Issue 05 | Fall 2019
Program Newsletter
for Basic and Clinical Research 
Fall 2019
Shared Resources
at Rutgers Cancer Institute of New Jersey 
Featured Resource: Small Molecule Screening
The use of small molecule probes can greatly enhance the enablement of cancer biology. As complements to the tools of genetics, these small molecule probes facilitate temporal and modulated control of the various pathways and processes in the biological mechanisms of cancer. The Small Molecule Screening Center at Princeton University was engaged as a Cancer Center Support Grant (CCSG) Developing Shared Resource in order to provide Research Program members with access to the expertise and instrumentation to perform small molecule screening and chemistry follow up processes. Access to the Small Molecule Screening Center offers investigators the unique opportunities provided by the discovery and chemical enablement of a small molecule probe.

The specific goals of this Developing Shared Resource are to:

  1. Understand potentially effective application of biological assays
  2. Provide expertise in helping the project champion to develop an appropriate biological assay
  3. Screen small molecule compound collection for potential hit compounds for the given assay
  4. Verify and identify potential small molecules that modulate the given biological context
  5. Provide chemistry expertise in follow-up chemistry for hit-to-lead
  6. Derive biological and clinical insights from the data  
As a CCSG Developing Shared Resource, access to the Small Molecule Screening Center currently differs from other Shared Resources. Access is granted to only Princeton University faculty and Research Program Members, through a collaborative agreement between Princeton University and Rutgers Cancer Institute. In order to access the Small Molecule Screening Center, Research Program members should apply to future RFAs, similar to the one listed in "Recent RFA Opportunities" section below.

To learn more about the Small Molecule Screening Center, contact Hahn Kim at
(609) 258-0131 or .
New Cancer Center Support Grant (CCSG)
Subproject Numbers

NCI has now assigned a unique subproject number for each CCSG component. When acknowledging the CCSG in publications that resulted from Pilot Award/New Investigator funds and/or use of any supported  Shared Resource  – please use all of the appropriate CCSG grant numbers from the following:  
Important Reminders
1. Please acknowledge the CCSG   in publications that resulted from any CCSG support: such as Pilot Award/New Investigator funds, use of Office of Human Research Services (OHRS), and/or use of any supported  Shared Resource .

2. Publications that acknowledge the CCSG must comply with the   NIH Public Access Policy .

Example:   "Services, results and/or products in support of the research project were generated by the Rutgers Cancer Institute of New Jersey Biomedical Informatics Shared Resource, supported, in part, with funding from NCI-CCSG P30CA072720."  (Note: please also consider including names of individuals from shared resources if they provided any intellectual input or additional effort.)

NOTE:   PMID  vs. PMCID  – PubMed (PMID) is an index of abstracts; PubMed Central (PMCID) is an index of full-text papers and a PMCID  is  required   when you publish research that was supported by any NIH funding.
Recent RFA Opportunities
Pilot award opportunities are offered throughout the year to support and stimulate collaborative cancer research. If you have any questions about recent or future pilot award opportunities, please contact . When applying to a pilot award RFA, review each funding announcement in its entirety and be sure to fill out the application form that corresponds to the specific RFA for which you are applying.
Recent Conferences & Retreats
2019 Radiation Oncology 4R Symposium
The 2019 Radiation Oncology 4R Symposium, entitled Radiotherapy and Immunotherapy: at the Crossroads, was a day-long meeting with three tracks: biology, medical physics and clinical/translational which brought to Rutgers national and international experts who provided participants with an overview of new advances in the use of radiotherapy in combination with immunotherapy. New research developments in these areas were presented to advance the integration of these findings into individualized radiation therapy clinical applications with the goal of improved patient outcomes. Close to 100 participants attended the bi-annual event. The event was provided by the Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, Rutgers New Jersey Medical School and was supported by Varian Medical Systems, Elekta, Inc, Oncology Services International, Inc, and Avante Health Solutions.
Dr. Andy Minn, University of Pennsylvania, presenting Opposing Role Interferon and Pattern Recognition Receptor Signaling in Cancer Immunotherapy at the Symposium
Speakers and Activity Directors at the Radiation Oncology 4R Symposium
From left to right: Zhiyuan Shen, Ke Nie, Bo Lu, Arta Monjazeb, Ying Xiao, David Kirsch, Salma Jabbour, Ralph Weischelbaum, Bruce Haffty, Harald Paganetti, Julie Schwarz, David Guis, Charles Kunos, Fangfang Yin, Andy Minn, and Terrence Williams
Tri-State Cancer Metabolism Meeting
Princeton University hosted a Tri-State Cancer Metabolism Meeting on July 18, 2019. Bringing together cancer metabolism researchers and their trainees from Rutgers University, Princeton University, Memorial-Sloan Kettering Cancer Center, Weill Cornell Medical College, University of Pennsylvania, and New York University, this meeting is held once or twice per year to offer a day of presentations and networking focused on cancer metabolism research. Presenters at the most recent Tri-State Cancer Metabolism Meeting included Laura Poillet-Perez ( Eileen White, PhD laboratory), Estela Jacinto, PhD , and Athena Li ( Joshua Rabinowitz, MD, PhD laboratory).
Laura Poillet-Perez presenting
Crash Course Symposium: Engineering Immune Cells to Fight Cancer
On October 29, 2019, Rutgers Institute for Quantitative Biomedicine and Rutgers Cancer Institute of New Jersey co-hosted a crash course symposium entitled "Engineering Immune Cells to Fight Cancer". This crash course symposium featured presentations on innovative cancer research technologies and topics related to immuno-oncology. It also provided a collaborative atmosphere for networking between researchers located in New Jersey and the surrounding regions. Presenters included Stephen Burley, MD, D.Phil Eileen White, PhD Edmund Lattime, PhD , and Andrew Evens, DO, MSc .
Speakers and attendees at the Crash Course Symposium: Engineering Immune Cells to Fight Cancer Cells event
Cancer Metabolism & Growth
Meet Our New Members!
Awards and Honors
Eric Klein, PhD was awarded the 2019 Theobald Smith Society of the American Society for Microbiology Young Investigator Award.

Jessie Yanxiang Guo, PhD was awarded a Research Scholar Grant from the American Cancer Society to be used towards the project titled "Targeting Metabolic Vulnerabilities to Improve Kras-driven Lung Cancer Treatment" Project Number: 134036-RSG-19-165-01-TBG Term: 01/01/2020 - 12/31/2023. Amount: $792,000.

Jessie Yanxiang Guo, PhD was awarded with the 2019 Busch Biomedical Grant from the Rutgers University Busch Biomedical Grant Program towards the project titled "Autophagy and Immunoresponse in LKB1-deficient KRAS-mutant NSCLC" Term: 09/01/2019 - 08/31/2021. Amount: $40,000.

Kenneth Irvine, PhD was awarded an NIH sponsored grant to be used towards the project titled "Regulation of Growth and Morphogenesis" Project Number: 1R35GM131748 Term: 05/01/2019 - 04/30/2024. Amount: $2,763,574.

Shawn Davidson, PhD was awarded a grant from New Objective, Inc. to be used towards the project titled "NanoLCMS using New Objective's PicoChip Technology for Routine Metabolomics" Grant Number: AGRMT 5-21-19 Term: 07/08/2019 - 07/08/2020. Amount: $113,500.

