Failures in Blend Uniformity or Content Uniformity?

GlobePharma's ProQbDTM line of Products is the Solution.

 

Sift-N-Blend®, from the ProQbDTM line of GlobePharma, is just one of our innovative solutions for

Blend and Content Uniformity issues


Achieving consistent content uniformity—especially in low-dose formulations—requires more than traditional blending. It requires technology designed from the ground up with Quality by Design (QbD) principles in mind.


That’s why GlobePharma is proud to introduce ProQbD™, our QbD-focused platform for formulation development—built on proven, patented technologies like Sift-N-Blend®.



The Standard for Content Uniformity: Sift-N-Blend®


Our patented Sift-N-Blend® technology continues to set the benchmark for blend quality by combining sifting and blending into a single, efficient operation. By repeatedly passing material through an integrated screen during blending, Sift-N-Blend®:

  • Reduces segregation risk
  • Improves content uniformity—especially for low-dose formulations
  • Eliminates the need for separate pre-sifting steps
  • Streamlines workflows and reduces processing time
  • Minimizes dust exposure in an enclosed blending environment


Unlike traditional intensifier bars, Sift-N-Blend® is lightweight, easy to install and clean, and available with interchangeable screens to support a wide range of formulations. Existing V-blenders, double-cone, and bin blenders can also be retrofitted, protecting your current equipment investment.


Proven Performance, Backed by Data


Testing has shown that blends prepared using Sift-N-Blend® are more dynamically stable and better able to resist segregation under stressed conditions—conditions that more accurately reflect real-world manufacturing environments.


When paired with GlobePharma’s DynaSeg™ Dynamic Powder Segregation Tester, Sift-N-Blend® enables formulators to identify robust formulations earlier in development, reducing the risk of scale-up failures and costly content uniformity issues downstream.


Introducing ProQbD™


ProQbD™ brings together GlobePharma’s patented technologies, application expertise, and testing tools to support smarter formulation decisions—earlier in the process—so quality is designed in, not tested in.

If you’d like to see how Sift-N-Blend®  and ProQbD™ can support your formulation or scale-up goals, we invite you to request a brief demonstration or technical discussion with our team—no obligation, just insight.


One Partner. Consistent Results. Lower Costs.




Begin the first step to the solution:

 

Mar 18

Webinar: Blend & Solid Dosage Form Content Uniformity Failures? Here's the Solution.

Join GlobePharma’s ProQbD™ Webinar Series as we address one of the industry’s most persistent challenges: Blend Uniformity (BU) & Content Uniformity (CU) failures in solid dosage forms.
Webinar Topic
Blend & Solid Dosage Form Content Uniformity
Problem Identified – Mechanism Explained – Solution Presented
We will explore:
• Why CU/BU failures occur, why static sampling often misses the root cause
• The true impact of powder segregation during scale-up
• How formulation & process variables influence blend robustness
• A QbD-aligned approach to proactively prevent costly manufacturing failures

Mar 18, 2026 01:00pm ET - Mar 18, 2026 02:00pm ET

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Free

The GlobePharma Advantage

GlobePharma specializes in solid dosage form equipment, especially powder blenders, both stand alone and with interchangeable shells, with optional intensifier bars and Sift-N-Blend® intensifier attachment which facilitates simultaneous sifting and blending, eliminating the need for separate sifting if ingredients such as silicon dioxide and lubricants; in addition it also provides a highly homogeneous blend by repeated sifting and blending of the powders.


Other equipment includes hammers and cone mills, high shear granulators, rotary and manual tablet presses and a powder segregation tester.


Click the link below for our brochures.

 
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