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Spotlight on:
Dr. Andrew Glatz

Andrew Glatz, MD, MSCE and colleagues recently published results of a study that compared the Blalock-Taussig (BT) shunt operation to a catheter-based stent procedure in infants with certain types of heart defects.

"Our findings support PDA stents over BT shunt placement for selected patients with [ductal-dependent pulmonary blood flow], particularly in experienced centers where this procedure can be performed safely and effectively," Dr. Glatz said in a press release. Read more here . The study involved four member centers of the Congenital Catheterization Research Collaborative.

Another recently published study by Dr. Glatz and colleagues looked at long-term survivors of the Fontan operation, the third in a series of reconstructive operations performed on children with a severely underdeveloped ventricle, and found that nearly two-thirds underwent another surgical procedure within 20 years. These results suggest a need for doctors to counsel families about the likelihood of re-intervention.

Dr. Glatz is a core faculty member at CPCE, a pediatric interventional cardiologist at CHOP, and associate professor of pediatrics at the University of Pennsylvania Perelman School of Medicine. To see a selection of his recent publications, click here .
Upcoming Events
The Design of Clinical Information Systems
Date: December 14, 2017
Time: 3:00 - 4:00 pm
Location: Stokes Auditorium, Main Hospital
Vimla L Patel, PhD, DSc (Hon), FRSC, FACMI is Senior Research Scientist and the Director of the Center for Cognitive Studies in Medicine and Public Health at the New York Academy of Medicine in Manhattan. She is also Professor of Biomedical Informatics at Arizona State University, Adjunct Professor of Biomedical Informatics at Columbia University College of Physician and Surgeons, and Adjunct Professor of Health Policy and Research (Health Informatics) at Weill Cornell College of Medicine. Learning Objectives:
  • Describe the evolution of the field of Cognitive Informatics and its relevance to the design of clinical information systems and to clinical decision support
  • Generate an experimental design, linking human reasoning to behavioral outcomes
  • List the cognitive factors that interact with the socio-economic environment that you believe must be considered to ensure safe practices

CPCE/PolicyLab Visiting Speaker: Lilliam Ambroggio, PhD
Date: December 15, 2017
Time: 12:00 - 1:00 pm
Location: Roberts Center, 1st Floor, Room 1120-A
CPCE & PolicyLab invite you to attend a research seminar, "Addressing Gaps in Pediatric Community Acquired Pneumonia," presented by Lilliam Ambroggio, PhD, Assistant Professor of Pediatrics, University of Cincinnati. Additional information available here. Please RSVP to cpce@email.chop.edu.

1st CHOP Education Symposium
Date: January 24, 2018
The event will feature Grand Round Speaker Barbara Brandt, PhD, Director of the National Center for Interprofessional Practice and Education. The CHOP Interprofessional Education (IPE) Committee invites staff from all departments to share their work and engage in shaping the future of learning. Submit an abstract that highlights your work in health professions education.
CPCE in
the News!
Recent Publications
Navigating requests from parents or family caregivers not to disclose poor prognosis to seriously ill children can be challenging, especially when the requests seem culturally mediated. Pediatric clinicians must balance obligations to respect individual patient autonomy, professional truth telling, and tolerance of multicultural values. Dr. Feudtner and colleagues use a hypothetical case example to provide suggestions for respectful and ethically appropriate responses to nondisclosure requests.

Skeletal surveys have been identified as a key component of the evaluation for suspected abuse in young children, but variability in skeletal survey utilization has been reported. Thus, CPCE researchers aimed to describe the utilization patterns, yield, and risks of obtaining skeletal surveys in young children through a systematic literature review.

Children with congenital heart disease (CHD) often require noncardiac surgery but may be at increased risk of complications compared to children without CHD. CPCE researchers compared outcomes following open and laparoscopic intraabdominal surgery among children with and without CHD and found that intraabdominal laparoscopic surgery was associated with lower morbidity and mortality in patients with minor CHD, but not in those with more severe CHD.

This research aimed to determine the proportion of US children hospitalized for a primary mental health condition who are discharged to postacute care (PAC); whether PAC discharge is associated with demographic, clinical, and hospital characteristics, and whether PAC use varies by state.

Studies of children with dilated cardiomyopathy (DCM) have suggested that improved survival has been primarily due to utilization of heart transplantation. This study sought to determine transplant-free survival for these children over 20 years and identify the clinical characteristics at diagnosis that predicted death.

Dr. Aletha Akers and colleagues examined what predicts low personal acceptability of four different contraceptive methods among young women. Their research found that young women with low personal acceptability of the four most common contraceptive methods had distinct demographic and reproductive health characteristics and that perceived negative experiences of friends and family members using contraception appeared most influential.

Recognition of pediatric sepsis is a key clinical challenge. Dr. Balamuth and colleagues evaluated the performance of a sepsis recognition process including an electronic sepsis alert and bedside assessment in a pediatric emergency department (ED) and found that implementation of an electronic sepsis alert was associated with improved recognition of severe sepsis.

This research characterized health care utilization for youth in the year preceding systemic lupus erythematosus (SLE) diagnosis compared to controls and found that youth with SLE have high health care utilization throughout the year preceding their diagnosis. Examining variable diagnostic trajectories of youth presenting for acute care preceding SLE diagnosis, and increased attention to psychiatric morbidity may help improve care for youth with new-onset SLE.

