Your Weekly Dose of #5ThoughtsFriday: A description of what we think is important at BIAMD
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#5Thoughts Friday
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Edition

9/15/2023


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Welcome to Impact Factor, your weekly dose of commentary on a new medical study. I'm Dr F. Perry Wilson of the Yale School of Medicine.
I want you to listen to this audio file and see if you can recognize it.
[Click on the video above to hear the audio clip.]
Take a second. Maybe play it back again. Does it ring a bell?

Some of you, particularly of my generation, may recognize the characteristic rhythm guitar and harmony of Pink Floyd's "Another Brick in the Wall." But you haven't heard it like this before. No one has heard any song like this before because this is the first song reconstructed from the electrical signals in a patient's brain.

The human brain is the most complex object in the known universe. It is the most fascinating and the most mysterious. The entire variety of human experience, all our emotions, our perceptions, our sensations are housed in those 1300 grams of interconnected tissue.

And the perception of music employs so many of the brain's faculties because music is more than a fancy form of speech. There is rhythm, harmony, tone, and timbre — all things we can consciously and even unconsciously perceive. How does that happen?

To investigate the way the brain processes music, researchers, led by Ludovic Bellier at UC Berkley, examined 29 patients undergoing neurosurgery. Their results appear in a new paper in PLOS Biology.


CLICK HERE to watch the video.
Headshot by Michael Short on Gladstone Institutes
For decades, many scientists have described the blood-brain barrier—a tight network of cells that separates the brain from the blood—as a nearly impenetrable border wall. But Andrew C. Yang, PhD, who is joining Gladstone Institutes as an assistant investigator, thinks there's more to it than that. He likens the blood-brain barrier to a family home.

"Your home has physical walls to form a barrier from the environment, but it also has windows and doors to let you bring in groceries and take out trash, and Wi-Fi so you can communicate with the outside world," says Yang, who is also an assistant professor in the Departments of Neurology and Anatomy at UC San Francisco (UCSF). "I think we'll come to appreciate that, similarly, the blood-brain barrier maintains a dynamic and sophisticated dialogue with other parts of the body."

Yang's research revolves around understanding how the blood-brain barrier may be more than its name implies. He wants to understand the rules that govern how the blood-brain barrier controls the movement of cells and molecules in and out of the brain, and how it becomes dysfunctional with age and disease. His research could inform the design of new drugs that can efficiently cross the blood-brain barrier, a current impediment to treating many brain conditions.


CLICK HERE to read more about Yang's research .
Photo by Evan Hein on Unsplash
Can you recognize someone you haven’t seen in years, but forget what you had for breakfast yesterday? Our brains constantly rearrange their circuitry to remember familiar faces or learn new skills, but the molecular basis of this process isn’t well understood. Today, scientists report that sulfate groups on complex sugar molecules called glycosaminoglycans (GAGs) affect “plasticity” in the brains of mice. Determining how GAGs function could help us understand how memory and learning work in humans, and provide ways to repair neural connectivity after injuries.

The researchers will present their results today at the fall meeting of the American Chemical Society (ACS). ACS Fall 2023 is a hybrid meeting being held virtually and in-person Aug. 13–17, and features about 12,000 presentations on a wide range of science topics.

The sugars that sweeten fruits, candies or cakes are actually just a few simple varieties of the many types of sugars that exist. When strung together, they can make a wide array of complex sugars. GAGs are formed by then attaching other chemical structures, including sulfate groups.


CLICK HERE to read more.
SATURDAY
Sept. 30th:
Blue Crabs 4
Brain Injury


WHEN: Saturday, September 30th

2500 Grays Road
Dundalk, MD 21222

WHAT:
  • Steamed Crabs, Maryland Corn on the Cob, BBQ and Pit Beef, Chesapeake Chips, Baked Beans, Salad, Watermelon, Soft Drinks
  • And, of course, great KEY Beer and Wine for Purchase

EARLY BIRD PRICING: (Till September 9th)

INDIVIDUAL TICKETS: $75
TABLES OF 8: $575
Brain Injury Connector Podcast is in Season 4 and we are looking for guests!

Because every brain is different, every brain injury is different, and every brain injury recovery is different, most individuals and families dealing with brain injuries have many more questions than answers. Join Bryan Pugh, Executive Director of the Brain Injury Association of Maryland, as he searches for answers by interviewing individuals with brain injuries, family members, healthcare providers, policy makers and other members of the brain injury community. Each episode contains powerful information to help you learn more about brain injury, discover new treatments and solutions, and meet inspirational people making meaningful impacts on their community by changing the world.

Join us and tell your story!

CLICK HERE to listen

CLICK HERE to sign up to become a guest

Lost in My Mind is a stunning memoir describing Kelly Bouldin Darmofal's journey from adolescent girl to special education teacher, wife, and mother - despite severe Traumatic Brain Injury (TBI). Spanning three decades, Kelly's journey is unique in its focus on TBI education in America (or lack thereof). Kelly also abridges her mother's journals to describe forgotten experiences. She continues the narrative in her own humorous, poetic voice, describing a victim's relentless search for success, love, and acceptance - while combating bureaucratic red tape, aphasia, bilateral hand impairment, and loss of memory. 


CLICK HERE to see more.
1) Quote We are Contemplating
"The journey of a thousand miles begins with one step" 

Looking for Something fun to do in Maryland this weekend?



Click the picture below and discover a world of possibilities for things to do this weekend!
Photo by Cole Keister on Unsplash

HAVE A WONDERFUL WEEKEND!

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 Thanks for reading! Have a wonderful weekend.