News from the Alzheimer's Research and Prevention Foundation
1st Quarter 2021
Mission Statement: The Alzheimer’s Research & Prevention Foundation (ARPF) is dedicated to the prevention of Alzheimer’s disease by funding research studies and providing professional training, educational outreach and memory screenings.
In this Issue:
President's Message: Surgery, Anesthesia and Memory Loss
Outreach & Education: Spiritual Practices and Brain Longevity: Imaging Research Revealed Webinar
New SAC Member: Len Wisneski, MD  
New Board Member: Le Craven, IMBA
Donor Spotlight: Arizona Cardinals Charities
Research Update: CAIDE Study / The Journals of Gerontology
Public Service Announcement: Rice University to help AD Caregivers
Brain Longevity® Spotlight: Tessa Elaina, Drewry Kindred, Linda Lang
Donor List – Thank You!
Ever Loved

President's Message
Surgery, Anesthesia and Memory Loss

Greetings!
Can surgery and anesthesia have an impact on cognition? The answer is yes.

Although the cause is unclear, this phenomenon has been described in the medical literature for at least 50 years. The stress of surgery and the effects of anesthetic drugs on the brain are postulated to be responsible. Anesthetic drugs may affect the brain’s neurobiological and chemical system, making the brain’s mechanism of action much slowed down. Anesthesia may also affect blood flow to the brain.

Although originally described following open-heart surgery, when blood pressure is sometimes quite low, it is now part of presentations at the Alzheimer’s Association conference as a recognized entity following various surgeries.

In my 20-year experience as an anesthesiologist, I rarely saw this situation develop. However, it was not as recognized then as it is now. It is possible that, if I had been involved in research on this topic, it would have been more apparent.

Apparently, what’s called memory loss or delirium associated with anesthesia, is age-dependent, and more pronounced in patients undergoing long operations of a complex nature.

For that reason, new research is pointing towards “multi-modal” anesthesia, where less of each drug is given, but more so-called specific agents are utilized to minimize this effect. Additionally, the recommendation of utilizing a regional anesthetic technique, such as an epidural, spinal, or nerve block is preferable to general anesthesia, whenever possible.

Future research should focus on the idea of preparing for surgery by utilizing all the pillars of our Brain Longevity® Therapy approach: especially Kirtan Kriya (KK) meditation. This will make a stronger brain going into the surgery, making it more resilient to face difficulties, should those arise.

Moreover, in a recent article called Major Surgery Affects Memory in Individuals with Cerebral Amyloid-β Pathology, researchers measured cognition and Amyloid-β levels before complex orthopedic surgery. β Amyloid is a pathologic marker of Alzheimer’s disease. After the procedure, half of the patients who had elevated levels of Amyloid-β before surgery, showed symptoms of cognitive decline mimicking Alzheimer’s disease nine months after surgery.

This confirms that elevated Amyloid-β levels may be present in a person with no symptoms of memory loss. Major surgery might therefore put enough strain on the person’s neurological system to cause an apparently sudden onset of Alzheimer’s-like symptoms.

My recommendation for someone having surgery is to speak to their physician, surgeon, and anesthesiologist about preparing their body and brain for surgery, as well as discussing their options for a regional anesthetic, as opposed to general anesthesia, especially if someone is over 55-60 or older. Beyond that, futuristic pre-surgical evaluation may even include Alzheimer’s biomarkers such as amyloid B and cognitive tests.

Our studies at West Virginia University with Dr. Karen Innes have suggested that Kirtan Kriya lowers Amyloid-β and improves memory even in subjects with early memory loss. Wouldn’t it be interesting and important work to study KK effects on memory in people having surgery?

If you’d like to support this potential cutting-edge study you may donate here, or contact me directly: drdharma@alzheimersprevention.org


Yours in Brain Health,
Dharma Singh Khalsa, M.D.
President / Medical Director

P.S. Here's the article reference.
FOLLOW US
Discover all the exciting activities ARPF has in store by visiting us on the web at: alzheimersprevention.org

Outreach & Education
Spiritual Practices and Brain Longevity: Imaging Research Revealed
Your ARPF is the first organization to do research on meditation and memory. Dr. Dharma and Dr. Newberg began this work years ago and want to share it with you, from its infancy to its future potential. Please join us on Thursday, March 4th for our next webinar, Spiritual Practices and Brain Longevity: Imaging Research Revealed. 

