Issue 03 | Fall 2018
Program Newsletter
for Basic and Clinical Research 
We are pleased to restart distribution (following a temporary hiatus) of the quarterly newsletter for the Rutgers Cancer Institute of New Jersey’s Basic Research and Clinical Research Programs. Comprised of content submitted by our Research Program Members, this newsletter will keep you informed of their awards, publications, presentations, and other matters of programmatic importance since the time of the last newsletter (Summer 2017).
Shared Resources
at Rutgers Cancer Institute of New Jersey 
Featured Resource: Metabolomics

In 2011, the consortium Cancer Center established a shared resource for Metabolomics, with both the Princeton and New Brunswick sites. This shared resource pushes the frontiers of tumor metabolism measurements and provides Rutgers Cancer Institute members with easy, cost-effective access to these capabilities. The overarching objective is to enable scientific discoveries that significantly impact cancer diagnosis and therapy.

The specific objectives of the Metabolomics Shared Resource are to:

  • Provide access to basic metabolism measurement capabilities, such as oxygen uptake by Seahorse analyzer
  • Provide more advanced services, such as large-scale quantitative metabolite measurement by LC-MS
  • Develop and collaboratively apply cutting-edge metabolism measurement capabilities including isotope tracing
  • Engage users at all stages of the metabolomics research process, guiding experimental design, conducting analyses, and assisting users with data analysis.
  • Enhance scientific interaction and productivity across the consortium
  • Accelerate research programs towards new diagnostic or therapeutic approaches for cancer
  • Provide cost-effective pricing and expeditious turnaround times
Services Provided:
  • Water-Soluble Metabolite Quantitation
  • Panel covers ~400 polar metabolites involved in glycolysis, TCA cycle, amino acid and nucleotide metabolism, etc.
  • Fatty acid and Lipid Quantitation 
  • Panel covers >1,800 lipid species including glycerides, cholesteryl ester, phosphatidylserine, sphingomyelin, ceramide etc
  • Design and Analyze Stable Isotope Labeling Experiments
  • Strong expertise in stable isotope labeling experiments using 13C,15N or 2H tracers. This can be done in cultured cells as well as living animals.
  • Simple biochemical measurements such as glucose uptake, lactate excretion, and oxygen consumption 
  • Novel or Unexpected Metabolite Discovery 
  • Expert Consultation and training
Equipment:
Princeton
  • Thermo Q-Exactive LC-MS/MS
  • Thermo Exactive LC-MS
  • Agilent 6550 iFunnel QTOF LC-MS/MS 
  • Bruker SolariX XR high-res imaging mass spectrometer        
  • Thermo TSQ Quantum triple quadrupole LC-MS/MS
  • YSI Automated Electrochemical Analyzer 
  • Seahorse XF Extracellular Flux Analyzer 
New Brunswick
  • Thermo-Q Exactive LC-MS/MS
  • Seahorse XF Extracellular Flux Analyzer 
  • NOVA Electrochemical Analyzer 
To learn more about the services available from the Metabolomics Shared Resource, please visit  the website page or contact Co-Director  Xiaoyang Su at 732-235-4022 or  xs137@rwjms.rutgers.edu   for the New Brunswick site and Research Specialist Wenyun Lu at 609-258-2715 or  wlu@Princeton.edu for the Princeton site.

Please remember to acknowledge the valuable services provided by the Metabolomics Shared Resource in your research papers, publications, and grant applications. The following acknowledgment statement is recommended:

"This research was supported by the Metabolomics Shared Resource of Rutgers Cancer Institute of New Jersey (P30CA072720)."
Upcoming Conferences & Retreats
SAVE THE DATE

April 11, 2019
The 2019 Governor’s Conference on Effective
Partnering in Cancer Research
Institute for Advanced Study
Wolfensohn Hall
1 Einstein Drive
Princeton, NJ 08540
 
May 23, 2019
The 2019 Annual Retreat on Cancer Research in New Jersey
College Avenue Student Center, Rutgers University
126 College Avenue
New Brunswick, NJ 08901

Keynote Speaker
Steven A. Rosenberg, MD, PhD
Chief, Surgery Branch
Senior Investigator
Head, Tumor Immunology Section
National Institutes of Health Center for Cancer Research
National Cancer Institute

MORE DETAILS TO FOLLOW

Recent Conferences & Retreats
Tri-State Metabolism Meeting
On March 2, 2018, Princeton University hosted the Tristate Cancer Metabolism Meeting. This day-long meeting occurs once or twice per year and brings together cancer metabolism researchers from Rutgers University, Princeton University, Memorial-Sloan Kettering Cancer Center, Weill Cornell Medical College, University of Pennsylvania, and New York University. 








Presenters at this meeting included Laura Poillet Perez ( Eileen White, PhD laboratory), Alex Bott ( Wei-Xing Zong, PhD laboratory), and Lukas Tanner ( Joshua D. Rabinowitz, MD, PhD laboratory). 
2018 Annual Retreat on Cancer Research in New Jersey

The 2018 Annual Retreat on Cancer Research in New Jersey gave researchers, staff, students, and the general public a day of learning and network about research opportunities and innovations. The retreat began with the public forum “Preventing HPV Related Cancers: Advances and Challenges", which included presentations and a panel discussion by  Mark H. Einstein, MD, MS, FACS, FACOG ,  Perry Halkitis, PhD, MS, MPH , and  Jennifer Tsui, PhD, MPH . 
Panel Discussion during the Public Forum
Poster presentations on research from the  Research Programs and on the  Shared Resources followed.
Steven K. Libutti, MD, FACS , Director of Rutgers Cancer Institute of New Jersey, then gave the welcome and introduction. The Keynote Address, entitled “Preventing HPV-Associated Cancers Through Vaccination and Screening", was given by Douglas R. Lowy, MD, Deputy Director of the National Cancer Institute. The retreat concluded with another poster session and focus sessions on the  Research Programs .
Dr. Libutti giving the Welcome and Introduction
Dr. Lowy giving the Keynote Address
Cancer Metabolism & Growth
Meet Our New Members!
Awards and Honors

Jessie Yanxiang Guo, PhD received a Lung Cancer Research Foundation grant for her project entitled “Elucidating the mechanism of autophagy in supporting Lkb1-deficient lung tumorigenesis”.  Term: 11/1/2018 – 10/31/2020. Amount: $150,000.  

Ahmed Lasfar, PhD and Andrew Zloza, MD, PhD , were awarded a multi-PI National Cancer Institute (NCI) R01 CA225993 Grant, entitled “Role of IFN-lambda in Promoting Breast Cancer Metastasis”.  Term: 07/15/2018 – 06/30/2023. Amount: $1,987,500.00.

Eileen White, PhD and  Joshua D. Rabinowitz, MD, PhD were awarded a multi-PI National Cancer Institute (NCI) R01 CA163591 Grant, entitled “Tumor Cell Dependence on Host Metabolism”.  Term: 7/1/2018 – 6/30/2022. Amount: $2,240,000.   

Tessa Bergsbaken, PhD received a Feldstein Medical Foundation Grant, entitled "Tissue IL-33 programs tissue-resident memory cells during infection and malignancy". Term: 7/2018-6/2019. Total Award Amount: $75,000.

 In July 2018,  Kenneth D. Irvine, PhD became Director of Rutgers Graduate Program in Cell & Developmental Biology.

Akshada Sawant, PhD, mentee of  Eileen White, PhD , received a Post-Doctoral Fellowship Award from New Jersey Commission on Cancer Research in the amount of $100,000 for the project “Identifying Mechanisms by which Tumors with High Mutation Burden Respond to Immunotherapy”.  

Andreas Kourouklis, PhD, mentee of  Celeste M. Nelson, PhD , received a Post-Doctoral Fellowship Award from New Jersey Commission on Cancer Research in the amount of $100,000 for the project “YAP-Regulated Metastasis in Engineered Human Breast Tumors”.  

Benjamin Winer, mentee of  Alexander Ploss, PhD , received a Pre-Doctoral Fellowship Award from New Jersey Commission on Cancer Research in the amount of $50,000 for the project “Characterizing the Molecular Determinants of Viral Hepatitis Induced Liver Cancer”.  

Carly Garrison, mentee of  Jean E. Schwarzbauer, PhD , received a Pre-Doctoral Fellowship Award from New Jersey Commission on Cancer Research in the amount of $50,000 for the project “Modulating the Alignment of Extracelluar Matrix Fibrils to Control Tumor Cell Invasion”.  

Fenfang Chen, PhD, mentee of  Yibin Kang, PhD , received a Post-Doctoral Fellowship Award from New Jersey Commission on Cancer Research in the amount of $100,000 for the project “Identification and Characterization of Novel Long-Non-Coding RNAs in TGFb Signaling”.  

Harry Hurley, mentee of  Patricia Fitzgerald-Bocarsly, PhD , received a Pre-Doctoral Fellowship Award from New Jersey Commission on Cancer Research in the amount of $50,000 for the project “Metabolic Regulation of Tumor Immunosurveillance”.  

Joseph Bulatowicz, mentee of  Teresa L. Wood, PhD , received a Pre-Doctoral Fellowship Award from New Jersey Commission on Cancer Research in the amount of $50,000 for the project “Cell Stress and Metastasis in Breast Cancer”.  

Khoosheh Khayati, PhD, mentee of  Yanxiang (Jessie) Guo, PhD , received a Post-Doctoral Fellowship Award from New Jersey Commission on Cancer Research in the amount of $100,000 for the project “Targeting Creatine Kinase Metabolism to Improve Kras-driven Lung Cancer Treatment”.  

LiFeng Yang, PhD, mentee of  Joshua D. Rabinowitz, MD, PhD , received a Post-Doctoral Fellowship Award from New Jersey Commission on Cancer Research in the amount of $100,000 for the project “Mitochondrial Serine Catabolism Regulates NADH Pool in an Arrest Mitochondrion”.

Eric Klein, PhD and Grace Brannigan, PhD were awarded a Rutgers University-Camden Provost’s Research Grant, entitled “Bacterial adhesion: A novel regulator of prokaryotic signal-transduction”.  Term: 1/1/2018-12/31/2019. Amount: $14,000.

Tessa Bergsbaken, PhD was awarded a K22 Career Development award from the National Cancer Institute, entitled "Defining the inflammatory signals that regulate CD8+ T cell recruitment/function in colorectal cancer". T erm: 9/2017- 8/2020. Total Award Amount: $567,000.
Presentations
Jessie Yanxiang Guo gave an oral presentation “Autophagy Modulates Lipid Metabolism to Maintain Metabolic Flexibility for Lkb1-deficient Kras-driven Lung Tumorigenesis” at the Cold Spring Harbor Laboratory (CSHL) Meeting: Mechanism & Models of Cancer held August 14-18, 2018 at CSHL in Cold Spring Harbor,NY, USA.
Dr. Guo, Dr. Laura Poillet-Perez, and Dr. Eileen White at Cold Spring Harbor Laboratory
Eileen White, PhD presented “Metabolic Dependencies of Tumor-Host Interaction” at the 17th International Biennial Congress of the Metastasis Research Society (MRS) held August 1-5, 2018 at Princeton University, Princeton, NJ. 

Eileen White, PhD presented “Role of Autophagy in Cancer Metabolism” at the Sanford Burnham Prebys Medical Discovery Institute’s 4 th Cancer Metabolism Symposium: Signaling and Metabolic Complexity in Cancer, held June 19-22, 2018 at Sanford Burnham Prebys Medical Discovery Institute in La Jolla, CA.

Tessa Bergsbaken, PhD gave a presentation entitled "Intestinal inflammation drives differentiation of tissue-resident memory CD8 + T cell populations" at the American Society for Microbiology (ASM) Microbe Annual Meeting held June 7-11, 2018 in Atlanta, GA.

Jessie Yanxiang Guo presented a poster “Autophagy modulates lipid metabolism to support LKB1-deficient lung tumor growth” at the Keystone Symposia conference "Selective Autophagy" held April 22-26, 2018 in Kyoto, Japan.

Eileen White, PhD presented “Autophagy and Cellular Metabolism in Cancer Progression and Treatment” at the American Association for Cancer Research (AACR) Annual Meeting 2018, held April 14-18, 2018 in Chicago, IL.

Eileen White, PhD presented “Inhibiting Autophagy as a Cancer Therapy” at the Keystone Symposium Tumor Metabolism, held January 21-25, 2018 in Snowbird, UT.
 
Eileen White, PhD presented “Autophagy and Cancer Metabolism” for the Perlmutter Cancer Center Research Seminar Series on January 3, 2018 at NYU Langone Medical Center in New York, NY.

Kenneth D. Irvine, PhD presented "Biomechanical regulation of organ growth" at a "Symposium in honor of Eric Wieschaus" held   December 1, 2017 at Princeton University, in Princeton, NJ.

Eileen White, PhD presented “Cancer Metabolism” for the Mari Lowe Comparative Oncology Seminar Series on October 31, 2017 at University of Pennsylvania in Philadelphia, PA.

Eileen White, PhD gave the Keynote Presentation “Autophagy and Cancer Metabolism” for the Mildred Scheel Lectureship of the German Network Oncology Centers of Excellence held October 26-28, 2017 at University Hospital Frankfurt in Frankfurt, Germany.

 Kenneth D. Irvine, PhD presented "Biomechanical regulation of Hippo signaling"at the EMBO Workshop “The Hippo pathway across species and disciplines”, held October 25-29, 2017 at Regina Elena Cancer Institute in Rome, Italy. 

Eileen White, PhD presented “Autophagy, Metabolism, and Cancer” at the EPFL-EMBO Press Symposium Frontiers in Metabolism: From System Physiology to Precision Medicineheld October 24-26, 2017 in Lausanne, Switzerland.

Eileen White, PhD gave the keynote presentation at the EMBO Conference Autophagy: From Molecular Principles to Human Diseasesheld September 25-29, 2017 in Cavtat-Dubrovnik, Croatia.

Eileen White, PhD gave the keynote presentation “Targeting Autophagy in Cancer” at the Cambridge Health Tech Institute meeting "Targeting Autophagy: Advances in Pharmaceutically Modulating Autophagy in Disease", held September 25, 2017 in Boston, MA.
Selected Publications

Misra JR, Irvine KD . The Hippo Signaling Network and Its Biological Functions. Annual review of genetics. 2018;52:65-87. Epub 2018/09/06. doi: 10.1146/annurev-genet-120417-031621. PubMed PMID: 30183404.

Lasfar A * , Zloza A, Silk AW, Lee LY, Cohen-Solal KA. Interferon Lambda: Toward a Dual Role in Cancer. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 2018. Epub 2018/07/19. doi: 10.1089/jir.2018.0046. PubMed PMID: 30020822.

Tsang CK, Chen M, Cheng X, Qi Y, Chen Y, Das I, Li X, Vallat B, Fu LW, Qian CN, Wang HY, White E , Burley SK, Zheng XFS. SOD1 Phosphorylation by mTORC1 Couples Nutrient Sensing and Redox Regulation. Molecular cell. 2018;70(3):502-15.e8. Epub 2018/05/05. doi: 10.1016/j.molcel.2018.03.029. PubMed PMID: 29727620; PMCID: PMC6108545.

Ibar C, Kirichenko E, Keepers B, Enners E, Fleisch K, Irvine KD . Tension-dependent regulation of mammalian Hippo signaling through LIMD1. Journal of cell science. 2018;131(5). Epub 2018/02/15. doi: 10.1242/jcs.214700. PubMed PMID: 29440237; PMCID: PMC5897721.

Mao Y, Sun S, Irvine KD . Role and regulation of Yap in KrasG12D-induced lung cancer. Oncotarget. 2017;8(67):110877-89. Epub 2018/01/18. doi: 10.18632/oncotarget.22865. PubMed PMID: 29340023; PMCID: PMC5762291.

Irvine KD , Shraiman BI. Mechanical control of growth: ideas, facts and challenges. Development (Cambridge, England). 2017;144(23):4238-48. Epub 2017/12/01. doi: 10.1242/dev.151902. PubMed PMID: 29183937; PMCID: PMC5769630.

Cohen-Solal KA, Kaufman HL, Lasfar A . Transcription factors as critical players in melanoma invasiveness, drug resistance, and opportunities for therapeutic drug development. Pigment cell & melanoma research. 2018;31(2):241-52. Epub 2017/11/02. doi: 10.1111/pcmr.12666. PubMed PMID: 29090514.

*Corresponding Author
Cancer Pharmacology
Meet Our New Members!
Awards and Honors

Daniel Herranz Benito, PhD was awarded a Leukemia Research Foundation (LRF) New investigator grant entitled “Dissecting the role of PKM2 in NOTCH1-induced T-ALL”.  Term 7/1/2018-6/30/2019. Amount: $100,000.
 
Manisha Bajpai, PhD and her FISH-EA team were among the 10 entrepreneurial teams selected for the National Science Foundation funded Rutgers I-Corps™ Site program in the Spring of 2018.

KiBum Lee, PhD   [ MPI,  Leading PI-KiBum Lee, other PI-Kelvin Kwan (CBN)] has been awarded a $1,642,275 R01 DC016612 grant through NIH. The main objective of this grant is to develop a bio-inspired platform that can replicate the structure and function on endogenous proteins called transfection factors (TFs), which are specific for the regeneration of functional hair cells. We aim to develop effective therapeutics against hearing loss from this proposed study.  The new grant will be funded from May 1, 2018 to April 30, 2023.

Caitlyn Moore, mentee of  Pranela Rameshwar, PhD , received a Pre-Doctoral Fellowship Award from New Jersey Commission on Cancer Research in the amount of $50,000 for the project “The Role of Perivascular Bone Marrow Microenvironment in Breast Cancer Dormancy”.

Manisha Bajpai, PhD received a New Jersey Health Foundation Grant, entitled “Clinical Validation of ‘FISH’ Based Probes that Detect Chromosomal Changes in Barrett’s Epithelial Adenocarcinoma”.  Term: 2018-2019. Amount: $35,000.
 
