Since the BRAIN Initiative's launch in 2013, FAS Research Development has disseminated information via this newsletter about all of the funding opportunities related to the initiative. We send this newsletter to a targeted list of faculty, including  faculty affiliates  of the  Center for Brain Science  (CBS) and the  Mind Brain Behavior  (MBB) Interfaculty Initiative. This project is being carried out in collaboration with the Center for Brain Science.  Please feel free to forward this newsletter  to interested colleagues. All Harvard University faculty and administrators may subscribe here , and recipients may unsubscribe at any time. In addition, you may access the Science Division Funding Spotlight here. For an archive of past newsletters, or for information about additional Research Development support (finding funding, proposal development resources, etc.), please visit the Research Development website .  
Funding Opportunities
Sponsor Deadline for Letters of Intent (requested): 30 days prior to the proposal deadline
OSP Deadline:  5 business days prior to submission
Sponsor Deadlines for Full Proposals: November 14, 2018; October 18, 2019; June 19, 2020; October 19, 2020
Award Information: Application budgets are not limited but need to reflect the actual needs of the proposed project. The maximum project period is 5 years. NIH intends to commit an estimated total of $8M to fund 5 awards per receipt date.

Invasive surgical procedures provide the unique ability to record and stimulate neurons within precisely localized brain structures in humans. Human studies using invasive technology are often constrained by a limited number of patients and resources available to implement complex experimental protocols and are rarely aggregated in a manner that addresses research questions with appropriate statistical power. Therefore, this RFA seeks applications to assemble diverse, integrated, multi-disciplinary teams that cross boundaries of interdisciplinary collaboration to overcome these fundamental barriers and to investigate high-impact questions in human neuroscience. Projects should maximize opportunities to conduct innovative in vivo neuroscience research made available by direct access to brain recording and stimulating from invasive surgical procedures. Projects should employ approaches guided by specified theoretical constructs and quantitative, mechanistic models where appropriate.

Awardees will join a consortium work group, coordinated by the NIH, to identify consensus standards of practice, including neuroethical considerations, to collect and provide data for ancillary studies, and to aggregate and standardize data for dissemination among the wider scientific community.
National Institutes of Health
BRAIN Initiative: Team-Research BRAIN Circuit Programs - TeamBCP (U19 Clinical Trial Required) and (U19 Clinical Trial Not Allowed)
Sponsor Deadline for Letters of Intent (requested): 30 days prior to the proposal deadline
OSP Deadline:  5 business days prior to submission
Sponsor Deadlines for Full Proposals: October 30, 2018; October 30, 2019; October 30, 2020
Award Information: Application budgets are not limited but need to reflect the actual needs of the proposed project. The maximum project period is 5 years. NIH intends to commit an estimated total of $22M in fiscal years 2019, 2020, 2021 to fund up to 5 new awards each year for these RFAs.

These RFAs will support integrated, interdisciplinary research teams from prior BRAIN technology and/or integrated approaches teams, and/or new projects from the research community that focus on examining circuit functions related to behavior, using advanced and innovative technologies. The goal will be to support programs with a team science approach that can realize meaningful outcomes within 5-plus years. Awards will be made for 5 years, with a possibility of one renewal. Projects will incorporate overarching principles of circuit function in the context of specific neural systems underlying sensation, perception, emotion, motivation, cognition, decision-making, motor control, communication, or homeostasis. Applications should incorporate theory-/model-driven experimental design and should offer predictive models as deliverables. Applications should seek to understand circuits of the central nervous system by systematically controlling stimuli and/or behavior while actively recording and/or manipulating relevant dynamic patterns of neural activity and by measuring the resulting behaviors and/or perceptions. Applications are expected to employ approaches guided by specified theoretical constructs, and are encouraged to employ quantitative, mechanistic models where appropriate. Applications will be required to manage their data and analysis methods in a prototype framework that will be developed and used in the proposed U19 project and exchanged with other BRAIN U19 awardees for further refinement and development. Model systems, including the possibility of multiple species ranging from invertebrates to humans, can be employed and should be appropriately justified. Programs should employ multi-component teams of research expertise - including neurobiologists, statisticians, physicists, mathematicians, engineers, computer scientists, and data scientists, as appropriate - that seek to cross boundaries of interdisciplinary collaboration.
OSP Deadline:  November 16, 2018
Sponsor Deadlines for Full Proposals: November 27, 2018
Award Information: Award sizes for Research Projects (both domestic and international) are expected to range from approximately $100,000-$250,000 per year in direct costs, with durations of 3-5 years. Awards for Data Sharing Projects will be scaled according to the needs of the project; typically they will be smaller in size than research awards. NSF anticipates that a minimum of $5M will be available each year for this competition, with potentially $15-$20M annually, depending on the quality of proposals and availability of funds.

Computational neuroscience provides a theoretical foundation and a rich set of technical approaches for understanding complex neurobiological systems, building on the theory, methods, and findings of computer science, neuroscience, and numerous other disciplines.
Through the CRCNS program, the National Science Foundation (NSF), the National Institutes of Health (NIH), the German Federal Ministry of Education and Research (Bundesministerium für Bildung und Forschung, BMBF), the French National Research Agency (Agence Nationale de la Recherche, ANR), the United States-Israel Binational Science Foundation (BSF), Japan's National Institute of Information and Communications Technology (NICT), and the State Research Agency (Agencia Estatal de Investigación, AEI) and National Institute of Health Carlos III (Instituto de Salud Carlos III, ISCIII), both of Spain, support collaborative activities that will advance the understanding of nervous system structure and function, mechanisms underlying nervous system disorders, and computational strategies used by the nervous system.

Two classes of proposals will be considered in response to this solicitation:
  • Research Proposals describing collaborative research projects, and
  • Data Sharing Proposals to enable sharing of data and other resources.
Domestic and international projects will be considered. As detailed in the solicitation, international components of collaborative projects may be funded in parallel by the participating agencies. Specific CRCNS opportunities for parallel funding are available for bilateral US-German Research Proposals, US-German Data Sharing Proposals, US-French Research Proposals, US-French Data Sharing Proposals, US-Israeli Research Proposals, US-Israeli Data Sharing Proposals, US-Japanese Research Proposals, US-Japanese Data Sharing Proposals, US-Spanish Research Proposals, US-Spanish Data Sharing Proposals, and multilateral proposals involving the United States and two or more CRCNS partner countries (please see Section VIII of the solicitation for country-specific instructions, areas of interest and limitations).  NSF will coordinate and manage the review of proposals jointly with participating domestic and foreign funding organizations, through a joint panel review process used by all participating funders.
News & Announcements
Questions about this newsletter or proposal submission may be directed to:

Jennifer Corby
Research Development Officer
jcorby@fas.harvard.edu | 617-495-1590

To see previous BRAIN Initiative Funding Newsletters, please visit our  email archive.
Research Development | Research Administration Services | research.fas.harvard.edu