Our esteemed guest speaker is Andrew B. Newberg, MD, Director of Research at the Marcus Institute of Integrative Health and physician at the Myrna Brind Center at Jefferson University Hospital in Philadelphia, PA. He is board-certified in internal medicine and nuclear medicine.

Dr. Newberg’s research now largely focuses on how brain function is associated with various mental states– in particular, religious and mystical experiences. In fact, he has written several highly acclaimed books on this subject. His research has included brain scans of people in prayer, meditation, rituals, and trance states, as well as surveys of people’s spiritual experiences and attitudes. Dr. Newberg has also evaluated the relationship between religious or spiritual phenomena and health, and the effect of meditation on memory, particularly with regards to the effects of Kirtan Kriya meditation. 
 
Dr. Newberg has also used neuroimaging research projects to study aging and dementia, Parkinson’s disease, epilepsy, depression, and other neurological and psychiatric disorders. He is a pioneer in the neurological study of religious and spiritual experiences, a field known as “neurotheology.”

Dr. Newberg is the author of many landmark books such as How God Changes Your Brain, Why We Believe What We Believe, Words Can Change Your Brain and the latest, The Rabbi’s Brain.

Save The Date:
Thursday, March 4th, 2021
4 pm PT / 5 pm MT / 6 pm CT / 7 pm ET for 60 min
This webinar will be recorded and sent out a few days after. If you cannot attend on March 4th, please register and you will still receive the recording.


New SAC Member
Leonard A. Wisneski, MD, FACP
Leonard A. Wisneski, MD, FACP is Clinical Professor of Medicine at George Washington University Medical Center, Adjunct Faculty in the Department of Biochemistry and Molecular Biology, Division of Integrative Physiology, at Georgetown University where he is a founding member of the Complementary and Alternative Medicine Curriculum Planning Committee and has taught a course in integrative medicine for several years. He also holds faculty positions in the Department of Medicine as well as The Department of Nursing at The University of Colorado. He was Vice-Chairman of the NIH Consensus Panel on Acupuncture and is Chairman of the NIH Advisory Board on Frontier Sciences at the University of Connecticut. He holds fellowship positions in The American College of Physicians and The American College of Nutrition.

He served on the board of the American Holistic Medical Association and was President of the International Society for the Study of Subtle Energies and Energy Medicine. He currently serves as Chairman Emeritus of the Integrative Health Policy Consortium which promotes national legislation pertaining to integrative healthcare. He is a Research Advisor to The International Hyperbaric Medicine Association and serves on the advisory board of The Academic Collaborative for Integrative Health. He has published over 30 scientific articles and a textbook, “Scientific Basis of Integrative Health, Third Edition.” He has been in the clinical practice of endocrinology and integrative medicine for over 30 years.

Dr. Wisneski co-founded and served as the regional President and Medical Director of American Whole Health, an integrative, multi-practitioner center devoted to fostering individuals in the achievement of health and life goals. His medical practice in endocrinology and integrative medicine, spanning three decades, embodies the true meaning of integrative healthcare delivery– an optimal synthesis of conventional and alternative medicine practiced with a whole-person approach delivered with reverence and humanism. He also served in the role of Medical Director and Chief Medical Editor of Integrative Medicine Communications, a publishing company that produced textbooks and newsletters devoted to this new field of medicine.

Dr. Wisneski graduated from Thomas Jefferson Medical College and performed his postgraduate training in the field of Internal Medicine and Endocrinology in the George Washington University healthcare system, where he served as Chief Medical Resident in Internal Medicine. From 1977 until 1997, Dr. Wisneski was the Corporate Medical Director of Marriott International, Inc., and Director of Medical Education at Holy Cross Hospital in Silver Spring, Maryland, an affiliate of George Washington University Medical School and Children’s National Medical Center where he devoted his efforts to teaching the fundamentals of internal medicine, as well as, an integrative, whole-person approach to medicine.

