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Spotlight on: Dr. Alex Fiks
Newly Appointed Medical Director of PeRC

On July 1, Alexander Fiks, MD, MSCE assumed the role of Medical Director of the Pediatric Research Consortium (PeRC) at The Children's Hospital of Philadelphia, taking over for Louis M. Bell, MD. PeRC was started in 2002 with a grant from the Agency for Healthcare Research and Quality (AHRQ). Over the last 15 years, PeRC has been recognized as one of the nation’s premier pediatric practice-based research programs. PeRC is involved in the approval, coordination, and facilitation of an average of 35 clinical research projects annually, which have resulted in more than 160 peer-reviewed publications. 

D r. Fiks had previously served as Associate Medical Director of PeRC, and is currently the Director of the American Academy of Pediatrics' Pediatric Research in Office Settings (PROS) network, in addition to his CPCE role as Associate Director for Outpatient Research Activities. 
Upcoming Events

Talking Diversity: NIH Addresses the Science of Diversity
Date: July 26, 2017
Time: 12:00 - 1:00 pm
Location: Colket Translational Research Building 1100-B
Irene Avila, PhD, Special Assistant to the Chief Officer for Scientific Workforce Diversity (SWD) at the NIH. The SWD office was established in 2013 and has been coordinating diversity efforts across the NIH extramural and intramural research programs by developing and implementing innovative and data-driven approaches to enhance diversity and promote equity in the biomedical research enterprise. Lunch will be provided. Register at MyCareer@CHOP.

Save the Date: CPCE & PolicyLab Summer Works in Progress Session
Date: August 11, 2017
Time: 12:00  – 1:00 pm
Location: Roberts Center for Pediatric Research, 11th Floor, Conference Room 11110
Informatics Fellows Daria Ferro, MD and Evan Orenstein, MD will present.

CHOP Pediatric Global Health Conference
Date: October 6, 2017 - October 7, 2017
Location: CHOP  Colket Translational Research Building
This conference will explore the state of immigrant and refugee health from a global, national and local perspective. Attendees will gain clinical, advocacy, public health and research tools to better serve these populations. Cases, discussions and stories will help us better understand the context of those who leave their homes seeking a better life. Find additional information online here. 
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Recent Publications

A Quantitative, Risk-Based Approach to the Management of Neonatal Early-Onset Sepsis.
Current algorithms for management of neonatal early-onset sepsis result in medical intervention for large numbers of uninfected infants. Dr. Puopolo and colleagues developed multivariable prediction models for estimating the risk of early-onset sepsis among late preterm and term infants based on objective data available at birth and the newborn's clinical status.

Technologic Distractions (Part 1): Summary of Approaches to Manage Alert Quantity With Intent to Reduce Alert Fatigue and Suggestions for Alert Fatigue Metrics.
Approaches for managing alert fatigue in the ICU are provided as a result of reviewing tested interventions that reduced alert quantity with the anticipated effect of reducing fatigue. Suggested alert management strategies include prioritizing alerts, developing sophisticated alerts, customizing commercially -available alerts, and including end user opinion in alert selection.

Immunogenicity and safety of the inactivated hepatitis A vaccine in children with juvenile idiopathic arthritis on methotrexate treatment: a matched case-control study.
This research looked at the immunogenicity and side effects of immunisation against hepatitis A virus in JIA patients on methotrexate treatment, who have not been previously exposed to hepatitis A virus.

Complications preceding early deaths in Black and White children with acute myeloid leukemia.
Black patients have a twofold increased risk of induction mortality compared to White patients with acute myeloid leukemia (AML). Dr. Aplenc and colleagues reviewed diagnosis and billing data from Pediatric Health Information System for 28 AML Induction I deaths to investigate conditions preceding death in White and Black patients. Future studies should assess management approaches of complications by race to identify modifiable processes that reduce mortality.

Update on enthesitis-related arthritis.
Dr. Pamela Weiss provides a detailed update regarding the genetics, pathogenesis, disease phenotype evaluation, therapies and expected outcomes for children with enthesitis-related arthritis (ERA).

See more...
Funding Opportunities

Community Access to Child Health (CATCH) (due July 31)
Planning and Innovation Grants: Up to $10,000 will be awarded on a competitive basis to individual pediatricians and fellowship trainees to plan innovative community-based child health initiatives that will ensure all children have medical homes, are properly immunized, and have access to health care services not otherwise available in their community. Resident grants: Up to $2,000 will be awarded on a competitive basis for pediatric residents to plan and/or implement community-based child health initiatives. Projects must include planning activities or demonstrate completed planning activities, and may include implementation activities.

New York Life Foundation Grief Reach -- Community Expansion (due August 7)
New York Life Foundation’s Grief Reach Community Expansion RFP awards nonprofits that will expand and increase access for grief support services to underserved populations in local communities.Proposals should clearly define the target population, local partners and strategy for expansion. Grants range from $15,000 to $100,000.

Elsa U. Pardee Foundation (due August 31)
The Elsa U. Pardee Foundation funds research to investigators in United States non-profit institutions proposing research directed toward identifying new treatments or cures for cancer. The Foundation particularly encourages grant applications for a one year period which will allow establishment of capabilities of new cancer researchers, or new cancer approaches by established cancer researchers.

Caplan foundation for Early Childhood (LoI due September 30)
The Caplan Foundation for Early Childhood is intended to be an incubator of promising research and development projects that may ultimately enhance the development, health, safety, education or quality of life of children from infancy through seven years of age across the country. Each of its grants is made with the expectation that a successful project outcome will be of significant interest to other investigators or developers, within the grantee’s field of endeavor, and will be amenable to beneficial application or adaptation elsewhere. In essence, the foundation’s goal is to provide seed money for those imaginative endeavors, addressed to the needs of young children, which appear most likely to bear fruit on a national scale.

OnPAR Program for Unfunded NIH Proposals
Last year, the NIH received approximately $30 billion in federal support. In spite of this amount, about 42,500 grants were not funded. To address these unfunded proposals, the NIH has a new Pilot Program that is designed to match researchers with nonprofit disease Foundations or with investments from private companies. Through a new collaboration between the NIH and the private contractor Leidos, researchers can now upload their unfunded NIH Proposals into an online portal at the Online Partnership to Accelerate Research (OnPAR). Foundations and other potential funders can review the NIH scores, and decide whether they might be interested in funding the Projects. Currently, this Pilot Program allows researchers with priority scores better than the 30th percentile to submit their abstracts. Interested Foundations might ask that a researcher send their full NIH Application along with its scores. The consensus opinion is that there are a lot of worthy grants being submitted to the NIH, but there is only so much funding available. OnPAR is one way of trying to match researchers with private Foundations. 

About CPCE
We are a pediatric research center dedicated to discovering and sharing knowledge about best practices in pediatric care by facilitating, organizing and centralizing the performance of clinical effectiveness research -- research aimed at understanding the best ways to prevent, diagnose and treat diseases in children. CPCE’s multidisciplinary team conducts research on a diverse range of clinical effectiveness topics grouped within four areas of research: