Hi Cure,

We’re just ONE DAY AWAY from International Angelman Day!

The global AS community has always recognized this day in so many wonderful ways, and we’re looking forward to seeing what everyone comes up with.

If you have updates you would like to be included in next week’s newsletter, please email us at info@cureangelman.org.

This week we are highlighting a FAST-funded study that falls under Pillar 4 – Accelerating and Preparing for Clinical Trials in our Roadmap to a Cure 2.0. The article we are discussing here titled “Typical and atypical neural mechanisms support spoken word processing in Angelman syndrome” by Dr. Key et al., investigates word recognition and processing by brain activity response in individuals with Angelman syndrome. 

Researchers have found that individuals with Angelman syndrome typically demonstrate severe functional impairment on standardized cognitive and adaptive functioning measures, with expressive communication being a major area impacted. This FAST-funded study from Vanderbilt University aimed to examine word processing in nonspeaking individuals with AS compared to their typically developing peers using auditory event-related potentials (ERPs) obtained during passive listening to known words and meaningless pseudowords (a fake word — a string of letters that resembles a real word).

For more information and to learn the findings, read the whole article here:

Before Superbowl LVII, Alana Newhouse hosted a special edition of “Genes & Juice” with Dr. Allyson Berent, Chief Science Officer and Nycole Copping, PhD, Science Director.

Our science experts shared the latest pre-clinical work being done in gene and cell therapy advancing potential therapeutics for Angelman syndrome.

Knowledge is power and great information was shared to help the community understand the work we are doing for our loved ones. A significant question was asked around the delivery of therapeutics in humans.

Click here to read the answer:

Today we wear red, tomorrow we go blue! 

Are you ready for IAD? We are very excited to see everyone’s creativity shine tomorrow as well help bring awareness to Angelman syndrome! Be sure to take photos and use hashtags #IADFeb15 #AngelmanDay2023 #Angelmansyndrome #CureAS #cureangelman.

It’s not too late to curate information to share tomorrow. Click below to see our templates:

Click here to see some of the cities and locations lighting up in blue:

In 2021, FAST France created a video for IAD to raise awareness about what Angelman syndrome is from a child's perspective. The video was a huge success and has been shared all over the world and translated into several languages.

This year for IAD, FAST France created a follow up video explaining the different treatment options for AS, again from a child's perspective.

Check out the new video here:

We’re so excited to see all of the International Angelman Day content tomorrow! Make sure you’re following us on social media, as we’ll be resharing community posts and photos.

As always, please share this link with anyone who would be interested in receiving our updates.