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Spotlight on: New PHEOT Fellows

This week, CPCE welcomed three new fellows to the Pediatric Hospital Epidemiology and Outcomes Research Training (PHEOT) program.

Heidi Herrick, MD is a fellow in the division of neonatology. Her intended area of research is a human factors approach to improve delivery room care with the ultimate goal of improving neonatal outcomes. Dr. Herrick is currently working on a project to identify and classify common flow disruptions or deviations during neonatal resuscitation, which will inform future interventional studies designed to optimize the delivery room environment, enable highly functional resuscitation teams, and ultimately improve patient outcomes.

Kevin O’Callaghan, MB BCh  is a fellow in the division of infectious diseases. With undergraduate training in theoretical physics before transferring to medical school, his research interests broadly are in the application of advanced mathematical methods to the investigation of clinical questions. His ultimate goal is to develop mathematical models of agent-based transmission in hospitalized children, in order to prospectively guide infection control policy and procedures.

Rosemary Peterson, MD  is a fellow in the division of rheumatology. Her research interests are in studying outcomes in systemic juvenile idiopathic arthritis (sJIA), which has particularly high morbidity and mortality compared to other subtypes of JIA. Treatment of sJIA has undergone dramatic changes in recent years with the use of IL-1 and IL-6 inhibition. Dr. Peterson plans to use large healthcare databases to investigate outcomes of children with sJIA and identify variations in their treatment.

PHEOT is funded by the Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (T32) program and managed by CPCE. Learn more about our training opportunities.
Upcoming Events
Children's Safety Network Webinar: How Social and Emotional Learning (SEL) Can Help Prevent Bullying 
Date: July 11, 2018
Time: 3:00 - 4:00 pm ET
Register now for this interactive webinar to learn about the latest research on bullying among children and adolescents and explore strategies for using social and emotional learning (SEL) to prevent bullying. Catherine Bradshaw, Ph.D., M.Ed. of the University of Virginia, Tracy Waasdorp, Ph.D., M.Ed of the Children’s Hospital of Philadelphia and the Johns Hopkins Bloomberg School of Public Health, and Michael Sulkowski, Ph.D. of the University of Arizona will describe their research and practice in applying social and emotional learning to the prevention of bullying. Find more information or register online here.

Emotional Intelligent Relationships, Management, and Leadership: What, Why, and How
Date: July 25, 2018
Time: 8:00 - 9:00 am
Location: Stokes Auditorium, CHOP Main Hospital
Chris Feudtner, MD, PhD, MPH, Professor of Pediatrics and Medical Ethics and Health Policy, Perelman School of Medicine at the University of Pennsylvania, Director of Research for the Pediatric Advanced Care Team at CHOP, and Steven D. Handler Endowed Chair in Medical Ethics will give the first in a series of summer Grand Rounds covering the theme of leadership in medicine.

If you have events to share, please let us know by e-mailing CPCE@email.chop.edu.
CPCE in
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Recent Publications
The development of antiretroviral therapy (ART) has resulted in rapid declines in HIV-associated morbidity and mortality, however, youth living with HIV are frequently poorly adherent to ART regimens. Mobile health interventions to promote adherence to antiretroviral therapy among adolescents and young adults living with HIV represent a promising strategy. This pilot study from Dr. Nadia Dowshen and colleagues evaluated the psychosocial impacts of an efficacious adherence intervention, cell phone support. Participants receiving cell phone support reported significant decreases in perceived stress, depression, and illicit substance use, and increases in self-efficacy in comparison to participants receiving usual care. 

Severe sepsis, a major source of morbidity and mortality in children, is increasing in prevalence over time. In pediatric sepsis, acute kidney injury (AKI) occurs more frequently than in the general PICU population, and pediatric AKI has been associated with longer mechanical ventilation and length of stay, development of chronic kidney disease, and increased mortality. Dr. Fran Balamuth and colleagues identified specific patient and infectious characteristics associated with AKI at severe sepsis presentation, contributing novel information to the current epidemiology of pediatric AKI.

Systems for standardizing physician payment have been shown to undervalue cognitive clinical encounters. Because health care reform emphasizes value-based approaches, we need an understanding of the way pediatric cognitive specialties are used to contribute to the provision of high-value care. Dr. Julie Szymczak sought to investigate how clinical and administrative stakeholders perceive the value of pediatric infectious disease specialists.