Manisha Bajpai, PhD was awarded a Tech Advance Grant from Rutgers University Office of Research and Economic Development (ORED).  Term: 2018-2019. Amount: $100,000. Role: PI.
      
Manisha Bajpai, PhD is Co-Investigator with PI Sunanada Gaur and community health education partner in a New Jersey Healthy Communities Network for the South Asian Total Health Initiative (SATHI).  Term: 2018-2020. Amount: $20,000.  
 
Manisha Bajpai, PhD was one among four Robert Wood Johnson Medical School faculty selected to participate in The Objective Analysis of Self and Institution Seminar (OASIS) Program 2018, a semester-long program with approximately 25 female faculty participating in workshops, networking, peer mentoring, and individual coaching, organized annually by the Rutgers Office of Faculty Development.

Daniel Herranz Benito, PhD was awarded an Alex’s Lemonade Stand Foundation (ALSF) Shark Tank Award, entitled “Uncovering the Myc enhancer-ome in pediatric cancer”.  Term 10/1/2017-7/31/2018. Amount: $14,500.
Presentations

Daniel Herranz Benito, PhD gave the presentation “Therapeutic effects and metabolic rewiring upon glutaminase loss in T-ALL” at the AACR Special Conference on Cancer Metabolism, held September 28-October 1, 2018 in Brooklyn, New York.
Dr. Herranz at the AACR Special Conference on Cancer Metabolism
KiBum Lee, PhD  gave an invited talk entitled “Bio-Inspired Hybrid Nanomaterials for Enhanced Stem Cell Therapy” at the US-Korea Conference on Science, Technology, and Entrepreneurship: Leading Discoveries in the Era of the 4 th  Industrial Revolution (UKC 2018), held August 1-4, 2018 at St. John’s University in Queens, NY. 

KiBum Lee, PhD  gave an invited talk entitled “Bio-inspired nanoparticle-based transcription factor to control stem cell fate and function” at the American Chemical Society National Meeting & Exposition: Nanoscience, Nanotechnology, and Beyond, held August 19-23, 2018 in Boston, MA. 

In July 2018,  KiBum Lee, PhD  gave an invited talk entitled “Bioinspired Nanomaterials for Cellular Reprogramming” to the Department of Biomedical Engineering at Dongguk University in Seoul, Korea.

KiBum Lee, PhD  presented “Bioinspired Nanomaterials for Cellular Reprogramming” at NanoKorea 2018’s Nano Convergence Special Session: Frontiers in Nanotechnology, held July 12, 2018 in Seoul, Korea.

In July 2018,  KiBum Lee, PhD  gave an invited talk entitled “Bioinspired Nanomaterials for Cellular Reprogramming” to the Department of Materials Science & Engineering at Gwangju Institute of Science and Technology (GIST) in Gwangju, Korea.

KiBum Lee, PhD  presented “Bioinspired Nanomaterials for Cellular Reprogramming” at the 10 th  US-Japan Workshop on Advances in Organic/Inorganic Hybrid Materials, held June 17-21, 2018 at Rutgers University’s Center for Law and Justice in Newark, NJ.

Daniel Herranz Benito, PhD was invited to give the presentation “Dissecting NOTCH1-controlled transcriptional and metabolic oncogenic programs in T-ALL” on June 4, 2018 at the Spanish National Cancer Center (CNIO) in Madrid, Spain.

In May 2018,  KiBum Lee, PhD  gave an invited talk entitled “Bioinspired Nanomaterials for Cellular Reprogramming” to the Department of Chemistry at Kyung Hee University in Seoul, Korea.

In May 2018,  KiBum Lee, PhD  gave an invited talk entitled “Bioinspired Nanomaterials for Cellular Reprogramming” to the Department of Mechanical Engineering at Sogang University in Seoul, Korea.

In May 2018,  KiBum Lee, PhD  gave an invited talk entitled “Bioinspired Nanomaterials for Cellular Reprogramming” to the College of Pharmacy at Kyung Hee University in Seoul, Korea.

KiBum Lee, PhD  gave a Keynote Speech entitled “Nanotechnology approaches to control stem cell fate” at the Korean-American Scientists and Engineers Association’s (KSEA’s) 27 th  Northeast Regional Conference, held March 24, 2018 at Montclair University in Montclair, NJ.

In March 2018,  KiBum Lee, PhD  gave an invited talk entitled “Bioinspired Nanomaterials for Cellular Reprogramming” to the Chemistry Department of Emory University at Atlanta, GA.

KiBum Lee, PhD  presented “Bioinspired Nanomaterials for Cellular Reprogramming” at the SPIRITS International Symposium 2018: Multidisciplinary Approaches for Cell Control, held February 27-28, 2018 at Kyoto University in Kyoto, Japan.
Daniel Herranz Benito, PhD was invited to give the presentation “Dissecting NOTCH1-controlled transcriptional and metabolic oncogenic programs in T-ALL” on December 20, 2017 the IMDEA Food Institute in Madrid, Spain.
Dr. Herranz presenting to the IMDEA Food Institute
Daniel Herranz, PhD was invited to give the presentation “Dissecting NOTCH1-controlled transcriptional and metabolic oncogenic programs in T-ALL” on December 18, 2017 at the Institut de Recherche en Cancérologie de Montpellier, in Montpellier, France.

KiBum Lee, PhD  gave an invited talk entitled  “Bioinspired Nanomaterials for Cellular Reprogramming”  at the 11th International Symposium on Nanomedicine, held December 13-15, 2017 at Tohoku University in Sendai, Japan.
Selected Publications

Minacapelli CD, Bajpai M , Geng X, Van Gurp J, Poplin E, Amenta PS, Brant SR, Das KM. miR-206 as a Biomarker for Response to Mesalamine Treatment in Ulcerative Colitis. Inflammatory bowel diseases. 2018. Epub 2018/09/12. doi: 10.1093/ibd/izy279. PubMed PMID: 30204869.

Bhamidipati M, Cho HY, Lee KB , Fabris L. SERS-Based Quantification of Biomarker Expression at the Single Cell Level Enabled by Gold Nanostars and Truncated Aptamers. Bioconjugate chemistry. 2018;29(9):2970-81. Epub 2018/08/16. doi: 10.1021/acs.bioconjchem.8b00397. PubMed PMID: 30110153.

Yang L, Chueng SD, Li Y, Patel M, Rathnam C, Dey G, Wang L, Cai L, Lee KB* . A biodegradable hybrid inorganic nanoscaffold for advanced stem cell therapy. Nature communications. 2018;9(1):3147. Epub 2018/08/10. doi: 10.1038/s41467-018-05599-2. PubMed PMID: 30089775; PMCID: PMC6082841. This publication was  highlighted in the Nature Bioengineering Blog.

Lee JH, Choi HK, Yang L, Chueng SD, Choi JW*, Lee KB * . Nondestructive Real-Time Monitoring of Enhanced Stem Cell Differentiation Using a Graphene-Au Hybrid Nanoelectrode Array. Advanced materials (Deerfield Beach, Fla). 2018;30(39):e1802762. Epub 2018/08/04. doi: 10.1002/adma.201802762. PubMed PMID: 30073706. This publication was selected as the  Cover Picture for this edition of Advanced Materials .

Yin PT, Pongkulapa T, Cho HY, Han J, Pasquale NJ, Rabie H, Kim JH, Choi JW, Lee KB . Overcoming Chemoresistance in Cancer via Combined MicroRNA Therapeutics with Anticancer Drugs Using Multifunctional Magnetic Core-Shell Nanoparticles. ACS applied materials & interfaces. 2018;10(32):26954-63. Epub 2018/07/22. doi: 10.1021/acsami.8b09086. PubMed PMID: 30028120.

Costa-Machado LF, Martin-Hernandez R, Sanchez-Luengo MA, Hess K, Vales-Villamarin C, Barradas M, Lynch C, de la Nava D, Diaz-Ruiz A, de Cabo R, Canamero M, Martinez L, Sanchez-Carbayo M, Herranz D* , Serrano M*, Fernandez-Marcos PJ*. Sirt1 protects from K-Ras-driven lung carcinogenesis. EMBO reports. 2018;19(9). Epub 2018/07/20. doi: 10.15252/embr.201643879. PubMed PMID: 30021836; PMCID: PMC6123659 .

Pang AH, Obiero JM, Kulczyk AW , Sviripa VM, Tsodikov OV. A crystal structure of coil 1B of vimentin in the filamentous form provides a model of a high-order assembly of a vimentin filament. The FEBS journal. 2018;285(15):2888-99. Epub 2018/06/16. doi: 10.1111/febs.14585. PubMed PMID: 29905014.

Marciel MP, Khadka VS, Deng Y, Kilicaslan P, Pham A, Bertino P, Lee K, Chen S , Glibetic N, Hoffmann FW, Matter ML, Hoffmann PR. Selenoprotein K deficiency inhibits melanoma by reducing calcium flux required for tumor growth and metastasis. Oncotarget. 2018;9(17):13407-22. Epub 2018/03/24. doi: 10.18632/oncotarget.24388. PubMed PMID: 29568366; PMCID: PMC5862587.

Cho HY, Lee T, Yoon J, Han Z, Rabie H, Lee KB , Su WW, Choi JW. Magnetic Oleosome as a Functional Lipophilic Drug Carrier for Cancer Therapy. ACS applied materials & interfaces. 2018;10(11):9301-9. Epub 2018/03/01. doi: 10.1021/acsami.7b19255. PubMed PMID: 29488744.

Chen HC, Sierra J, Yu LJ, Cerchio R, Jr., Wall BA, Goydos J, Chen S . Activation of Grm1 expression by mutated BRaf (V600E) in vitro and in vivo. Oncotarget. 2018;9(5):5861-75. Epub 2018/02/22. doi: 10.18632/oncotarget.23637. PubMed PMID: 29464040; PMCID: PMC5814180.

Isola AL, Eddy K, Zembrzuski K, Goydos JS, Chen S . Exosomes released by metabotropic glutamate receptor 1 (GRM1) expressing melanoma cells increase cell migration and invasiveness. Oncotarget. 2018;9(1):1187-99. Epub 2018/02/09. doi: 10.18632/oncotarget.23455. PubMed PMID: 29416686; PMCID: PMC5787429.

Bliss SA, Paul S, Pobiarzyn PW, Ayer S, Sinha G, Pant S, Hilton H, Sharma N, Cunha MF, Engelberth DJ, Greco SJ, Bryan M, Kucia MJ, Kakar SS, Ratajczak MZ, Rameshwar P . Evaluation of a developmental hierarchy for breast cancer cells to assess risk-based patient selection for targeted treatment. Scientific reports. 2018;8(1):367. Epub 2018/01/13. doi: 10.1038/s41598-017-18834-5. PubMed PMID: 29321622; PMCID: PMC5762675.

Han TT, Yang L, Lee K-B , Mainelis GJA, Research AQ. Design and Development of a Novel Nanofiber Nasal Filter (NNF) to Improve Respiratory Health.Aerosol and Air Quality Research. 2018;18:2064-76.

Prabhas V. Moghe, PhD spoke to Rutgers Today about his publication in Nature Biomedical Engineering, entitled "Surveillance nanotechnology for multi-organ cancer metastases". Published online on December 11, 2017, read more about the publication here.

Chaker M, Minden A, Chen S , Weiss RH, Chini EN, Mahipal A, Azmi AS. Rho GTPase effectors and NAD metabolism in cancer immune suppression. Expert opinion on therapeutic targets. 2018;22(1):9-17. Epub 2017/12/07. doi: 10.1080/14728222.2018.1413091. PubMed PMID: 29207896; PMCID: PMC6056002.

Cho HY, Hossain MK, Lee JH, Han J, Lee HJ, Kim KJ, Kim JH, Lee KB , Choi JW. Selective isolation and noninvasive analysis of circulating cancer stem cells through Raman imaging. Biosensors & bioelectronics. 2018;102:372-82. Epub 2017/11/28. doi: 10.1016/j.bios.2017.11.049. PubMed PMID: 29174970.

Minacapelli CD, Bajpai M , Geng X, Cheng CL, Chouthai AA, Souza R, Spechler SJ, Das KM. Barrett's metaplasia develops from cellular reprograming of esophageal squamous epithelium due to gastroesophageal reflux. American journal of physiology Gastrointestinal and liver physiology. 2017;312(6):G615-g22. Epub 2017/03/25. doi: 10.1152/ajpgi.00268.2016. PubMed PMID: 28336546.

*Corresponding Author
Clinical Investigations &
Precision Therapeutics
Meet Our New Members!
Awards and Honors

Lauren Aleksunes, PharmD, PhD, DABT was awarded a multi-PI National Institute of General Medical Sciences R01GM123330 Grant, entitled “Drug Disposition and Nephrotoxicity”. Term: 9/15/18-8/30/22. Amount: $1,997,738. This grant is in collaboration with the Cancer Centers at the University of Colorado and Memorial Sloan Kettering where oncology patients will be recruited. 

Andrew M. Evens, DO, MSc is the Principal Investigator on the investigator initiated clinical trial entitled “A Phase I-II Trial of DA-EPOCH-R Plus Ixazomib as Frontline Therapy for Patients with MYC-aberrant Lymphoid Malignancies: The DACIPHOR Regimen”.  Project Start & End Date: 06/19/2018 - 06/30/2023. Sponsor: Northwestern University. Project Total Amount: $117,463.80.

Andrew M. Evens, DO, MSc is the Principal Investigator on the investigator initiated clinical trial entitled “Phase II study of PET-directed frontline therapy with pembrolizumab and AVD for patients with classical Hodgkin lymphoma”.  Project Start & End Date: 06/19/2018 - 06/30/2021. Sponsor: Northwestern University. Project Total Amount: $35,512.70.

Salma Jabbour, MD  received the Association of Residents in Radiation Oncology (ARRO) Educator of the Year Award in June 2018.

Andrew M. Evens, DO, MSc was awarded a multi-PI NIH   R33CA223908 Grant with T. Konry and T. Huang, entitled “Determining treatment sensitivity in B cell lymphoma by novel microfluidics-based NK cell immunogenicity platform”.  Term: 05/01/2018 – 04/30/2021. Total Direct Costs: $1,186,103.

In February 2018,  John L. Nosher, MD  was a recipient of Rutgers University’s 2017 Open and Affordable Textbooks (OAT) Program Award, for the development of content on a platform that is built to accommodate rapid advances in radiology technology. Read more about Dr. Nosher’s award  here .

Anshuman Panda, PhD, mentee of  Shridar Ganesan, MD, PhD , received a Post-Doctoral Fellowship Award from New Jersey Commission on Cancer Research in the amount of $100,000 for the project “Mechanisms and Biomarkers of Response to Immune Checkpoint Therapy”. 

Salma Jabbour, MD  received the American Association for Women Radiologists (AAWR) Mid-Career Award to attend the Association of American Medical Colleges (AAMC) Mid-Career Women Faculty Leadership Development Seminar, held December 2-5, 2017 at Westin Kierland Resort & Spa in Scottsdale, AZ.

John L. Nosher, MD  was selected as a “Top Doctor – All Specialties” for Inside Jersey Magazine’s October 2017 issue.
Presentations

Andrew M. Evens, DO, MSc presented“Lymphoma Clinical Update: Hodgkin Lymphoma and T-cell lymphoma” on September 27, 2018 for a Disease Education seminar at Hunterdon Regional Cancer Center in Flemington, NJ.
 
Andrew M. Evens, DO, MSc presented“Support Systems and Infrastructure for Young Cancer Investigators” at the Lymphoma Research Foundation’s Biden Cancer Community Summit, held September 21, 2018 in New York, NY.
 
John L. Nosher, MD gave an invited talk entitled “RFA and TACE” at the Loco-Regional Therapy section of the North American Neuroendocrine Tumor Society (NANETS) Regional NET Education: the Multidisciplinary Management of NET Cancers, held September 15, 2018 at Rutgers Cancer Institute of New Jersey in New Brunswick, NJ. 
 
Slavamir Sokalaw, a medical student mentored by  John L. Nosher, MD , through the Rutgers-Robert Wood Johnson Medical School Summer Research Program, was nominated and presented “Computational Ultrasound for Diagnosis and Monitoring of Liver and Kidney Cancers” for the Summer Research Program Symposium, held August 8, 2018 at Rutgers Robert Wood Johnson Medical School in Piscataway, NJ.
 
Salma Jabbour, MD  presented “Checkpoint Inhibition in Chemoradiation for NSCLC” in the Translational Science Lung Cancer Workshop at the 2018 NRG Oncology Semiannual Meeting, held July 12-14, 2018 at Philadelphia Downtown Marriott in Philadelphia, PA. 

Shridar Ganesan, MD, PhD , was an invited panelist at the 3 rd Annual Precision Medicine Leaders Summit, which was held June 26-28, 2018 in Jersey City, NJ.  

Andrew M. Evens, DO, MSc presented a “Post-ASCO Overview” on June 19, 2018 for the Lymphoma Research Foundation (LRF) Staff Learning Lab in New York, NY.

Andrew M. Evens, DO, MSc presented on “Aggressive B-cell Lymphomas” for the Leukemia & Lymphoma Society’s Emerging Therapies for Lymphomas continuing education program, held May 17 th , 2018 in Newark, DE.

Andrew M. Evens, DO, MSc participated in “Oncology Grand Rounds: Nurse and Physician Investigators Discuss New Agents, Novel Therapies and Actual Cases from Practice—A 6-Part CNE Symposia Series: Part 1: Lymphoma and Chronic Lymphocytic Leukemia” at the Oncology Nursing Society (ONS) 43 rd Annual Meeting, held May 16 th , 2018 in Washington, DC.
 
Andrew M. Evens, DO, MSc was the Co-chair, and presented “Oral Chemotherapy Adherence & Management of Toxicities”and “Small Molecules on the Horizon in Lymphoma” for the 15 th International Ultmann Chicago Lymphoma Symposium (IUCLS) on the Diagnosis and Management of Lymphoma, held May 4-5, 2018 at the University of Chicago and The Robert H. Lurie Comprehensive Cancer Center of Northwestern University in Chicago, IL.

