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CPCE has moved! Our new location is:
Roberts Center for Pediatric Research
2716 South Street
Philadelphia, PA 19146-2305. 
Spotlight on: PAS 2017

The Pediatric Academic Societies (PAS) 2017 meeting is May 6-9 in San Francisco. The PAS Meeting brings together thousands of pediatricians and other health care providers united by a common mission: improve the health and well-being of children worldwide. This international gathering includes researchers, academics, as well as clinical care providers and community practitioners. Presentations cover issues of interest to generalists as well as topics critical to a wide array of specialty and subspecialty areas.

Every year, a number of CPCE members attend PAS. Click here to view the PolicyLab, CPCE, and General Pediatrics schedule of posters, presentations, and panels. Please note the schedule is being continuously updated as PAS releases schedule information. Also, if you are participating and do not see your event on the list, please e-mail us.
Upcoming Events

Accelerating Policies and Research on Food Access, Diet, and Obesity Prevention
Date: Friday April 28, 2017
Time: 8:00 am to 4:00 pm
Location: Inn at Penn, 3600 Sansom Street
This one-day interdisciplinary event will highlight the most current research on food access, diet and obesity. Join us for an exciting event which will foster an exchange of ideas led by distinguished scholars and leaders to bridge the gap between research and practice. Click here for more information and to register.

2017 CHOP Research Institute Scientific Symposium
Date: Tuesday May 2, 2017
Time: 8:00 am to 6:00 pm
Location: Colket Translational Research Building (CTRB)
Presentations from research faculty will focus on “Significant Pediatric Research Themes for the Future” and align thematically with the research strategic plan working group areas:
 *   Understanding the Causes and Developing Therapies for Rare and Complex Diseases
 *   Innovating in Research Along the Fetal -> Adult Lifespan
 *   Advancing CHOP’s Leadership in Novel Therapeutics and Device Development
 *   Developing Breakthrough Precision Health Research
Click here for more information and to register.

iHealth 2017 Clinical Informatics Conference
Dates: May 2-4, 2017
Location: Loews Philadelphia Hotel
iHealth is where clinicians, informatics professionals and other interested parties convene, share, and learn about improving team-based, integrated health care driven by data and evidence to impact outcomes for patients, families, and communities. Click here for more information and to register.

CPCE / PolicyLab Health Services Research Seminar: "Implementation Research in Healthcare"
Date: May 12, 2017
Time: 12:00 noon to 1:00 pm
Location: Abramson Research Center, 123-ABC
Visiting speaker Joshua P. Metlay, MD, PhD, is the Chief of the Division of General Internal Medicine at Massachusetts General Hospital. Click here for more information or e-mail us  to RSVP.

7th Annual Quality and Safety Day
Date: May 16, 2017
Time: 9:00 am to 4:00 pm
Location: Stokes Auditorium, CHOP Main Hospital
Open to all CHOP staff, the agenda will include keynote speaker Rahul K. Shah, MD, MBA, Vice-President, Chief Quality and Safety Officer, Children’s National Health System; as well as breakout sessions and poster presentations. Click here for more information and to register.

CPCE in
the News!
Recent Publications

Mortality and Morbidity after Laparoscopic Surgery in Children with and without Congenital Heart Disease
Dr. Chu and colleagues concluded that children with major or severe CHD have higher morbidity and mortality after laparoscopic surgery. Clinicians should consider the increased risks of laparoscopic surgery for these children during medical decision making.

Clinical and Microbiologic Characteristics of Early-onset Sepsis Among Very Low Birth Weight Infants: Opportunities for Antibiotic Stewardship
Most very low birth weight (VLBW) infants receive empiric antibiotics for risk of early-onset sepsis (EOS). The objective of this study was to determine the characteristics of VLBW infants with culture-confirmed EOS at a single center during 25 years and to identify opportunities for antibiotic stewardship.

Pilot study comparing the Childhood Arthritis & Rheumatology Research Alliance (CARRA) systemic Juvenile Idiopathic Arthritis Consensus Treatment Plans
The CARRA systemic JIA CTP pilot study demonstrated successful implementation of CTPs using the CARRA registry infrastructure. Having demonstrated feasibility, a larger study using CTP response to better determine the relative effectiveness of treatments for new-onset systemic JIA is now underway.

Validity and Reliability of a Tool to Assess Quality Improvement Knowledge and Skills in Pediatrics Residents
Residency programs are expected to educate residents in quality improvement (QI). Effective assessments are needed to ensure residents gain QI knowledge and skills. Dr. Doupnik and colleagues provide evidence for the validity of the Assessment of Quality Improvement Knowledge and Skills (AQIKS), which is a new tool that provides a summative assessment of pediatrics residents' ability to recall QI concepts and apply them to a clinical scenario.

The Emergence of Kidney Stone Disease During Childhood-Impact on Adults
Among pediatric patients, kidney stone disease has been increasing at a rate of approximately 5-10% annually. Current guidelines often lack recommendations for evaluation, medical, and surgical management of children with kidney stone disease. Kidney stone disease often exists over the lifetime and is associated with serious conditions that are important for pediatric and adult urologists to recognize and consider in their evaluation and treatment of patients.

Population Pharmacokinetic Analysis of Bortezomib in Pediatric Leukemia Patients: Model-Based Support for Body Surface Area-Based Dosing Over the 2- to 16-Year Age Range
This population analysis described the pharmacokinetics of bortezomib after twice-weekly, repeat-dose, intravenous administration in pediatric patients participating in 2 clinical trials: the phase 2 AALL07P1 (NCT00873093) trial in relapsed acute lymphoblastic leukemia and the phase 3 AAML1031 (NCT01371981) trial in de novo acute myelogenous leukemia.

Children's Decision-Making Involvement About Research Participation: Associations With Perceived Fairness and Self-Efficacy
The primary objective of this study was to examine the associations of children's involvement in decisions about research participation with their perceptions of the decision-making process and self-efficacy. Participants were children (ages 8-17) who enrolled in research studies in the prior 2 months.
Funding Opportunities

Elsa U. Pardee Foundation (due April 30)
The Elsa U. Pardee Foundation funds research to investigators in United States non-profit institutions proposing research directed toward identifying new treatments or cures for cancer. The Foundation particularly encourages grant applications for a one year period which will allow establishment of capabilities of new cancer researchers, or new cancer approaches by established cancer researchers.

Donaghue Foundation Greater Value Portfolio grant program (LOI due May 1)
The Donaghue Foundation announces its 2017 Greater Value Portfolio grant program that will fund research projects for three, four or five years with a maximum amount of $600,000 per award for the purpose of creating new approaches to achieving a higher value healthcare system. The goal of this program is to test new approaches and tools that organizations can readily use to improve the value of the healthcare they provide to their patients and communities.

The Bridge Grants program will provide at least thirty one-year awards annually, in the amount of $150,000 each, to ASH members who applied for an NIH R01 grant or equivalent but were denied funding due to budget cuts. Grants support projects in basic, translational, patient-oriented, and outcomes-based research.

Systems for Action (S4A) is a national program that aims to discover and apply new evidence about ways of aligning the delivery and financing systems for medical, social, and public health services that support a Culture of Health. S4A uses a wide research lens that includes and extends beyond medical care and public health systems to include other sectors that affect health and well-being, such as housing, transportation, social services, education, criminal and juvenile justice, and economic and community development. The goal of this call for proposals is to fund research that supports new scientific evidence on ways to optimize delivery and financing systems in ways that improve health and reduce inequities. 

Alex's Lemonade Stand (due May 22)
Reach Grants are designed to move hypothesis-driven research into the clinic. The $250,000, two year grant is intended to fund developmental therapeutic studies in the late stage of preclinical testing. A successful application will identify an unmet clinical need relevant to the care of pediatric patients with cancer and describe how the work performed will allow for the translation to the clinic within two years of completion. A plan and timeline for clinical testing and trial implementation is expected. This grant does not fund clinical trial expenses.  The ‘A’ Award is a four-year grant designed for the early independent career scientist who wants to establish a career in pediatric oncology research. The ideal applicant has an original project that is not currently being funded. Demonstration of a future commitment to pediatric cancer investigation as well as institutional support for the career development of the investigator are critical components of a successful application.

The mission of the Gerber Foundation is to enhance the nutrition, care, and development of infants and young children. To that end, the foundation is accepting concept papers for health and/or nutrition-related research projects with potential to have a significant impact on issues affecting infants and young children from birth to three years of age. The total requested grant size should be no more than $350,000. Concept papers must be received no later than June 1, 2017. Upon review, selected applicants will be invited to submit a full proposals by August 15, 2017.

Grants of up to $100,000 per year for a maximum of two years will be awarded for new research in the areas of molecular genetics/biochemistry, devices/procedural research (catheterization and surgical), and long-term care of children with congenital heart defects as they become adults.

van Ameringen Foundation, Inc. (LOI due June 9)
Within its broad focus on mental health, the Foundation is interested in encouraging and attracting innovative and practical programs in areas which: 
1. increase the accessibility of the poor and needy to mental-health services;
2. offer preventive and early-intervention strategies;
3. advocate for systemic change with local or national impact.
The Foundation generally awards up to two-year grants in the range of $25,000 to $50,000 in metropolitan New York and Philadelphia. The Foundation has in the past and may continue to increase the amount of a grant based on timely or successful efforts.

Children's Cardiomyopathy Foundation (LOI due June 14)
The Children's Cardiomyopathy Foundation (CCF) is committed to improving outcomes and quality of life for children with all forms of cardiomyopathy. CCF's research grant program aims to advance medical knowledge on the causes and mechanism of pediatric cardiomyopathy and to develop diagnostic guidelines and targeted therapies. Funding is available in the range of US$25,000 to US$50,000 for one year of total direct costs. Following the completion of the proposed study, a second year of funding may be requested by application.

Children's Leukemia Research Association (due June 30)
CLRA was founded in 1965 to support research efforts aimed at finding the causes of and a cure for leukemia. To that end, CLRA is seeking applications from investigators for promising research on childhood leukemia. Grants of up to $30,000 will be awarded for the most promising projects with the shared goal of isolating the causes of and finding a cure for childhood leukemia. Any doctor at the Ph.D. or M.D. level involved in research on the causes of and a cure for leukemia may apply.

Rheumatology Research Foundation Investigator Award (due July 3)
This award is intended to support junior investigators during the period that they are developing a project that will be competitive for NIH funding. The purpose is to provide support for basic science, translational, and clinical investigators engaged in research relevant to the rheumatic diseases for the period between the completion of post-doctorate fellowship training and establishment as an independent investigator. The award will fund up to $375,000 for up to 3 years.

OnPAR Program for Unfunded NIH Proposals
Last year, the NIH received approximately $30 billion in federal support. In spite of this amount, about 42,500 grants were not funded. To address these unfunded proposals, the NIH has a new Pilot Program that is designed to match researchers with nonprofit disease Foundations or with investments from private companies. Through a new collaboration between the NIH and the private contractor Leidos, researchers can now upload their unfunded NIH Proposals into an online portal at the Online Partnership to Accelerate Research (OnPAR). Foundations and other potential funders can review the NIH scores, and decide whether they might be interested in funding the Projects. Currently, this Pilot Program allows researchers with priority scores better than the 30th percentile to submit their abstracts. Interested Foundations might ask that a researcher send their full NIH Application along with its scores. The consensus opinion is that there are a lot of worthy grants being submitted to the NIH, but there is only so much funding available. OnPAR is one way of trying to match researchers with private Foundations. 
About CPCE
We are a pediatric research center dedicated to discovering and sharing knowledge about best practices in pediatric care by facilitating, organizing and centralizing the performance of clinical effectiveness research -- research aimed at understanding the best ways to prevent, diagnose and treat diseases in children. CPCE’s multidisciplinary team conducts research on a diverse range of clinical effectiveness topics grouped within four areas of research: