How the brain gathers threat cues and turns them into fear |
Assistant Professor Sung Han and team discovered that a molecule called CGRP enables neurons to bundle threatening sensory cues—such as sights, sounds and smells—into a unified signal, tag it as negative and convey it to the amygdala, which translates the signal into fear. The research may lead to new therapies for fear-related disorders such as post-traumatic stress disorder (PTSD) or hypersensitivity disorders such as autism, migraines and fibromyalgia. |
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Discovery advances the potential of gene therapy to restore hearing loss |
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Assistant Research Professor Uri Manor and collaborators discovered that by adding the protein EPS8 to the inner ears of mice they can restore the function of hair cells that transduce sound. This finding could lead to the development of gene therapies to repair hearing loss. Read more »
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Scientists find surprising link between mitochondrial DNA and increased atherosclerosis risk |
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Professor Gerald Shadel and collaborators discovered a link between mitochondria, inflammation and DNMT3A and TET2—two genes that normally help regulate blood cell growth but, when mutated, are associated with an increased risk of atherosclerosis. The findings could lead to new therapeutics for atherosclerosis and other inflammatory diseases. Read more »
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New target identified for treatment of premature aging disease |
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Professor Juan Carlos Izpisua Belmonte and team discovered a piece of RNA that accumulates in people with the premature aging disease called progeria. Inhibiting the RNA reversed signs of aging and increased life span in mice. The findings could lead to more effective treatments for progeria syndromes and other age-related conditions. Read more »
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CBS8
Salk Institute’s High School Summer Scholar Program explores science careers with paid internships
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Scientific American
Newfound brain switch labels experiences as good or bad
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ABC10 News
Late school start leads to better health for kids
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San Diego Business Journal
HIV research breakthroughs at Salk, Scripps
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Collaboration and Innovation Grants announced |
Salk’s Innovation Grants program, launched in 2006 from the forward-thinking minds of then-Board chair Irwin Jacobs and his wife, Joan, is designed to fund out-of-the-box ideas that hold significant promise but may not yet have the track record to attract attention from more traditional funding sources. The latest awardees are:
Professors Janelle Ayres, Joseph Noel and Christian Metallo, who will collaborate to determine if asymptomatic and symptomatic infected animals emit different chemicals—signals that help group mates respond to the infection. The methods they develop may help diagnose community spread of infectious diseases and develop new treatments based on emitted chemicals.
Professor Tony Hunter and team, who generated the first antibodies recognizing phosphorylated histidine (pHis), a protein modification that may play a role in cancer. Now, they will engineer the antibodies to bind even better to pHis proteins and use them to probe pHis function in health and disease.
Assistant Professor Sung Han, who will explore how single neurons orchestrate the release of different transmitters—glutamate vs. neuropeptides, for example.
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Postdoctoral Fellow Wen Mai Wong named Damon Runyon Fellow |
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Wong, a member of Associate Professor Shrek Chalasani’s lab, has been named one of 16 new Damon Runyon Fellows by the Damon Runyon Cancer Research Foundation. The prestigious, four-year fellowship encourages the nation’s most promising young scientists to pursue careers in cancer research by providing them with independent funding.
Wong is using ultrasound to examine specific neurons and their impact on animal behavior and disease physiology, including the tumor microenvironment. Read more »
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Postdoctoral Fellow Jonathan Swift receives Australia to USA Graduate Education Scholarship |
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Swift, a member of Professor Joseph Ecker’s lab, received the scholarship from the American Australian Association. He is helping adapt agriculture to our changing climate by studying how plants respond to water at the molecular level. Read more »
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Check out the latest issue of Inside Salk magazine
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Read about what makes Salk so special. (Hint: it has a lot to do with our people!) Learn more about our latest research findings in neuroscience, metabolism, aging and more. Get a sneak peek inside the planned Joan and Irwin Jacobs Science and Technology Center. The fall 2022 issue of our award-winning magazine also includes scientist profiles, event coverage and a tribute to the late Distinguished Professor Emerita Ursula Bellugi.
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26th annual Symphony at Salk raised $1.1 million for research |
Salk’s acclaimed annual concert and fundraiser was held in the Institute’s iconic Courtyard on August 20. The event featured a breathtaking performance by Tony, Grammy and Emmy Award-winning singer Ben Platt and the San Diego Symphony. This year’s concert raised more than $1.1 million to support the Institute’s leading-edge research in the fields of aging, cancer, neuroscience, immunology, climate change and more. Thank you to all attendees for your generous support!
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Time is running out to maximize your donations to Salk’s Campaign for the Future: Building a More Resilient World—a bold, five-year, $500 million effort to attract the people and acquire the technology and space necessary to advance life-changing discoveries for decades to come. At the center of this goal is the plan to build the 100,000-square-foot Joan and Irwin Jacobs Science and Technology Center. For the next month, the Jacobs will contribute $1 for every $2 donated to the Campaign, up to $100 million.
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Which of the following is NOT a place to view carnivorous plants in San Diego?
Here are the results from our March newsletter quiz:
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Enjoy Salk science on your devices |
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Looking for a unique background image for your computer, Zoom meeting, iPad or phone?
This image shows short (left), intermediate (center) and long (right) hair stereocilia of the inner ear, which transduce sound in mice. In a recent study, Salk scientists discovered that adding the protein EPS8 (magenta) to the inner ears of mice helps elongate stereocilia, which can restore the function of cells that transduce sound. This finding could lead to the development of gene therapies to repair hearing loss.
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Credit: Salk Institute/Waitt Advanced Biophotonics Core |
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