Funding Opportunities
The American Kidney Fund Clinical Scientist in Nephrology (CSN) fellowship program enhances the training of nephrologists who wish to pursue an academic career and whose primary professional commitment is to scholarship in the provision of patient care. CSN fellows conduct prevention and outcomes research while receiving advanced training in essential skills such as medical ethics, biostatistics and epidemiology.

The Doris Duke Charitable Foundation Clinical Scientist Development Award (CSDA) program provides grants to junior physician-scientists in any disease area to facilitate their transition to independent clinical research careers.To be eligible, applicants must have received an MD, DO, or foreign equivalent degree from an accredited institution; have a valid, active U.S. medical license at the time of application; work at a U.S. academic institution that grants doctoral degrees and is able to receive an award; and be in a full-time assistant professor faculty position (appointed between December 1, 2012, and December 1, 2016).

The one-year awards include $25,000 for predoctoral and medical students and $35,000 for postdoctoral students. The proposed training must be scientifically linked to autism and may be broadened to include training in a closely related area of scientific research, including but not limited to human behavior across the lifespan, neurobiology, pharmacology, neuropathology, genetics, epigenetics, genomics, epigenomics, immunology, molecular and cellular mechanisms, studies employing model organisms and systems, and studies of treatment and service delivery.

The American Society of Nephrology fights to prevent, treat, and cure kidney diseases by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients. As part of this mission, the ASN Foundation is accepting applications for its William and Sandra Bennett Clinical Scholars Program. The goal is to produce the next generation of clinician educators by enabling applicants to improve their teaching skills through the acquisition of education tools and by supporting aspiring nephrology educators interested in conducting a project that advances all facets of nephrology education and teaching. To that end, grants of $100,000 over two years will be awarded in support of projects that explore any aspect of nephrology education.

Innovation grants are designed as seed funding for researchers with a novel approach to pediatric oncology scientific investigation. This may represent a change in research direction and/or an innovative new idea that moves away from an investigator’s prior research but for which a strong case is made for the potential impact on childhood cancers. Innovation Grants will support research proposals to be carried out by investigators who are already established, have a track record of peer-reviewed publications and evidence of successfully competing for extramural funding. The grant is for two years up to $125,000 per year for direct costs only. A no-cost extension is permitted if progress is demonstrated and budget properly justified.

Young Investigator Grants are 3 year awards designed to support scientists in the early stages of their research careers, such as postdoctoral or clinical fellows. Outstanding mentorship and demonstration of a career plan that shows commitment to pediatric cancer investigation are critical components of a successful application.

Alex’s Lemonade Stand Epidemiology Grants are $100,000 per year for two years. Funding allows investigators to pursue research studies in human populations, using epidemiological approaches, in order to significantly contribute to the understanding of childhood cancers. Hypothesis-driven research may focus on risk factors, early detection, prevention, effectiveness and treatment outcomes.

This award provides $25,000 for one year to a recipient at any career stage performing research in gastroenterology- or hepatology-related areas. The objective of this pilot research award is to provide funds to early career investigators to help establish their research careers, or to support projects that represent new research directions for established investigators. 

The American Gastroenterological Association is accepting applications for its AGA-Elsevier Gut Microbiome Pilot Research Award. The objectives of the program are to help early-career investigators establish their research careers and support research projects that represent new directions for established investigators. Projects must focus on the relationship of gut microbiota to digestive health and disease. 

The Caplan Foundation for Early Childhood is intended to be an incubator of promising research and development projects that may ultimately enhance the development, health, safety, education or quality of life of children from infancy through seven years of age across the country. Each of its grants is made with the expectation that a successful project outcome will be of significant interest to other investigators or developers, within the grantee’s field of endeavor, and will be amenable to beneficial application or adaptation elsewhere. In essence, the foundation’s goal is to provide seed money for those imaginative endeavors, addressed to the needs of young children, which appear most likely to bear fruit on a national scale.

The Damon Runyon Cancer Research Foundation has joined together with the Sohn Conference Foundation, dedicated to curing pediatric cancers, to establish the Damon Runyon-Sohn Pediatric Cancer Fellowship Award. This award provides funding to basic scientists and clinicians who conduct research with the potential to significantly impact the prevention, diagnosis or treatment of one or more pediatric cancers.

Last year, the NIH received approximately $30 billion in federal support. In spite of this amount, about 42,500 grants were not funded. To address these unfunded proposals, the NIH has a new Pilot Program that is designed to match researchers with nonprofit disease Foundations or with investments from private companies. Through a new collaboration between the NIH and the private contractor Leidos, researchers can now upload their unfunded NIH Proposals into an online portal at the Online Partnership to Accelerate Research (OnPAR). Foundations and other potential funders can review the NIH scores, and decide whether they might be interested in funding the Projects. Currently, this Pilot Program allows researchers with priority scores better than the 30th percentile to submit their abstracts. Interested Foundations might ask that a researcher send their full NIH Application along with its scores. The consensus opinion is that there are a lot of worthy grants being submitted to the NIH, but there is only so much funding available. OnPAR is one way of trying to match researchers with private Foundations. 
About CPCE
We are a pediatric research center dedicated to discovering and sharing knowledge about best practices in pediatric care by facilitating, organizing and centralizing the performance of clinical effectiveness research -- research aimed at understanding the best ways to prevent, diagnose and treat diseases in children. CPCE’s multidisciplinary team conducts research on a diverse range of clinical effectiveness topics grouped within four areas of research: