Basic and Clinical Research Programs |
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Welcome to our Basic and Clinical Research Programs Newsletter.
The goal in creating this newsletter is to keep our members informed and involved. We are highlighting opportunities for collaborations, new funding opportunities, new grants and promotions, new members, along with past and upcoming seminars and events.
We always welcome your suggestions and contributions for future issues. Past issues of the Basic and Clinical Research Programs Newsletter can be found online here at the Rutgers Cancer Institute's website.
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Dear Program Members,
As 2020 comes to a close, I reflect on the inspiring efforts made by the Research Program members to continue their cancer research in the midst of an unprecedented pandemic. New findings, publications, and grants occurred even as laboratories operated at significantly reduced capacities in order to practice social distancing and curtail the spread of viral disease. The efforts of our clinical research teams, working under difficult circumstances, provided our patients with continuing access to clinical trials and new cancer therapies during this time. With research meetings, conferences, and symposia moved to entirely virtual platforms, we continue to foster the sharing of ideas and grow potential collaborations to advance cancer research. With the new vaccines against COVID-19 beginning to be administered, the curtailment of the pandemic is finally within reach, and with it comes the prospect of a gradual return to a more normal routine. As the end of these unprecedented times appears in sight, it is important that we continue to advance our scientific mission, but we must remain vigilant with respect to public health safety measures to keep our patients and ourselves safe.
I wish everyone a healthy and enjoyable holiday season.
Best wishes,
Eileen White, PhD
Deputy Director, Chief Scientific Officer, and Associate Director for Basic Research
Rutgers Cancer Institute of New Jersey
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2021 Virtual Program Meetings |
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Program Meetings Carry On Despite COVID-19! |
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Upcoming CMG Program Meetings:
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Upcoming CP Program Meetings:
3/16/21 @12:00pm: Zheng Shi, PhD
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Upcoming CIPT Program Meetings:
2/1/21 @3:00pm: TBD
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Upcoming GICG Program Meetings:
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Research Programs and Catchment Area Alignment |
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The term “catchment area” is often not immediately familiar to members of the Research Programs. In the simplest terms, the catchment area is the geographic area served by an institution. Rutgers Cancer Institute’s catchment area is the entire state of New Jersey, a place with great racial, ethnic, socioeconomic, and other diversity and multiple cancer health equity issues. As the only NCI-designated cancer center in New Jersey, Rutgers Cancer Institute’s catchment area work includes establishing and aligning research priorities based upon populations and communities for which there are the greatest disparities in cancer incidence, morbidity, and/or mortality.
Research relevant to the catchment area applies to basic, translational, and clinical researchers as much as it does to those in population science. For example, basic laboratory research on lung cancer, efforts to engage more diverse patient populations in cancer clinical trials, and genomics research on hereditary cancer could all be considered catchment area relevant, for they align with research priorities set forth by Rutgers Cancer Institute to promote cancer health equity and reduce disparities. Researchers who consider their current and future research endeavors from the catchment area perspective may find new opportunities for funding and collaboration, as well as added significance to their already important work. This new section of the newsletter will serve to inform and link the Basic and Clinical Research Program members with such resources and opportunities.
Those interested in learning more about catchment area alignment, and who may already be doing catchment area relevant research, are encouraged to contact Rita Musanti, PhD, APN-BC, Assistant Director for Community Outreach and Engagement, at rita.musanti@rutgers.edu
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Virtual Cancer Research Symposium |
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Rutgers Cancer Institute of New Jersey and Princeton University jointly hosted the inaugural Cancer Research Symposium on Friday, November 20, 2020. This virtual event began with Opening Remarks by Eileen White, PhD and featured sessions on Cancer Metabolism (chaired by Joshua Rabinowitz, MD, PhD), Cancer Genomics (chaired by Shridar Ganesan, MD, PhD), Tumor Microenvironment (chaired by Yibin Kang, PhD) and Understanding and Addressing Cancer Burden in the Population (chaired by Anita Kinney, PhD, RN, FAAN, FABMR). Presenters included Joshua Rabinowitz, MD, PhD, Eileen White, PhD, Shridar Ganesan, MD, PhD, Olga Troyanskaya, PhD, Yibin Kang, PhD, Michael Verzi, PhD, Anita Kinney, PhD, RN, FAAN, FABMR, Cristine Delnevo, PhD, MPH, and Heather Howard, JD. The symposium also included short ten-minute presentations by trainees and faculty members from Rutgers University and Princeton University and three-minute poster flash talks. The evaluation surveys indicated uniformly outstanding feedback from the participants.
Close to 230 participants attended the virtual symposium, with strong representation from Princeton University and Rutgers University. We hope future symposia will have in-person attendees.
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Cancer Metabolism & Growth |
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Alexander Valvezan, PhD was awarded a DoD grant entitled "Defiining Cellular Stresses Sensed Through the TSC Complex to Identify Vulnerabilities in TSC Tumors" Grant Number: TS190025 Term: 09/01/2020 - 08/31/2022. Annual Direct Cost: $75,000.