Dr. Wisneski is currently engaged in facilitating a National University Library consortium of integrative health book collections with one of the core collections being The Strauss-Wisneski Indigenous and Integrative Medicine Collection at The University of Colorado Health Sciences Library. He served on the steering committee of the National Coordinating Center for Integrative Medicine whose mission is to facilitate the education of integrative and preventive healthcare. His current passion is serving on the board of directors of The Viktor Frankl Institute of logotherapy and serving as Chief Medical Officer of Parallel Profile, a genomics testing company. He also has an interest in therapeutic applications involving the endocannabinoid system and is a member of the Society of Cannabis Clinicians and The International Cannabinoid Research Association.

New Board Member
Le Craven, IMBA 
Le Craven lives in Tucson, Arizona where she managed ARPF public events and served as Office Manager for four years.
 
With a background in both entrepreneurial and non-profit leadership, her heartfelt interest in serving on the ARPF board comes out of caring for family members with dementia and Alzheimer’s disease.
 
As a lifelong learner and self-taught manager and accountant, Le’s early work history included being one of the first accountants to transition to a Building Manager position in class A properties developed by Wright Runstad & Company in Washington State. After moving to Arizona, she joined the staff at a nonprofit adoption and foster care agency where she rose to Senior Director of Operation. During her tenure, she was a member of the management team that accomplished the successful accreditation of the agency in the top one-third of applicants.
 
At this point, she found a university that was willing to create a degree plan based on credits accumulated from 5 different schools over the years. She finished 160 additional credits to qualify for a Bachelor of Arts in Management (2003) and subsequently passed the GMAT and other qualifications to attend Thunderbird School of Global Management where she completed her International MBA (2004). This IMBA included six months of classes in France near enough to the United Nations that she worked with a nonprofit helping to feed refugees.

Le is also a fine art photographer and enjoys travel and baking. Her favorite days at ARPF were working at events, sharing the hope-filled message of lifestyle changes that delay and prevent the damages of dementia and Alzheimer’s disease.

Donor Spotlight
Arizona Cardinals Charities
Your ARPF is honored to have received a generous grant from the Arizona Cardinals Charities organization. We will use this money to further expand our Brain Longevity® Therapy Training (BLTT) program which will enable more communities to utilize our tools, resources, and life-changing research.

Needless to say, we are extremely excited and grateful. Thank you!

Research Update
Cardiovascular health metrics from mid- to late-life and risk of dementia: A population-based cohort study


A recent study was published emphasizing how healthy habits – as outlined in the 4 Pillars of Prevention® – help reduce dementia risk, even if started mid-life. 

The Finnish Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) study observed that maintaining a healthy heart decreased the risk of dementia. Even starting healthy habits at mid-life reduced the risk of dementia compared to having poor cardiovascular health metrics.

Researchers looked at behaviors that affect heart health: smoking, physical activity, body mass index (BMI), fasting plasma glucose, blood pressure, and total cholesterol. 1,449 participants were followed from mid-life (average age of 50.4 years; 62.1% female) to late-life, and then 744 dementia-free survivors were followed further into late-life. 

Having an intermediate or ideal level of cardiovascular health in both mid-life and late-life (versus poor level in both mid-life and late-life) was significantly associated with lower dementia risk.


Research Update II
Telomere Length Change in a Multidomain Lifestyle Intervention to Prevent Cognitive Decline

The Journals of Gerontology published research on the brain health benefits of having longer telomeres and how to use lifestyle intervention to encourage telomere longevity.

Background
Shorter leukocyte telomere length (LTL) is associated with aging and dementia. Impact of lifestyle changes on LTL, and its relation to cognition and genetic susceptibility for dementia, has not been investigated in randomized controlled trials (RCTs).

Results
This exploratory LTL substudy included 756 participants (377 intervention, 379 control) with baseline and 24-month LTL measurements. Interaction analyses indicated better LTL maintenance among apolipoprotein E (APOE)-ε4 carriers versus noncarriers; younger versus older participants; and those with more versus less healthy lifestyle changes. Cognitive intervention benefits were more pronounced among participants with better LTL maintenance for executive functioning and long-term memory, with a similar trend for Neuropsychological Test Battery total score.

Conclusions
This is the first large RCT showing that a multidomain lifestyle intervention facilitated LTL maintenance among subgroups of older people at risk for dementia, including APOE-ε4 carriers. LTL maintenance was associated with more pronounced cognitive intervention benefits.


