Since the BRAIN Initiative's launch in 2013, FAS Research Development has disseminated information via this newsletter about all of the funding opportunities related to the initiative. We send this newsletter to a targeted list of faculty, including  faculty affiliates  of the  Center for Brain Science  (CBS) and the  Mind Brain Behavior  (MBB) Interfaculty Initiative. This project is being carried out in collaboration with the Center for Brain Science.  Please feel free to forward this newsletter  to interested colleagues. All Harvard University faculty and administrators may subscribe here , and recipients may unsubscribe at any time. For an archive of past newsletters, or for information about additional Research Development support (finding funding, proposal development resources, etc.), please visit the Research Development website .  
Funding Opportunities
National Institutes of Health
Sponsor Deadline for Letters of Intent (requested):  30 days prior to the application deadline
Sponsor Deadlines for Full Proposals: December 8, 2017; March 15, 2018
OSP Deadline: 5 business days prior to submission 
Award Information:  Application budgets are not limited but need to reflect the actual needs of the proposed project. The maximum project period is 5 years. Issuing IC and partner  components intend to commit an estimated total of $14M to fund 20 awards.
  
This FOA solicits applications for research projects that use innovative and methodologically-integrated approaches to understand how circuit activity gives rise to mental experience and behavior. The goal is to support projects that can realize a meaningful outcome within 5 years. Applications should address circuit function in the context of specific neural systems such as sensation, perception, attention, reasoning, intention, decision-making, emotion, navigation, communication, or homeostasis. Projects should link theory and data analysis to experimental design and should produce predictive models as deliverables. Projects should aim to improve the understanding of circuits of the central nervous system by systematically controlling stimuli and/or behavior while actively recording and/or manipulating dynamic patterns of neural activity.  Projects can use non-human animal species, and applications should explain how the selected species offers ideal conditions for revealing general principles about the circuit basis of a specific behavior.
Sponsor Dea dline for Letters of Intent (requested):  30 days prior to the application deadline
Sponsor Deadlines for Full Proposals: December 15, 2017; October 17, 2018; October 17, 2019
OSP Deadline: 5 business days prior to submission
Award Information:  Application budgets are not limited, but are expected to range between $150,000-$250,000 in direct costs per year. Awards are for 3 years of support. The NIH BRAIN Initiative anticipates providing $6M per year to fund up to 15 awards each year.
  
This FOA solicits new theories, computational models, and statistical tools to derive understanding of brain function from complex neuroscience data. Proposed tools could include the creation of new theories, ideas, and conceptual frameworks to organize/unify data and infer general principles of brain function; new computational models to develop testable hypotheses and design/drive experiments; and new mathematical and statistical methods to support or refute a stated hypothesis about brain function, and/or assist in detecting dynamical features and patterns in complex brain data. It is expected that the tools developed under this FOA will be made widely available to the neuroscience research community for their use and modification. Investigative studies should be limited to validity testing of the tools being developed.
Sponsor Dea dline for Letters of Intent (requested):  30 days prior to the application deadline
Sponsor Deadlines for Full Proposals: December 20, 2017; December 11, 2018
OSP Deadline: 5 business days prior to submission
Award Information: Application budgets are limited to $300,000 in direct costs in any project year. The maximum project period is 2 years. Issuing IC and partner  components intend to commit an estimated total of $4M to fund 6-12 awards.
  
This funding opportunity announcement (FOA), in support of the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative, aims to support early stage development of entirely new and novel noninvasive human brain imaging technologies and methods that will lead to transformative advances in our understanding of the human brain. The FOA solicits unusually bold and potentially transformative approaches and supports small-scale, proof-of-concept development based on exceptionally innovative, original and/or unconventional concepts.
Sponsor Dea dline for Letters of Intent (requested):  30 days prior to the application deadline
Sponsor Deadlines for Full Proposals: December 20, 2017; December 11, 2018
OSP Deadline: 5 business days prior to submission
Award Information: Application budgets are not limited but need to reflect the actual needs of the proposed project. The maximum project period is 5 years. Issuing IC and partner  components intend to commit an estimated total of $8M to fund 3-6 awards.
  
