CAADE Newsletter

Hangovers Happen as Your Body Tries to Protect Itself from Alcohol's Toxic Effects
By  Daryl Davies Joshua Silva Terry David Church  12/25/19
When all is said and done, you’re the cause of your own hangover pain, and you’re the one who must pay for all the fun of the night before. 
Debaucherous evening last night? You’re probably dealing with veisalgia right now. More commonly known as a hangover, this unpleasant phenomenon has been dogging humanity since our ancestors first happened upon fermentation.

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Industry News
Chemicals in vaping flavors cause widespread damage to lung tissue
UNIVERSITY OF ROCHESTER MEDICAL CENTER
NEWS RELEASE 18-DEC-2019
New research appearing in the journal Scientific Reports unpacks the list of chemicals that comprise flavored e-liquids and pods used in vaping and details their harmful effects to lung tissue, including inflammation and genetic damage that could indicate long-term risk for respiratory disease and even cancer.
"While names like mango, cucumber, and mint give the impression that the flavors in e-juices are benign, the reality is that these sensations are derived from chemicals," said Irfan Rahman, Ph.D., a professor in the University of Rochester Medical Center's (URMC) Department of Environmental Medicine and lead author of the study. "These findings indicate that exposure to these chemicals triggers damage and dysfunction in the lungs that are a precursor to long-term health consequences."

Can We Reverse the Brain Damage That Drug Use Causes?
Drugs can cause permanent harm to the brain. We're only beginning to find ways to heal the hurt.
By Alex Orlando December 15, 2019 6:00 PM
All addictive drugs work within the brain, but the feelings of euphoria that they produce often come at a cost. Some can cause brain damage by triggering seizures or strokes — or even result in direct, toxic effects on brain cells.
For example, cocaine can cause microscopic strokes in the brain, creating dead spots among the organ’s neural circuitry. And drug addiction , in part, is defined by its ability to cause long-lasting changes in the brain. These changes can distort the functioning of different brain circuits, including those that control pleasure, stress, impulse control, learning and memory.
For years, researchers have been working to counteract these changes by tapping into the brain’s ability to adapt and repair itself. Because the brain is “plastic,” or able to adapt and change, it can use other neural circuits to perform functions that have been disabled by damaged cells. 
Scientists are making progress on treatments to reverse drug-related brain damage. Earlier this year, researchers were able to reverse brain inflammation — and even damage to nerve cells — in rats who were given alcohol as adolescents.
A NEW Ex-Offender education program
In this country, there is a plethora of individuals who have a great deal of difficulty with job placement and that group is: ex-offenders. The large number of ex-offenders in our society face discrimination in employment. There are few positions available for them and many lack an education to compete in a more academic job environment. As one man reported, he had not been to school for many years and then only to get his GED while in prison. He wanted help so that he could return to a life where he was able to influence others to stay away from his life of poor decisions, drug use, and incarceration. Fortunate for him, he found a program that was all but designed for him.
Dr. Lisa Vartanian at the East Los Angeles College Addiction Studies Program has recently received a grant to provide free classes, tutoring and other assistance for ex-offenders who wish to enter the field of drug and alcohol prevention. The program, FOCIS (Formerly or Currently Incarcerated Student) Program, recently graduated its first class. Upon completion of only three East Los Angeles College Addiction Studies classes, the student will earn a Prevention Specialist Certificate and will be able, with the program’s assistance, to begin to work in the field. Interested persons can contact the program at (323) 265-8955 and ask for Gilbert. 
Remembering Dr. Martin R. Haskell
Beginning in 1971, for more than ten years, I was privileged to work with Dr. Martin R. Haskell, a sociologist and psychologist, until his death. He often spoke against the concept of defining people by their diagnosis. As a psychodramatist, he was more focused on the behavior of individuals than on a diagnosis, a position I often see in textbooks when I teach. The idea is reflected in the Transactional Analysis literature as well with the concept “I can’t do that, I’m an alcoholic”. Rather, Martin focused on the strengths of the individual, and the behavior that needs to change.  He believed that by focusing on changing behaviors, the self-esteem of the individual would be raised, and that person would be more likely to improve. Instead of saying “’I’m an alcoholic” , it is better to say “I’m a father, a spouse, a carpenter, a good friend, and a man who drinks too much.” This psycholinguistic approach seemed to help those individuals maintain their motivation, and move ahead, feel empowered, and focus on changing behavior. Rest in peace, Martin.
Barry Levy
DECEMBER 5, 2019
New protein function could be key to treatment of drug addiction and behavioral disorders
Novel mechanism for regulating the reward behavior can potentially be explored for new treatments of Schizophrenia & other addiction-based disorders Credit: Kozo Kaibuchi and Yasuhiro Funahashi
The human brain consists of several intricate networks or "circuits." One such complex circuit, called the " reward  circuit," is involved in reward-associated learning, a process in which nerve cell activity changes in response to a "reward" stimulus (something that the brain perceives as a reward). This process is what usually causes feelings of desire and motivation, but excessive stimulus may also cause dependence and addiction.
Why is it so difficult to say no to that piece of cake?
Written by Lisa Templeton on December 23, 2019 - Fact checked by Gianna D'EmilioNew
Using rats, researchers have discovered that a specific circuit in the brain seems to drive impulsive eating. Could this lead to a therapy for people who are dealing with the adverse effects of overeating? 
Blood pressure drug could help problem drinkers
December 11, 2019
A drug used to treat high blood pressure may alleviate anxiety induced by long-term heavy alcohol use, and also halt the damage such drinking can cause to the brain's ability to grow new cells, QUT research shows. 

MDMA Could Be Tailored to Make It More Suitable for Treating Mental Illness
A mouse study demonstrates it is possible to separate the substance’s ability to enhance sociability from its addictive potential
MDMA, or ecstasy, once had the reputation of exclusively being an illicit party drug popular at raves and dance clubs. That view has changed in recent years. The substance, known for its ability to produce feelings of euphoria and affection for others, has developed a new identity as a promising therapeutic tool. Researchers are currently investigating MDMA-assisted therapy as a potential treatment for post-traumatic stress disorder in late-stage clinical trials . The drug’s capacity to enhance sociability has also led to studies investigating its benefits for other conditions, such as social anxiety in individuals with autism spectrum disorder.
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Disclaimer:
CAADE Newsletter is a general dissemination of information for addiction professionals. We seek to inform the community by posting upcoming events, addiction related articles, and recommendations for scholastic excellence. CAADE does not necessarily endorse the opinions or views put forth in these articles, neither guarantees the accuracy of the information provided by external sources/links nor accepts responsibility or liability for any consequences arising from the use of such data.