Seeding the next generation of biomedical visionaries. 

Whether it's bringing single-cell technologies to tackle HIV in Africa or launching a national breast cancer research initiative, BroadIgnite supports the ideas that lead to biomedical breakthroughs.
New Award Recipients
Evan Macosko - Psychiatric Disease

There are 100 billion cells in the brain, and Evan intends to learn which ones  malfunction in complex disorders. In pursuit of this research, he has pioneered new technologies, including one method that simultaneously profiles thousands of cells by separating them into barcoded droplets.

Ashlee Earl - Infectious Disease

In 2017, the World Health Organization listed carbapenem-resistant Enterobacteriaceae (CRE) as the drug-resistant pathogen posing the biggest risk to human health. Ashlee is taking a deep dive into the genes of CRE to learn its secrets, and devise ways to defeat it.

Amit Khera - Heart Disease

Sudden cardiac death kills 325,000 people a year in the United States. Amit plans to put a dent in this figure by analyzing the genetic mutations that increase the risk of cardiovascular disease. He'll then use analytics to link those mutations to the measurable heart data that doctors like him already gather from patients, such as high cholesterol and heart pumping function.

Evan Macosko and Amit Khera photos courtesy of Juliana Sohn
Project Updates
Alex Shalek

Alex received BroadIgnite funding in 2015 to support his investigation of immune response in HIV-positive individuals. In collaboration with labs in Durban, South Africa, Alex and his team trained 15 South African scientists in single-cell analysis methods. They also pioneered new single-cell methods, yielding fresh insights about host-bacteria interactions. All of this exciting progress helped Alex and his team earn a $2.7 million grant from the Gates Foundation to advance their important work.

Nick Wagle

Nick, a 2016 BroadIgnite awardee, leads the Metastatic Breast Cancer (MBC) Project, a groundbreaking direct-to-patient platform through which patients share tissue samples and medical information. Nearly 3,400 patients have registered since the program's launch in October 2015. So far, Nick's team has successfully sequenced 67 patient samples. What's more, their preliminary data helped them secure a $375,000 grant from a major breast cancer foundation. 

Moran Yassour

Moran Yassour received a BroadIgnite grant in 2016 to study the bacteria passed from mother to infant during birth. She enrolled 190 families in her study at Massachusetts General Hospital. With most of the samples now sequenced, her team is gearing up to investigate questions like whether mothers who have C-sections transmit bacteria less efficiently to their newborns, which bacteria are affected, and what that means for baby microbiomes. She discussed her work on a recent episode of the BroadIgnite podcast and in a Q&A.

BroadIgnite Podcast
Season 1, Episode 5: Eli Van Allen

BroadIgnite awardee Eli Van Allen discusses his research of patients with exceptional responses to immunotherapies. 

Photos from Our Annual Event
BroadIgnite Summer Science Fair

This annual event took place at the Broad on June 15, convening nearly 100 guests. Attendees met award recipients and learned firsthand about how BroadIgnite funding has bolstered their research.  

BroadIgnite Awardees in the Media
Daniel MacArthur

The American Society of Human Genetics (ASHG) recently named Daniel MacArthur, a 2014 BroadIgnite awardee, as the inaugural recipient of its $10,000 Early-Career Award . Daniel led the development of the Exome Aggregation Consortium (ExAC) database and Genome Aggregation Database (gnomAD), widely used resources that have abetted our collective understanding of disease and therapeutic pathways. Daniel and Monkol Lek, a member of his lab, talked about their work on the BroadIgnite podcast .

Sonia Vallabh and Eric Minikel

Sonia Vallabh and Eric Minikel, the wife-and-husband team who received a BroadIgnite grant in 2015 for their work advancing the understanding of prion disease, recently spoke with NPR about how "prevention is everything" in their quest. NPR produced two features about them. The first is Sonia and Eric's personal story; the second is about their push for preventive clinical trials
Abby Kussell Hopper