Vrushank Bhatt, a graduate student in the Yanxiang Jessie Guo, PhD laboratory, was awarded the 2019 Aaron Shatkin Graduate Scholarship at the Annual Aaron Shatkin Lecture in Piscataway, NJ. Term: 10/21/2019 - 06/30/2020 Amount: $3,000.
Vrushank Bhatt at the Annual Aaron Shatkin Lecture
Yibin Kang, PhD was awarded a Research Professional Grant from the American Cancer Society to be used towards the project titled Stromal Niche as Regulators of Breast Cancer Metastasis Term: 01/01/2020 – 12/31/2024. Amount: $400,000.
Chung Yang, PhD presented "Research on esophageal cancer: A personal perspective" at the 10th China US-Forum on Cancer Research held September 10, 2019 in Zhengzhou, China.

Chung Yang, PhD presented "Cancer causation and prevention: New insight and old wisdom" at the Shanghai 5th People's Hospital held September 20, 2019 in Shanghai, China.

Eileen White, PhD presented “Role of Autophagy in Cancer” at the Frontiers in Metabolism: Mechanisms of Metabolic Disease held September 16-18, 2019, at the Morgridge Institute for Research, Madison, WI.

Eileen White, PhD presented “Control of Cancer Metabolism and an Anti-cancer Immune Response by Autophagy” at the 6th International Conference on Tumor Microenvironment and Cellular Stress: Signaling, Metabolism, Imaging and Therapeutic Targets held September 23-28, 2019 in Crete, Greece.

Eileen White, PhD presented “Role of Autophagy in Cancer” at the Roche Tissue Diagnostics Research Forum held October 14, 2019, at Roche Tissue Diagnostics in Tucson, AZ

Eileen White, PhD presented “Autophagy as a Therapeutic Target in Cancer” at The Standard of Cure Cancer Symposium held November 5, 2019, at Beth Israel Deaconess Medical Center, Boston, MA.

Eileen White, PhD presented “Role of Autophagy in Cancer” at Forbeck Forum focused on Cancer and Aging held November 7-10, 2019, at Geneva National, Lake Geneva, WI

Eileen White, PhD presented “Role of Autophagy in Cancer” at Epigenetics, Metabolism and Human Disease held November 14-16, 2019, at Simpson Querrey Center for Epigenetics, Chicago, IL.

Eric Klein, PhD presented “Caulobacter crescentus adapts to phosphate starvation by synthesizing anionic glycoglycerolipids and a novel glycosphingolipid” at the Gordon Research Conference on the Molecular and Cellular Biology of Lipids held July 28-August 2, 2019 at the Waterville Valley Resort, Waterville Valley, NH.

Eric Klein, PhD moderated “Extreme makeover: Cell Wall Edition” at the American Society for Microbiology Annual Microbe Conference held June 20-24, 2019 at the Moscone Center, San Francisco, CA.

Kenneth Irvine, PhD presented "Morphogenesis in Animals and Plants: Search for Principles" at KITP Workshop, held July 28 - August 10, 2019 at UCSB in California.

Kenneth Irvine, PhD presented "Biomechanical Regulation of Organ Growth" at a seminar held April 16, 2019, at the University of Chicago.

Raymond Birge, PhD presented on "Novel Therapeutic and Diagnostic Strategies for Human Cancers" at the 38th Sapporo International Cancer Symposium held July 11-13, 2019 in Sapporo, Hokkaldo, Japan.

Raymond Birge, PhD presented on "Cell Signaling and Intracellular Trafficking in Cancer Biology: interplay, targeting and therapy" a Biochemical Society Scientific Meeting held October 21-24, 2019 in Turin, Italy.

Shawn Davidson, PhD presented "Investigating metabolic heterogeneity in cancer with MALDI-IMS" at the Governor Cancer Conference held July 2019, at the Institute for Advanced Study in Princeton, NJ.
Selected Publications
Alegot H, Markosian C, Rauskolb C, Yang J, Kirichenko E, Wang YC, Irvine KD . Recruitment of Jub by alpha-catenin promotes Yki activity and Drosophila wing growth. J Cell Sci. 2019;132(5). Epub 2019/01/20. doi: 10.1242/jcs.222018. PubMed PMID: 30659113; PMCID: PMC6432719.

Bott AJ, Maimouni S, Zong WX . The Pleiotropic Effects of Glutamine Metabolism in Cancer. Cancers (Basel). 2019;11(6). Epub 2019/06/07. doi: 10.3390/cancers11060770. PubMed PMID: 31167399; PMCID: PMC6627534.

Bott AJ, Shen J, Tonelli C, Zhan L, Sivaram N, Jiang YP, Yu X, Bhatt V, Chiles E, Zhong H, Maimouni S, Dai W, Velasquez S, Pan JA, Muthalagu N, Morton J, Anthony TG, Feng H, Lamers WH, Murphy DJ, Guo JY , Jin J, Crawford HC, Zhang L, White E , Lin RZ, Su X, Tuveson DA, Zong WX . Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism. Cell Rep. 2019;29(5):1287-98.e6. Epub 2019/10/31. doi: 10.1016/j.celrep.2019.09.056. PubMed PMID: 31665640.

Chen X, Kost J, Sulovari A, Wong N, Liang WS, Cao J , Li D. A virome-wide clonal integration analysis platform for discovering cancer viral etiology. Genome Res. 2019;29(5):819-30. Epub 2019/03/16. doi: 10.1101/gr.242529.118. PubMed PMID: 30872350; PMCID: PMC6499315.

Crespo-Enriquez I, Hodgson T, Zakaria S, Cadoni E, Shah M, Allen S, Al-Khishali A, Mao Y, Yiu A, Petzold J, Villagomez-Olea G, Pitsillides AA, Irvine KD , Francis-West P. Dchs1-Fat4 regulation of osteogenic differentiation in mouse. Development. 2019;146(14). Epub 2019/07/31. doi: 10.1242/dev.176776. PubMed PMID: 31358536.

Hamza B, Ng SR, Prakadan SM, Delgado FF, Chin CR, King EM, Yang LF, Davidson SM , DeGouveia KL, Cermak N, Navia AW, Winter PS, Drake RS, Tammela T, Li CM, Papagiannakopoulos T, Gupta AJ, Shaw Bagnall J, Knudsen SM, Vander Heiden MG, Wasserman SC, Jacks T, Shalek AK, Manalis SR. Optofluidic real-time cell sorter for longitudinal CTC studies in mouse models of cancer. Proc Natl Acad Sci U S A. 2019 Feb 5;116(6):2232-2236. PMID: 30674677.

Husain K, Zhang A, Shivers S, Davis-Yadley A, Coppola D, Yang CS , Malafa MP. Chemoprevention of Azoxymethane-induced Colon Carcinogenesis by Delta-Tocotrienol. Cancer Prev Res (Phila). 2019 Apr 2. doi: 10.1158/1940-6207.CAPR-18-0290.

Kasikara C, Davra V, Calianese D, Geng K, Spires TE, Quigley M, Wichroski M, Sriram G, Suarez-Lopez L, Yaffe MB, Kotenko SV , De Lorenzo MS, Birge RB . Pan-TAM Tyrosine Kinase Inhibitor BMS-777607 Enhances Anti-PD-1 mAb Efficacy in a Murine Model of Triple-Negative Breast Cancer. Cancer Res. 2019;79(10):2669-83. Epub 2019/03/17. doi: 10.1158/0008-5472.Can-18-2614. PubMed PMID: 30877108.

