ICRF Grant Investigates Alternate Treatments to Immunotherapy |
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Ofer Mandelboim, PhD, of Hebrew University of Jerusalem/Hadassah Medical School, an ICRF Research Professorship grantee and a past recipient of several ICRF grants, discusses why he is researching new approaches to currently available immunotherapies.
Can you tell us about the urgent need to find alternatives to immunotherapy?
Although immunotherapy has had a dramatic effect on cancer treatment, the majority of cancer patients do not respond to currently available immunotherapies. The reasons for this are not completely understood. The activity of immune cells is regulated by activating inhibitory proteins. Inhibitory proteins suppress immune cell activity. Immunotherapy of tumors is largely based on medicine that prevents inhibition of the immune system.
One possible explanation for why the majority of cancer patients do not respond to immunotherapy might be that we have not yet discovered all of the inhibitory proteins expressed by immune cells, nor have we developed substances to block them.
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ICRF has supported my research for the past 20 years.
This support was essential for my career...it helped me to obtain additional grants,
such as the European Research Council Advanced Grant.
Professor Ofer Mandelboim
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- Cancer is the second most common cause of death in the U.S., after heart disease.
- More than 16.9 million Americans with a history of invasive cancer are alive today, most of whom were diagnosed several years ago and have no current evidence of disease.
- Over 1.9 million new cancer cases will be diagnosed in 2022. (This excludes most skin cancers.)
- Approximately 603,360 deaths from cancer are expected in 2022.
- Cancer-related medical costs in the U.S. were $183 billion in 2015 and are projected to reach $246 billion by 2030.
- Everyone is at risk of developing cancer. The likelihood increases with age, with 80 percent of people diagnosed at 55 or older.
Source: American Cancer Society
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ICRF Tower of Hope Galas Return to Live Format |
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Join us for a joyous night of entertainment, science and hope at an ICRF celebration nearest to you. Our honorees will be feted for their extraordinary contributions to their communities and for their support of ICRF.
Stay tuned for monthly updates!
Chicago, IL
September 29
Westin North Shore, Wheeling
Honoree: Richard Edelheit, Retired Partner from RSM US LLP; ICRF Chicago Board of Directors and ICRF International Treasurer
Inspiration Awardee: Lisa Alter Krule, Chicago Director, IsraelNow – Jewish Federation of Metropolitan Chicago
Stamford, CT
October 23
Stamford Marriott Hotel
Honoree: In Memoriam - Alan Kalter, former announcer for the "Late Show with David Letterman"
New York, NY
October 27
The Harmonie Club
Leadership Honoree: Rob Densen, Founder and CEO of Tiller, LLC, ICRF International Vice Chair and President Emeritus
Inspiration Honoree: Arnold M. Baskies, MD, Surgical Oncologist, former Chairman, American Cancer Society, ICRF International Vice President
Partnership Honoree: Ambassador Asaf Zamir, Consul General of Israel in New York
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Join ICRF Mission to Israel — November 6-10, 2022
You have never experienced Israel like this before. Journey to the land of milk and honey with ICRF. Immerse yourself in the culture, cuisine, and cutting-edge research of Israeli scientists seeking an end to the suffering caused by cancer. Take a look behind-the-scenes at an actual research lab. Spend time in Tel Aviv, Haifa, and Jerusalem and enjoy all the different facets of Israel.
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ICRF Drives for a Cure at Inaugural Tri-State
Golf Outing
Seventy-two golfers, and several additional dinner guests, attended the Inaugural ICRF Tri-State Golf Outing at GlenArbor Golf Club on June 28. The group included old and new friends of ICRF who joined together to play a magnificent course in support of ICRF’s mission.
The day netted in excess of $44,000 which will be directed toward funding groundbreaking cancer research in Israel.
Plans are already underway for the Second Annual Tri-State Golf Outing in June 2023!
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ICRF Chicago Golf Tournament
Ravinia Green Country Club was the perfect setting for a fun filled day of golf and pickleball, lunch and dinner in support of ICRF and E.P.C.F. (Employee Partners Care Foundation) as 185 people enjoyed the mid July weather. ICRF thanks Ravinia Green for the partnership and all the participants, sponsors and volunteers who helped to make the event such a success.
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In 1986, ICRF awarded its first Research Professorship grant to Howard Cedar, MD, PhD, of Hebrew University. Professor Cedar, an Israel Prize winner whose research focuses on DNA methylation in cancer, a molecular process that turns genes on and off, is the longest-running ICRF grantee, having been funded continuously for 35 years.
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Yoga, Canasta, Mahjong Event in New Jersey
Montammy Country Club in Alpine, New Jersey, will be the idyllic setting for an ICRF event featuring canasta, mahjong, yoga and more! Join other supporters on September 14 at 9:00 am for this exciting half-day of activities, including breakfast, lunch, raffles and on-site vendors. Canasta lessons will be available for new players.
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Bike for the Fight in Full Gear in Toronto
Join ICRF’s 10th annual Bike for the Fight in memory of Howard Anson z"l, on September 18, 1 pm and 2 pm at SPINCO in Thornhill or Summerhill. Participants and teams will push their limits in the fight against cancer. Assemble your own team or peddle it out on your own! Set your own fundraising goal and watch the thermometer rise! Prizes will be awarded to the top fundraisers and teams.
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Raise Funds for Team ICRF!
TCS New York City Marathon
ICRF is an Official Charity Partner of the TCS New York City Marathon. If you already have an entry spot for the November 6, 2022 NYC Marathon, you can run as part of Team ICRF and help raise money for life-saving cancer research in Israel. We will set up your fundraising page and provide you with Team ICRF race day gear. If you do not have a guaranteed entry, we will gladly add you to our waitlist as we try to secure additional guaranteed entrees.
Please contact New York Executive Director Alan Herman for more details at [email protected].
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