aged garlic extract at Amazon.com.

Time-released garlic powder tablets lower systolic and diastolic blood pressure in men with mild and moderate arterial hypertension - Hypertens Res. 2009 Apr 24 - "hypotensive action of time-released garlic powder tablets (Allicor) was compared with that of regular garlic pills (Kwai) in 84 men with mild or moderate arterial hypertension ... Allicor treatment (600 mg daily) resulted in a reduction of both systolic and diastolic blood pressures by 7.0 mm Hg (95% confidence interval (95% CI): 5.3-8.7) and 3.8 mm Hg (95% CI: 2.7-4.8), respectively. Increasing the Allicor dosage to 2400 mg daily did not provide any additional benefit. Treatment with Kwai resulted in the same decrease in systolic blood pressure (5.4 mm Hg, 95% CI: 1.9-8.8) as that seen with Allicor, but no decrease in diastolic blood pressure was observed with Kwai ... The results of this study show that time-released garlic powder tablets are more effective for the treatment of mild and moderate arterial hypertension than are regular garlic supplements"  - See aged garlic extract at Amazon.com.

Effects of Garlic on Blood Pressure in Patients With and Without Systolic Hypertension: A Meta-Analysis - Ann Pharmacother. 2008 Nov 18 - "Garlic reduced SBP by 16.3 mm Hg (95% CI 6.2 to 26.5) and DBP by 9.3 mmHg (95% CI 5.3 to 13.3) compared with placebo in patients with elevated SBP"  - See aged garlic extract at Amazon.com.

Garlic reduces dementia and heart-disease risk - J Nutr. 2006 Mar;136(3):810S-2S - "compelling evidence supports the beneficial health effects attributed to AGE in helping prevent cardiovascular and cerebrovascular diseases and lowering the risk of dementia and AD"  - See aged garlic extract at Amazon.com.

Nature's Bounty Garlic, 2000mg, Odor-Free, 120 Tablets (Pack of 4)
by Nature's Bounty
Health and Beauty
List Price: $31.56
Our Price: $19.88
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