Six multidisciplinary research teams selected to turn collective ideas into translational projects
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The Community and Collaboration Component of the CTSC has selected six multidisciplinary research teams to turn collective ideas into translational research projects, with a special focus on the integration of community, clinical and industry stakeholders as part of the endeavor. Teams range from six to 18 investigators from all eight schools and colleges at the university.
The overall goal of the projects will be to turn observations in the laboratory, clinic and community into interventions that improve the health of individuals and populations, ranging from diagnostics and therapeutics to medical procedures and behavioral interventions.
The six teams will be provided a package of support to help develop their translational ideas, including a four-hour retreat, professional group facilitator, graphic recorder and administrative support to pursue their projects. In return, the teams are responsible for developing a team action plan that outlines three specific translational project ideas.
The selected teams had to include investigators from multiple disciplines and at least one translational stakeholder—one who has a stake in the outcome and whose input could greatly enhance the research endeavor.
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The Cryo-Electron Microscopy Core is eligible for CTSC Core Utilization Pilot Grantsng
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The Clinical and Translational Science Collaborative (CTSC)
Core Utilization Pilot Award Program
supports investigator use of eligible Core facilities at our partner institutions. This program is designed to collect preliminary data that will lead to extramural sponsored grant funding and/or publications in peer-reviewed journals. Awards up to $10,000 are available.
The CWRU School of Medicine's Cryo-Electron Microscopy Facility, featuring the newly purchased Titan Krios, under the Leadership of Dr. Sudha Chakrapani, is
eligible for CTSC Core Utilization Pilot Grants
. The Core provides critical ultrastructural skills, including immunocytochemistry, in addition to conventional EM techniques. The methodology can be tailored to specific needs. The Facility includes a T12 microscope, a fully equipped sample processing laboratory, a sectioning room, and a dark room. The Facility offers complete transmission electron microscopic services including sample processing, ultramicrotomy, film developing, and photographic printing, as well as immunocytochemistry.
Learn More:
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Clinical Research Scholars Program (CRSP) is Accepting Applications for its Master of Science in Clinical Research Type A and Type B Programs
Application Deadline: April 15, 2019
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The Case Western Reserve University's Clinical Research Scholars Program offers a Master's in Clinical Research through two pathways:
Type A (Thesis)
Type B (Capstone/Internship/Practicum)
Both pathways are flexible two-to four-year Master's programs which provide rigorous didactic education in clinical research methods coupled with either an in-depth mentored investigative thesis (Type A Pathway) or hands-on experience in conducting clinical research through a Capstone Project (Type B Pathway).
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Getting to the Heart of the Matter
Cardi-OH’s 2nd Annual Statewide Conference
May 17, 2019
Nationwide Hotel & Conference Center, Columbus, OH
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The purpose of Cardio-OH is to expand the primary care team capacity to prevent, diagnose and manage cardiovascular disease in Ohio’s Medicaid population and Identify and address disparities in cardiovascular health care and outcomes affecting the Ohio Medicaid population.
At this second annual statewide conference, Dr. LaPrincess C. Brewer, Assistant Professor of Medicine at Mayo Clinic will give the keynote address: "Inspiring and Empowering Communities to Improve Cardiovascular Health".
Workshops include a simulated Project ECHO
® clinic where clinicians from allied disciplines will use real-world cases to discuss cardiovascular disease best practices, as well as a workshop on innovative interventions and current resources that focus on enhancing community health.
Who should attend?
Primary care and outpatient medical teams, medical trainees, public health professionals, managed care plans, private payers, advocates and other community health-related organizations, employers, and consumers.
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Broadly Engaged Team Science Workshop
April 23, 2019
2:00pm - 6:00pm
Washington, DC
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Dean Pamela Davis, MD
Case Western Reserve University
School of Medicine
Event Chair
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Darcy Freedman, PhD, MPH
Director, Mary Ann Swetland Center for Environmental Health, Case Western Reserve University, School of Health
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Clinical Research Forum and AAAMC GRAND cordially invite you to a half-day workshop on the role and importance of broadly engaged, interdisciplinary teams in resolving many of the most daunting scientific problems in medical research. Featured speakers will present:
- Successful approaches to team science
- How institutions have successfully managed, supported and advanced team collaborations
- Successful engagement of patient communities
- Keynote from Dr. Michelle Bennett, NIH, author of the "Broadly Engaged Team Science" blog
- Examples and best practices from: University at Buffalo, University of Miami, Case Western Reserve University, Washington University in St. Louis.