Kenneth D. Irvine, PhD was elected a fellow of the American Association for the Advancement of Science (AAAS) on November 24, 2020 with the ceremony being held on February 13, 2021.
Jared Toettcher, PhD was awarded a NIDDK grant entitled "Control of the 4D Chromatin Landscape Underlying Gene Activity During Development" Grant Number: 1U01DK127429-01 Term: 09/17/2020 - 06/30/2025. Annual Direct Cost: $145,269.
Jian Cao, PhD was awarded the Busch Biomedical Seed Grant entitled "Hepatitis B virus hijacks the histone methyltransferase complex to drive hepatocellular carcinoma development" Term: 10/01/2020 - 09/30/2022. Total Award Amount: $40,000.
Jian Cao, PhD, with a sub-contract with Dr. Dawei Li from University of Vermont, was awarded the FY19 Lung Cancer Research Program; Concept Award from DoD. Project number: W81XWH-20-1-0610 Term: 09/30/2020 - 09/29/2021. Total Award Amount: $100,000 (subcontract: $10,000).
Vrushank Bhatt, a graduate student in the Yanxiang (Jessie) Guo, PhD lab, was awarded the Mistletoe Research Fellowship from the project entitled "Targeting autophagy to sensitize LKB1-deficient Kras-driven lung tumors to MEK inhibitor" Term: 10/01/2020 - 06/30/2021. Unfettered Research Grant: $10,000.
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Eileen White, PhD gave the Keynote Presentation at the Mechanisms & Models of Cancer by Cold Spring Harbor held August 11 - August 14, 2020 virtually.
Yanxiang (Jessie) Guo, PhD presented "O ncogenic events determine tumor de novo lipogenesis and reprogram host de novo lipogenesis in Kras-driven NSCLC" at the CSHL Virtual Conference: Mechanisms & Models of Cancer held August 11-14, 2020 virtually.
Eileen White, PhD presented "Metabolic Regulation of the Anti-cancer Immune Response" at the 9th Annual Metabolism in Cancer Symposium by MD Anderson Cancer Center held September 17, 2020 virtually.
Yanxiang (Jessie) Guo, PhD presented "Autophagy Compensates for Lkb1 Loss to Maintain Adult Mice Homeostasis and Survival" at the Keystone eSymposia: Autophagy: Mechanisms and Disease held October 4-8, 2020 virtually.
Vrushank Bhatt, a graduate student in the Yanxiang (Jessie) Guo, PhD lab, presented "Autophagy inhibition sensitizes Liver Kinase B1 (LKB1) - deficient Kras-driven lung tumors to MEK inhibitor Trametinib" at the ASPET Virtual Seminar series: Focus on Pharmacology “Tribute to Cancer Pharmacology Young Investigators held November 18, 2020 virtually.
Vrushank Bhatt, a graduate student in the Yanxiang (Jessie) Guo, PhD lab, presented "Autophagy inhibition sensitizes Liver Kinase B1 (LKB1) - deficient Kras-driven lung tumors to MEK inhibitor Trametinib" at the Rutgers Cancer Institute-Princeton University Annual Cancer Research Symposium held November 20, 2020 virtually.
Jian Cao, PhD presented "Clonal viral integration analysis for discovering novel oncoviral etiology and oncogenic events" at the CHI Science Seminar Series held November 22, 2020 virtually.
Khoosheh Khayati, a postdoctoral fellow in the Yanxiang (Jessie) Guo, PhD lab, presented "Autophagy Compensates for Lkb1 Loss to Maintain Adult Mice Homeostasis and Survival" at the Women in Autophagy Conference held November 30, 2020 virtually.
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Anlaş AA, Nelson CM. Soft Microenvironments Induce Chemoresistance by Increasing Autophagy Downstream of Integrin-Linked Kinase. Cancer Res. 2020 Oct 01;80(19):4103-4113.
Cai WL, Greer CB, Chen JF, Arnal-Estapé A, Cao J, Yan Q, Nguyen DX. Specific chromatin landscapes and transcription factors couple breast cancer subtype with metastatic relapse to lung or brain. BMC Medical Genomics. 2020;13(1):33. doi: 10.1186/s12920-020-0695-0. PubMed PMID: 32143622; PMCID: PMC7060551.
Fan H, Wang X, Li W, Shen M, Wei Y, Zheng H, Kang Y. ASB13 inhibits breast cancer metastasis through promoting SNAI2 degradation and relieving its transcriptional repression of YAP. Genes Dev. 2020 Oct 01;34(19-20):1359-1372.
Ghergurovich JM, Esposito M, Chen Z, Wang JZ, Bhatt V, Lan T, White E, Kang Y, Guo JY, Rabinowitz JD. Glucose-6-Phosphate Dehydrogenase Is Not Essential for K-Ras-Driven Tumor Growth or Metastasis. Cancer Res. 2020 Sep 15;80(18):3820-3829.
