Dear Steve,

DID YOU KNOW that there is a "new" hypothesis about inflammation, according a new study in Frontiers in Immunology?

The new hypothesis is called unalamation, which means the compounds that lead to inflammation in our body are always present in everyday healthy physiology, but they are under the control of anti-inflammatory compounds. For example, when we breathe oxygen, we create free radicals which must be quenched or they create oxidative inflammation. Fruit and vegetables provide anti-inflammatory, free radical quenching compounds, unless you do not consume enough of them.

Acute inflammation results from an increase of the inflammatory compounds at the site of an injury. However, chronic inflammation comes from a decrease of the anti-inflammatory compounds in a normal healthy physiological state. Because the balance of inflammatory and anti-inflammatory compounds helps maintain a normal health state, the authors purport that the goal of treatment for chronic inflammation may not be to decrease inflammatory compounds but to find a way to increase anti-inflammatory compounds.

The goal is surely to increase anti-inflammatory compounds with optimal diet and supplements. This reduces chronic inflammation, which is behind many autoimmune diseases. But you cannot reduce chronic inflammation without limiting the daily inflammatory insults (i.e. gluten, dairy, sugar). It is a delicate balance to bring this into balance.

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Steve: More researchers are seeing Alzheimer's as principally an autoimmune disorder within the brain.

When you trip and fall, the immune system helps to mend the damaged tissues. When you experience a viral or bacterial infection, the immune system helps in the fight against these microbial invaders. When you eat too much sugar, the immune system mobilizes to increase glucose metabolism.

The exact same processes are present in the brain. When there is head trauma, the brain's immune system kicks into gear to help repair. When bacteria are present in the brain, the immune system is there to fight back. When one continues to eat food your immune system see as toxic, it wants to calm inflammation in the brain, but exposure day after day, year after year, leads to autoimmunity in which the immune system never turns off (chronic inflammation).

The key to reducing immune-related inflammation begins and ends with optimal diet and lifestyle choices.

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