Spotlight on: Antibiotic
Stewardship Research
In a study published in
JAMA
, CPCE researchers found that narrow-spectrum antibiotics performed equally well or better than broad-spectrum antibiotics when assessed by both practical and clinical outcomes for acute upper respiratory tract infections (ARTIs).
Specifically, children receiving narrow-spectrum antibiotics had a higher health-related quality of life and a reduced risk of antibiotic side effects as compared to children receiving broad-spectrum antibiotics. Conversely, use of broad-spectrum antibiotics was significantly associated with increased risk of adverse drug effects, and not associated with any improved family-centered outcomes.
This study was funded by the Patient-Centered Outcomes Research Institute (PCORI). Read more about the study
here
.
To accompany the release of this study, CPCE published
Promoting Antibiotic Stewardship in Pediatric Outpatient Settings
, a research brief summarizing seven years of research to develop effective stewardship strategies.
The work summarized in this brief demonstrates the promise of programs using EHR platforms to audit antibiotic prescribing practices and provide feedback and continuing education to prescribers.
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Inaugural Innovation Series Lecture
Date: January 23, 2018
Time: 1:00 - 2:00 pm
Location: Colket Translational Research Building, 1200A
The Offices of Entrepreneurship and Innovation, and Tech Transfer, Commercialization, and Innovation have created a new education opportunity for those interested in developing innovation, being more entrepreneurial, and supporting the next breakthroughs – The Innovation Series. Featuring Anthony Green and Sri Sriadibhatla from Ben Franklin Technology Partners (BFTP), this lecture will provide attendees the opportunity to learn how BFTP supports local innovation and startup companies with seed funding from a variety of sources. Register
here.
1st CHOP Education Symposium
Date: January 24, 2018
Time: 8:00 am - 5:00 pm
Location: CHOP Main Hospital, Stokes Auditorium; and Colket Translational Research Building, first floor conference rooms
The event will feature Grand Round Speaker Barbara Brandt, PhD, Director of the National Center for Interprofessional Practice and Education. The CHOP Interprofessional Education (IPE) Committee invites staff from all departments to share their work and engage in shaping the future of learning. Learn more and register
here.
Writing/Designing Winning NIH Proposals Workshop
January 30, 2018
Time: 8:30 am - 4:30 pm
Location: The Arch, 3601 Locust Walk, Room 108
Sponsored by The Grant Training Center, this one-day comprehensive workshop is geared towards those who wish to submit winning proposals to the National Institutes of Health (NIH), in time for the next NIH grant submission deadline. A workshop fee of $395.00 includes a comprehensive directory, workbook, certificate of completion, and continental breakfast.
Learn more.
Save the Date: 10th Annual CHOP Research Safety Day
Date: April 19, 2018
Time: 10:00 am - 2:00 pm
Location: Colket Translational Research Building lobby and conference rooms
Formal invitations and more details will follow soon. Please feel free to contact Research Safety with any questions at (267) 426-2272 or at
researchsafety@email.chop.edu.
Penn MSHP 2018 Implementation Science Institute
Dates: June 19 - 21, 2018
Location: Jordan Medical Education Center
The purpose of the Implementation Science Institute is to provide participants with the tools to design and execute rigorous implementation science research. The Institute will give an introduction to the foundations of implementation science, cover implementation strategies and sustainability, tips for grant writing and skill development. Limited scholarships will be available for affiliates of CHOP. Register
here or contact
mshp@mail.med.upenn.edu for more information.
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Asthma is the most common chronic medical condition among children in the United States and is a leading cause of hospitalization in children. CPCE researchers conducted a retrospective cohort study using electronic health records to examine the effect of ambulatory health care processes on asthma hospitalizations. This research found that in children with asthma, more frequent primary care visits are associated with reduced asthma hospitalizations.
Alarm fatigue is a widely recognized safety and quality problem where exposure to high rates of clinical alarms results in desensitization leading to dismissal of or slowed response to alarms. Dr. Bonafide and colleagues performed a systematic review of the literature focused on clinical alarms asking the primary key question; “what interventions have been attempted and resulted in the success of reducing alarm fatigue?"
Continuous-flow ventricular assist devices (CF VADs) designed for adults are increasingly used in pediatric patients. However, there is greater risk of device inflow obstruction as a result of size and anatomy. Dr. Rossano and colleagues reviewed all cases of systemic atrioventricular valve (AVV) excision with HeartWare HVAD implantation in the systemic ventricle performed at CHOP from November 2015 to May 2016 and found that CF VAD implantation with AVV excision can successfully support complex pediatric patients in a wide range of size and anatomy (small chambers, systemic right ventricles). This technique may allow for CF VAD implantation in patients previously deemed too small for such support.
As a consequence of acquired or intrinsic disease resistance, the prognosis for patients with relapsed or refractory T-cell acute lymphoblastic leukemia (T-ALL) is dismal. Novel, less toxic drugs are clearly needed. One of the most promising emerging therapeutic strategies for cancer treatment is targeted immunotherapy. This research suggest that daratumumab, a human IgG1κ monoclonal antibody that binds CD38, is a promising novel therapy for pediatric T-ALL patients.
The pediatric rheumatic diseases are a heterogeneous group of rare diseases, posing a number of challenges for the use of traditional clinical and translational research approaches. Innovative comparative effectiveness approaches are needed to efficiently study treatment approaches and disease outcomes. Dr. Weiss, as a member of The Childhood Arthritis and Rheumatology Research Alliance (CARRA), assisted with developed the consensus treatment plan (CTP) approach as a comparative effectiveness tool for research in pediatric rheumatology.
Hospitals use antibiograms to guide optimal empiric antibiotic therapy, reduce inappropriate antibiotic usage, and identify areas requiring intervention by antimicrobial stewardship programs. Creating a hospital antibiogram is a time-consuming manual process that is typically performed annually. This work aimed to apply visual analytics software to electronic health record (EHR) data to build an automated, electronic antibiogram ("e-antibiogram") that adheres to national guidelines and contains filters for patient characteristics, thereby providing access to detailed, clinically relevant, and up-to-date antibiotic susceptibility data.
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This award provides $25,000 for one year to a recipient at any career stage performing research in gastroenterology- or hepatology-related areas. The objective of this pilot research award is to provide funds to early career investigators to help establish their research careers, or to support projects that represent new research directions for established investigators.
The American Gastroenterological Association is accepting applications for its AGA-Elsevier Gut Microbiome Pilot Research Award. The objectives of the program are to help early-career investigators establish their research careers and support research projects that represent new directions for established investigators. Projects must focus on the relationship of gut microbiota to digestive health and disease.
The Caplan Foundation for Early Childhood is intended to be an incubator of promising research and development projects that may ultimately enhance the development, health, safety, education or quality of life of children from infancy through seven years of age across the country. Each of its grants is made with the expectation that a successful project outcome will be of significant interest to other investigators or developers, within the grantee’s field of endeavor, and will be amenable to beneficial application or adaptation elsewhere. In essence, the foundation’s goal is to provide seed money for those imaginative endeavors, addressed to the needs of young children, which appear most likely to bear fruit on a national scale.
Planning and Implementation Grants: Grants of up to $10,000 will be awarded to individual pediatricians and fellowship trainees for the planning of innovative community-based child health initiatives that ensure all children in the community have access to healthcare services not otherwise available. Priority will be given to projects that serve communities with the greatest health disparities. Outreach must be to the community at large, not to practice or clinic patients only, and all initiatives should incorporate screening for or connecting children to medical homes and available insurance programs. Resident Grants: Grants of up to $2,000 will be awarded to pediatric residents for the planning and/or implementation of community-based child health initiatives. Projects must include planning activities or demonstrate completed planning activities, and may include implementation activities.