Dr. Aleksunes presenting at the 1st UConn/URI-AAPS Joint Symposium
Lauren Aleksunes, Pharma, PhD, DABT presented “Improving the Prediction and Detection of Drug-Induced Renal Injury in Cancer Patients: Coupling Transporter Pharmacogenetics and Urinary Biomarkers” at the 1 st UConn/URI-AAPS Joint Symposium, University of Connecticut, Storrs, CT in May 2018.
Andrew M. Evens, DO, MSc presented “Modern Treatment of Hodgkin Lymphoma: Prognostication, Curability & Survivorship” on April 11, 2018 for the Medical Grand Rounds of St. Barnabas Medical Center in Livingston, NJ.

On April 4, 2018,  John L. Nosher, MD presented “Interventional Oncology” to the Rutgers Robert Wood Johnson Medical School Radiology Interest Group in Piscataway, NJ.

Andrew M. Evens, DO, MSc presented “Formulating a Career Development Plan/Research Grants Beyond CDAs” and “How to publish for Lymphoma Related Research” for the Lymphoma Research Foundation’s Annual Clinical Research Mentoring Program meeting, held March 9-10, 2018 at Lymphoma Research Foundation in Scottsdale, AZ.

Lorna Rodriguez-Rodriguez, MD, PhD , was invited to speak at the conference on "Advancing the Science of Cancer in Latinos," hosted by the University of Texas - San Antonio on February 22, 2018. Dr. Rodriguez spoke to an audience of health professionals in a panel session on "Cancer in the Era of Precision Medicine," presenting her research, which asked, "Is Precision Medicine Widening Cancer Care Disparities in Latino Populations?"

Salma Jabbour, MD  presented “Immunotherapy and Non-Small Cell Lung Cancer” at the Radiation Oncology Summit: American College of Radiation Oncology (ACRO) 2018, held February 1-3, 2018 in Ft. Lauderdale, FL.

Andrew M. Evens, DO, MSc   mentored Hematology/Oncology fellow, Dr. Pallvi Popli, and moderated a session/presentation on “Breast Implant Associated Lymphoma” for the Lymphoma Research Foundation’s New York Lymphoma Rounds meeting, held January 28th, 2018 at Lymphoma Research Foundation in New York, New York.

Shridar Ganesan, MD, PhD spoke on the “Expression of endogenous retroviruses and response to immune checkpoint therapy in renal cell cancer” at the 2018 ASCO-SITC Clinical Immuno-Oncology Symposium, held January 25-27, 2018 in  San Francisco, CA. This presentation received  coverage in Oncology Practice on February 9, 2018. 

Rajat Bannerji, MD, PhD presented a session entitled “Bispecific Antibodies and CAR T cells” at the 59 th American Society of Hematology (ASH) Annual Meeting, held December 9-12, 2017 in Atlanta, GA. 
Lauren Aleksunes, PharmD, PhD, DABT presented “Kidney Transporter Genetics and Sensitive Biomarkers of Drug Toxicity in Oncology Patients” at the 3 rd Ling-nan DMPK Forum at Sun Yat-Sen University, Guangzhou, China in December 2017. 
Dr. Aleksunes presenting at the 3rd Ling-nan DMPK Forum
Salma Jabbour, MD  presented “Imaging in Gastrointestinal Cancers in Radiation Oncology” at Radiological Society of North America (RSNA) 103 rd  Scientific Assembly and Annual Meeting, held November 26-December 1, 2017 in Chicago, IL. 

 Salma Jabbour, MD  presented “GI Abstract Review” at the Best of ASTRO, held November 10-11, 2017 in Miami Beach, FL.

Salma Jabbour, MD  presented “GI Science Highlights” at the American Society for Radiation Oncology (ASTRO) 59 th  Annual Meeting, held September 24-27, 2017 in San Diego, CA.

John L. Nosher, MD  and colleagues presented “Local Phase-Based Learning for Needle Detection and Localization in 3D Ultrasound” at the Clinical Image-based Procedures (CLIP) Workshop of the 20 th  International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI), held September 10-14, 2017 in Quebec, Canada.
Selected Publications

Badar T, Hamadani M, Bachanova V, Maddocks KJ, Umyarova E, Chavez JC, Epperla N, Chhabra S, Xavier AC, Karmali R, Salhab M, Reddy N, Glenn MJ, Hernandez-Ilizaliturri FJ, Flowers CR, Evens AM , Zhou Z, Lansigan F, Barta SK, Cohen JB, Fenske TS, Costa LJ. Efficacy of salvage chemotherapy in diffuse large B cell lymphoma with primary treatment failure according to putative cell of origin. Leukemia & lymphoma. 2018:1-7. Epub 2018/10/03. doi: 10.1080/10428194.2018.1515944. PubMed PMID: 30277110.
 
Sharman JP, Forero-Torres A, Costa LJ, Flinn IW, Inhorn L, Kelly K, Bessudo A, Fayad LE, Kaminski MS, Evens AM , Flowers CR, Sahin D, Mundt KE, Sandmann T, Fingerle-Rowson G, Vignal C, Mobasher M, Zelenetz AD. Obinutuzumab plus CHOP is effective and has a tolerable safety profile in previously untreated, advanced diffuse large B-cell lymphoma: the phase II GATHER study. Leukemia & lymphoma. 2018:1-10. Epub 2018/10/03. doi: 10.1080/10428194.2018.1515940. PubMed PMID: 30277102.
 
Ibrahim ME, Chang C, Hu Y, Hogan SL, Mercke N, Gomez M, O'Bryant CL, Bowles DW, George B, Wen X, Buckley B, Aleksunes L , Joy MS. Pharmacokinetic determinants of cisplatin-induced subclinical kidney injury in oncology patients. European journal of clinical pharmacology. 2018. Epub 2018/09/17. doi: 10.1007/s00228-018-2552-z. PubMed PMID: 30220072.

Yegya-Raman N, Zou W, Nie K, Malhotra J, Jabbour SK *. Advanced radiation techniques for locally advanced non-small cell lung cancer: intensity-modulated radiation therapy and proton therapy. Journal of thoracic disease. 2018;10(Suppl 21):S2474-s91. Epub 2018/09/13. doi: 10.21037/jtd.2018.07.29. PubMed PMID: 30206493; PMCID: PMC6123184.

Evens AM , Advani RH, Helenowski IB, Fanale M, Smith SM, Jovanovic BD, Bociek GR, Klein AK, Winter JN, Gordon LI, Hamlin PA. Multicenter Phase II Study of Sequential Brentuximab Vedotin and Doxorubicin, Vinblastine, and Dacarbazine Chemotherapy for Older Patients With Untreated Classical Hodgkin Lymphoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2018:Jco2018790139. Epub 2018/09/05. doi: 10.1200/jco.2018.79.0139. PubMed PMID: 30179569.

Hurwitz ME, Markowski P, Yao X, Deshpande H, Patel J, Mortazavi A, Donadio A, Stein MN, Kelly WK, Petrylak DP, Mehnert JM . Multicenter Phase 2 Trial of Gemcitabine, Carboplatin, and Sorafenib in Patients With Metastatic or Unresectable Transitional-Cell Carcinoma. Clinical genitourinary cancer. 2018;16(6):437-44.e6. Epub 2018/09/05. doi: 10.1016/j.clgc.2018.07.021. PubMed PMID: 30177237.

David JM, Gresham G, Jabbour SK , Deek M, Thomassian S, Robertson JM, Newman NB, Herman JM, Osipov A, Kabolizadeh P, Tuli R. Neoadjuvant PET and MRI-based intensity modulated radiotherapy leads to less toxicity and improved pathologic response rates in locally advanced rectal cancer. Journal of gastrointestinal oncology. 2018;9(4):641-9. Epub 2018/08/29. doi: 10.21037/jgo.2018.03.10. PubMed PMID: 30151260; PMCID: PMC6087868.

Yegya-Raman N, Reyhan M, Kim S, Deek MP, Yue N, Zou W, Malhotra J, Aisner J, Jabbour SK . Association of Target Volume Margins With Locoregional Control and Acute Toxicities for Non-Small Cell Lung Cancer Treated With Concurrent Chemoradiation Therapy. Practical radiation oncology. 2018. Epub 2018/08/26. doi: 10.1016/j.prro.2018.08.007. PubMed PMID: 30144583.

Panda A, de Cubas AA, Stein M, Riedlinger G , Kra J, Mayer T, Smith CC, Vincent BG, Serody JS, Beckermann KE, Ganesan S , Bhanot G , Rathmell WK. Endogenous retrovirus expression is associated with response to immune checkpoint blockade in clear cell renal cell carcinoma. JCI insight. 2018;3(16). Epub 2018/08/24. doi: 10.1172/jci.insight.121522. PubMed PMID: 30135306; PMCID: PMC6141170.

