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Still Trending, Still Overlooked:
7-Hydroxy’s Impact in 2025
A top-trending drug/opioid that most people haven’t heard of… yet it’s a top seller in many communities. 7-Hydroxymitragynine is a drug that has made its way into convenience stores, smoke shops, and street-level drug markets.
So, what is 7-Hydroxymitragynine, also known as 7-OH or simply 7-Hydroxy? It’s an alkaloid that naturally occurs in the kratom plant and is extracted through a semi-synthetic process. 7-Hydroxy is significantly more potent than kratom.
At the street level, kratom has evolved into stronger, underregulated substances that are being sold over the counter. Due to its low public awareness and inconsistent or unconfirmed testing standards, this substance can be difficult to detect. Mitragynine is the main alkaloid in kratom. “Mitragynine is the main alkaloid in kratom. The alkaloid 7-hydroxymitragynine is only a minor kratom constituent, but it is much more potent than mitragynine (Obeng et al., 2020). Mitragynine constitutes about 66% of the total alkaloid content, while 7-hydroxymitragynine makes up just 2% (Hassan et al., 2013).' 7-Hydroxymitragynine is also an active metabolite of mitragynine.
I’m not a chemist, and I don’t have a chemistry degree, as is the case for most people reading this. So, to put it simply: 7-Hydroxy is one of the most popular newer substances being sold, and it comes in many forms, including drinks, pills, and even flavored chewables.
If your state allows the sale of kratom, you can almost guarantee that 7-Hydroxy is being sold alongside it. In fact, I’ve encountered several cases where 7-Hydroxy was sold out due to high local demand.
And now, it’s finally starting to get national attention. In July 2025, the FDA issued warning letters to several companies illegally marketing products containing 7‑Hydroxymitragynine. These include drinks, tablets, gummies, and other products often sold over the counter or online, many of which are not clearly labeled or regulated.
Read the full FDA announcement to learn what this could mean for community-level prevention and regulation.
Read the full article written by Jermaine Galloway HERE:
in the Tall Cop Says Stop blog.
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