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✅ Crohn’s disease starts before diagnosis and can be managed by diet
💡Findings from the PIONIR trial, presented by Dan Turner, PhD MD, suggested that the best time to intervene with a whole food diet to prevent Crohn’s is when:
🔸 Fecal calprotectin is between 70-215 mcg/g
🔸 IBD-like visible lesions in the gut have not developed
âś… Using both biologics and nutritional therapies together can make a difference for IBD
👉 Findings from the BIOPIC study found that the replacement of 50% of habitual food intake with specialized liquid nutrition formulations in adults with active Crohn’s treated with first-line biologics (adalimumab) improved:
🔸Remission rates and remission maintenance
🔸Nutritional parameters (two-in-one treatment)
👉 Luca Scarallo, MD PhD, presented data coming from sources other than clinical trials showing that combining the Crohn’s disease exclusion diet and biologics:
🔸Improved control of biochemical inflammation
🔸Had a greater impact on outcomes compared with biologic therapy alone
👉 Rotem Sigall Boneh, PhD RD, updated the benefits of combining both biologics and the Crohn’s disease exclusion diet to overcome the lack of response to biologics in some patients and to improve long-term maintenance:
🔸Combining dietary and biologic therapy is a marathon, not a sprint
🔸Diet targets the microbiome and gut barrier, whereas biologics act on the inflammation when it is initiated
🔸The gut microbial make-up could predict which patients will have sustained remission
âś… The balance between protein and fiber matters for ulcerative colitis
đź’ˇAlice Day, PhD RD, shared human data on the role of diet in igniting and extinguishing the flame in ulcerative colitis:
👉 Excess meat can ignite the flame in ulcerative colitis
👉 High-quality whole food diets prescribed and supported by an IBD dietitian may be enough to induce early response and sustained remission adjunct to medical therapy
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