Public Service Announcement to Help Alzheimer’s Caregivers
By Rice University

Rice University is looking for participants to join a study examining The Impact of Emotions on Social Distancing among spousal caregivers for Alzheimer’s disease or related dementias during the COVID-19 Pandemic. 

The purpose of this research study is to understand the factors (e.g., feeling unhappy, lonely, frustrated) that influence compliance with social distancing recommendations during the COVID-19 pandemic. In addition, this study aims to understand how negative emotions (e.g., feeling unhappy, lonely, frustrated) along with social distancing requirements influence caregivers’ confidence in their ability to provide high-quality care for their spouse with dementia during the COVID-19 pandemic. To learn more, click here

Brain Longevity® Specialist Spotlights
Tessa Elaina

Tessa Elaina is a professional musician known for her heartfelt, angelic voice. She performs original music, covers, and mantras played with guitar, harmonium, synthesizer, and loopers. She streams live performances to audiences that span the U.S., U.K., France, Switzerland, Chile, and Australia.

Tessa loves to improvise new songs in the moment. During her live streams, she does this by turning the positive affirmations volunteered by her listeners into original songs on-the-spot. Tessa graduated from BLTT in 2018 and she is a certified yoga teacher for both adults and children.

Please join her on Tuesdays at 3 pm EST for her live music stream. She can be found on Instagram @tessaelaina or at www.tessaelaina.com

Tessa currently lives in Reston, Virginia with her mother and dog, Sophie.
Drewry Kindred

Drewry Kindred is a Yoga Therapist and a seasoned yoga teacher. Drewry's path to understanding Alzheimer’s started when her mother began showing signs of the disease. Observing dementia first-hand, she became interested in studying holistic alternatives. Drewry co-led a workshop called "A Therapeutic Yoga Approach to Alzheimer’s Disease" which brought her to become certified as a Brain Longevity Specialist with ARPF.
 
Drewry currently enjoys teaching online chair yoga with people who have early-onset dementia at The Memory Tree. She also teaches Gentle Yoga and Yoga for Arthritis. Before Covid, Drewry worked with a fantastic team of yoga therapists and acupuncturists in a clinical research study. Patients were drawn from underserved communities with chronic pain. The study was affiliated with Mount Sinai and Montefiore Hospitals in the New York City area. When Covid began the study concluded, but success was found in feedback and clinical data.
 
Drewry lives in NYC. Her class listings can be found on the Integral Yoga site, C-IYAT.
Linda Lang

Linda Lang is a dedicated practitioner of all things yogic: a therapeutic teacher, C-IAYT, and a Brain Longevity Specialist, working with individuals and groups while mentoring yoga therapists and medical professionals.
 
Her newest programs, Stronger Longer, Memory Café, and Very Gentle, Very Deep highlight and celebrate a new perspective on the idea of setting intentions: identifying an intention is no longer enough, what we truly need to have, and aspire to, are finite and realistic goals.
 
She’s a certified yoga therapist known for innovative, interprofessional, and creative contributions to the field of therapeutic yoga. Linda serves on the Advisory Board of the International Association of Yoga Therapists, presents seminars and symposia at the Smithsonian Institution, and is a clinical instructor in the Department of Psychiatry and Behavioral Sciences at the George Washington University School of Medicine. 
If you’d like to shake things up this year, create a birthday fundraiser for ARPF that everyone can celebrate. Creating a Facebook birthday fundraiser is a popular way to give back to a cause you’re passionate about on your special day. Facebook makes it easy– all you have to do is invite friends and family members to donate to your ARPF fundraiser. Friends from around the globe can take part– it's quick and simple with no exchange rates or banks necessary. If you are interested in holding a fundraiser to support AD prevention, education, outreach or our research initiatives, please contact chelsea@alzheimersprevention.org
Do you buy or sell on eBay? You can easily round up your purchase or donate a portion of your sale to ARPF! Just follow the prompts and look for “Alzheimer’s Research and Prevention Foundation.”








In Memory/ In Honor Donors
October to December 2020
Thank you for giving ARPF the opportunity to honor your loved ones and your special occasions. Donor list from October to December 2020.
Your ARPF is honored to be a part of Ever Loved’s memorial website. This is a beautiful way to celebrate a loved one’s life in an elegant, community-oriented memorial fund. Ever Loved makes funeral planning and connecting with providers, friends, and family as simple as possible.

