CPCE is accepting applications to our Pilot Grant Program through April 2.
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Spotlight on: Dr. Jennifer Walter
CPCE Core Faculty member
Jennifer Walter, MD, PhD, MS
recently discussed her work in a blog post by the Cambia Health Foundation. The Foundation's Sojourns Scholar Leadership Program is an initiative designed to identify, cultivate and advance the next generation of palliative care leaders.
Dr. Walter's Sojourns Scholar project is to develop guidelines for how high functioning interprofessional clinical teams prepare for and conduct meetings with families of children with serious illness.
"Before meeting with a family, team members need to coordinate their actions and agree on what their goals are for the family meeting. Each participating team member should understand what roles need to be performed, determine their contributions to optimize the skills of each member, and support each other in performing those tasks," Dr. Walter explained. Read the full post
here
.
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Improving Your Chances of Grant Proposal Success: NIH F and K Awards
Date: April 12, 2018
Time: 2:30 - 3:30 pm
Location: Abramson Research Center (ARC), Room 124
Matthew Weitzman, PhD, Professor, Division of Cancer Pathobiology will leverage his extensive experience writing and reviewing grant applications to help you significantly improve your chances of creating an application that stands out and is fundable. This session will specifically focus on the Specific Aims and Biosketch sections of NIH grants. Space is limited. To register, e-mail
Janet Stuart. Learn more
here.
Save the Date: 10th Annual CHOP Research Safety Day
Date: April 19, 2018
Time: 10:00 am - 2:00 pm
Location: Colket Translational Research Building lobby and conference rooms
Formal invitations and more details will follow soon. Please feel free to contact Research Safety with any questions at (267) 426-2272 or at
researchsafety@email.chop.edu.
K Awards: Day-Long, Hands-on Workshop
Date: April 27, 2018
Time: 10:00 am to 3:00 pm
Location: Colket Translational Research Building, Room 1200A
Dr. Beth Schachter holds a PhD in Cell and Molecular Biology. She currently dedicates her time to her consulting work and has over ten years’ experience presenting grant-writing workshops at the Perelman School of Medicine. Register
here.
Neonatology Clinical Research Symposium
Dates: May 9 - 10, 2018
Location: The Union League of Philadelphia
Children's Hospital of Philadelphia (CHOP) is sponsoring a research symposium in recognition of the retirement of Barbara Schmidt, MD, FRCP(C), MSC, and Haresh Kirpalani, BM, MRCP, FRCP, MSc. This course is designed to highlight evidence-based medicine and innovative, randomized clinical trials in Neonatology. Learn more
here.
CHOP Quality and Safety Day 2018
Date: May 15, 2018
Time: 8:00 am - 4:00 pm
Location: Stokes Auditorium, CHOP Main Hospital
Paula Davis-Laak, JD, MAPP, will present the keynote address, “Thriving in Healthcare: Your Blueprint for Stress Resilience.”
Register for the conference or
submit an abstract that highlights the way your team has applied the CHOP Improvement Framework, Safety Behaviors for Error Prevention, or other strategies. Abstracts are due Friday March 30, 2018 at 5:00 pm.
Penn MSHP 2018 Implementation Science Institute
Dates: June 19 - 21, 2018
Location: Jordan Medical Education Center
The purpose of the Implementation Science Institute is to provide participants with the tools to design and execute rigorous implementation science research. The Institute will give an introduction to the foundations of implementation science, cover implementation strategies and sustainability, tips for grant writing and skill development. Limited scholarships will be available for affiliates of CHOP. Register
here or contact
mshp@mail.med.upenn.edu for more information.
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Pulmonary hypertension (PH) is a type of high blood pressure that affects the pulmonary arteries, or arteries of the lungs. PH is a progressive disease where the pulmonary arteries continue to shrink, making it difficult for the heart to push blood through the narrowed arteries. Pulmonary hypertension (PH) has no cure. However, treatment may help relieve symptoms and slow the progress of the disease. Cardiac catheterization is the gold standard for assessment and follow-up of patients with pulmonary hypertension. However, patients with PH may be less stable than other children during induction of anesthesia, the procedure itself, and during recover from anesthesia. This increases their risk of catheterization-associated catastrophic adverse outcomes. This cohort study of children and adolescents with PH undergoing cardiac catheterization provides a new accurate estimate of the risk of catheterization in this population, which is important for preprocedural evaluation of risk and benefit.
What ethical considerations should guide the design and evaluation of systems of care for children with medical complexity? Those in hospitals and health care systems, when designing clinical programs for children with medical complexity, often talk about needing to develop and implement a system of risk stratification. Dr. Chris Feudtner and team use the framework of an ethical evaluation of a health care program to examine what this task of risk stratification might entail. Here they present a set of 8 ethically relevant considerations that are foundational for building and evaluating any program in which people aim to identify high risk children with medical complexity and enroll them in a clinical program to mitigate those risks.
Miscommunication has been implicated as a leading cause of medical errors, and standardized handover programs have been associated with improved patient outcomes. However, the role of structured handovers in pediatric emergencies remains unclear. Dr. Chris Bonafide and colleagues sought to determine if training with an airway, breathing, circulation, situation, background, assessment, recommendation handover tool could improve the transmission of essential patient information during multidisciplinary simulations of critically ill children.
Leukemia accounts for one third of childhood cancers. Outcomes for children with leukemia continue to improve, including outcomes for critically ill children with leukemia requiring ICU support. However, single-center studies have reported a wide range of mortality rates for children with leukemia who require ICU support. It is not known if this outcome variability exists when examining a large national dataset or what factors contribute to such variability. This retrospective cohort study evaluated hospital-level variability in resource utilization and mortality in children with new leukemia who require ICU support and identified factors associated with variation. Researchers found that wide hospital-level variability in resource utilization and mortality exist and that patient mix and overall hospital payer mix may explain some of the observed mortality variability. Additional study into how ICU support could be standardized and the subsequent impact on patient outcomes is warranted.
Previous studies of hospitalized children reported that 57-79% of those admitted to a Pediatric intense care unit (PICU) received antibiotics, and 34% of antibiotics were broad-spectrum agents. It has been estimated that 20-50% of antibiotic use in hospitalized patients is unnecessary or inappropriate. Inappropriate antibiotic prescribing including overuse contributes to the development of antibiotic resistance and to more frequent adverse drug events, increased costs of medical care, and disturbances of the normal human microbiome. This retrospective analysis compared antibiotic prescribing across PICUs to evaluate the degree of variability. Researchers observed wide variation in antibiotic use across children’s hospital PICUs, suggesting inappropriate antibiotic use.
Respiratory virus infection (RVI) is a leading cause for hospitalization in children, and RVI in pediatric solid organ transplant recipients poses a significant risk. A large multicenter retrospective cohort of pediatric solid organ transplant recipients was assembled to determine the incidence of RVI hospitalization in the first year after transplant and to identify factors associated with poor outcomes in these patients after RVI. A more comprehensive understanding of the frequency and outcomes of RVI in solid organ transplant recipients, particularly in the first year after transplant when immunosuppression is the highest, should help guide future investigations of RVI management and identify needs for novel prevention and treatment strategies.
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The purpose of the foundation is to support patient safety education for healthcare professionals in training and in practice, as well as patient safety research with clinically useful applications. To advance this mission, the foundation is accepting applications for research and education programs and projects designed to enhance patient safety. Grant amounts will be determined on an individual basis based on project budget and availability of funds.
Grants of up to $20,000 are available to help support the research of faculty members or post-doctoral researchers affiliated with non-profit human service organizations in the United States and Canada. Areas of interest to the Fund are: studies to develop, refine, evaluate, or disseminate innovative interventions designed to prevent or ameliorate major social, psychological, behavioral or public health problems affecting children, adults, couples, families, or communities, or studies that have the potential for adding significantly to knowledge about such problems.
CPCE offers awards twice each year through its Pilot Grant Program. The purpose of this program is to promote and support CHOP investigators in clinical effectiveness pilot research studies that will attract external support for large-scale studies. Selected proposals will be supported for up to a maximum of $10,000 for one year. Projects should be able to be completed within one year.
The American Cancer Society is accepting proposals for research projects with the potential to generate new knowledge of the effects of the United States healthcare system structure and the role of insurance in both access to and the outcomes of cancer screening, early detection, and treatment services. Awards will not exceed $200,000 per year (direct costs) for up to four years. Independent investigators at all stages of their career are encouraged to apply.
The mission of the American Society for Hematology is to further the understanding, diagnosis, treatment, and prevention of disorders affecting the blood, bone marrow, and immunologic, hemostatic and vascular systems through the promotion of research, clinical care, education, training, and advocacy in hematology. To that end, ASH is accepting proposals from hematologists whose research would not otherwise be accomplished due to cuts in NIH funding. The Bridge Grants program will provide at least thirty one-year awards annually, in the amount of $150,000 each, to ASH members who applied for an NIH R01 grant or equivalent but were denied funding due to budget cuts. Grants will support projects in basic, translational, patient-oriented, or outcomes-based research.
The foundation awards grants for research focused on issues faced by care providers that, when implemented, will improve health, nutrition, and/or developmental outcomes for infants and young children. Projects can address the etiologic mechanisms of disease; new, improved, or less invasive diagnostic procedures; the reduction or elimination of side effects; the alleviation of symptoms; new, improved, or less invasive therapies or treatments; dosage or dosing requirements or mechanisms for drugs, nutrient supplementation, or other therapeutic measures (under or overdosing); and preventative measures. The total requested grant size should be no more than $350,000.
The American Legion Child Welfare Foundation supports organizations that contribute to the physical, mental, emotional, and spiritual welfare of children. The foundation awards grants for the dissemination of information about new and innovative programs designed to benefit youth or information already possessed by well-established organizations. Projects must have the potential to help American children in a large geographic area (more than one state).
Last year, the NIH received approximately $30 billion in federal support. In spite of this amount, about 42,500 grants were not funded. To address these unfunded proposals, the NIH has a new Pilot Program that is designed to match researchers with nonprofit disease Foundations or with investments from private companies. Through a new collaboration between the NIH and the private contractor Leidos, researchers can now upload their unfunded NIH Proposals into an online portal at the Online Partnership to Accelerate Research (OnPAR). Foundations and other potential funders can review the NIH scores, and decide whether they might be interested in funding the Projects. Currently, this Pilot Program allows researchers with priority scores better than the 30th percentile to submit their abstracts. Interested Foundations might ask that a researcher send their full NIH Application along with its scores. The consensus opinion is that there are a lot of worthy grants being submitted to the NIH, but there is only so much funding available. OnPAR is one way of trying to match researchers with private Foundations.
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About CPCE
We are a pediatric research center dedicated to discovering and sharing knowledge about best practices in pediatric care by facilitating, organizing and centralizing the performance of clinical effectiveness research -- research aimed at understanding the best ways to prevent, diagnose and treat diseases in children. CPCE’s multidisciplinary team conducts research on a diverse range of clinical effectiveness topics grouped within four areas of research:
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