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Welcome To Allergy Season!

Please Stop Scratching! 

If you're a pet parent of an itchy pet, you know how painful it can be to watch them scratch at themselves and chew on their feet to the point of drawing blood at times.

At this point, you would do almost anything to stop the incessant itching and scratching.  Out of desperation, you visit the vet.  Conventional medicine's answer is typically a round of steroids and antibiotics. And to help keep the itching at bay, you most likely will be offered a drug like Apoquel, Atopica, or the latest injectable, Cytopoint.  Immediately, it seems like magic has happened! The itching has subsidized and you let out a big sigh of relief... but wait!  

Many of the same medications that stop the itch are also immuno-suppressive.  As a result, these drugs have been linked to many side effects including vomiting, diarrhea, fever, lethargy and ultimately cancer due to suppressing the bodies life-sustaining Janus Kinase or JAKs.  

JAKs are  important signaling compounds that the body's cells use to communicate with each other. JAKs are key elements in controlling both growth and development. JAKs are vital to sustaining a properly functioning immune system and keeping tumors at bay.  With these very important signaling compounds suppressed, it is no wonder that dogs are the #1 mammal on the planet to be diagnosed with cancer.  In fact, 1 in every 1:65 dogs are being diagnosed with cancer. 

It is so important that you know that there ARE alternatives to these pharmaceuticals that can be so very detrimental to our pets health. Sometimes, it may be as simple as knowing what foods or environmental triggers could be causing the issue.  We can help you with uncovering those.  

But most importantly, we will work to support your pet's immune system by helping balance things out. And if we are not able to help you achieve your goals, we have a team of holistic vets that we can put you in contact with.

At the end of this newsletter, you will find an article written by a holistic vet titled,
"Why I Would Never Give My Dog Apoquel".  Take a minute to read through this to truly understand the downside to this "miracle" drug.  

What is also very interesting is the study that was conducted on Apoquel in particular was only conducted for 7 days and another study was conducted for 30 days.  Most dogs take it far longer than that.  You will find more info on the long-term use and side effects in the article listed below.

Don't forget to read the article at the end of the newlestter from Dr. Deva Khalsa right below Upcoming Events.

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Sale On These TWO Highlighted Brands This Month
Northwest Naturals & My Perfect Pet 


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For more information on Northwest Naturals, click on the following link:


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OUR PHILOSOPHY IS SIMPLE. 

If it's good enough for us, it's good enough for them.

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June Specials

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  • 15% Off All Frozen 6lb Nuggets and 5lb Chubs (Excludes 25lb Bulk Boxes)

My Perfect Pet
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Bravo Homestyle Complete
  • 20% Off All Sizes of Turkey, Beef & Pork

Fromm Kibble 
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Fromm Cans
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Upcoming Events

June 

Saturday, June 2nd 
12 - 1pm

Flea & Tick Control Naturally, Featuring Austin Lilley from Cedercide
Join us to learn more about treating your pet, home and lawn naturally for pests.  Austin Lilley from Cedarcide visited with our staff recently to give us information and usage about all Cedarcide products. We found Austin's training to be so informative that we asked him to come back and speak to our customers. 
If you are interested in joining us, please call 817-656-2275 to sign up. There is no fee for this, however there space is limited.

Saturday, June 9th 
12 - 1pm

The Benefits of Chiropractic Work For Your Pet
We are pleased to host Dr. Jacqueline Botts, D.C. to discuss the benefits of chiropractic therapies for our companion animals. Dr. Botts is a practicing chiropractor for both humans and animals.  We are looking forward to hearing more about how chiropractic work can bring your pets into balance.
If you are interested in joining us, please call 817-656-2275 to sign up . There is no fee for this, however there space is limited.


Saturday, June 16th
10:30 - 5:00 pm

The Pet Fur'tographer
The Pet fur'tographer will  be returning for more super cute themed photos. This time, her themes include July 4th, Baseball, Beach, Red Dog House and Spring Flowers! 
 If you are interested in signing up for an appointment, please call 817-656-2275.
Why I Wouldn't Give My Dog Apoquel
Deva Khalsa, VMD
Dogs Naturally Magazine


Does your dog have allergies? If so, your conventional veterinarian may offer you a popular allergy drug called Apoquel®.

It's touted as "a fast-acting and safe treatment for the control of acute and chronic canine pruritus."

Pruritus means itching ... and if you've got an  itchy dog you're probably desperate to make your dog more comfortable and stop his constant scratching. Apoquel is said to ease your dog's itching in as little as 4 to 24 hours. And dog owners report that it does relieve their dogs' itching.

Sounds like something you might want to try, right?

Well, not so fast ...

Before you expose your dog to the risks associated with this drug, read on. And if your dog is already on Apoquel you'll probably want to stop the drug as soon as you can, once you find out how it demolishes essential parts of your dog's internal disease fighting systems.


Allergies And The Immune System
An allergy is an exaggerated and inappropriate response of the immune system. Conventional medicine loves to suppress symptoms.

Suppressing can be defined as getting rid of the symptoms without helping the body to rid itself of the illness or disease. So if allergies are an improper response of the immune system, what are the kinds of drugs that have typically been used to suppress and destroy that same immune system?


The History Of Dog Allergy Drugs
First came prednisolone, prednisone and other steroids, which work by suppressing the functioning of the immune system.

Then, when allergic dogs stopped responding to steroids, veterinarians started using Atopica (cyclosporine). Cyclosporine was initially developed to prevent organ transplant rejections in humans. It works by suppressing the immune system so that the patient doesn't reject the transplanted organ.

And then they started using it for dogs with allergies. Atopica has a devastating and destructive effect on the immune system.

Atopica is still harming dogs today. The Food and Drug Administration (FDA) has  17 pages of adverse events  (starting on page 452) that have been reported for oral use of Atopica (cyclosporine) in dogs!

Here are just the top 12 from the first page!


Those are some pretty alarming numbers ... and it's ironic that the fifth side effect on the list is pruritus, which means itching - the very thing the drug is designed to stop! And now, there's another scary allergy drug called Apoquel® (oclacitinib maleate) that suppresses your dog's immune system in a different way.

Read on to learn what it does.


What is Apoquel For Your Dog And How Does It Work?
Apoquel affects kinases. Kinases are important signaling compounds that the body's cells use to communicate with each other.

In the 1980s, an Australian chemist discovered some new ones, known as JAK1, JAK2, JAK3 and TKY2.

JAK initially stood for Just Another Kinase but was later renamed Janus Kinase.

JAKs are key elements in controlling both growth and development. These particular JAKs do the work of:
  1. Policing the body against tumor formation
  2. Controlling body growth and development
  3. Forming white and red blood cells
  4. Providing immunity with proper functioning of your dog's antibody-producing cells (B cells) and the "policing" cells (T-cells)
  5. Regulating inflammatory response
Recognizing the epidemic of dogs with allergies, pharmaceutical companies saw the opportunity to create a drug would stop these JAKs in their tracks.

They sure succeeded.

Oclacitinib maleate, under the brand name Apoquel®, is a Janus kinase inhibitor. That means it stops JAKs from doing their job.


Apoquel Stops Life-Sustaining JAKs
Apoquel's mechanism is to interrupt JAKs and prevent them from working.

Without JAKs your dog's immune system, along with other systems, cannot function correctly.

JAK1 is vital for the constant surveillance within your dog's body to find and destroy abnormal cells that have become cancerous before they form tumors.

JAK1 also is an imperative messenger necessary for destroying invading parasites, fungi, bacteria and viruses.

JAK2 is central to the production of bone marrow stem cells that then become red and white blood cells and platelets.

Your dog's antibody system (B cells) and its killer-cell system (T cells) need JAK3 in order to work well.

These JAKs all talk to each other and share information to keep your dog's body healthy. So you can see that by preventing JAKs from working, Apoquel seriously undermines your dog's immune system.


What The Research Says
A study conducted by the manufacturer  to test Apoquel's safety and efficacy stated:

"There were no fatalities and no abnormal health events that necessitated hospitalization in either the study phase [day 0-7 (+3 days)] or the continuation phase [day 8-28 (±20 days)] of the study. Given that the majority of dogs in the placebo group withdrew after the completion of the study phase, the incidence of abnormal clinical signs was similar in both groups (Table 3)."