Han S, Jeong YY, Sheshadri P, Su X, Cai Q. Mitophagy regulates integrity of mitochondria at synapses and is critical for synaptic maintenance. EMBO Rep. 2020 Sep 03;21(9):e49801.
Hui S, Cowan AJ, Zeng X, Yang L, TeSlaa T, Li X, Bartman C, Zhang Z, Jang C, Wang L, Lu W, Rojas J, Baur J, Rabinowitz JD. Quantitative Fluxomics of Circulating Metabolites. Cell Metab. 2020 Oct 06;32(4):676-688.e4.
Khayati K, Bhatt V, Hu ZS, Fahumy S, Luo X, Guo JY. Autophagy compensates for Lkb1 loss to maintain adult mice homeostasis and survival. Elife. 2020;9. Epub 2020/11/26. doi: 10.7554/eLife.62377. PubMed PMID: 33236987; PMCID: PMC7714393.
Li W, Shen M, Jiang YZ, Zhang R, Zheng H, Wei Y, Shao ZM, Kang Y. Deubiquitinase USP20 promotes breast cancer metastasis by stabilizing SNAI2. Genes Dev. 2020 Oct 01;34(19-20):1310-1315.
Nerger BA, Brun PT, Nelson CM. Marangoni flows drive the alignment of fibrillar cell-laden hydrogels. Sci Adv. 2020 Jun;6(24):eaaz7748.
Poillet-Perez L, Sharp DW, Yang Y, Laddha SV, Ibrahim M, Bommareddy PK, Hu ZS, Vieth J, Haas M, Bosenberg MW, Rabinowitz JD, Cao J, Guan J-L, Ganesan S, Chan CS, Mehnert JM, Lattime EC, White E. Autophagy promotes growth of tumors with high mutational burden by inhibiting a T-cell immune response. Nature Cancer. 2020;1(9):923-34. doi: 10.1038/s43018-020-00110-7.
Tseng HC, Xiong W, Badeti S, Yang Y, Ma M, Liu T, Ramos CA, Dotti G, Fritzky L, Jiang JG, Yi Q, Guarrera J, Zong WX, Liu C, Liu D. Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma. Nat Commun. 2020 09 23;11(1):4810.
Vrla GD, Esposito M, Zhang C, Kang Y, Seyedsayamdost MR, Gitai Z. Cytotoxic alkyl-quinolones mediate surface-induced virulence in Pseudomonas aeruginosa. PLoS Pathog. 2020 09;16(9):e1008867.
Winkelman JT, Pukhrambam C, Vvedenskaya IO, Zhang Y, Taylor DM, Shah P, Ebright RH, Nickels BE. XACT-Seq Comprehensively Defines the Promoter-Position and Promoter-Sequence Determinants for Initial-Transcription Pausing. Mol Cell. 2020 09 03;79(5):797-811.e8.
Zheng Y, Chen Z, Han Y, Han L, Zou X, Zhou B, Hu R, Hao J, Bai S, Xiao H, Li W, Bueker A, Ma Y, Xie G, Yang J, Chen S, Li H, Cao J, Shen L. Immune suppressive landscape in the human esophageal squamous cell carcinoma microenvironment. Nat Commun. 2020 Dec 8;11(1):6268. doi: 10.1038/s41467-020-20019-0. PMID: 33293583 PMCID: PMC7722722.
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Steven An, PhD was awarded an Industry grant entitled "Structure and Function of Kras Mutations in Cancer" Term: 10/01/2020 - 11/30/2021. Annual Direct Cost: $106,747.
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Daniel Herranz Benito, PharmD, PhD presented "A Tumor Suppressor Enhancer of PTEN in T-cell Development and Transformation" at the AACR Annual Meeting held June 24, 2020 virtually.
Luca Tottone, PhD, a postdoctoral fellow in the Daniel Herranz Benito, PhD lab, presented "A Tumor Suppressor Enhancer of PTEN in T-cell development and leukemia" at the Princeton University Rutgers University Joint Cancer Research Symposium / Cancer Genomics Session held November 20, 2020 virtually.
Olga Lancho, PhD, a postdoctoral fellow in the Daniel Herranz Benito, PhD lab, presented "Sirt1 is a novel therapeutic target in T-ALL" at the Princeton University Rutgers University Joint Cancer Research Symposium / Cancer Genomics Session held November 20, 2020 virtually.
Daniel Herranz Benito, PharmD, PhD presented "Overcoming NOTCH1-Driven Chemoresistance in T-Cell Acute Lymphoblastic Leukemia Via Metabolic Intervention with Oxphos Inhibitor" at the 2020 American Society of Hematology Annual Meeting & Exposition held December 5-7, 2020.
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Goodsell DS, Burley SK. RCSB Protein Data Bank tools for 3D structure-guided cancer research: human papillomavirus (HPV) case study. Oncogene. 2020 Oct;39(43):6623-6632.
Tottone L, Lancho O, Loh JW, Singh A, Kimura S, Roels J, Kuchmiy A, Strubbe S, Lawlor MA, Da Silva- Diz V, Luo S, Gachet S, García-Prieto SA, Hagelaar R, Esteller M, Meijerink JPP, Soulier J,Taghon T, Van Vlierberghe P, Mullighan CG, Khiabanian H, Rocha PP and Herranz D. A Tumor Suppressor Enhancer of PTEN in T-cell development and leukemia. Blood Cancer Discov. Epub 2020/11/24. doi: 10.1158/2643-3230.BCD-20-0201
Yang C, Luo J, Polunas M, Bosnjak N, Chueng SD, Chadwick M, Sabaawy HE, Chester SA, Lee KB, Lee H. 4D-Printed Transformable Tube Array for High-Throughput 3D Cell Culture and Histology. Adv Mater. 2020 Oct;32(40):e2004285.
Zhao JY, Liang L, Gu X, Li Z, Wu S, Sun L, Atianjoh FE, Feng J, Mo K, Jia S, Lutz BM, Bekker A, Nestler EJ, Tao YX. Author Correction: DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons. Nat Commun. 2020 09 14;11(1):4696.
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Clinical Investigations &
Precision Therapeutics
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Bruce Haffty, MD was awarded a Breast Cancer Research FDN grant entitled "Novel Molecular Targets in Combination with Radiation Therapy for Breast Cancer" Grant Number: BCRF-20-063 Term: 10/01/2020 - 09/30/2021. Annual Direct Cost: $145,833.
Lanjing Zhang, MD, MS, FCAP, FASCP and his team were awarded a COVID-19 Research Award entitled "State heterogeneity of COVID-19 epidemics in the European Union" from the Chinese American Pathologists Association. Term: 06/14/2020 - 12/31/2020. Total Award Amount: $1,200.
Lauren Aleksunes, PharmD, PhD, DABT was awarded, as the Co-I, a NIH/NIEHS grant entitled "Mechanism-Driven Virtual Adverse Outcome Pathway Modeling for Hepatotoxicity" Grant Number: 1R01ES031080 Term: 05/2020 - 02/2025. Annual Direct Costs: $303,376.
Michael Steinberg, MD, MPH is the Project Lead for NCI Grant 3P30CA072720-21S4, entitled "Enhancement and Expansion of the C3I Program: Develop tobacco cessation treatment capacity and infrastructure for cancer patients". This project is an administrative supplement to the NCI Cancer Center Support Grant Grant Number: P30CA072720 (PI: Steven Libutti, MD, FACS). Term: 03/01/2020 - 02/28/2021. Total Award Amount: $390,587.
Michael Steinberg, MD, MPH was awarded a FEMA grant entitled "Cancer Risk and Risk Factors in Volunteer Firefighters: The NJ Firefighters Cancer Prevention Study" Grant Number: EMW-2019-FP-00517 Term: 09/28/2020 - 09/27/2023. Annual Direct Cost: $71,144.
Roger Howell, PhD was awarded a NIH-OD grant entitled "Vector/CT/OI Multimodal Imaging for Biomedical Research" Grant Number: 1S10OD026875-01A1 Term: 09/04/2020 - 09/03/2021. Annual Direct Cost: $1,438,853.
Sunita Chaudhary, PhD was awarded a NCI grant entitled "Rutgers Youth Enjoy Science (RUYES) Program" Grant number: 1R25CA247785-01 Term: 09/01/2020 - 08/31/2025. Annual Direct Cost: $188,293.
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Rajdev L; Ambinder R; Chiao E ; Einstein M; Henry D; Ramos J; Lee MS; Sparano J; Mitsuyasu R; Lensing SY; Ratner L; Wang C-C; Dittmer D; Mitcheltree A-L; Pugliese J; Rubinstien P; Baiocchi R. AMC 095: A Report Of Nivolumab (Nivo) In Advanced HIV Associated Solid Tumors (ST). ESMO Congress 2020, Virtual Meeting. September 2020.
Lauren Aleksunes, PharmD, PhD, DABT presented “Clues to Predicting Cancer Drug Toxicity in Patients: From Genetics to Biomarkers” at the University of Kansas Medical Center held September 2020.
Shridar Ganesan, MD, PhD presented "Endogenous Retrovirus Expression, Chromatin Abnormalities, and Response to Immune Checkpoint Blockade in Clear Cell RCC" at the Kidney Cancer Research Summit held October 22, 2020.
Malcolm Mattes, MD presented “A Roadmap for Recruiting Medical Students into Radiation Oncology During a Period of Waning Interest” at the American Society for Radiation Oncology (ASTRO) Annual Meeting held October 24-28, 2020.
Malcolm Mattes, MD presented “Overcoming Barriers to Radiation Oncology Access in Low-Resource Environments” at the American Society for Radiation Oncology (ASTRO) Annual Meeting held October 24-28, 2020.
Mark H. Einstein, MD, MS, FACS, FACOG presented at the Philippine Society of Obstetrical and Gynecologic Society and the Philippine Society for Cervical Pathology and Colposcopy. Virtual Annual Convention of the Philippine Obstetrical and Gynecological Society (POGS), held November 12, 2020.
Mark H. Einstein, MD, MS, FACS, FACOG presented Innovation in HPV-Cancer Screening and Treatments for Women, Society for Women's Health Research - Virtual Round Table, held November 12, 2020.
Malcolm Mattes, MD presented “Ask a Radiation Oncologist: Radiation Therapy for Lung Cancer” at the American Society for Radiation Oncology (ASTRO) RTAnswers Facebook Live Event held November 30, 2020.
Andrew M. Evens, DO, MSc presented "A Phase I-II Trial of DA-EPOCH-R Plus Ixazomib As Frontline Therapy for Patients with MYC-Aberrant Lymphoid Malignancies: The Daciphor Regimen" at the 2020 American Society of Hematology Annual Meeting & Exposition held December 5-7, 2020.
Dennis Cooper, MD presented "A Phase I Dose Escalation Study of PT-112 in Patients with Relapsed or Refractory Multiple Myeloma" at the 2020 American Society of Hematology Annual Meeting & Exposition held December 5-7, 2020.
Dennis Cooper, MD presented "REGN5458, a BCMA x CD3 Bispecific Monoclonal Antibody, Induces Deep and Durable Responses in Patients with Relapsed/Refractory Multiple Myeloma (RRMM) " at the 2020 American Society of Hematology Annual Meeting & Exposition held December 5-7, 2020.
Peter D. Cole, MD presented "Frequency and Prognostic Significance of Recurrent Gene Mutations in Pediatric B-ALL: Report from the DFCI ALL Consortium" at the 2020 American Society of Hematology Annual Meeting & Exposition held December 5-7, 2020.
Andrew M. Evens, DO, MSc presented "Prognostication for Advanced Stage Hodgkin Lymphoma (HL) in the Modern Era: A Project from the Hodgkin Lymphoma International Study for Individual Care (HoLISTIC) Consortium" at the 2020 American Society of Hematology Annual Meeting & Exposition held December 5-7, 2020.
Andrew M. Evens, DO, MSc presented "Patient-Reported Outcomes Among Patients with High-Risk Untreated Follicular Lymphoma (FL) Randomized to Bendamustine/Rituximab (BR) or Bendamustine/Rituximab with Bortezomib (BVR) Therapy: Results from the ECOG-ACRIN E2408 Study" at the 2020 American Society of Hematology Annual Meeting & Exposition held December 5-7, 2020.
Rajat Bannerji, MD, PhD presented "Baseline Biomarkers of T-Cell Function Correlate with Clinical Responses to Odronextamab (REGN1979), and Loss of CD20 Target Antigen Expression Identified As a Mechanism of Treatment Resistance" at the 2020 American Society of Hematology Annual Meeting & Exposition held December 5-7, 2020.
Andrew M. Evens, DO, MSc presented "Patient and Disease Factors Predict Risk of 1-Year Mortality Among Older Adults Who Receive Intensive Chemotherapy for Hodgkin Lymphoma (HL)" at the 2020 American Society of Hematology Annual Meeting & Exposition held December 5-7, 2020.
Mansi Shah, MD presented “Environmental Sars-Cov-2 Surface Testing: Low Incidence of Virus Positivity in Outpatient and Inpatient Hematology/Oncology Settings” at the 2020 American Society of Hematology Annual Meeting & Exposition held December 5-7, 2020. Senior Author: Andrew M. Evens, DO, MSc. Authors: Imraan Jan, DO, Norma Belarmino, MHSA, Kara Saggiomo, MSN, Carolyn Hayes, RN, PhD, Deborah L. Toppmeyer, MD, Bruce G. Haffty, MD, Steven K. Libutti, MD, FACS.
Richard A. Drachtman, MD presented "Final Report of Reduced Anthracycline Dose Intensity with the Addition of Dose Dense Rituximab in Children, Adolescents and Young Adults with De Novo Good Risk Mature B-Cell Non Hodgkin Lymphoma (B-NHL)" at the 2020 American Society of Hematology Annual Meeting & Exposition held December 5-7, 2020.
Rajat Bannerji, MD, PhD presented "Odronextamab (REGN1979), a Human CD20 x CD3 Bispecific Antibody, Induces Durable, Complete Responses in Patients with Highly Refractory B-Cell Non-Hodgkin Lymphoma, Including Patients Refractory to CAR T Therapy" at the 2020 American Society of Hematology Annual Meeting & Exposition held December 5-7, 2020.
Kevin A. David, MD and Andrew M. Evens, DO, MSc presented "Real World (RW) Outcomes and Prognostication of Older Patients with Primary Central Nervous System Lymphoma (PCNSL) in the Contemporary Era" at the 2020 American Society of Hematology Annual Meeting & Exposition held December 5-7, 2020.