If you would like to leave a legacy for your loved one through supporting ARPF research and initiatives, please visit our page. We are so thankful to those who wish to include ARPF during such a sensitive time. We will continue to make strides in Alzheimer’s prevention in memory of all those who have been afflicted by dementia. We are forever grateful.
Officers and Board Members
PRESIDENT/MEDICAL DIRECTOR - Dharma Singh Khalsa, M.D.
VICE PRESIDENT - Randal Brooks, MA, LPC
TREASURER - Bert Beatty, MHA
SECRETARY - Kirti K. Khalsa 
MEMBERS - Fletcher Wilkins, BS
- Edward Gellert, BSM
- Le Craven

Executive Staff
VICE PRESIDENT OF EDUCATION AND OUTREACH - Chris Walling, PsyD, MBA, C-IAYT
SENIOR ADVISOR - Simran S. Stuelpnagel
NEWSLETTER EDITOR - Chelsea Pyne
Follow Us!
Discover all the exciting activities the ARPF has in store for you by visiting us on the web at alzheimersprevention.orgfollowing us on Twitter‘Liking’ us on Facebook, following us on Instagram.
ARPF is a Proud Member of:
Medical and Scientific Advisory Council
CHIEF SCIENCE OFFICER
George Perry, Ph.D., Professor of Biology & Chemistry, Chief Scientist, Brain Health Consortium University of Texas at San Antonio, TX 
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Daniel Amen, M.D., Director of the Amen Clinics, Costa Mesa, CA
Ma Gloria Borras-Boneu, M.D., GRD Health Institute - Barcelona, Spain
Hiroko Dodge, Ph.D., Kevreson Research Professor of Neurology University of Michigan, Ann Arbor, Oregon Health & Science University
Nancy Emerson Lombardo, Ph.D., Adjunct Research Assistant Professor of Neurology Boston University, School of Medicine, Alzheimer’s Disease Center, Boston, MA
Elissa Epel, Ph.D., Professor of Psychiatry, University of California, San Francisco, CA
Annie Fenn, M.D., Women’s health specialist & Founder of Brain Health Kitchen, Jackson Hole, WY
Karen E. Innes, MSPH, Ph.D.,Professor of Epidemiology, Western Virginia University School of Public Health, Morgantown, WV
Richard S. Isaacson, M.D., Director, Alzheimer’s Prevention Clinic Weill Cornell Medical College, New York, NY
Sat Bir S. Khalsa, Ph.D., Assistant Professor of Medicine, Harvard Medical School, Brigham and Women’s Hospital – Boston, MA
Tejinder Kaur Khalsa, M.D., M.S., FRCP, Senior Associate Consultant, General Internal Medicine, Mayo Clinic, Rochester, MN
Miia Kivipelto, M.D., Ph.D., Aging Research Center and Alzheimer’s Disease Research Center, Karolinska Institute - Stockholm, Sweden
Karen Koffler, M.D., Medical Director of the Osher Center for Integrative Medicine at University of Miami, FL
Helen Lavretsky, M.D., M.S., Professor, Department of Psychiatry, UCLA Semel Institute and Resnick Neuropsychiatric Hospital- Los Angeles, CA
Lisa Mosconi, Ph.D., Associate Director, Alzheimer’s Prevention Clinic Weill Cornell Medical College, New York, NY
Andrew B. Newberg, M.D., Director, Marcus Institute of Integrative Health –Myrna Brind Center Jefferson University Hospital, Philadelphia, PA
Arti Prasad, M.D., FACP, Chief of Medicine, Hennepin Medical Ctr Professor/Vice Chair of Medicine, University of Minnesota Minneapolis, MN
Kateřina Sheardová, M.D., Head of the Memory Center ICRC St. Anne´s University Hospital Brno, Czech Republic
Michelle Sierpina, Ph.D., Founding Director, UTMB Osher Institute for Lifelong Learning University of Texas Medical Branch Galveston, TX 
Leonard A. Wisneski, MD, FACP, Clinical Professor of Medicine at George Washington University Medical Center, Washington, DC