Editor's Note: In this study, participants with mild to moderate asthma were given an herbal composition containing extracts of Boswellia serrata gum resin and Aegle marmelos fruit. The composition was found to dampen airway inflammation in the subjects within the first two weeks. At the end of the 56-day trial period, participants showed significant improvements suggesting the composition is tolerable and an effective intervention for management of mild to moderate asthma.

Phytotherapy Research
DOI: 10.1002/ptr.5963
December 6, 2017


LI13109F is a novel herbal composition containing the extracts of  Boswellia serrata  gum resin and  Aegle marmelos  fruit. This composition dampens leukotriene dependent inflammatory reactions via inhibiting 5-lipoxygenase pathway. In a Sephadex LH-20 induced airway inflammation model of Sprague Dawley rats, LI13109F significantly reduced infiltrated granulocyte population in the bronco-alveolar lavage fluid and normalized Th1/Th2 cytokine balance. Further, a 56-day placebo-controlled and randomized double blind study (Clinical Trial Registration No. CTRI/2016/10/007393) on subjects with mild to moderate asthma has evaluated the clinical efficacy of LI13109F. The study subjects received either 200 mg/day of LI13109F (n  = 18) or a similar dosage of placebo (n  = 18). At the end of the trial period, LI13109F conferred significant improvements in the clinical parameters; the emotional function (p  = .0305) and asthma symptoms scores (p  = .0002) were improved even at 14 days, compared with the placebo. Further, 56 days supplementation of LI13109F resulted in significant increase in serum IFN-╬│ (p  = .0014) and reduction in IL-4 (p  = .0497), compared with placebo. LI13109F supplementation did not yield any serious adverse events or any abnormal observations in routine laboratory examinations during the study. Together, these observations suggest that LI13109F (AlvioLife┬«) is tolerable and an effective intervention for management of mild to moderate asthma such as airway inflammation.

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