Kevin A. David, MD presented "CNS Prophylaxis during Front-Line Therapy in Aggressive Non-Hodgkin Lymphomas: Real-World Outcomes and Practice Patterns from 19 US Academic Institutions" at the 2020 American Society of Hematology Annual Meeting & Exposition held December 5-7, 2020.
Vimal D. Patel, MD, Anne A Tyno, RN, MSN, APN-C, Dale G. Schaar, MD, PhD, Roger K. Strair, MD, PhD, and Dennis Cooper, MD presented "Reduction of Clostridium Difficile Infection in an Academic Medical Center Blood and Marrow Transplant Population" at the 2020 American Society of Hematology Annual Meeting & Exposition held December 5-7, 2020.
Andrew M. Evens, DO, MSc presented "Radiation-Based Approaches as an Alternative to Stem Cell Transplant for Relapsed/Refractory Classical Hodgkin Lymphoma: A Multicenter Retrospective Analysis" at the 2020 American Society of Hematology Annual Meeting & Exposition held December 5-7, 2020.
Kevin A. David, MD and Andrew M. Evens, DO, MSc presented "EBV-Positive Primary CNS Lymphomas in Older Patients: Incidence, Characteristics, Tumor Pathology, and Outcomes across a Large Multicenter Cohort" at the 2020 American Society of Hematology Annual Meeting & Exposition held December 5-7, 2020.
Rajat Bannerji, MD, PhD presented "Polatuzumab Vedotin Plus Venetoclax with Rituximab in Relapsed/Refractory Diffuse Large B-Cell Lymphoma: Primary Efficacy Analysis of a Phase Ib/II Study" at the 2020 American Society of Hematology Annual Meeting & Exposition held December 5-7, 2020.
Peter D. Cole, MD presented "Pegaspargase Re-Challenge after Grade 2 Hypersensitivity Reaction in Childhood Acute Lymphoblastic Leukemia: Results from DFCI 16-001" at the 2020 American Society of Hematology Annual Meeting & Exposition held December 5-7, 2020.
Andrew M. Evens, DO, MSc presented "The Burkitt Lymphoma International Prognostic Index (BL-IPI)" at the 2020 American Society of Hematology Annual Meeting & Exposition held December 5-7, 2020.
Andrew M. Evens, DO, MSc presented "Prognostication, Survival and Treatment-Related Outcomes in HIV-Associated Burkitt Lymphoma (HIV-BL): A US and UK Collaborative Analysis" at the 2020 American Society of Hematology Annual Meeting & Exposition held December 5-7, 2020.
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Arap W, Pasqualini R, Costello JF. Prostate Cancer Progression and the Epigenome. N Engl J Med. 2020 Dec 3;383(23):2287-2290. doi: 10.1056/NEJMcibr2030475. PMID: 33264551.
Attia CG, Fei N, Almubarak M, Ma PC, Mattes MD. Patterns of disease progression to checkpoint inhibitor immunotherapy in patients with stage IV non-small cell lung cancer. J Med Imaging Radiat Oncol. 2020 Sep 2. doi: 10.1111/1754-9485.13096. Epub ahead of print. PMID: 32881332.
Chan N, Willis A, Kornhauser N, Ward MM, Lee SB, Nackos E, Seo BR, Chuang E, Cigler T, Moore A, Donovan D, Cobham MV, Fitzpatrick V, Schneider S, Wiener A, Guillaume-Abraham J, Aljom E, Zelkowitz R, Warren JD, Lane ME, Fischbach C, Mittal V, Vahdat L. \Influencing the Tumor Microenvironment: A Phase II Study of Copper Depletion Using Tetrathiomolybdate in Patients with Breast Cancer at High Risk for Recurrence and in Preclinical Models of Lung Metastases. Clin Cancer Res. 2020 Sep 15;26(18):5051.
Chiao E, Lensing SY, Wiley DJ, Deshmukh AA, Lee J, Darragh TM, Einstein MH, Jay N, Berry-Lawhorn JM, Palefsky JM, Wilkin T, Barroso LF, Cranston RD, Levine R, Guiot HM, French AL, Citron D, Rezaei MK, Goldstone SE, Stier EA. Screening strategies for the detection of anal high-grade squamous intraepithelial lesions in women living with HIV. AIDS. 2020 Sep 17. Online ahead of print. .PMID: 32947592.
Deng F, Zhou H, Lin Y, Heim J, Shen L, Li Y, Zhang L. (2020) Predict multicategory causes of death in lung cancer patients using clinicopathologic factors. Comput Biol Med Doi: 10.1016/j.compbiomed.2020.104161
Desai K, Kayode, Ajenifuja O, Banjo A, Adepiti CA, Novetsky A, Sebag C, Einstein M, Oyinloye T, Litwin T, Horning M, Olanrewaju FO, Oripelaye MM, Afolabi E, Odujoko OO, Castle PE, Antani S, Wilson B, Hu L, Mehanian C, Demarco M, Gage JC, Xue Z, Long LR, Cheung L, Egemen D, Wentzensen N, Schiffman M. Design and feasibility of a novel program of cervical screening in Nigeria: self-sampled HPV testing paired with visual triage (IAAC-D-20-00094) Infectious Agents and Cancer.2 020 Oct 14;15:60. PMID: 33072178.
Doose M, Steinberg MB, Xing CY, Lin Y, Cantor JC, Hong CC, Demissie K, Bandera EV, Tsui J. Comorbidity Management in Black Women Diagnosed with Breast Cancer: the Role of Primary Care in Shared Care. J Gen Intern Med. 2020 Sep 24. doi: 10.1007/s11606-020-06234-x. Epub ahead of print. PMID: 32974725.
Fung CY, Vapiwala N, Mattes MD, Mohindra P, Shah C, Yechieli R, Truong MT, Sanders T, Arnone A, Royce TJ, Ennis RD. US Radiation Oncologists (Re)Defined: An American Society for Radiation Oncology Scope of Practice Study. Int J Radiat Oncol Biol Phys. 2020 Sep 18:S0360-3016(20)34301-7. doi: 10.1016/j.ijrobp.2020.09.029. Epub ahead of print. PMID: 32956745; PMCID: PMC7500393.
George B, Wen X, Mercke N, Gomez M, O’Bryant C, Bowles D, Hu Y, Hogan S, Joy M, Aleksunes L (2020) Time-dependent changes in kidney injury biomarkers in patients receiving multiple cycles of cisplatin. Toxicol Rep. 7:571-576. PMCID:PMC32382514.
Gorczyca L, Aleksunes L (2020) Transcription factor-mediated regulation of the BCRP/ABCG2 efflux transporter: a review across tissues and species. Expert Opin Drug Metab Toxicol. 16(3):230-253. PMCID:PMC7167287
Gulhati P, Yin J, Pederson L, Schmoll HJ, Hoff P, Douillard JY, Hecht JR, Tournigand C, Tebbut N, Chibaudel B, Gramont A, Shi Q, Overman MJ. Threshold Change in CEA as a Predictor of Non-Progression to First-Line Systemic Therapy in Metastatic Colorectal Cancer Patients With Elevated CEA. J Natl Cancer Inst. 2020 Nov 01;112(11):1127-1136.
Hathout L, Ennis R, Mattes MD, Wagman R, Grann A, Jabbour SK, Singh R, Yue N, Haffty B, Vergalasova I. The Impact of COVID-19 on brachytherapy during the pandemic: a Rutgers-Robert Wood Johnson Barnabas Health multi-site experience. Adv Radiat Oncol. 2020 Nov 2:100600. doi: 10.1016/j.adro.2020.10.013. Epub ahead of print. PMID: 33163697; PMCID: PMC7605726.
Jabbour S, Simone CB, Malhotra J. Assessing Expression of PD-L1 in Tumor-Associated Macrophages-Reply. JAMA Oncol. 2020 Oct 01;6(10):1634-1635.
Jan I, Chen K, Sayan M, Uprety P, Laumbach RJ, Ennis RD, Haffty BG. Prevalence of Surface Contamination With SARS-CoV-2 in a Radiation Oncology Clinic. JAMA Oncol. 2020 10 01;6(10):1632-1634.
Li JL, Huynh DL, Simborio H, Cornwell W, Huang J, Kosmider B, Rogers T, Steinberg MB, Le TLT, Pham K, Liu C, Tang MS, Wang H. Electronic cigarettes trigger toll-like receptor 9-mediated inflammation by inducing mitochondrial DNA damage and contribute to atherosclerosis development in ApoE−/− mice. Submitted to ATVB; Aug 2020
McDermott DM, Seldomridge A, Maniar A, Mattes MD. Patterns of palliative care consultation among patients with brain metastasis: an opportunity for radiation oncologists to facilitate earlier referral. Ann Palliat Med. 2020 Sep;9(5):3513-3521. doi: 10.21037/apm-20-462. Epub 2020 Aug 27. PMID: 32921075.
Pham K, Huynh D, Le L, Delitto D, Yang L, Huang J, Kang Y, Steinberg MB, Li J, Zhang L, Liu D, Tang MS, Liu C, Wang H. (2020) E-cigarette promotes breast carcinoma progression and lung metastasis: Macrophage-tumor cells crosstalk and the role of CCL5 and VCAM-1. Cancer Lett. 28;491:132-145. doi: 10.1016/j.canlet.2020.08.010. PMID: 32829009
Pierce JP, Benmarhnia T, Chen R, White M, Abrams DB, Ambrose BK, Blanco C, Borek N, Choi K, Coleman B, Compton WM, Cummings KM, Delnevo CD, Elton-Marshall T, Goniewicz ML, Gravely S, Fong GT, Hatsukami D, Henrie J, Kasza KA, Kealey S, Kimmel HL, Limpert J, Niaura RS, Ramôa C, Sharma E, Silveira ML, Stanton CA, Steinberg MB, Taylor E, Bansal-Travers M, Trinidad DR, Gardner LD, Hyland A, Soneji S, Messer K. Role of e-cigarettes and pharmacotherapy during attempts to quit cigarette smoking: The PATH Study 2013-16. PLoS One. 2020 Sep 2;15(9):e0237938. doi: 10.1371/journal.pone.0237938. PMID: 32877429; PMCID: PMC7467279.
