QualityCounts.com Newsletter of May 18, 2016
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Lithium study helps scientists unlock ageing puzzle - BBC News, 4/7/16 - "fruit flies lived 16% longer than average when given low doses of lithium ... At high doses, lithium reduced their lifespan ... We found low doses not only prolong life but also shield the body from stress and block fat production for flies on a high sugar diet" - See lithium supplements at Amazon.com.

Should We All Take a Bit of Lithium? - NYTimes.com, 9/13/14 - "Lithium is a naturally occurring element, not a molecule like most medications, and it is present in the United States, depending on the geographic area, at concentrations that can range widely, from undetectable to around .170 milligrams per liter. This amount is less than a thousandth of the minimum daily dose given for bipolar disorders and for depression that doesn't respond to antidepressants ... Suicide rates were inversely correlated with the lithium content in the local water supply ... Lithium is, by far, the most proven drug to keep neurons alive, in animals and in humans, consistently and with many replicated studies ... If lithium prevents dementia, then we may have overlooked a very simple means of preventing a major public health problem" - See lithium supplements at Amazon.com.

Lithium profoundly prevents brain damage associated with Parkinson's disease, mouse study suggests - Science Daily, 6/24/11 - "lithium has recently been suggested to be neuroprotective in relation to several neurodegenerative conditions including Alzheimer's disease, Huntington's disease and amyotrophic lateral sclerosis and has been touted for its anti-aging properties in simple animals" - See lithium supplements at Amazon.com.

Controversial call to add lithium to drinking water for mental health - The Daily, 5/22/11 - "It's a provocative prospect that research suggests might reduce rates of suicide, violent crime and hard drug use ... The idea gained widespread traction in 2009, when researchers studying 18 communities in Japan concluded that areas whose water supplies contained higher natural levels of lithium were significantly less vulnerable to suicide ... A subsequent study published this month in the British Journal of Psychiatry, surveying all 99 counties in Austria over five years, replicated the findings and concluded that - conservatively - 4 to 15 percent of the country's geographic variations in suicides was due to lithium content in regional water supplies" - See lithium supplements at Amazon.com.

More Lithium in Drinking Water Equals Lower Suicide Rates - Medscape, 5/12/11 - "The finding, similar to that from 3 different countries on different continents, adds to the evidence that lithium in the drinking water may have beneficial effects for mental health ... examined a nationwide sample of 6460 lithium measurements and then compared suicide rates across 99 districts in Austria ... the overall suicide rate and the suicide mortality ratio were inversely associated with lithium levels in drinking water ... In the 10 most lithium-depleted regions in Austria, the suicide rate was 16 per 100,000, whereas in the 10 most lithium-rich regions; the suicide rate was just 11 per 100,000" - See lithium supplements at Amazon.com.

Fountain of youth from the tap? Environmental lithium uptake promotes longevity, scientists demonstrate in worms - Science Daily, 2/18/11 - "A regular uptake of the trace element lithium can considerably promote longevity ... even a low concentration of lithium leads to an increased life expectancy in humans as well as in a model organism, the roundworm Caenorhabditis elegans ... the Jena scientists analyzed the mortality rate in 18 adjacent Japanese municipalities in relation to the amount of lithium contained in tap water from the respective regions. "We found that the mortality rate was considerably lower in those municipalities with more lithium in the drinking water," Ristow explains the key finding. In a second experiment, the Jena scientists examined exactly this range of concentration in the model organism C. elegans. The result was confirmed: "The average longevity of the worms is higher after they have been treated with lithium at this dosage," ... we know already that a higher uptake of lithium through drinking water is associated with an improvement of psychological well-being and with decreased suicide rates" - See lithium supplements at Amazon.com.

Leukocyte telomere length positively correlates with duration of lithium treatment in bipolar disorder patients - Eur Neuropsychopharmacol. 2016 Apr 12 - "Our data support previous findings showing that long-term lithium treatment associates with longer telomeres in BD, though this effect appeared to be independent from clinical response to the treatment. Moreover, we suggested for the first time that lithium increases the expression of telomerase gene in human neural progenitor cells" - See lithium supplements at Amazon.com.

Does Lithium Prevent Alzheimer's Disease? - Drugs Aging. 2012 Apr 14 - "Lithium salts have a well-established role in the treatment of major affective disorders. More recently, experimental and clinical studies have provided evidence that lithium may also exert neuroprotective effects. In animal and cell culture models, lithium has been shown to increase neuronal viability through a combination of mechanisms that includes the inhibition of apoptosis, regulation of autophagy, increased mitochondrial function, and synthesis of neurotrophic factors. In humans, lithium treatment has been associated with humoral and structural evidence of neuroprotection, such as increased expression of anti-apoptotic genes, inhibition of cellular oxidative stress, synthesis of brain-derived neurotrophic factor (BDNF), cortical thickening, increased grey matter density, and hippocampal enlargement ... A recent placebo-controlled clinical trial in patients with amnestic mild cognitive impairment (MCI) showed that long-term lithium treatment may actually slow the progression of cognitive and functional deficits, and also attenuate Tau hyperphosphorylation in the MCI-AD continuum" - See lithium supplements at Amazon.com.

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