Gastric tumors with a genetic abnormality called microsatellite instability-high (MSI-H) can be treated with immune-targeted drugs, but there’s a much more common form of disordered DNA in stomach tumors that’s not as well understood. It’s called “chromosomal instability” (CIN), and the Gastric Cancer Foundation has awarded a new one-year grant to researchers who are studying this abnormality in gastric cancer—and looking for potential drug targets related to it.
The Foundation has awarded $75,000 to the lab of Adam Bass, M.D., associate professor of medicine at Harvard Medical School, which will be used to fund early-stage research focused on finding new therapies for CIN-driven gastric tumors.
“One of the things we’re trying to do is gain a better understanding from cancer genome data so we can characterize and categorize chromosomal instability,” Bass says. “Then we can figure out what’s unique about this process in gastric cancer. By building metrics to classify and refine understanding of CIN we will be more able to define novel therapeutics to address it.”