Song M, Kumaran MN, Gounder M, Gibbon DG, Nieves-Neira W, Vaidya A, Hellmann M, Kane MP, Buckley B, Shih W, Caffrey PB, Frenkel GD, Rodriguez-Rodriguez L . Phase I trial of selenium plus chemotherapy in gynecologic cancers. Gynecologic oncology. 2018;150(3):478-86. Epub 2018/08/03. doi: 10.1016/j.ygyno.2018.07.001. PubMed PMID: 30068487; PMCID: PMC6154492.

Krishnamurthy A, Dasari A, Noonan AM, Mehnert JM , Lockhart AC, Leong S, Capasso A, Stein MN, Sanoff HK, Lee JJ, Hansen A, Malhotra U, Rippke S, Gustafson DL, Pitts TM, Ellison K, Davis SL, Messersmith WA, Eckhardt SG, Lieu CH. Phase Ib Results of the Rational Combination of Selumetinib and Cyclosporin A in Advanced Solid Tumors with an Expansion Cohort in Metastatic Colorectal Cancer. Cancer research. 2018;78(18):5398-407. Epub 2018/07/26. doi: 10.1158/0008-5472.Can-18-0316. PubMed PMID: 30042150; PMCID: PMC6139073.

Ascierto PA, Puzanov I, Agarwala SS, Bifulco C, Botti G, Caraco C, Ciliberto G, Davies MA, Dummer R, Ferrone S, Gajewski TF, Garbe C, Luke JJ, Marincola FM, Masucci G, Mehnert JM , Mozzillo N, Palmieri G, Postow MA, Schoenberger SP, Wang E, Thurin M. Perspectives in melanoma: Meeting report from the Melanoma Bridge (30 November-2 December, 2017, Naples, Italy). Journal of translational medicine. 2018;16(1):207. Epub 2018/07/23. doi: 10.1186/s12967-018-1568-6. PubMed PMID: 30031393; PMCID: PMC6054754.

Jabbour SK , Apisarnthanarax S, Hallemeier CL, Huguet F, Murphy JD, Olsen JR. GI Cancers-Modulating the Modern Management of Gastrointestinal Malignancies: A Look at Liver Metastases, Rectal Cancer, Esophagogastric Cancer, and Anal Cancer. International journal of radiation oncology, biology, physics. 2018;101(4):749-58. Epub 2018/07/07. doi: 10.1016/j.ijrobp.2017.11.031. PubMed PMID: 29976479.

Olsen JR, Murphy JD, Hallemeier CL, Apisarnthanarax S, Huguet F, J abbour SK . Cross-Modality Comparisons Between Radiofrequency Ablation and Stereotactic Body Radiotherapy for Treatment of Hepatocellular Carcinoma: Limitations of the National Cancer Database. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2018;36(24):2564-5. Epub 2018/06/28. doi: 10.1200/jco.2018.78.2904. PubMed PMID: 29945521.

Zou W, Burgdorf B, Yue NJ, Yin L, Zhang M, Khan A, Jabbour SK , McDonough J, Dong L, Teo BK. Efficient double-scattering proton therapy with a patient-specific bolus. Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB). 2018;50:1-6. Epub 2018/06/13. doi: 10.1016/j.ejmp.2018.05.003. PubMed PMID: 29891088.

McDonald JT, Kritharis A, Beheshti A, Pilichowska M, Burgess K, Ricks-Santi L, McNiel E, London CB, Ravi D, Evens AM . Comparative oncology DNA sequencing of canine T cell lymphoma via human hotspot panel. Oncotarget. 2018;9(32):22693-702. Epub 2018/06/02. doi: 10.18632/oncotarget.25209. PubMed PMID: 29854308; PMCID: PMC5978258.

Sullivan RJ, Atkins MB, Kirkwood JM, Agarwala SS, Clark JI, Ernstoff MS, Fecher L, Gajewski TF, Gastman B, Lawson DH, Lutzky J, McDermott DF, Margolin KA, Mehnert JM , Pavlick AC, Richards JM, Rubin KM, Sharfman W, Silverstein S, Slingluff CL, Jr., Sondak VK, Tarhini AA, Thompson JA, Urba WJ, White RL, Whitman ED, Hodi FS, Kaufman HL. An update on the Society for Immunotherapy of Cancer consensus statement on tumor immunotherapy for the treatment of cutaneous melanoma: version 2.0. Journal for immunotherapy of cancer. 2018;6(1):44. Epub 2018/06/01. doi: 10.1186/s40425-018-0362-6. PubMed PMID: 29848375; PMCID: PMC5977556.

Weiner AA, Gui B, Newman NB, Nosher JL , Yousseff F, Lu SE, Foltz GM, Carpizo D, Lowenthal J, Zuckerman DA, Benson B, Olsen JR, Jabbour SK , Parikh PJ. Predictors of Survival after Yttrium-90 Radioembolization for Colorectal Cancer Liver Metastases. Journal of vascular and interventional radiology : JVIR. 2018;29(8):1094-100. Epub 2018/05/15. doi: 10.1016/j.jvir.2018.02.020. PubMed PMID: 29754852.

Yegya-Raman N, Kim S, Deek MP, Li D, Gupta A, Bond L, Dwivedi A, Braver JK, Reyhan M, Mittal A, Gui B, Malhotra J, Aisner J, Jabbour SK . Daily Image Guidance With Cone Beam Computed Tomography May Reduce Radiation Pneumonitis in Unresectable Non-Small Cell Lung Cancer. International journal of radiation oncology, biology, physics. 2018;101(5):1104-12. Epub 2018/05/08. doi: 10.1016/j.ijrobp.2018.03.025. PubMed PMID: 29730063.

Parsons SK, Kelly MJ, Cohen JT, Castellino SM, Henderson TO, Kelly KM, Keller FG, Henzer TJ, Kumar AJ, Johnson P, Meyer RM, Radford J, Raemaekers J, Hodgson DC, Evens AM . Early-stage Hodgkin lymphoma in the modern era: simulation modelling to delineate long-term patient outcomes. British journal of haematology. 2018;182(2):212-21. Epub 2018/05/01. doi: 10.1111/bjh.15255. PubMed PMID: 29707774; PMCID: PMC6055753.

Bryan J., Nosher J.L. , and Jabbour S.  Radiolabeled Spheres:  Precision Radiation Oncology, Rutgers University Press Medicine, New Jersey. Chapter 10, pp.206-22225. Published May 2018.   

Huang Q, Jabbour SK , Xiao Z, Yue N, Wang X, Cao H, Kuang Y, Zhang Y, Nie K. Dosimetric feasibility of 4DCT-ventilation imaging guided proton therapy for locally advanced non-small-cell lung cancer. Radiation oncology (London, England). 2018;13(1):78. Epub 2018/04/27. doi: 10.1186/s13014-018-1018-x. PubMed PMID: 29695284; PMCID: PMC5918906.

Omene C , Bandera EV. Anti-VEGF therapy - a role in obesity-related breast cancer. Nature reviews Endocrinology. 2018;14(6):329-30. Epub 2018/04/27. doi: 10.1038/s41574-018-0021-5. PubMed PMID: 29695750.

David KA, Kritharis A, Evens AM . Does Q fever contribute to pathogenesis of non-Hodgkin lymphoma? The Lancet Haematology. 2018;5(5):e186-e7. Epub 2018/04/14. doi: 10.1016/s2352-3026(18)30049-8. PubMed PMID: 29650494.

Chen T, Zhang M, Jabbour S , Wang H, Barbee D, Das IJ, Yue N. Principal component analysis-based imaging angle determination for 3D motion monitoring using single-slice on-board imaging. Medical physics. 2018;45(6):2377-87. Epub 2018/04/11. doi: 10.1002/mp.12904. PubMed PMID: 29635762.

Newman JH, Augeri DJ, NeMoyer R, Malhotra J, Langenfeld E, Chesson CB, Dobias NS, Lee MJ, Tarabichi S, Jhawar SR, Bommareddy PK, Marshall S, Sadimin ET, Kerrigan JE, Goedken M, Minerowicz C, Jabbour SK , Li S, Carayannopolous MO, Zloza A, Langenfeld J. Novel bone morphogenetic protein receptor inhibitor JL5 suppresses tumor cell survival signaling and induces regression of human lung cancer. Oncogene. 2018;37(27):3672-85. Epub 2018/04/07. doi: 10.1038/s41388-018-0156-9. PubMed PMID: 29622797.

Dhami J, Hirshfield KM, Ganesan S , Hellmann M, Rojas V, Amorosa JK, Riedlinger GM , Zhong H, Ali SM, Pavlick D, Elvin JA, Rodriguez-Rodriguez L . Comprehensive genomic profiling aids in treatment of a metastatic endometrial cancer. Cold Spring Harbor molecular case studies. 2018;4(2). Epub 2018/03/29. doi: 10.1101/mcs.a002089. PubMed PMID: 29588307; PMCID: PMC5880253.

NeMoyer RE, Shah MM, Hasan O, Nosher JL , Carpizo DR. A novel combined interventional radiologic and hepatobiliary surgical approach to a complex traumatic hilar biliary stricture. International journal of surgery case reports. 2018;44:185-90. Epub 2018/03/12. doi: 10.1016/j.ijscr.2018.02.043. PubMed PMID: 29525612; PMCID: PMC5928284.

Mwikirize C, Nosher JL , Hacihaliloglu I. Convolution neural networks for real-time needle detection and localization in 2D ultrasound. International journal of computer assisted radiology and surgery. 2018;13(5):647-57. Epub 2018/03/08. doi: 10.1007/s11548-018-1721-y. PubMed PMID: 29512006.

Wang SJ, Hathout L, Malhotra U, Maloney-Patel N, Kilic S, Poplin E, Jabbour SK . Decision-Making Strategy for Rectal Cancer Management Using Radiation Therapy for Elderly or Comorbid Patients. International journal of radiation oncology, biology, physics. 2018;100(4):926-44. Epub 2018/02/28. doi: 10.1016/j.ijrobp.2017.12.261. PubMed PMID: 29485072.

Kelly K, Infante JR, Taylor MH, Patel MR, Wong DJ, Iannotti N, Mehnert JM , Loos AH, Koch H, Speit I, Gulley JL. Safety profile of avelumab in patients with advanced solid tumors: A pooled analysis of data from the phase 1 JAVELIN solid tumor and phase 2 JAVELIN Merkel 200 clinical trials. Cancer. 2018;124(9):2010-7. Epub 2018/02/23. doi: 10.1002/cncr.31293. PubMed PMID: 29469949; PMCID: PMC5947549.

Mehnert JM , Silk AW, Lee JH, Dudek L, Jeong BS, Li J, Schenkel JM, Sadimin E, Kane M, Lin H, Shih WJ, Zloza A, Chen S, Goydos JS. A phase II trial of riluzole, an antagonist of metabotropic glutamate receptor 1 (GRM1) signaling, in patients with advanced melanoma. Pigment cell & melanoma research. 2018;31(4):534-40. Epub 2018/02/18. doi: 10.1111/pcmr.12694. PubMed PMID: 29453787; PMCID: PMC6013351.

Xiao Z, Zou WJ, Chen T, Yue NJ, Jabbour SK , Parikh R, Zhang M. Using gEUD based plan analysis method to evaluate proton vs. photon plans for lung cancer radiation therapy. Journal of applied clinical medical physics. 2018;19(2):204-10. Epub 2018/02/13. doi: 10.1002/acm2.12281. PubMed PMID: 29436163; PMCID: PMC5849822.

Zheng S, Jabbour SK , O'Reilly SE, Lu JJ, Dong L, Ding L, Xiao Y, Yue N, Wang F, Zou W. Automated Information Extraction on Treatment and Prognosis for Non-Small Cell Lung Cancer Radiotherapy Patients: Clinical Study. JMIR medical informatics. 2018;6(1):e8. Epub 2018/02/03. doi: 10.2196/medinform.8662. PubMed PMID: 29391345; PMCID: PMC5814605.

Nosher JL , Patel A, Jagpal S, Gribbin C, Gendel V. Endovascular treatment of pulmonary embolism: Selective review of available techniques. World journal of radiology. 2017;9(12):426-37. Epub 2018/01/23. doi: 10.4329/wjr.v9.i12.426. PubMed PMID: 29354208; PMCID: PMC5746646.

Herman JM, Jabbour SK , Lin SH, Deek MP, Hsu CC, Fishman EK, Kim S, Cameron JL, Chekmareva M, Laheru DA, Narang AK, Pawlik TM, Hruban RH, Wolfgang CL, Iacobuzio-Donahue CA. Smad4 Loss Correlates With Higher Rates of Local and Distant Failure in Pancreatic Adenocarcinoma Patients Receiving Adjuvant Chemoradiation. Pancreas. 2018;47(2):208-12. Epub 2018/01/13. doi: 10.1097/mpa.0000000000000985. PubMed PMID: 29329157; PMCID: PMC5800523.

Herman JM, Jabbour SK , Lin SH, Deek MP, Hsu CC, Fishman EK, Kim S, Cameron JL, Chekmareva M, Laheru DA, Narang AK, Pawlik TM, Hruban RH, Wolfgang CL, Iacobuzio-Donahue CA. Smad4 Loss Correlates With Higher Rates of Local and Distant Failure in Pancreatic Adenocarcinoma Patients Receiving Adjuvant Chemoradiation. Pancreas. 2018;47(2):208-12. Epub 2018/01/13. doi: 10.1097/mpa.0000000000000985. PubMed PMID: 29329157; PMCID: PMC5800523.

Mwikirize C, Nosher JL , Hacihaliloglu I. Signal attenuation maps for needle enhancement and localization in 2D ultrasound. International journal of computer assisted radiology and surgery. 2018;13(3):363-74. Epub 2018/01/03. doi: 10.1007/s11548-017-1698-y. PubMed PMID: 29294213.

George B, Joy MS, Aleksunes LM . Urinary protein biomarkers of kidney injury in patients receiving cisplatin chemotherapy. Experimental biology and medicine (Maywood, NJ). 2018;243(3):272-82. Epub 2017/12/13. doi: 10.1177/1535370217745302. PubMed PMID: 29231123; PMCID: PMC5813872.

Sozio SJ, Jabbour S , Parikh R, Kim S. Locoregional Failure Rounds: A Meaningful Quality Improvement Project. Journal of the American College of Radiology : JACR. 2018;15(3 Pt A):437-9. Epub 2017/12/10. doi: 10.1016/j.jacr.2017.10.005. PubMed PMID: 29221998.

Apisarnthanarax S, Jabbour SK , Liauw SL, Murphy JD, Olsen JR, Chang DT. Gastrointestinal Cancers: Timing Is Everything. International journal of radiation oncology, biology, physics. 2017;99(5):1051-8. Epub 2017/11/23. doi: 10.1016/j.ijrobp.2017.05.040. PubMed PMID: 29165271.

Ma R, Levy M, Gui B, Lu SE, Narra V, Goyal S, Danish S, Hanft S, Khan AJ, Malhotra J, Motwani S, Jabbour SK . Risk of leptomeningeal carcinomatosis in patients with brain metastases treated with stereotactic radiosurgery. Journal of neuro-oncology. 2018;136(2):395-401. Epub 2017/11/22. doi: 10.1007/s11060-017-2666-7. PubMed PMID: 29159778.
 
Panda A, Mehnert JM , Hirshfield KM, Riedlinger G , Damare S, Saunders T, Kane M, Sokol L, Stein MN, Poplin E, Rodriguez-Rodriguez L , Silk AW, Aisner J, Chan N, Malhotra J, Frankel M, Kaufman HL, Ali S, Ross JS, White EP , Bhanot G , Ganesan S . Immune Activation and Benefit From Avelumab in EBV-Positive Gastric Cancer. Journal of the National Cancer Institute. 2018;110(3):316-20. Epub 2017/11/21. doi: 10.1093/jnci/djx213. PubMed PMID: 29155997.

Baik CS, Rubin EH, Forde PM, Mehnert JM , Collyar D, Butler MO, Dixon EL, Chow LQM. Immuno-oncology Clinical Trial Design: Limitations, Challenges, and Opportunities. Clinical cancer research : an official journal of the American Association for Cancer Research. 2017;23(17):4992-5002. Epub 2017/09/03. doi: 10.1158/1078-0432.Ccr-16-3066. PubMed PMID: 28864727; PMCID: PMC5735832.

Mehnert JM , Monjazeb AM, Beerthuijzen JMT, Collyar D, Rubinstein L, Harris LN. The Challenge for Development of Valuable Immuno-oncology Biomarkers. Clinical cancer research : an official journal of the American Association for Cancer Research. 2017;23(17):4970-9. Epub 2017/09/03. doi: 10.1158/1078-0432.Ccr-16-3063. PubMed PMID: 28864725; PMCID: PMC5657536.

Hsu C, Lee SH, Ejadi S, Even C, Cohen RB, Le Tourneau C, Mehnert JM , Algazi A, van Brummelen EMJ, Saraf S, Thanigaimani P, Cheng JD, Hansen AR. Safety and Antitumor Activity of Pembrolizumab in Patients With Programmed Death-Ligand 1-Positive Nasopharyngeal Carcinoma: Results of the KEYNOTE-028 Study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2017;35(36):4050-6. Epub 2017/08/25. doi: 10.1200/jco.2017.73.3675. PubMed PMID: 28837405.

Ott PA, Elez E, Hiret S, Kim DW, Morosky A, Saraf S, Piperdi B, Mehnert JM . Pembrolizumab in Patients With Extensive-Stage Small-Cell Lung Cancer: Results From the Phase Ib KEYNOTE-028 Study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2017;35(34):3823-9. Epub 2017/08/17. doi: 10.1200/jco.2017.72.5069. PubMed PMID: 28813164.

*Corresponding Author
Genomic Instability & Cancer Genetics
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Awards and Honors

Zhaohui Feng, MD, PhD was awarded a Department of Defense (DoD) W81XWH-18-1-0510   Grant, entitled “The Role of TRIM6 in Breast Cancer Metabolism and Cancer Prevention”.  Term: 9/2018 – 8/2021. Amount: $1,192,500. 

