Biofortification is a process of increasing the density of minerals and vitamins in a food crop through conventional plant breeding, transgenic techniques, or agronomic practices. Biofortified staple food crops, when consumed regularly substituting one-for-one with non-biofortified staple food crops, will generate measurable improvements in human nutrition and health. This paper describes the progress made in disseminating, testing, and developing biofortified food crops with both conventional plant breeding and genetic engineering.