The Health Effects Institute is a nonprofit corporation chartered in 1980 to provide high-quality, impartial, and relevant science on the health effects of air pollution. HEI established the Walter A. Rosenblith New Investigator Award to provide funding to outstanding investigators who are beginning independent research. Each award will grant up to $150,000 per year, with a maximum of $450,000 over three years. Scientists of any nationality holding a PhD, ScD, MD, DVM, or DrPH degree or equivalent are eligible to apply.
NKF will award grants of up to $35,000 in support of research projects in the field of nephrology and related disciplines conducted by individuals who have completed fellowship training and who hold a junior faculty position at a university-affiliated medical center in the United States. Projects must be patient-oriented. Elements of patient-oriented research activities may include but are not limited to development of new technologies, mechanisms of human disease, educational or therapeutic interventions, epidemiological studies, health policy studies, and clinical trials.
The
Thrasher Research Fund provides grants for clinical, hypothesis-driven research that offers substantial promise for meaningful advances in the prevention, diagnosis, and treatment of children's diseases, particularly research that offers broad-based applications. The fund is inviting concept papers for its Early Career Awards Grants program. Through the program, the fund awards small grants of up to $25,000 to new researchers to help them gain a foothold in the area of pediatric research. The program will consider a variety of research topics important to children's health but will give priority to applicants who show great potential to impact children's health through medical research.
The Damon Runyon Cancer Research Foundation has joined together with the Sohn Conference Foundation, dedicated to curing pediatric cancers, to establish the Damon Runyon-Sohn Pediatric Cancer Fellowship Award. This award provides funding to basic scientists and clinicians who conduct research with the potential to significantly impact the prevention, diagnosis or treatment of one or more pediatric cancers.
Grants of up to $20,000 are available to help support the research of faculty members or post-doctoral researchers affiliated with non-profit human service organizations in the United States and Canada. Areas of interest to the Fund are: studies to develop, refine, evaluate, or disseminate innovative interventions designed to prevent or ameliorate major social, psychological, behavioral or public health problems affecting children, adults, couples, families, or communities, or studies that have the potential for adding significantly to knowledge about such problems.
The foundation awards grants for research focused on issues faced by care providers that, when implemented, will improve health, nutrition, and/or developmental outcomes for infants and young children. Projects can address the etiologic mechanisms of disease; new, improved, or less invasive diagnostic procedures; the reduction or elimination of side effects; the alleviation of symptoms; new, improved, or less invasive therapies or treatments; dosage or dosing requirements or mechanisms for drugs, nutrient supplementation, or other therapeutic measures (under or overdosing); and preventative measures. The total requested grant size should be no more than $350,000.
The American Legion Child Welfare Foundation supports organizations that contribute to the physical, mental, emotional, and spiritual welfare of children. The foundation awards grants for the dissemination of information about new and innovative programs designed to benefit youth or information already possessed by well-established organizations. Projects must have the potential to help American children in a large geographic area (more than one state).
Last year, the NIH received approximately $30 billion in federal support. In spite of this amount, about 42,500 grants were not funded. To address these unfunded proposals, the NIH has a new Pilot Program that is designed to match researchers with nonprofit disease Foundations or with investments from private companies. Through a new collaboration between the NIH and the private contractor Leidos, researchers can now upload their unfunded NIH Proposals into an online portal at the Online Partnership to Accelerate Research (OnPAR). Foundations and other potential funders can review the NIH scores, and decide whether they might be interested in funding the Projects. Currently, this Pilot Program allows researchers with priority scores better than the 30th percentile to submit their abstracts. Interested Foundations might ask that a researcher send their full NIH Application along with its scores. The consensus opinion is that there are a lot of worthy grants being submitted to the NIH, but there is only so much funding available. OnPAR is one way of trying to match researchers with private Foundations.
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About CPCE
We are a pediatric research center dedicated to discovering and sharing knowledge about best practices in pediatric care by facilitating, organizing and centralizing the performance of clinical effectiveness research -- research aimed at understanding the best ways to prevent, diagnose and treat diseases in children. CPCE’s multidisciplinary team conducts research on a diverse range of clinical effectiveness topics grouped within four areas of research:
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