This funding opportunity announcement (FOA), in support of the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative, aims to support full development of entirely new or next generation noninvasive human brain imaging tools and methods that will lead to transformative advances in our understanding of the human brain. The FOA seeks innovative applications that are ready for full-scale development of breakthrough technologies with the intention of delivering working tools within the  timeframe of the BRAIN Initiative ("BRAIN 2025: A Scientific Vision,"  http://braininitiative.nih.gov/). This FOA represents the second stage of the tool/technology development effort that started with  RFA-MH-14-217 and  RFA-MH-15-200.
Sponsor Dea dline for Letters of Intent (requested):  December 19, 2017
Sponsor Deadline for Full Proposals: January 19, 2018
OSP Deadline: January 11, 2018 
Award Information:  Application budgets are not limited but need to reflect the actual needs of the proposed project. The maximum project period is 2 years. Issuing IC and partner  components intend to commit an estimated total of $4M to fund up to 4 awards.
  
Invasive surgical procedures provide the unique ability to record and stimulate neurons within precisely localized brain structures in humans. Human studies using invasive technology are often constrained by a limited number of patients and resources available to implement complex experimental protocols and are rarely aggregated in a manner that addresses research questions with appropriate statistical power. Therefore, this FOA seeks applications to assemble integrated, multi-disciplinary teams to overcome these fundamental barriers. Projects should investigate high-impact questions in human neuroscience. The research should be offered as exploratory research and planning activities to establish feasibility, proof-of-principle and early-stage development that will later compete for continued funding under new or ongoing FOAs of the BRAIN Initiative or under NIH Institute appropriations. Projects should maximize opportunities to conduct innovative in vivo neuroscience research made available by direct access to brain recording and stimulating from invasive surgical procedures. In addition, projects that aim to implement novel methods of temporally-linked brain-behavior quantification in laboratory and real-world settings are encouraged.

Awardees will join a consortium work group, coordinated by the NIH, to identify consensus standards of practice as well as supplemental opportunities to collect and provide data for ancillary studies, and to aggregate and standardize data for dissemination among the wider scientific community.
National Science Foundation
Sponsor Deadlines:  January 5, 2018; November 27, 2018; November 25, 2019
OSP Deadline: 5 business days prior to submission
Award Information:  Award sizes for Research Projects (both domestic and international) are expected to range from approximately $100,000-$250,000 per year in direct costs, with durations of 3-5 years.  Awards for Data Sharing Projects will be scaled according to the needs of the project; typically they will be smaller in size than research awards. It is anticipated that a minimum of $5 million will be available each year for this competition.

Computational neuroscience provides a theoretical foundation and a rich set of technical approaches for understanding complex neurobiological systems, building on the theory, methods, and findings of computer science, neuroscience, and numerous other disciplines.
Through the CRCNS program, the National Science Foundation (NSF), the National Institutes of Health (NIH), the German Federal Ministry of Education and Research (Bundesministerium für Bildung und Forschung, BMBF), the French National Research Agency (Agence Nationale de la Recherche, ANR), the United States-Israel Binational Science Foundation (BSF), and Japan's National Institute of Information and Communications Technology (NICT) support collaborative activities that will advance the understanding of nervous system structure and function, mechanisms underlying nervous system disorders, and computational strategies used by the nervous system.

Two classes of proposals will be considered in response to this solicitation:
  • Research Proposals describing collaborative research projects, and
  • Data Sharing Proposals to enable sharing of data and other resources.
Domestic and international projects will be considered. As detailed in the solicitation, international components of collaborative projects may be funded in parallel by the participating agencies. Specific CRCNS opportunities for parallel funding are available for bilateral US-German Research Proposals, US-German Data Sharing Proposals, US-French Research Proposals, US-French Data Sharing Proposals, US-Israeli Research Proposals, US-Israeli Data Sharing Proposals, US-Japanese Research Proposals, US-Japanese Data Sharing Proposals, and multilateral proposals involving the United States and two or more partnering countries.  NSF will coordinate and manage the review of proposals jointly with participating domestic and foreign funding organizations, through a joint panel review process used by all participating funders.  
Questions about this newsletter or proposal submission may be directed to:

Jennifer Corby
Research Development Officer
jcorby@fas.harvard.edu | 617-495-1590

To see previous BRAIN Initiative Funding Newsletters, please visit our  email archive.
Research Development | Research Administration Services | research.fas.harvard.edu