Rahem SM, Epsi NJ, Coffman FD, Mitrofanova A. Genome-wide analysis of therapeutic response uncovers molecular pathways governing tamoxifen resistance in ER+ breast cancer. EBioMedicine 2020 Nov;61:103047. doi: 10.1016/j.ebiom.2020.103047. Epub 2020 Oct 21.
Santos JB, Nobre MRC, Oliveira CZ, Safatle-Ribeiro AV, Kawaguti F, Martins B, Nahas SC, Ribeiro U Jr, Zhang L, Maluf-Filho F. (2020) Risk factors for adverse events of colorectal endoscopic submucosal dissection: a systematic review and meta-analysis. Eur J Gastroenterol Hepatol. 2020 Nov 17. Epub ahead of print. PMID: 33208681.
Schaafsma E, Zhao Y, Zhang L, Li Y, Cheng C. (2020) MYC activity inference captures diverse mechanisms of aberrant MYC pathway activation in human cancers. Mol Cancer Res. 2020 Nov 24:molcanres.0526.2020. PMID: 33234576.
Singh SA, McDermott DM, Mattes MD. Impact of Systemic Therapy Type and Timing on Intracranial Tumor Control in Patients with Brain Metastasis from Non-Small-Cell Lung Cancer Treated With Stereotactic Radiosurgery. World Neurosurg. 2020 Dec;144:e813-e823. doi: 10.1016/j.wneu.2020.09.082. Epub 2020 Sep 18. PMID: 32956881.
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Genomic Instability & Cancer Genetics |
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Karen A. Schindler, PhD was awarded a NIGMS grant entitled “Signaling mechanisms that control chromosome segregation during female meiosis” Grant Number: R35 GM136340 Term: 09/17/20 - 07/03/2025. Amount: $1,926,655.
Michael Levine, PhD was awarded a NIDDK grant entitled "Control of the 4D Chromatin Landscape Underlying Gene Activity During Development" Grant Number: 1U01DK127429-01 Term: 09/17/2020 - 06/30/2025. Annual Direct Cost: $145,269.
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Karen A. Schindler, PhD presented “Understanding the genetic contributions to making a healthy egg” at the Invited seminar for Colorado State University Fall Webinar Series held October 2020.
Karen A. Schindler, PhD presented “Understanding the genetic contributions to making a healthy egg” at the Invited seminar for Rutgers Cancer Institute of New Jersey held September 2020.
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Biswas L, El Yakoubi W, Tyc K, Morgan K, Xing X, Schindler K. 2020. Meiosis interrupted: the genetics of female infertility via meiotic failure. Reproduction. doi: 10.1530/REP-20-0422.
Chen L, Marishta A, Ellison CE, Verzi MP. Identification of Transcription Factors Regulating SARS-CoV-2 Entry Genes in the Intestine. Cell Mol Gastroenterol Hepatol. 2021; 11(1): 181–184. Published online 2020 Aug 15. doi: 10.1016/j.jcmgh.2020.08.005
Replogle JM, Norman TM, Xu A, Hussmann JA, Chen J, Cogan JZ, Meer EJ, Terry JM, Riordan DP, Srinivas N, Fiddes IT, Arthur JG, Alvarado LJ, Pfeiffer KA, Mikkelsen TS, Weissman JS, Adamson B. Combinatorial single-cell CRISPR screens by direct guide RNA capture and targeted sequencing. Nat Biotechnol. 2020 08;38(8):954-961.
Singh VK, Rastogi A, Hu X, Wang Y, De S. Mutational signature SBS8 predominantly arises due to late replication errors in cancer. Commun Biol. 2020 Aug 03;3(1):421.
Vazquez BN, Vaquero A, Schindler K. 2020. Sirtuins in female meiosis and in reproductive longevity. Molecular Reproduction and Development. doi: 10.1002/mrd.23437.
Ye C, Liu B, Lu H, Liu J, Rabson AB, Jacinto E, Pestov DG, Shen Z. 2020. BCCIP is required for nucleolar recruitment of eIF6 and 12S pre-rRNA production during 60S ribosome biogenesis. Nucleic Acid Research, DOI: 10.1093/nar/gkaa1114
Zaccaria, S., Raphael BJ. Characterizing allele- and haplotype-specific copy numbers in single cells with CHISEL. Nat Biotechnol (2020). https://doi.org/10.1038/s41587-020-0661-6
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Basic Research & Clinical Research Programs
Rutgers Cancer Institute of New Jersey
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