Wenwei Hu, PhD was awarded a DoD Peer Reviewed Cancer Research Program W81XWH-18-1-0238   Grant, entitled “Chronic stress and its effect on cancer therapy: mechanism and intervention”.  Term: 7/15/2018 – 7/14/2020. Amount: $636,000.   

Zhaohui Feng, MD, PhD was awarded a National Cancer Institute (NCI) R01CA214746 Grant, entitled “SENP6, a novel p53 negative regulator, is an important new player in cancer”.  Term: 7/2018 – 6/2023. Amount:$1,818,565. 

Gabriele Vincelli, PhD, mentee of  Bing Xia, PhD , received a Post-Doctoral Fellowship Award from New Jersey Commission on Cancer Research in the amount of $100,000 for the project “Understanding the Mechanisms of BRCA2 in DNA Replication and Cell Cycle Checkpoints”.

Jui Wan Loh, mentee of  Hossein Khiabanian, PhD , received a Pre-Doctoral Fellowship Award from New Jersey Commission on Cancer Research in the amount of $50,000 for the project “Investigating Clonal Dynamics of Chronic Lymphocytic Leukemia Under Targeted Therapy”.  

Kubra Karagos, PhD, mentee of  Michael L. Gatza, PhD , received a Post-Doctoral Fellowship Award from New Jersey Commission on Cancer Research in the amount of $100,000 for the project “ADNP is an Essential Driver of High Grade Serous Ovarian Cancer”.  

Lei Chen, PhD, mentee of  Michael Verzi, PhD , received a Post-Doctoral Fellowship Award from New Jersey Commission on Cancer Research in the amount of $100,000 for the project “Mechanisms Controlling Colorectal Oncogenesis by the Transcription Factor HNF4”.  

Ning Ang Liu, PhD, mentee of  Zhiyuan Shen, MD, PhD , received a Post-Doctoral Fellowship Award from New Jersey Commission on Cancer Research in the amount of $100,000 for the project “Role of 53BP1 in the development and therapy of BCCIP Deficient Breast Cancer”.

Presentations

Hossein Khiabanian, PhD presented “Inference of mutational status, loss of heterozygosity, and clonality in tumor-only data” at Genome Informatics 2018, held September 17-20, 2018 in Cambridge, UK.

Wenwei Hu, PhD gave a presentation entitled “LIF, A Friend or Foe - its role in reproduction and cancer” at the European Association for Cancer Research (EACR) Conference LIF As We Know It: From Basic Science to Clinical Trials, held May 28-29, 2018 at Vall d'Hebron Institute of Oncology in Barcelona, Spain.
  
Hossein Khiabanian, PhD presented “Inference of germline mutational status and of loss of heterozygosity in high-depth tumor-only sequencing data” at the Research in Computational Molecular Biology (RECOMB) and RECOMB-Computational Cancer Biology 2018, held April 29-24, 2018 at Campus Pierre et Marie Curie, Sorbonne Université in Paris, France.


Selected Publications

Chan CS , Laddha SV, Lewis PW, Koletsky MS, Robzyk K, Da Silva E, Torres PJ, Untch BR, Li J, Bose P, Chan TA, Klimstra DS, Allis CD, Tang LH. ATRX, DAXX or MEN1 mutant pancreatic neuroendocrine tumors are a distinct alpha-cell signature subgroup. Nature communications. 2018;9(1):4158. Epub 2018/10/14. doi: 10.1038/s41467-018-06498-2. PubMed PMID: 30315258; PMCID: PMC6185985.

Khiabanian H , Hirshfield KM, Goldfinger M, Bird S, Stein M, Aisner J, Toppmeyer D, Wong S, Chan N, Dhar K, Gheeya J, Vig H, Hadigol M, Pavlick D, Ansari S, Ali S, Xia B, Rodriguez-Rodriguez L , Ganesan S . Inference of Germline Mutational Status and Evaluation of Loss of Heterozygosity in High-Depth, Tumor-Only Sequencing Data. JCO precision oncology. 2018;2018. Epub 2018/09/25. doi: 10.1200/po.17.00148. PubMed PMID: 30246169; PMCID: PMC6148761.

Rabadan R, Bhanot G, Marsilio S, Chiorazzi N, Pasqualucci L, Khiabanian H . On statistical modeling of sequencing noise in high depth data to assess tumor evolution. Journal of statistical physics. 2018;172(1):143-55. Epub 2018/07/24. doi: 10.1007/s10955-017-1945-1. PubMed PMID: 30034030; PMCID: PMC6051708.

Hadigol M, Khiabanian H . MERIT reveals the impact of genomic context on sequencing error rate in ultra-deep applications. BMC bioinformatics. 2018;19(1):219. Epub 2018/06/10. doi: 10.1186/s12859-018-2223-1. PubMed PMID: 29884116; PMCID: PMC5994075.

Severson EA, Riedlinger GM , Connelly CF, Vergilio JA, Goldfinger M, Ramkissoon S, Frampton GM, Ross JS, Fratella-Calabrese A, Gay L, Ali S, Miller V, Elvin J, Hadigol M, Hirshfield KM, Rodriguez-Rodriguez L , Ganesan S , Khiabanian H* . Detection of clonal hematopoiesis of indeterminate potential in clinical sequencing of solid tumor specimens. Blood. 2018;131(22):2501-5. Epub 2018/04/22. doi: 10.1182/blood-2018-03-840629. PubMed PMID: 29678827; PMCID: PMC5981171.

Zhao Y, Wu L, Yue X, Zhang C, Wang J, Li J, Sun X, Zhu Y, Feng Z, Hu W . A polymorphism in the tumor suppressor p53 affects aging and longevity in mouse models. eLife. 2018;7. Epub 2018/03/21. doi: 10.7554/eLife.34701. PubMed PMID: 29557783; PMCID: PMC5906094.

Tzoneva G, Dieck CL, Oshima K, Ambesi-Impiombato A, Sanchez-Martin M, Madubata CJ, Khiabanian H , Yu J, Waanders E, Iacobucci I, Sulis ML, Kato M, Koh K, Paganin M, Basso G, Gastier-Foster JM, Loh ML, Kirschner-Schwabe R, Mullighan CG, Rabadan R, Ferrando AA. Clonal evolution mechanisms in NT5C2 mutant-relapsed acute lymphoblastic leukaemia. Nature. 2018;553(7689):511-4. Epub 2018/01/18. doi: 10.1038/nature25186. PubMed PMID: 29342136; PMCID: PMC5931372.

Tong K, Pellon-Cardenas O, Sirihorachai VR, Warder BN, Kothari OA, Perekatt AO, Fokas EE, Fullem RL, Zhou A, Thackray JK, Tran H, Zhang L, Xing J, Verzi MP* . Degree of Tissue Differentiation Dictates Susceptibility to BRAF-Driven Colorectal Cancer. Cell reports. 2017;21(13):3833-45. Epub 2017/12/28. doi: 10.1016/j.celrep.2017.11.104. PubMed PMID: 29281831; PMCID: PMC5747303.

Marsilio S, Khiabanian H , Fabbri G, Vergani S, Scuoppo C, Montserrat E, Shpall EJ, Hadigol M, Marin P, Rai KR, Rabadan R, Devereux S, Pasqualucci L, Chiorazzi N. Somatic CLL mutations occur at multiple distinct hematopoietic maturation stages: documentation and cautionary note regarding cell fraction purity. Leukemia. 2018;32(4):1041-4. Epub 2017/12/06. doi: 10.1038/leu.2017.343. PubMed PMID: 29203856; PMCID: PMC5886053.

Liu J, Zhang C, Zhao Y, Yue X, Wu H, Huang S, Chen J, Tomsky K, Xie H, Khella CA, Gatza ML, Xia D, Gao J, White E , Haffty BG, Hu W*, Feng Z* . Parkin targets HIF-1alpha for ubiquitination and degradation to inhibit breast tumor progression. Nature communications. 2017;8(1):1823. Epub 2017/11/29. doi: 10.1038/s41467-017-01947-w. PubMed PMID: 29180628; PMCID: PMC5703960.

Yue X, Zhang C, Zhao Y, Liu J, Lin AW, Tan VM, Drake JM, Liu L, Boateng MN, Li J, Feng Z, Hu W . Gain-of-function mutant p53 activates small GTPase Rac1 through SUMOylation to promote tumor progression. Genes & development. 2017;31(16):1641-54. Epub 2017/09/28. doi: 10.1101/gad.301564.117. PubMed PMID: 28947497; PMCID: PMC5647935.

Yang J, Axelrod DE , Komarova NL. Determining the control networks regulating stem cell lineages in colonic crypts. Journal of theoretical biology. 2017;429:190-203. Epub 2017/07/04. doi: 10.1016/j.jtbi.2017.06.033. PubMed PMID: 28669884; PMCID: PMC5689466.

Axelrod DE , Bravo R. Chemoprevention of colon cancer: advantage of intermittent pulse treatment schedules quantified by computer simulation of human colon crypts. JCSPO 2017; 3(3):035004.

  *Corresponding Author
Basic Research & Clinical Research Programs 
Rutgers Cancer Institute of New Jersey