Lea MA , Batista E, Cue L, desBordes C. Variability in the induction of alkaline phosphatase by histone deacetylase inhibitors in bladder and colon cancer cell lines. J. Cancer Res. Ther., 2019: 7 (2). 9-16. doi: 10.14312/2052-4994.2019-2.

Liu J, Zhang Q, Ruan B, Chen W, Zheng J, Xu B, Jiang P, Miao Z, Li F, Guo JY , Cao L, Wang G. MORC2 regulates C/EBPalpha-mediated cell differentiation via sumoylation. Cell Death Differ. 2019;26(10):1905-17. Epub 2019/01/16. doi: 10.1038/s41418-018-0259-4. PubMed PMID: 30644437; PMCID: PMC6748086.

Malhotra J , Jabbour S , Orlick M, Riedlinger G , Guo JY , White E , Aisner J. Phase Ib/II study of hydroxychloroquine in combination with chemotherapy in patients with metastatic non-small cell lung cancer (NSCLC). Cancer Treat Res Commun. 2019;21:100158. Epub 2019/09/15. doi: 10.1016/j.ctarc.2019.100158. PubMed PMID: 31521049.

Portal DE, Weiss RE, Wojtowicz M, Mansour A, Monken C, Mehnert JM , Aisner JA , Kane M, Nishioka J, Aisner S, Peters S, Stein MN , Kim IY , Mayer TM , Shih W , Gulley J, Streicher H, Singer EA , Lattime EC . Phase I neoadjuvant study of intravesical recombinant fowlpox-GM-CSF (rF-GM-CSF) or fowlpox-TRICOM (rF-TRICOM) in patients with bladder carcinoma. Cancer Gene Ther. 2019. Epub 2019/06/22. doi: 10.1038/s41417-019-0112-z. PubMed PMID: 31222182.

Rauskolb C, Cervantes E, Madere F, Irvine KD . Organization and function of tension-dependent complexes at adherens junctions. J Cell Sci. 2019;132(7). Epub 2019/03/07. doi: 10.1242/jcs.224063. PubMed PMID: 30837288; PMCID: PMC6467489.

Stankeviciute G, Guan Z, Goldfine H, Klein EA . Caulobacter crescentus adapts to phosphate starvation by synthesizing anionic glycoglycerolipids and a novel glycosphingolipid. MBio. 2019;10(2):e00107-19. Epub 2019/04/04. doi: 10.1128/mBio.00107-19. PubMed PMID: 30940701; PMCID: PMC6445935.

Stankeviciute G, Miguel AV, Radkov A, Chou S, Huang KC, Klein EA . Differential modes of crosslinking establish spatially distinct regions of peptidoglycan in Caulobacter crescentus. Mol Microbiol. 2019;111(4):995-1008. Epub 2019/01/08. doi: 10.1111/mmi.14199. PubMed PMID: 30614079.
Wang Y, Xiong H, Liu D, Hill C, Ertay A, Li J, Zou Y, Miller P, White E , Downward J, Goldin RD, Yuan X, Lu X. Autophagy inhibition specifically promotes epithelial-mesenchymal transition and invasion in RAS-mutated cancer cells. Autophagy. 2019;15(5):886-99. Epub 2019/02/21. doi: 10.1080/15548627.2019.1569912. PubMed PMID: 30782064; PMCID: PMC6517269.

Wang H, Xiang D, Liu B, He A, Randle HJ, Zhang KX, Dongre A, Sachs N, Clark AP, Tao L, Chen Q, Botchkarev VV, Jr., Xie Y, Dai N , Clevers H, Li Z, Livingston DM. Inadequate DNA Damage Repair Promotes Mammary Transdifferentiation, Leading to BRCA1 Breast Cancer. Cell. 2019;178(1):135-51.e19. Epub 2019/06/30. doi: 10.1016/j.cell.2019.06.002. PubMed PMID: 31251913; PMCID: PMC6716369.

White, E ., Blockade of RAF and autophagy is the one-two punch to take out Ras. Proc Natl Acad Sci U S A, 2019. Epub 2019/02/21. PubMed PMID: 30782814.

Wu X, Zhao G, He Y, Wang W, Yang CS , Zhang J. Pharmacological mechanisms of the anticancer action of sodium selenite against peritoneal cancer in mice. Pharmacol Res. 2019;147:104360. Epub 2019/07/22. doi: 10.1016/j.phrs.2019.104360. PubMed PMID: 31326526.

Yang Y, Yang H, Tang B, Wu AML, Flanders KC, Moshkovich N, Weinberg DS, Welsh MA, Weng J, Ochoa HJ, Hu TY, Herrmann MA, Chen J, Edmondson EF, Simpson RM, Liu F , Liu H, Lee M, Wakefield LM. The outcome of TGFbeta antagonism in metastatic breast cancer models in vivo reflects a complex balance between tumor-suppressive and pro-progression activities of TGFbeta. Clin Cancer Res. 2019. Epub 2019/10/05. doi: 10.1158/1078-0432.Ccr-19-2370. PubMed PMID: 31582516.

Zhang L, He Y, Wu X, Zhao G, Zhang K, Yang CS , Reiter RJ, Zhang J. Melatonin and (-)-Epigallocatechin-3-Gallate: Partners in Fighting Cancer. Cells. 2019;8(7). Epub 2019/07/25. doi: 10.3390/cells8070745. PubMed PMID: 31331008; PMCID: PMC6678710.

Zhou Z, Alegot H, Irvine KD . Oriented Cell Divisions Are Not Required for Drosophila Wing Shape. Curr Biol. 2019;29(5):856-64.e3. Epub 2019/02/26. doi: 10.1016/j.cub.2019.01.044. PubMed PMID: 30799243; PMCID: PMC6430976.
Cancer Pharmacology
Meet Our New Members!
Awards and Honors
Daniel Herranz Benito, PhD was awarded a Research Scholar Grant from the American Cancer Society to be used towards the project titled “The role of SIRT1 in T-Cell Acute Lymphoblastic Leukemia”. Project Number: 133916-RSG-19-161-01-TBE Term: 01/01/2020 – 12/31/2023. Amount: $792,000.

Steven An, PhD was awarded the Elected Fellow of the American Thoracic Society in 2019.

Daniel Herranz Benito, PhD presented “Novel metabolic and epigenetic targets for the treatment of T-Cell Acute Lymphoblastic Leukemia” at Hackensack Meridian Health Center for Discovery & Innovation (HMH-CDI), held September 24, 2019 in Nutley, NJ.
Dr. Herranz Benito presenting at the Hackensack Meridian Health Center for Discovery & Innovation
Daniel Herranz Benito, PhD presented “Novel metabolic and epigenetic targets for the treatment of T-Cell Acute Lymphoblastic Leukemia” at Memorial Sloan Kettering Cancer Center (MSKCC), held October 8, 2019 in New York, NY.
Selected Publications
Ahuja K, Rather GM, Lin Z, Sui J, Xie P, Le T, Bertino JR , Javanmard M. Toward point-of-care assessment of patient response: a portable tool for rapidly assessing cancer drug efficacy using multifrequency impedance cytometry and supervised machine learning. Microsyst Nanoeng. 2019;5:34. doi: 10.1038/s41378-019-0073-2. PubMed PMID: 31645995; PMCID: PMC6799891.

Bajpai M , Seril DN, Van Gurp J, Geng X, Alvarez J, Minacapelli CD, Gorin S, Das KK, Poplin E, Cheng J, Amenta PS, Das KM. Effect of Long-Term Mesalamine Therapy on Cancer-Associated Gene Expression in Colonic Mucosa of Patients with Ulcerative Colitis. Dig Dis Sci. 2019;64(3):740-50. Epub 2018/11/28. doi: 10.1007/s10620-018-5378-8. PubMed PMID: 30478770.

