BRInj eNews!

                Volume No. 1                                 May 2014               




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The William G. & Helen C. Hoffman Foundation
for helping us to continue to grow our BioBank.


Our BioBank is a collection of biological samples, such as blood, that can be used to rapidly answer complex medical questions.

















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We are excited to share with you the latest news from The Biomedical Research Institute of New Jersey.
Dr. Liz Eckman
Alzheimer's Research


Scientists from the Biomedical Research Institute of New Jersey and colleagues at the Medical University of South Carolina help to rethink the development of new treatments for Alzheimer's disease


A small protein called amyloid β-peptide (Aβ) accumulates in the brains of Alzheimer's disease patients, ultimately leading to the death of brain cells. Reducing Aβ levels has long been considered a promising therapeutic approach. In recent years drugs have been developed to inhibit the activity of gamma secretase, an enzyme that is required for the production of Aβ. Our recent study published in PLOS One shows that, unexpectedly, partial inhibition of gamma secretase may actually increase Aβ. This appears to occur by shifting the production of the protein away from compartments that contain endothelin-converting enzyme, a protein that normally breaks down Aβ soon after it is made. This finding may help to redefine our search for new treatments to cure Alzheimer's disease.


 Click here to read the entire article


Neonatal Research


A scientist from the Biomedical Research Institute of New Jersey publishes article with Nobel Prize Laureate 


Dr. Nair, a BRInj scientist looks at new therapeutic interventions to treat preterm babies with brain injuries due to lack of oxygen. Lack of proper brain oxygenation due to apnea of prematurity (episodes of stopped breathing) is a serious condition that affects preterm infants. Poor oxygenation leads to less growth hormone release in the brain, affecting normal growth, development, and cognition. In her recent study, Dr. Nair used a model of sleep apnea to study the effects of a drug that stimulates the release of growth hormone. She found that treating with the drug improved cognition and reduced depression and anxiety. This research may lead to the development of therapeutics to fight the damage caused by poor brain oxygenation in infants, children and adults suffering from apnea.

 Click here to read more

Dr. Diego Iacono
Alzheimer's Research


Alzheimer's, Genetics and Environment



A recent publication on identical and fraternal twins by Dr. Iacono and colleagues at the Karolinska Institute in Sweden looks at similarities and differences between twins that share the same paternal imprinting, similar social stimuli and environments, equivalent nutrition and who were diagnosed with Alzheimer's disease. The study demonstrates that the interaction between genetics and environment plays a major role in Alzheimer's disease.



"We hope that this study will open new perspectives in human neuroscience including gene-environment interaction," said Dr. Iacono from BRInj.


Click here to read more  


Follow the links below to read more.






News Health


U.S. News & World Report


USC News



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To advance medical knowledge through research, discover novel methods for prevention and treatment, and educate the next generation of medical research scientists.
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