Join your colleagues in roundtable discussions of how to address challenges and barriers to advancing team science your institution, including:
- Ways to influence tenure and promotion success;
- The opportunities and perils of patient-driven research;
- Creating collaborative opportunities between academic disciplines to solve clinical problems.
Discussion will be focused on overcoming obstacles at academic health centers and replicating success within your own university and hospital environment.
At the end of the workshop, AAMC/GRAND is hosting a complimentary reception for workshop participants from 6pm to 7pm.
Registration Fee: $25
Includes all workshop materials, drinks and snacks. AAMC is hosting a complimentary evening reception from 6pm - 7pm.
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CTSC Innovation Symposium:
Bridges to Global Innovation
The Linsalata Alumni Center
Thursday, May 23, 2019
9 AM – 4 PM
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Join us to learn about global collaboration and innovation, participate in innovation workshops, and network with people from across the globe.
We have a full day of events planned, including a team building and implementation workshop, and how to create your elevator pitch.
Save the date now, more details coming soon!
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Health Informatics Update from the
Cleveland Institute for
Computational Biology
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CICB to Host OHDSI/OMOP Face-to-Face Meeting
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Stay tuned for a mid-April update announcing the final agenda for the CICB hosted OHDSI annual face-to-face meeting, to be held in the Wolstein Research Building auditorium on June 2-4, 2019.
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PRCHN Monthly Seminar Series
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Wednesday, April 10, 2019
BreatheFree: Partnering with Residents to Increase Smoking
Cessation in Low-Income Neighborhoods
Erika Trapl, PhD, Associate Director, PRCHN,
Associate Professor, CWRU
Wednesday, May 8, 2019
Center on Trauma and Adversity: Innovating beyond Violence Exposure and PRSD
Megan Holmes, PhD, MSW, LISW, Director, Center on Trauma and Adversity, CWRU
Seminars are held the second Wednesday of each mo
nth from 12:00-1:15 pm
in the PRCHN Ground Floor Conference Room, BioEnterprise Building, 11000 Cedar Avenue. Parking is available and a light lunch is served.
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CWRU researchers author paper on cigarillo use among young people
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Four Case Western Reserve University researchers wrote a paper on their work on cigarillo use among young people. The paper, titled “A comparison of methods to measure daily cigarillo consumption among adolescents and young adults,” was published in Tobacco Control.
The four researchers are:
- Elizabeth Antognoli, research associate at the Center for Community Health Integration;
- Karen Ishler, senior research associate at the Jack, Joseph and Morton Mandel School of Applied Social Sciences;
- Erika Trapl, associate professor of population and quantitative health sciences and associate director of the Prevention Research Center for Healthy Neighborhoods; and
- Susan Flocke, the Gertrude Donnelly Hess MD Research Professor of Oncology.
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News from the Urban Health Intiative
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As we prepare for the April launch of our new Health Data Matters LiveStories portal, we want to highlight some new data sets and also alert you to some upcoming presentations that might be of interest.