Belver L, Yang AY, Albero R, Herranz D , Brundu FG, Quinn SA, Perez-Duran P, Alvarez S, Gianni F, Rashkovan M, Gurung D, Rocha PP, Raviram R, Reglero C, Cortes JR, Cooke AJ, Wendorff AA, Cordo V, Meijerink JP, Rabadan R, Ferrando AA. Gata3-controlled nucleosome eviction drives Myc enhancer activity in T-cell development and leukemia. Cancer Discov. 2019. Epub 2019/09/15. doi: 10.1158/2159-8290.Cd-19-0471. PubMed PMID: 31519704.

Bhagat TD, Von Ahrens D, Dawlaty M, Zou Y, Baddour J, Achreja A, Zhao H, Yang L, Patel B, Kwak C, Choudhary GS, Gordon-Mitchell S, Aluri S, Bhattacharyya S, Sahu S, Yu Y, Bartenstein M, Giricz O, Suzuki M, Sohal D, Gupta S, Guerrero PA, Batra S, Goggins M, Steidl U, Greally J, Agarwal B, Pradhan K, Banerjee D , Nagrath D, Maitra A, Verma A. Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts. Elife. 2019 Oct 30;8. pii: e50663. doi: 10.7554/eLife.50663. [Epub ahead of print] PubMed PMID: 31663852.

Hughes RM, Simons BW, Khan H, Miller R, Kugler V, Torquato S, Theodros D, Haffner MC, Lotan T, Huang J, Davicioni E, An SS , Riddle RC, Thorek DLJ, Garraway IP, Fertig EJ, Isaacs JT, Brennen WN, Park BH, Hurley PJ. Asporin Restricts Mesenchymal Stromal Cell Differentiation, Alters the Tumor Microenvironment, and Drives Metastatic Progression. Cancer Res. 2019;79(14):3636-3650. doi: 10.1158/0008-5472.CAN-18-2931. Epub 2019 May 23. PubMed PMID: 31123087; PMCID: PMC6734938.

Kilic O, Yoon A, Shah SR, Yong HM, Ruiz-Valls A, Chang H, Panettieri RA Jr, Liggett SB, Quiñones-Hinojosa A, An SS , Levchenko A. A Microphysiological Model of the Bronchial Airways Reveals the Interplay of Mechanical and Biochemical Signals in Bronchospasm. Nat. Biomed. Eng. 2019;3(7):532-544. doi: 10.1038/s41551-019-0366-7. Epub 2019 Mar 11. PubMed PMID: 31150010; PMCID: PMC6653686.

Kumar R, Paul AM, Rameshwar P , Pillai MR. Epigenetic Dysregulation at the Crossroad of Women's Cancer. Cancers (Basel). 2019;11(8). Epub 2019/08/21. doi: 10.3390/cancers11081193. PubMed PMID: 31426393; PMCID: PMC6721458.

Malekshah OM, Sarkar S, Nomani A, Patel N, Javidian P, Goedken M, Polunas M, Louro P, Hatefi A . Bioengineered adipose-derived stem cells for targeted enzyme-prodrug therapy of ovarian cancer intraperitoneal metastasis. J Control Release. 2019;311-312:273-87. Epub 2019/09/10. doi: 10.1016/j.jconrel.2019.09.006. PubMed PMID: 31499084.

Mishra D, Banerjee D . Lactate Dehydrogenases as Metabolic Links between Tumor and Stroma in the Tumor Microenvironment. Cancers (Basel). 2019;11(6). Epub 2019/05/31. doi: 10.3390/cancers11060750. PubMed PMID: 31146503; PMCID: PMC6627402.

Ojiaku CA, Chung E, Parikh V, Williams JK, Schwab A, Fuentes AL, Corpuz ML, Lui V, Paek S, Bexiga NM, Narayan S, Nunez FJ, Ahn K, Ostrom RS, An SS , Panettieri RA Jr. Transforming Growth Factor-β1 Decreases β 2 -Agonist-induced Relaxation in Human Airway Smooth Muscle. Am. J. Respir. Cell Mol. Biol. 2019;61(2):209-218. doi: 10.1165/rcmb.2018-0301OC. PubMed PMID: 30742476; PMCID: PMC6670035.

Perez-Gonzalez NA, Rochman ND, Yao K, Tao J, Le MT, Flanary S, Sablich L, Toler B, Crentsil E, Takaesu F, Lambrus B, Huang J, Fu V, Chengappa P, Jones TM, Holland AJ, An S , Wirtz D, Petrie RJ, Guan KL, Sun SX. YAP and TAZ Regulate Cell Volume. J. Cell. Biol. 2019;218(10):3472-3488. doi: 10.1083/jcb.201902067. Epub 2019 Sep 3. PubMed PMID: 31481532; PMCID: PMC6781432.

Rameshwar P . Cancer stem cell gene profile getting closer to the clinic to enhance precise treatment. EBioMedicine. 2019;42:22-3. Epub 2019/03/25. doi: 10.1016/j.ebiom.2019.03.036. PubMed PMID: 30904608; PMCID: PMC6491416.

Suresh K, Carino K, Johnston L, Servinsky L, Machamer CE, Kolb TM, Lam H, Dudek SM, An SS , Rane MJ, Shimoda LA, Damarla M. A Nonapoptotic Endothelial Barrier-Protective Role for Caspase-3. Am. J. Physiol. Lung Cell Mol. Physiol. 2019; 316(6):L1118-L1126. doi: 10.1152/ajplung.00487.2018. Epub 2019 Mar 25. PubMed PMID: 30908935; PMCID: PMC6620669.

Steppan J, Wang H, Bergman Y, Rauer MJ, Tan S, Jandu S, Nandakumar K, Barreto-Ortiz S, Cole RN, Boronina TN, Zhu W, Halushka MK, An SS , Berkowitz DE, Santhanam L. Lysyl Oxidase-like 2 Depletion is Protective in Age-Associated Vascular Stiffening. Am. J. Physiol. Heart Circ. Physiol. 2019;317(1):H49-H59. doi: 10.1152/ajpheart.00670.2018. Epub 2019 Apr 19. PubMed PMID: 31002285; PMCID: PMC6692735.

Tuday E, Nomura Y, Ruhela D, Nakano M, Fu X, Shah A, Roman B, Yamaguchi A, An SS , Steenbergen C, Baraban JM, Berkowitz DE, Das S. Deletion of the MicroRNA-Degrading Nuclease, Translin/Trax, Prevents Pathogenic Vascular Stiffness. Am. J. Physiol. Heart Circ. Physiol. 2019 Oct 18. doi: 10.1152/ajpheart.00153.2019. [Epub ahead of print]. PubMed PMID: 31625778.
Clinical Investigations &
Precision Therapeutics
Meet Our New Members!
Awards and Honors
Bruce Haffty, MD was assigned as the Principle Investigator of the project titled "Novel Molecular Targets in Combination with Radiation therapy in Breast Cancer" by the Breast Cancer Research Foundation. Project Number: BCRF 18-063. Term: October 2019 - October 2020. Amount: $250,000.

Lanjing Zhang, MD was a course co-director at The Fourth Cancer Biomarker Conference held on October 5 and October 6, 2019 at Saddle Brook, NJ.
Dr. Zhang co-directing at The Fourth Cancer Biomarker Conference
Dummer R, Gyorki DE, Hyngstrom J, Berger AC , et al. 1 year recurrence-free survival from a randomized, open-label phase 2 study of neoadjuvant talimogene laherparepvec plus surgery versus surgery for resectable stage IIIB-IVM1a melanoma. (Poster Discussion Presentation) American Society for Clinical Oncology, June 2019. Chicago, IL.

Dummer R, Gyorki DE, Hyngstrom J, Berger AC , et al. Primary 2-year results of the phase 2, multicenter, randomized, open-label trial of efficacy and safety for talimogene laherparepvec (T-VEC) neoadjuvant treatment plus surgery vs surgery in patients with resectable stage IIIB-IVM1a Melanoma. (Oral Presentation). European Society of Medical Oncology (ESMO, 2019). Barcelona, Spain.

Janice Mehnert, MD presented “Cancer Immunotherapy: Where Do We Go Next?” at the Society of Immunotherapy of Cancer Advances in Education this year in Cleveland, OH.

Peter Cole, MD presented “Improving Therapy for Children with Acute Lymphoblastic Leukemia” at the Pediatric Grand Rounds, Robert Wood Johnson University Hospital, Rutgers RWJMS, held March 7, 2019 in New Brunswick, NJ.

Peter Cole, MD presented “Reducing late effects of curative therapy for childhood cancer” at the Pediatric Grand Rounds, University Hospital, held March 20, 2019 in Newark, NJ.

Peter Cole, MD presented “Dissecting the pathophysiology of chemotherapy-induced cognitive deficits” at a Research Seminar, Mouse Imaging Centre, Hospital for Sick Children, held April 25, 2019 in Toronto, ON, Canada.

Peter Cole, MD presented “What’s all this excitement about immunotherapy for children with cancer?” at the Pediatric Grand Rounds, Englewood Hospital and Medical Center, held November 12, 2019 in Englewood, NJ.

Peter Cole, MD presented “Improving Therapy for Children with Acute Lymphoblastic Leukemia” at the Pediatric Grand Rounds, Children’s Hospital of New Jersey, Newark Beth Israel, held November 13, 2019 in Newark, NJ.
Selected Publications
Ahlering T, Huynh LM, Kaler KS, Williams S, Osann K, Joseph J, Lee D, Davis JW, Abaza R, Kaouk J, Patel V, Kim IY , Porter J, Hu JC. Correction to: Unintended consequences of decreased PSA-based prostate cancer screening. World J Urol. 2019. Epub 2019/07/25. doi: 10.1007/s00345-019-02877-6. PubMed PMID: 31332511.

Andtbacka RHI, Amatruda T, Nemunaitis J, Zager JS, Walker J, Chesney JA, Liu K, Hsu CP, Pickett CA, Mehnert JM . Biodistribution, shedding, and transmissibility of the oncolytic virus talimogene laherparepvec in patients with melanoma. EBioMedicine. 2019;47:89-97. Epub 2019/08/15. doi: 10.1016/j.ebiom.2019.07.066. PubMed PMID: 31409575; PMCID: PMC6796514.

Brace KM, Lee WW, Cole PD , Sussman ES. Childhood leukemia survivors exhibit deficiencies in sensory and cognitive processes, as reflected by event-related brain potentials after completion of curative chemotherapy: A preliminary investigation. J Clin Exp Neuropsychol. 2019;41(8):814-31. Epub 2019/06/04. doi: 10.1080/13803395.2019.1623865. PubMed PMID: 31156064; PMCID: PMC6663575.

Brocato TA, Brown-Glaberman U, Wang Z, Selwyn RG, Wilson CM, Wyckoff EF, Lomo LC, Saline JL, Hooda-Nehra A, Pasqualini R , Arap W , Brinker CJ, Cristini V. Predicting breast cancer response to neoadjuvant chemotherapy based on tumor vascular features in needle biopsies. JCI Insight. 2019;5. Epub 2019/03/06. doi: 10.1172/jci.insight.126518. PubMed PMID: 30835256; PMCID: PMC6538356.

Catenacci DVT, Hochster H , Klempner SJ. Keeping Checkpoint Inhibitors in Check. JAMA Netw Open. 2019;2(5):e192546. Epub 2019/05/06. doi: 10.1001/jamanetworkopen.2019.2546. PubMed PMID: 31050772.

Chesney J, Puzanov I, Collichio F, Milhem MM, Hauschild A, Chen L, Sharma A, Garbe C, Singh P, Mehnert JM . Patterns of response with talimogene laherparepvec in combination with ipilimumab or ipilimumab alone in metastatic unresectable melanoma. Br J Cancer. 2019;121(5):417-20. Epub 2019/07/30. doi: 10.1038/s41416-019-0530-6. PubMed PMID: 31353364; PMCID: PMC6738060.

Coups EJ, Manne SL, Ohman Strickland P, Hilgart M, Goydos JS, Heckman CJ, Chamorro P, Rao BK , Davis M, Smith FO, Thorndike FP, Ritterband LM. Randomized controlled trial of the mySmartSkin web-based intervention to promote skin self-examination and sun protection behaviors among individuals diagnosed with melanoma: study design and baseline characteristics. Contemp Clin Trials. 2019;83:117-27. Epub 2019/07/01. doi: 10.1016/j.cct.2019.06.014. PubMed PMID: 31255801; PMCID: PMC6690854.

D'Agostino L, Nie Y, Goswami S, Tong K, Yu S, Bandyopadhyay S, Flores J, Zhang X, Balasubramanian I, Joseph I, Sakamori R, Farrell V, Li Q, Yang CS, Gao B,Ferraris RP, Yehia G, Bonder EM, Goldenring JR, Verzi MP, Zhang L , Ip YT, Gao N. Recycling Endosomes in Mature Epithelia Restrain Tumorigenic Signaling. Cancer Res. 2019 Aug 15;79(16):4099-4112. doi: 10.1158/0008-5472.CAN-18-4075. Epub 2019 Jun 25. PubMed PMID: 31239271; PubMed Central PMCID: PMC6726494.

Dauzier E, Lacas B, Blanchard P, Le QT, Simon C, Wolf G, Janot F, Horiuchi M, Tobias JS, Moon J, Simes J, Deshmane V, Mazeron JJ, Mehta S, Zaktonik B, Tamura M, Moyal E, Licitra L, Fortpied C, Haffty BG , Ghi MG, Gregoire V, Harris J, Bourhis J, Auperin A, Pignon JP. Role of chemotherapy in 5000 patients with head and neck cancer treated by curative surgery: A subgroup analysis of the meta-analysis of chemotherapy in head and neck cancer. Oral Oncol. 2019;95:106-14. Epub 2019/07/28. doi: 10.1016/j.oraloncology.2019.06.001. PubMed PMID: 31345376.

Erkes D, Field CO, Capparelli C, Tiago M, Purwin TJ, Cheroneva I, Berger AC , Hartsough EJ, Villanueva J, Aplin AE. The next generation BET inhibitor, PLX51107, delays melanoma growth in a CD-8-mediated manner. Pigment Cell and Melanoma Research. 2019; 32(5):687-96. doi: 10.1111/pcmr.12788. Epub 2019 May 20. PMID: 31063649.

Guercio BJ, Zhang S, Ou FS, Venook AP, Niedzwiecki D, Lenz HJ, Innocenti F, O'Neil BH, Shaw JE, Polite BN, Hochster HS , Atkins JN, Goldberg RM, Sato K, Ng K, Van Blarigan E, Mayer RJ, Blanke CD, O'Reilly EM, Fuchs CS, Meyerhardt JA. Associations of Physical Activity With Survival and Progression in Metastatic Colorectal Cancer: Results From Cancer and Leukemia Group B (Alliance)/SWOG 80405. J Clin Oncol. 2019;37(29):2620-31. Epub 2019/08/14. doi: 10.1200/jco.19.01019. PubMed PMID: 31408415.

Gupta A, Khan AJ, Yegya-Raman N, Sayan M, Ahlawat S, Ohri N, Goyal S, Moore DF, Eladoumikdachi F, Toppmeyer D, Haffty BG . 5-Year Results of a Prospective Phase 2 Trial Evaluating 3-Week Hypofractionated Whole Breast Radiation Therapy Inclusive of a Sequential Boost. Int J Radiat Oncol Biol Phys. 2019;105(2):267-74. Epub 2019/06/09. doi: 10.1016/j.ijrobp.2019.05.063. PubMed PMID: 31175905.

Haffty BG , McCall LM, Ballman KV, Buchholz TA, Hunt KK, Boughey JC. Impact of Radiation on Locoregional Control in Women with Node-Positive Breast Cancer Treated with Neoadjuvant Chemotherapy and Axillary Lymph Node Dissection: Results from ACOSOG Z1071 Clinical Trial. Int J Radiat Oncol Biol Phys. 2019;105(1):174-82. Epub 2019/05/16. doi: 10.1016/j.ijrobp.2019.04.038. PubMed PMID: 31085287; PMCID: PMC6699883.

Jhawar SR, Rivera-Nunez Z, Drachtman R, Cole PD , Hoppe BS, Parikh RR . Association of Combined Modality Therapy vs Chemotherapy Alone With Overall Survival in Early-Stage Pediatric Hodgkin Lymphoma. JAMA Oncol. 2019;5(5):689-95. Epub 2019/01/04. doi: 10.1001/jamaoncol.2018.5911. PubMed PMID: 30605220; PMCID: PMC6512456.

Kelly KM, Cole PD , Pei Q, Bush R, Roberts KB, Hodgson DC, McCarten KM, Cho SY, Schwartz C. Response-adapted therapy for the treatment of children with newly diagnosed high risk Hodgkin lymphoma (AHOD0831): a report from the Children's Oncology Group. Br J Haematol. 2019;187(1):39-48. Epub 2019/06/11. doi: 10.1111/bjh.16014. PubMed PMID: 31180135.

Kim IE, Jr., Kim S, Srivastava A, Saraiya B, Mayer T, Kim WJ, Kim IY . Similar incidence of DNA damage response pathway alterations between clinically localized and metastatic prostate cancer. BMC Urol. 2019;19(1):33. Epub 2019/05/08. doi: 10.1186/s12894-019-0453-9. PubMed PMID: 31060606; PMCID: PMC6501301.

Kim IY . Commentary on local therapy in men who present with a metastatic prostate cancer from special issue senior guest editor. Am J Clin Exp Urol. 2019;7(2):61-3. Epub 2019/05/30. PubMed PMID: 31139700; PMCID: PMC6526358.

Khullar K, Rivera-Nunez Z, Jhawar SR, Drachtman R, Cole PD , Hoppe BS, Parikh RR . Pediatric hodgkin lymphoma: disparities in survival by race. Leuk Lymphoma. 2019:1-11. Epub 2019/10/24. doi: 10.1080/10428194.2019.1680841. PubMed PMID: 31640446.

Khullar K, Parikh RR . The role of radiotherapy in metastatic prostate cancer. Am J Clin Exp Urol. 2019;7(2):92-7. Epub 2019/05/30. PubMed PMID: 31139704; PMCID: PMC6526359.

Lee GT, Kim JH, Kwon SJ, Stein MN , Hong JH, Nagaya N, Billakanti S, Kim MM, Kim WJ, Kim IY . Dihydrotestosterone Increases Cytotoxic Activity of Macrophages on Prostate Cancer Cells via TRAIL. Endocrinology. 2019;160(9):2049-60. Epub 2019/06/12. doi: 10.1210/en.2019-00367. PubMed PMID: 31184711; PMCID: PMC6691685.

Lee GT, Rosenfeld JA , Kim WT, Kwon YS, Palapattu G, Mehra R, Kim WJ, Kim IY . TCF4 induces enzalutamide resistance via neuroendocrine differentiation in prostate cancer. PLoS One. 2019;14(9):e0213488. Epub 2019/09/20. doi: 10.1371/journal.pone.0213488. PubMed PMID: 31536510; PMCID: PMC6752758.

Leung CN, Canter BS, Rajon D, Back TA, Fritton JC, Azzam EI, Howell RW . Dose-Dependent Growth Delay of Breast Cancer Xenografts in the Bone Marrow of Mice Treated with Radium-223: The Role of Bystander Effects and their Potential for Therapy. J Nucl Med. 2019. Epub 2019/09/15. doi: 10.2967/jnumed.119.227835. PubMed PMID: 31519805.

Mehnert JM , Kaveney AD, Malhotra J , Spencer K, Portal D, Goodin S, Tan AR, Aisner J , Moss RA, Lin H, Bertino JR , Gibbon D, Doyle LA, White EP , Stein MN . A phase I trial of MK-2206 and hydroxychloroquine in patients with advanced solid tumors. Cancer Chemother Pharmacol. 2019;84(4):899-907. Epub 2019/08/30. doi: 10.1007/s00280-019-03919-x. PubMed PMID: 31463691.

Morse MA, Hochster H , Benson A. Perspectives on Treatment of Metastatic Colorectal Cancer with Immune Checkpoint Inhibitor Therapy. Oncologist. 2019. Epub 2019/08/07. doi: 10.1634/theoncologist.2019-0176. PubMed PMID: 31383813.

Mruthyunjayappa S, Zhang K, Zhang L , Eltoum IA, Siegal GP, Wei S. Synchronous and metachronous bilateral breast cancer: clinicopathologic characteristics and prognostic outcomes. Hum Pathol. 2019 Jul 24;92:1-9. doi: 10.1016/j.humpath.2019.07.008. [Epub ahead of print] PubMed PMID: 31351153.

Na JC, Nagaya N, Rha KH, Han WK, Kim IY . DNA Damage Response Pathway Alteration in Locally Advanced Clear-Cell Renal-Cell Carcinoma Is Associated With a Poor Outcome. Clin Genitourin Cancer. 2019;17(4):299-305.e1. Epub 2019/06/18. doi: 10.1016/j.clgc.2019.05.004. PubMed PMID: 31204211.

Ohri N, Haffty BG . Mastectomy First, Keeping Chemotherapy and Radiation in Reserve. Int J Radiat Oncol Biol Phys. 2019;105(1):20. Epub 2019/08/20. doi: 10.1016/j.ijrobp.2019.05.019. PubMed PMID: 31422808.

Parikh RR , Saraiya B. Multidisciplinary Care in High-Risk Prostate Cancer Is the New Standard of Care. J Clin Oncol. 2019;37(14):1143-7. Epub 2019/03/23. doi: 10.1200/jco.19.00298. PubMed PMID: 30901303.

Polotti CF, Sterling JA, Kim IY . Cytoreductive prostatectomy in metastatic prostate cancer: current knowledge and future directions. Am J Clin Exp Urol. 2019;7(2):80-4. Epub 2019/05/30. PubMed PMID: 31139702; PMCID: PMC6526356.