So, it seems from these comments and Table 3 showing adverse effects that the drug is fairly safe ...

... but did you notice the duration of the study? That's right - only 7 days!

There was a "continuation phase" after the 7 day study period, from 8 to 30 days. The researchers report:

"Six dogs (four oclacitinib and two placebo group) were withdrawn from the study during the continuation phase for abnormal health events. Abnormal health events were reported in 11 of 179 oclacitinib-treated dogs post-study. These were as follows: diarrhoea (four dogs; severe enough to warrant cessation of treatment in one dog); vomiting (four dogs); fever, lethargy and cystitis (one dog); an inflamed footpad and vomiting (one dog); and diarrhoea, vomiting and lethargy (one dog)."

So about 6% of dogs tested had abnormal health events. That doesn't seem very high.
But that was only for 30 days!

If your dog takes this drug, he could be on it for years!

Years when his immune system will be compromised by the drug - because that's how it works!

And although the manufacturer quotes  a study that says it is safe for long term use, the study results say something different. Here are some of the serious side effects:
  • One dog was euthanized after developing abdominal ascites and pleural effusion of unknown etiology after 450 days of APOQUEL administration.
  • Six dogs were euthanized because of suspected malignant neoplasms.
  • Two dogs each developed a Grade II mast cell tumor after 52 and 91 days.
  • One dog developed low grade B-cell lymphoma after 392 days.
  • Two dogs each developed an apocrine gland adenocarcinoma (one dermal, one anal sac) after approximately 210 and 320 days.
  • One dog developed a low grade oral spindle cell sarcoma after 320 days.
Is it worth the risk? I don't think so.


Does Age Matter?
The manufacturer has limited Apoquel for use only in dogs over 12 months old.

That's because, when they conducted "margin of safety" studies on 6 and 12 month old dogs, they had to discontinue the study for 6-month old dogs when the dogs developed bacterial pneumonia and demodectic mange infections!

In the margin of safety study on 12-month old dogs, some of the symptoms that were considered likely to be related to Apoquel included:
  • Papillomas (warts)
  • Interdigital furunculosis (cysts) with related dermatitis symptoms (local alopecia, erythema, abrasions, scabbing/crusts)
  • Edema of feet
  • Pneumonia
  • Lymphadenopathy (abnormal or swollen lymph nodes) in peripheral nodes
Yes, you read right ... the side effects include various types of skin disease in dogs who are being treated for allergies!

The drug was also found to lower white and red blood cell count and affect certain types of lymphatic tissue and lymph nodes as well as bone marrow.

Detailed information about the studies is provided under the  Prescribing Information tab on the company's website ... and if you're considering giving your dog Apoquel, you (and your vet) should read it before you make a decision.

Sometimes I feel that the world of modern medicine has gone mad. One in two dogs is getting cancer.

And yet here is a new anti-itch drug that not only opens up the door to cancer - but hangs up a welcome sign as well.

There Are Apoquel Alternatives For Your Dog
There are better and safer alternatives to this dangerous allergy drug.

It's important to find out what's causing the allergies to begin with.

As just one example, when I see dogs with allergies in my own practice, I create a tailored Allergy Elimination Program - based on the original work in NAET (Nambudripad's Allergy Elimination Technique) - and it works incredibly well for over 90% of the patients I treat.

It's non-toxic and has the effect of creating a stronger immune system that will fight off cancer and disease.

Meanwhile, this new drug that stops that worrisome and at times intolerable itching, causes low white cell count, low red cell count, stunted growth - and can increase your dog's risk of cancer.

When I became a veterinarian I vowed to protect the health of our pets. I wanted to make them healthier and help them live longer and happier lives.

Sometimes, with all these new and confusing drugs that pet owners rush to without understanding, I feel like I'm swimming upstream.
Dr Will Falconer has written the e-book, "Vital Animals Don't Get Heartworms".  
It truly is a life-changing way to look at heartworm prevention.  Click on the following link to get your copy today:   http://vitalanimal.com/drugfreeheartworm





Tammy & John | Bark Avenue Market & Bakery | 817-656-2275 | tammy@barkavenuemarket.com |   www.barkavenuemarket.com
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