New Data Sets
With much thanks to our partners, the Cuyahoga County Board of Health and the Medical Examiner’s Office, several datasets available through Health Data Matters have been updated with the most recent data available. The “Childhood Lead Poisoning 2017 by City of Cleveland Neighborhood and Suburban Municipality” and the “Opioid-related deaths in Cuyahoga County 2015-Sept. 2017” datasets are among those updated and are available through our LiveStories platform and at healthdatamatters.org
Last Month’s Events
APTR 2019 Conference: Teaching Prevention- Building a New Paradigm for Population Health
The Association for Prevention Teaching and Research (APTR) held their annual conference on April 1-3. It was the first time the conference was held in Cleveland, giving local public health professionals a unique and exciting opportunity to represent the work happening in our city. Dr. Scott Frank (MD, MS) co-director of Health Data Matters, as well as HDM team member Matthew Kucmanic (MPH, MA), presented on some of the innovative work happening through Urban Health Initiative projects:
This talk featured a panel of experts facilitated by Dr. Scott Frank (MD, MS) of CWRU’s SOM. The panelists, Matthew Kucmanic (MPH, MA) of CWRU’s SOM, Rachel Lovell, PhD of CWRU’s MSASS, Kristina Knight, PhD of Kent State, and Maya Simek, JD of CWRU’s SOL, d
escribed the higher level of violence present in urban settings compared to suburban and rural locations. The panel invited attendees to explore a spectrum of programs related to primary, secondary and tertiary prevention of violence in the Cleveland Community and to discuss the components of a public health approach to violence. The panelists, which exception to Dr. Knight, are members of the Virtual Advocate (VirA) project, a team working to utilize “surroundables” and the Internet of Things (IoT) in violence prevention and intervention.
With another talk addressing the potential of utilizing surveillance for public health gain, Dr. Scott Frank (MD, MS) and Martha A. Wojtowycz (
Director, Central New York Master of Public Health Program)
provided a framework for understanding how innovations in digital and spatial epidemiology, the Internet of Things (IoT), "surroundables", and social media analytics can be used to reinvent public health surveillance. Attendees had the opportunity to consider the role of digital and spatial epidemiology in public health surveillance and intervention and to discuss opportunities and limitations of IoT surroundables as a component of such interventions.
In this presentation,
Drs. Scott Frank (MD, MS) and N. Ruth Gaskins Little (EdD, MPH of East Carolina University Brody School of Medicine)
described a metric for toxic stress created by utilizing existing items on the Youth Risk Behavior Survey among an urban high school population. Attendees explored correlations between adolescent toxic stress and physical and mental health outcomes as well as associations between toxic stress and adolescent risk and protective factors.
Upcoming Events
April 9, Gainesville, FL
: Amy Sheon will be representing the CTSC at the
Un-Meeting on Rural Health and Health Equit
y,
hosted by the University of Florida’s Clinical and Translational Science Institute and the Center for Leading Innovation and Collaboration (CLIC) coordinating center for the National Institutes of Health’s Clinical and Translational Science Awards Program. The event brings together experts and stakeholders from more than 30 states to “expand potential solutions that promote rural health and health equity.” Amy’s focus will be on raising awareness of how digital disparities—that are especially profound in rural areas, affect health and the ability to participate in clinical research.
April 15, Cleveland,
Data Days Cleveland
: As noted in a recent
story
on Cleveland.com, “
What began as a small meetup inside a City Hall archival library has since grown into a regional movement, drawing in hundreds of data experts, advocates and dreamers who see data as an engine for building equity, reducing bias and creating accountability, according to Taylor Henschel, co-chair of the event and Microsoft Civic Innovation Fellow. It’s also a place where novices can learn the fundamentals of making maps, using spreadsheets or creating data visualizations.
”
For the first time, Data Days Cleveland will be held at Case Western Reserve University, at the Tinkham Veale University Center.
Registration ($40) is required
. Amy Sheon will discuss the role Health Data Matters played in the annual Cleveland Medical Hackathon at a 3:30pm session entitled, “Are Hackathons Working?” Shout-out to Health Data Matter’s public health specialist Matthew Kucmanic for serving on the 2019 Data Days planning committee.
April 24, Cleveland
: Amy Sheon will give a kickoff talk on placed-based health disparities and Social Determinants of Health at
Connecting Healthcare & Community Development: Investing in Healthy Communities
. The Federal Reserve Bank of Cleveland, the FDIC and the Office of the Comptroller of the Currency are convening at this event to increase awareness of ways that financial institutions can use the funds they provide through their obligations under the
Community Reinvestment Act
(
CRA) to improve the health of communities.
The CRA was enacted in 1977 to ensure that banks address their “continuing and affirmative obligation to help meet the credit needs of their local communities, including low- and moderate-income neighborhoods where they are chartered.” The Act was established in conjunction with outlawing of redlining—the practice whereby “lending institutions refused to offer home loans in neighborhood based on the income, racial, or ethnic composition or residents.”
(CRA Fact Sheet.)
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Biomedical and Health Informatics (BHI) Program
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The Biomedical and Health Informatics (BHI) program, includes a curriculum for a range of career or research interests: Certificate, Master of Science, and PhD.
Offered through the CWRU Department of Population and Quantitative Health Sciences, the new BHI program brings together faculty from across the University for an interdisciplinary course of study immediately relevant in contemporary health systems or research enterprises. These programs are unique in that they encompass both biomedical research and clinical care informatics, with applications to health care delivery, precision medicine, accountable care organizations, and reproducible science.
To learn more:
- Visit the BHI website
- Join webinar on Sunday, April 7, at 8pm Eastern/ 7pm Central. See directly below.
- Contact program director Mendel Singer at mendel@case.edu.
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Webinar: Master’s Degree in Biomedical and Health Informatics
Sunday, April 7, 2019
8:00 PM
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The Department of Population and Quantitative Health Sciences' Certificate, Master of Science, and PhD in Biomedical and Health Informatics (BHI) offer pragmatic, interdisciplinary areas of study immediately relevant in contemporary health systems or research enterprises. Our programs are unique in that they encompass both biomedical research and clinical care informatics with applications to health care delivery, precision medicine, accountable care organizations, and reproducible science.
Our programs provide grounding across multiple disciplines and will be of interest if you seek a career in which you:
- Analyze patient diagnoses, treatments and outcomes, based on electronic health records, to inform clinical practice
- Design or manage studies to inform quality and safety process improvements
- Collaborate in analysis of large genetic and various “omics” studies, integrated with clinical or population data, to advance the understanding of diseases
- Design and manage studies that draw from clinical, cohort or population data to assess and develop devices, therapeutics or other interventions
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Check out the
NIH Extramural Nexus for important grant related news! Here are some important articles from the past month:
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CLIC Un-Meeting on Machine Learning & Artificial Intelligence Applications in Translational Science
Saturday, June 1, 2019
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The Center for Leading Innovation & Collaboration (CLIC) Un-Meeting will focus on the development, enhancement, standardization and regulation of artificial intelligence (AI) and machine learning approaches at all stages of the translational science spectrum. Through the unique, attendee-driven
Un-Meeting format
,
our intent is to foster new collaborations and ideas, advance research, and explore innovative approaches for technology's use in translational science.
Space is limited and registration is on a first-come first-serve basis, so don't delay! Registration will close on May 13, 2019.
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Apply for CLIC Support and Funding to Write a Synergy Paper
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Cross-network translational research Synergy Papers are designed to focus on substantial challenges in clinical and translational science, address gaps in research, and convene new, innovative writing teams.
Collaborative teams are invited to apply for CLIC assistance for a paper that focuses on either:
- A new approach to a significant translational science process or method roadblock and how to address this challenge to advance translational science; or
- A content/knowledge review of a pressing translational science topic across several stages of the translational continuum, identifying gaps and approaches to move the field forward (that would also include a section on relevant process gaps as well).
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A Meeting of the Minds on Dementia in Northeast Ohio
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The Cleveland Brain Health Initiative (CBHI), housed at CWRU, includes the Clinic, UH, MetroHealth, the local VA, NEOMED and Kent State University. So far, the initiative has spent a lot of time creating opportunities for collaboration, including a few established discussion groups that meet regularly to spark ideas. The network built through the CBHI will allow researchers to translate basic science discoveries into clinical care and clinical outcomes, thereby improving the health of Northeast Ohioans.
Jonathan Haines, co-Lead of our CTSC Informatics component and
professor and chair of the department of population and quantitative health sciences at Case Western Reserve University School of Medicine, last year
received a $14.6 million grant
from the National Institute on Aging at the NIH to lead a national multi-institution effort to understand the complete genetics of Alzheimer's disease with a real focus on diverse and minority populations.
As funding grows, technology advances and experts come together, it's a "fortunate time" for dementia research, he said. "Everything is sort of coming together to make things happen now," Haines said.
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A cure for HIV? Feasible but not yet realized
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This week a team of scientists and physicians from the U.K. published news of a second HIV positive man, in London,
who is in long-term (18-month) HIV remission
after undergoing treatment for
Hodgkins lymphoma
. The unexpected success has launched a new round of discussion about a potential cure for HIV.
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A Patient's Guide to Asthma
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“Asthma is a chronic lung condition that affects the airways,” says Dr. Sumita Khatri, Research Subject Advocate in our CTSC program and co-director of the asthma center at the
Cleveland Clinic
.
Asthma stems from inflammation that causes airways to narrow, producing symptoms such as cough, tightness in the chest, wheezing and shortness of breath. Asthma also causes the cells that line the airways to produce more mucus.”
In this patient guide, Dr. Khatri weighs in on several key points including the risk factors, diagnosis, and treatment of asthma.
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ORTM Education Opportunities for the Spring
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The Basics, MODULE 8: Adverse Events & Protocol Deviations
4/11/2019 11:30 - 1:00
UH Lakeside, Room 1400
Getting Started with your Research
4/16/2019 11:30 - 1:00
UH Lakeside, Room 1400
Sparta IRB: Getting Started
4/26/2019 11:00 - 12:00
Sears Library Building, Room 670
Research Misconduct: Tips & Tactics to Safeguard Your Research
5/2/2019 11:00 - 12:00
Sears Library Building, Room 670
Submitting an Investigational New Drug (IND) to the FDA
5/3/2019 11:30 - 1:00
UH Lakeside, Room 1400
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Research ShowCASE 2019
Friday, April 19, 2019
9:00 AM - 3:00 PM
CWRU Veale Convocation Center
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Join CWRU faculty, staff and students at Research ShowCASE 2019. The event provides an opportunity for CWRU researchers to display their research in a traditional scientific poster session and by other creative means.
Keynote Address
9-10 AM
Mona Chalabi
is a journalist who really loves numbers. She is the Data Editor of The Guardian where she writes articles, produces documentaries, and illustrates, as well as animates, data. She is also a data journalist for NPR.
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2019 GRAND Spring Conference:
Advancing Academic Medical Research
April 24 - 25, 2019
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AAMC Learning Center
655 K Street, NW
Washington, DC
The AAMC and GRAND Leadership are convening an annual spring conference to engage research deans and other leaders on how to advance academic medical research in a challenging policy and regulatory environment. Participants will have the opportunity to meet with government and NIH leaders, network with their peers, and take new insights back to their institutions.
Join for discussion on topics including:
- The Value of and Remaining Obstacles to Achieving Team Science
- The NIH HEAL (Helping End Addiction Long-Term) Initiative
- Emerging Areas of Science: Conversation about Cryo-EM with NIGMS Director Jon Lorsch
- Space Infrastructure and Strategic Planning
- Harmonizing Financial Disclosures
- Regulatory Oversight of Research
On Tuesday, April 23, there will be an optional pre-workshop on Broadly Engaged Team Science from 2:00 to 6:00 pm, convened in collaboration with GRAND and the Clinical Research Forum. GRAND participants are encouraged to attend; a small, separate registration fee applies
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8th Annual Graft vs Host Disease National Symposium
Friday, April 26, 2019
Cleveland Airport Marriott
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This unique conference focuses on cutting edge research and new treatments and consists of two tracks: one designed for physicians and other health care professionals, and one for bone marrow transplant (BMT) survivors, their families and their caregivers.
The Meredith A. Cowden Foundation, in collaboration with the Case Comprehensive Cancer Center, University Hospitals Seidman Cancer Center, and Cleveland Clinic Taussig Cancer Institute, created the National GvHD Health Symposium in 2010 to raise awareness about Graft vs. Host Disease (GvHD), to promote research to further our understanding of its cause, and to review cutting edge approaches to prevention and treatment.