Radadia KD, Rivera-Nunez Z, Kim S, Farber NJ, Sterling J, Falkiewicz M, Modi PK, Goyal S, Parikh R , Weiss RE , Kim IY , Elsamra SE, Jang TL, Singer EA. Accuracy of clinical nodal staging and factors associated with receipt of lymph node dissection at the time of surgery for nonmetastatic renal cell carcinoma. Urol Oncol. 2019;37(9):577.e17-.e25. Epub 2019/07/10. doi: 10.1016/j.urolonc.2019.06.003. PubMed PMID: 31280982; PMCID: PMC6698424.

Riedlinger GM, Chojecki A, Aviv H , Weissmann D, Joshi S, Murphy SM , Hirshfield KM, Ganesan S . Hodgkin Lymphoma and Cutaneous T-Cell Lymphoma Sharing the PCM1-JAK2 Fusion and a Common T-Cell Clone. JCO Precis Oncol. 2019;3. Epub 2019/10/11. doi: 10.1200/po.19.00082. PubMed PMID: 31598574.

Sayan M, Abou Yehia Z, Gupta A, Toppmeyer D, Ohri N, Haffty BG . Acute Cardiotoxicity With Concurrent Trastuzumab and Hypofractionated Radiation Therapy in Breast Cancer Patients. Front Oncol. 2019;9:970. Epub 2019/10/22. doi: 10.3389/fonc.2019.00970. PubMed PMID: 31632906; PMCID: PMC6779787.

Shang G, Jin Y, Zheng Q, Shen X, Yang M, Li Y, Zhang L . Histology and oncogenic driver alterations of lung adenocarcinoma in Chinese. Am J Cancer Res. 2019 Jun 1;9(6):1212-1223. eCollection 2019. PubMed PMID: 31285953; PubMed Central PMCID: PMC6610061.

Srivastava R, Wassef C, Rao BK . The Dayanara effect: increasing skin cancer awareness in the Hispanic community. Cutis. 2019;103(5):257-8. Epub 2019/06/25. PubMed PMID: 31233576.

Stein MN , Malhotra J , Tarapore RS, Malhotra U, Silk AW, Chan N, Rodriguez L, Aisner J , Aiken RD, Mayer T, Haffty BG , Newman JH, Aspromonte SM, Bommareddy PK, Estupinian R, Chesson CB, Sadimin ET, Li S, Medina DJ, Saunders T, Frankel M, Kareddula A, Damare S, Wesolowsky E, Gabel C, El-Deiry WS, Prabhu VV, Allen JE, Stogniew M, Oster W, Bertino JR , Libutti SK , Mehnert JM , Zloza A. Safety and enhanced immunostimulatory activity of the DRD2 antagonist ONC201 in advanced solid tumor patients with weekly oral administration. J Immunother Cancer. 2019;7(1):136. Epub 2019/05/24. doi: 10.1186/s40425-019-0599-8. PubMed PMID: 31118108; PMCID: PMC6532211.

Suwan K, Yata T, Waramit S, Przystal JM, Stoneham CA, Bentayebi K, Asavarut P, Chongchai A, Pothachareon P, Lee KY, Topanurak S, Smith TL, Gelovani JG, Sidman RL, Pasqualini R , Arap W , Hajitou A. Next-generation of targeted AAVP vectors for systemic transgene delivery against cancer. Proc Natl Acad Sci U S A. 2019;116(37):18571-7. Epub 2019/08/04. doi: 10.1073/pnas.1906653116. PubMed PMID: 31375630; PMCID: PMC6744886.

Tahir, Alifiya,  Chaudhary, Sunita . How Social Variables Influence Career Interests of Biomedical Science and Engineering PhD Graduates. Understanding Interventions Journal, 2019, Vol. 10, Issue 1,  Article URL .

Tomlinson-Clarke, Saundra,  Chaudhary, Sunita , Gailliard, Bernadette. Exploring Personal and Contextual Factors Influencing Career Choice Among Biomedical PhD Students and Post-Doctoral Fellows. Understanding Interventions Journal, 2019, Vol. 10, Issue 1 , Article URL .

Vetto JT, Hsueh EC, Gastman BR, Dillon LD, Monzon FA, Cook RW, Keller J, Huang X, Fleming A, Hewgley P, Gerami P, Leachman S, Wayne JD, Berger AC , Fleming MD. Use of a 31-gene expression profile prognostic test to guide sentinel lymph node biopsy decisions in patients with invasive melanoma. Future Oncology. 2019; 15(11):1207-17. doi: 10.2217/fon-2018-0912. Epub 2019 Jan 29. PMID:30691297

Yuan X, Song F, Zhang L . Trend analysis of diabetic mortality. Lancet. 2019 May 11;393(10184):1931-1932. doi: 10.1016/S0140-6736(18)33051-4. PubMed PMID: 31084957.

Yuh BE, Kwon YS, Shinder BM, Singer EA, Jang TL, Kim S, Stein MN , Mayer T, Ferrari A, Lee N, Parikh RR , Ruel N, Kim WJ, Horie S, Byun SS, Ahlering TE, Kim IY . Results of Phase 1 study on cytoreductive radical prostatectomy in men with newly diagnosed metastatic prostate cancer. Prostate Int. 2019;7(3):102-7. Epub 2019/09/06. doi: 10.1016/j.prnil.2018.10.002. PubMed PMID: 31485434; PMCID: PMC6713798.

Zhang J, Lin Y, Zhang L . Trends in Alcoholic Fatty Liver Disease. JAMA. 2019 Sep 10;322(10):979-980. doi: 10.1001/jama.2019.10347. PubMed PMID: 31503302.

Zhang N, Zhang J, Zhang H, Liu Y, Zhao W, Wang L, Chen B, Moran MS, Haffty BG , Yang Q. Individualized Prediction of Survival Benefit from Postmastectomy Radiotherapy for Patients with Breast Cancer with One to Three Positive Axillary Lymph Nodes. Oncologist. 2019. Epub 2019/07/19. doi: 10.1634/theoncologist.2019-0124. PubMed PMID: 31315963.

Zheng XJ, Liu Y, Zhang WC, Liu Y, Li C, Sun XN, Zhang YY, Xu J, Jiang X, Zhang L , Yang W, Duan SZ. Mineralocorticoid receptor negatively regulates angiogenesis through repression of STAT3 activity in endothelial cells. J Pathol. 2019Aug;248(4):438-451. doi: 10.1002/path.5269. Epub 2019 May 6. PubMed PMID: 30900255.
Genomic Instability & Cancer Genetics
Meet Our New Members!
Awards and Honors
Hossein Khiabanian, PhD was awarded a Translational Award from the V Foundation for Cancer Research to study chronic lymphocytic leukemia (CLL) with the aim of developing research models that may help investigators better understand how CLL cells are influenced by new therapies. (T2019-012) Term: 11/01/2019 - 10/31/2022. Amount: $600,000.

Michael Gatza, PhD was awarded a Research Scholar Grant from the American Cancer Society to be used towards the project titled “Dissecting the Role of BRG1-SOX4 in Triple Negative Breast Cancer”. Project Number: 133887-RSG-19-160-01-TBE Term: 01/01/2020 – 12/31/2023. Amount: $792,000.

Rutgers Discovery Informatics Institute awarded a Fellowship of Excellence in Computational and Data Science to James Kelley, a graduate student in the Andrey Grigoriev, PhD laboratory.

Subhajyoti De, PhD was one of the winners of the Single Cell Genomes Scientific Challenge awarded by 10X Genomics Inc. and Genewiz Inc. on August 2, 2019.

Subhajyoti De, PhD was awarded the IIT Kharagpur Young Alumni Achiever Award 2019 by the Indian Institute of Technology on August 18, 2019 in Kharagpur, India. Details of the award can be found in India Today.
Subhajyoti De, PhD presented "Heterogeneity and Plasticity of Tumor Cell Dormancy" during the Distinguished Seminar Series held on July 17, 2019 at the Genesis Biotechnology Group in Hamilton, NJ.

Subhajyoti De, PhD presented "Evolution and Cancer" during the Special Alumni Seminar Series held on August 19, 2019 at the Indian Institute of Technology in Kharagpur, India.
Selected Publications
Epsi NJ, Panja S, Pine SR , Mitrofanova A. pathCHEMO, a generalizable computational framework uncovers molecular pathways of chemoresistance in lung adenocarcinoma. Commun Biol. 2019;2:334. Epub 2019/09/12. doi: 10.1038/s42003-019-0572-6. PubMed PMID: 31508508; PMCID: PMC6731276.

Fuentes RR, Chebotarov D, Duitama J, Smith S, De la Hoz JF, Mohiyuddin M, Wing RA, McNally KL, Tatarinova T, Grigoriev A , Mauleon R, Alexandrov N. Structural variants in 3000 rice genomes. Genome Res. 2019;29(5):870-80. Epub 2019/04/18. doi: 10.1101/gr.241240.118. PubMed PMID: 30992303; PMCID: PMC6499320.

Gordon D, Axelrod DE . A reliable method to determine which candidate chemotherapeutic drugs effectively inhibit tumor growth in patient-derived xenografts (PDX) in single mouse trials. Cancer Chemother Pharmacol. 2019. Epub 2019/09/13. doi: 10.1007/s00280-019-03942-y. PubMed PMID: 31512030.

Guan L, Grigoriev A . Age-related Argonaute loading of ribosomal RNA fragments. Microrna. 2019. Epub 2019/09/21. doi: 10.2174/2211536608666190920165705. PubMed PMID: 31538909.

Guan L, Karaiskos S, Grigoriev A . Inferring targeting modes of Argonaute-loaded tRNA fragments. RNA Biol. 2019:1-11. Epub 2019/10/16. doi: 10.1080/15476286.2019.1676633. PubMed PMID: 31613177.

Hu W, Feng Z . The role of p53 in reproduction, an unexpected function for a tumor suppressor. J Mol Cell Biol. 2019;11(7):624-7. Epub 2019/07/17. doi: 10.1093/jmcb/mjz072. PubMed PMID: 31310660; PMCID: PMC6735926.

Li A, Geyer FC, Blecua P, Lee JY, Selenica P, Brown DN, Pareja F, Lee SSK, Kumar R, Rivera B, Bi R, Piscuoglio S, Wen HY, Lozada JR, Gularte-Merida R, Cavallone L, Rezoug Z, Nguyen-Dumont T, Peterlongo P, Tondini C, Terkelsen T, Ronlund K, Boonen SE, Mannerma A, Winqvist R, Janatova M, Rajadurai P, Xia B , Norton L, Robson ME, Ng PS, Looi LM, Southey MC, Weigelt B, Soo-Hwang T, Tischkowitz M, Foulkes WD, Reis-Filho JS. Homologous recombination DNA repair defects in PALB2-associated breast cancers. NPJ Breast Cancer. 2019;5:23. Epub 2019/08/21. doi: 10.1038/s41523-019-0115-9. PubMed PMID: 31428676; PMCID: PMC6687719.

Liggett LA, Sharma A, De S , DeGregori J. FERMI: A Novel Method for Sensitive Detection of Rare Mutations in Somatic Tissue. G3 (Bethesda). 2019;9(9):2977-87. Epub 2019/07/29. doi: 10.1534/g3.119.400438. PubMed PMID: 31352405; PMCID: PMC6723130.

Liu J, Zhang C, Hu W, Feng Z . Tumor suppressor p53 and metabolism. J Mol Cell Biol. 2019;11(4):284-92. Epub 2018/12/01. doi: 10.1093/jmcb/mjy070. PubMed PMID: 30500901; PMCID: PMC6487777.

Meaney CL, Mitchell KA, Zingone A, Brown D, Bowman E, Yu Y, Wenzlaff AS, Neslund-Dudas C, Pine SR , Cao L, Schwartz AG, Ryan BM. Circulating Inflammation Proteins Associated With Lung Cancer in African Americans. J Thorac Oncol. 2019;14(7):1192-203. Epub 2019/04/07. doi: 10.1016/j.jtho.2019.03.014. PubMed PMID: 30953795; PMCID: PMC6592767.

Mehta GA, Khanna P, Gatza ML . Emerging Role of SOX Proteins in Breast Cancer Development and Maintenance. J Mammary Gland Biol Neoplasia. 2019;24(3):213-30. Epub 2019/05/10. doi: 10.1007/s10911-019-09430-6. PubMed PMID: 31069617; PMCID: PMC6790170.

Mitchell KA, Shah E, Bowman ED, Zingone A, Nichols N, Pine SR , Kittles RA, Ryan BM. Relationship between West African ancestry with lung cancer risk and survival in African Americans. Cancer Causes Control. 2019;30(11):1259-68. Epub 2019/08/31. doi: 10.1007/s10552-019-01212-z. PubMed PMID: 31468279.

Park PH, Yamamoto TM, Li H, Alcivar AL, Xia B , Wang Y, Bernhardy AJ, Turner KM, Kossenkov AV, Watson ZL, Behbakht K, Casadei S, Swisher EM, Mischel PS, Johnson N, Bitler BG. Amplification of the mutation-carrying BRCA2 allele promotes RAD51 loading and PARP inhibitor resistance in the absence of reversion mutations. Mol Cancer Ther. 2019. Epub 2019/10/03. doi: 10.1158/1535-7163.Mct-17-0256. PubMed PMID: 31575654.

Turanli B, Karagoz K, Bidkhori G, Sinha R, Gatza ML , Uhlen M, Mardinoglu A, Arga KY. Multi-Omic Data Interpretation to Repurpose Subtype Specific Drug Candidates for Breast Cancer. Front Genet. 2019;10:420. Epub 2019/05/28. doi: 10.3389/fgene.2019.00420. PubMed PMID: 31134131; PMCID: PMC6514249.

Wiltshire T, Ducy M, Foo TK, Hu C, Lee KY, Belur Nagaraj A, Rodrigue A, Gomes TT, Simard J, Monteiro ANA, Xia B , Carvalho MA, Masson JY, Couch FJ. (2019) Functional characterization of 84 PALB2 variants of uncertain significance. Genet Med. doi: 10.1038/s41436-019-0682-z. [Epub ahead of print]

Wrobel JA, Xie L, Wang L, Liu C, Rashid N, Gallagher KK, Xiong Y, Konze KD, Jin J, Gatza ML , Chen X. Multi-omic Dissection of Oncogenically Active Epiproteomes Identifies Drivers of Proliferative and Invasive Breast Tumors. iScience. 2019;17:359-78. Epub 2019/07/25. doi: 10.1016/j.isci.2019.07.001. PubMed PMID: 31336272; PMCID: PMC6660457.
Basic Research & Clinical Research Programs 
Rutgers Cancer Institute of New Jersey