-1200 patients were randomized with 90% completing the study. The mean age was 61 with 55% being men. Mean
was 7.2%. BMI was 34 kg/m2.
The number of additional anti-hypertensives and diabetic agents required during the course of the study were similar between groups.
-BP fell from 149/86 on entry to 132/77 mm Hg upon study completion. The average carvedilol dose required was 17.5mg BID; average metoprolol tartrate dose was 125 mg BID.
-After 5 months of therapy, body weight rose 1.2 kg among those prescribed metoprolol but only 0.2 kg among those receiving carvedilol.
-Table: Those with the highest BMIs upon study initiation experienced the most weight gain.