Over 1,400 people have attended this event, which provides an opportunity for attendees to interact with some of the world's leading authorities on GvHD, a complication that affects over 60% of bone marrow transplant patients.
Save $10 on your registration with code: CANCERCENTER
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Frontiers of Biological NMR and EPR Spectroscopy
Saturday, April 27, 2019
Wolstein Research Auditorium (WRB 1413)
9AM – 6PM
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Organizers: Matthias Buck and Sudha Chakrapani, CWRU
Plenaries by:
David Cafiso – University of Virginia
Gary Lorigan – Miami University
Art Palmer – Columbia University
Charles Sanders – Vanderbilt University
The symposium will also include local NMR/EPR experts, a poster session and poster-blitz talks.
For inquiries, contact Matthias Buck (mxb150)
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Great Lakes Breast Cancer Research Symposium
May 2-4, 2019
Grand Event Center, Columbus, OH
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T
he Great Lakes Breast Cancer Research Symposium (GLBCRS) will highlight ongoing basic, translational, clinical and population studies addressing the biological mechanisms, management and prevention of breast cancer. Researchers from participating institutions will share their exciting work with a goal to develop cross-institutional collaborations.
Speakers from the Case Comprehensive Cancer Center include: Ruth Keri, PhD, Mark Jackson, PhD, Ofer Reiszes, PhD, Bill Schiemann, PhD, Khalid Sossey-Alaoui, PhD, Vinay Varadan, PhD, Megan Kruse, MD and Lily Wang, PhD
The GLBCRS is made possible through the collaboration of The Ohio State University Comprehensive Cancer Center (The James), the UPMC Hillman Cancer Center affiliated with the University of Pittsburgh Schools of the Health Sciences, the Case Comprehensive Cancer Center at Case Western Reserve University (Case CCC) and the WVU Cancer Institute at West Virginia University
.
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Re(ACT) Congress America
May 8-11, 2019
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NCATS is jointly hosting the first
2019 RE(ACT) Congress America
event that will bring together leading scientific experts, patients and advocates to discuss rare diseases research. The goal is to facilitate and promote international scientific cooperation in this field. The event, which takes place May 8-11 in Toronto, is the first to be held in North America.
Panel discussion topics include:
- Gene editing
- Cell and gene therapies and their clinical application
- Multi-national patient registries
- Patient-focused drug development
- Therapeutic approaches for rare diseases
- Indigenous populations
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Administrative Supplements for the INCLUDE Project
Applications Due: May 24, 2019
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Supplement applications will be considered eligible for funding if they address one or more of the following components related to the INCLUDE Project research objectives:
- Component 1: Targeted, high risk-high reward, basic science studies in Down syndrome: For basic science studies, supplements should target areas of science of highest impact. Topics of emphasis may include: chromosome silencing, immune system dysregulation, epigenetic/metabolomic/transcriptomic profiling in model organisms/iPSCs/brain organoids, development of novel model systems, and development of a molecular atlas for cardiac and other specimens. Supplements could also support projects that will inform the other two components, namely a cohort study and a clinical trials network.
- Component 2: Molecular snapshot of Down syndrome through a cohort study: The goal is to add to or expand an existing Down syndrome cohort, with data collected in a shared database using common data elements and building on the DS-Connect® patient registry. Supplements could add comprehensive molecular (i.e., pan-‘omics) analyses to existing Down syndrome cohorts or support existing infrastructure for sample and neuroimaging collection in the Down syndrome population.
- Component 3: Inclusive clinical research for individuals with Down syndrome: Supplement requests could leverage existing clinical trials infrastructure to expand or extend an existing DS cohort in a currently funded trial or build component(s) into an existing clinical trials infrastructure that includes Down syndrome but could be expanded to accommodate additional Down syndrome clinical trials in the future.
If you are interested in applying for this supplement through our CTSA Hub, click on the button below to Learn More.
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NIH Funding Opportunities and Notices
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Following in their long traditions of helping to support important scientific research, the National Institutes of Health and the Department of Health and Human Services have released information on new grant and award programs that we encourage members to take advantage of.
Notices, Requests for Applications, and Program Announcements:
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