Among infants ≤60 days old with bacteremia and/or bacterial meningitis, pathogens were commonly identified from blood or cerebrospinal fluid within 24 and 36 hours. However, clinicians must weigh the potential for missed bacteremia in non-ill-appearing infants discharged within 24 hours against the overall low prevalence of infection.

CPCE Director Dr. Theo Zaoutis, along with colleagues in the Neonatal Infection Surveillance Network in Greece, sought to describe the epidemiology of neonatal infections and of antimicrobial use in Greek Neonatal Units (NNUs) in order to develop national, evidence-based guidelines on empiric antimicrobial use for neonatal sepsis in Greece. 

Funding Opportunities
The National Institute for Health Care Management Foundation is a nonprofit, nonpartisan organization dedicated to improving the effectiveness, efficiency, and quality of the U.S. healthcare system. To that end, the foundation is inviting Letters of Inquiry for its Investigator-Initiated Health Services Research Grants program. The foundation will award seven or eight grants totaling $400,000. Priority will be given to studies that address issues of broad significance for the U.S. healthcare system and that have high potential to produce timely results and reach key target audiences.

The Future Leaders in Pain Research grant program was established in 2005 to fund pain research projects of doctoral-prepared investigators who have not yet attained NIH R01 level funding. The purpose of this grant is to encourage research in pain that will add to the existing body of knowledge, and to allow investigators to develop pilot data that will aid them in securing additional major grant funding for continued pain research.

The American Legion Child Welfare Foundation supports organizations that contribute to the physical, mental, emotional, and spiritual welfare of children. The foundation awards grants for the dissemination of information about new and innovative programs designed to benefit youth or information already possessed by well-established organizations. Projects must have the potential to help American children in a large geographic area (more than one state).

Community Access to Child Health, a program of the American Academy of Pediatrics, provides support to pediatricians looking to collaborate with others in their communities so that all children have access to needed health services. Planning and Implementation Grants of up to $10,000 will be awarded to individual pediatricians and fellowship trainees in support of the planning of innovative community-based child health initiatives aimed at ensuring that all children have medical homes and access to healthcare services not otherwise available in their community. Resident Grants of up to $2,000 will be awarded to pediatric residents to support the planning and/or implementation of community-based child health initiatives.

The foundation is accepting Letters of Intent from community-based organizations working in the areas of HIV/AIDS care and direct services, education, and research. Grants will be awarded in support of developing or established programs, with emphasis on the direct benefit to clients or the target audience.
 
The Gerber Foundation is accepting concept papers for research projects focused on improving the health, nutrition, and/or development of infants and young children. In particular, the foundation is looking for practical solutions that can be rapidly implemented on a broad scale and within a predictable time frame to clinical application. Major target areas include new diagnostic tools, new treatment regimens, symptom relief, preventative measures, assessment of deficiencies or excesses (vitamins, minerals, drugs, etc.), and risk assessment tools or measures for environmental hazards, trauma, etc. Grant amounts will range up to $350,000.

The American Congress of Obstetricians and Gynecologists is accepting applications for the 2015 Warren H. Pearse Women's Health Policy Research Award. The annual program includes a single grant of $10,000 for research that explores an aspect of healthcare policy that assists, defines, or restricts the ability of a physician to deliver health care to women in either the general population or a specific area. Applicants must be a junior fellow or fellow of the college at the time of application.

Last year, the NIH received approximately $30 billion in federal support. In spite of this amount, about 42,500 grants were not funded. To address these unfunded proposals, the NIH has a new Pilot Program that is designed to match researchers with nonprofit disease Foundations or with investments from private companies. Through a new collaboration between the NIH and the private contractor Leidos, researchers can now upload their unfunded NIH Proposals into an online portal at the Online Partnership to Accelerate Research (OnPAR). Foundations and other potential funders can review the NIH scores, and decide whether they might be interested in funding the Projects. Currently, this Pilot Program allows researchers with priority scores better than the 30th percentile to submit their abstracts. Interested Foundations might ask that a researcher send their full NIH Application along with its scores. The consensus opinion is that there are a lot of worthy grants being submitted to the NIH, but there is only so much funding available. OnPAR is one way of trying to match researchers with private Foundations. 
About CPCE
We are a pediatric research center dedicated to discovering and sharing knowledge about best practices in pediatric care by facilitating, organizing and centralizing the performance of clinical effectiveness research -- research aimed at understanding the best ways to prevent, diagnose and treat diseases in children. CPCE’s multidisciplinary team conducts research on a diverse range of clinical effectiveness topics grouped within four areas of research: