October 5, 2019
TART CHERRIES - a food source of melatonin

Think Pink? Melatonin - weapon against breast cancer & much more!
I played this presentation last week on the air. Dr. Shallenberger's focus is on melatonin with regard to cancer, which is fascinating in itself, but you will learn much more with regard to this life protective hormone. If you haven't heard this yet, please take time to listen when you have a chance.
Oncotarget . 2017 Jun 13; 8(24): 39896–39921.
Published online 2017 Mar 18. 
Melatonin for the prevention and treatment of cancer
Ya Li , 1   Sha Li , #2   Yue Zhou , 1   Xiao Meng , 1   Jiao-Jiao Zhang , 1   Dong-Ping Xu , 1  and  Hua-Bin Li

The epidemiological studies have indicated a possible oncostatic property of melatonin on different types of tumors. Besides, experimental studies have documented that melatonin could exert growth inhibition on some human tumor cells in vitro and in animal models.

The underlying mechanisms include:
  • antioxidant activity
  • modulation of melatonin receptors MT1 and MT2
  • stimulation of apoptosis
  • regulation of pro-survival signaling and tumor metabolism
  • inhibition on angiogenesis
  • inhibition of metastasis
  • induction of epigenetic alteration.

Melatonin could also be utilized as adjuvant of cancer therapies, through reinforcing the therapeutic effects and reducing the side effects of chemotherapies or radiation.

Melatonin could be an excellent candidate for the prevention and treatment of several cancers, such as breast cancer, prostate cancer, gastric cancer and colorectal cancer.

This review summarized the anticancer efficacy of melatonin, based on the results of epidemiological,experimental and clinical studies, and special attention was paid to the mechanisms of action.

With specific regard to breast cancer:
  • melatonin presented an anti-metastatic effect
  • demonstrated that melatonin might control tumor growth in advanced cancer patients
  • melatonin could inhibit aromatase activity in breast cancer cells
  • downregulation of oncogenic genes and upregulation of tumor suppressive genes
  • synergistic effect of melatonin with other treatments such as chemotherapy and radiation
  • control of metastatic breast cancer
  • reduction of tumor size and cell proliferation
  • Collectively, melatonin has exhibited inhibitory effect on both ER-positive and ER-negative breast cancers. Melatonin's anti-breast cancer effect was not only mediated by its interaction with both the estrogen receptors and the melatonin receptors, but also through activating various receptor-independent and estrogen-independent signaling pathways. Given the wide spectrum of melatonin's action on breast cancer, coupled with its low toxicity, it could be considered as a potential therapeutic choice for prevention and treatment of breast cancer.
More on melatonin...so many applications...
Melatonin Powder
Purchase 5 grams of Melatonin Powder
Includes a 60 mg scoop for accurate dosing. Each jar of powder (the same one used by Shallenberger and Russell Reiter) contains 83 60-mg servings. Use 1-3 scoops about 30 minutes before desired sleep time. Simply add to a bit of water or other beverage and drink.

Can be purchased online or picked up at Wondrous Roots in Keene, NH. Cost effective as compared with other melatonin supplements at these recommended doses, pure (no fillers), and easy to use.
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Saturday, October 5, 2019  - Noon to 1:00

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