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CPCE has moved! Our new location is:
Roberts Center for Pediatric Research
2716 South Street
Philadelphia, PA 19146-2305. 
Spotlight on: Joanne Wood
Dr. Wood Receives Excellence in Mentoring Award

Joanne Wood, MD, MSHP is among the winners of the second annual Award for Excellence in Mentoring Research Trainees from the CHOP Research Institute. The Award recognizes faculty members who effectively guide the training and professional development of postdocs and research fellows. Mentors are nominated by current and former research trainees, and the winners are selected by the Research Trainee Advisory Committee. 

Kate Henry, MD, MSCE (pictured here) credits Dr. Wood for inspiring her to pursue a child abuse fellowship. Dr. Wood’s own research interests focus on improving the quality of care for abused and neglected children, and her PriCARE (Positive Parenting Program to Improve Problem Behaviors in Preschool-Age Children) intervention was nominated for a Scattergood Foundation Innovation Award earlier this year. 

Dr. Wood’s award is evidence of CPCE’s commitment to training post-doctoral fellows and early-career investigators in clinical effectiveness research methods and tools for determining best practices in pediatric clinical care. 

Upcoming Events

CHOP Research Institute Seminar on Working with Language Services
Date: June 14, 2017
Time: 1:00 - 2:00 pm
Location: Colket Translational Research Building, 1200B
Beginning July 1, 2017, interpreter / translation services will be available to families participating in research studies at CHOP, through a partnership with the hospital’s Division of Language Services made possible through Research Institute support. The seminar on June 14th will describe, in greater detail, how to work with interpreter services. Language Services will also prepare a job aid that will guide clinical research teams through the process. Learn more here

CHOP Office of Diversity and Inclusion Seminar: Talking Diversity: What’s Race Got to Do with Medicine?
Date: June 20, 2017
Time: 11:30 am – 1:00 pm
Location: Abramson Research Center, 1st Floor, ABC-123
Doctors often take a patient's race into account when making a diagnosis—or ruling one out. Professor Dorothy Roberts says this practice is both outdated and dangerous, and she offers some suggestions as alternatives. Join us to hear her perspective and how this simple question can raise a host of problems, and be a part of a discussion that may present some unique solutions.
Please register in Learning, found in myCareer@CHOP

Developing Your Mentoring Style
Date: June 22, 2017
Time: 1:15 to 2:30 pm (lunch served at 1:00 pm)
Location: Abramson Research Center 123-C
This session will focus on how to get the most out of your relationship with your (busy) mentor as well as lay the foundation for becoming an effective mentor yourself. Panelists are Nadia L. Dowshen, MD, Daniel J. Licht, MD, Nancy B. Spinner, PhD, FACMG, and Matthew D. Weitzman, PhD, and the moderator is Dennis R. Durbin, MD, MSCE. All are welcome. Learn more here.

CPCE in
the News!
Recent Publications

Depression Risk in Young Adults with Childhood- and Adult-Onset Lupus: 12 Years of Follow-up.
Young adults with SLE, particularly those with childhood-onset disease, are at high risk for major depression, which is associated with increased disease activity, poorer physical functioning, and lower educational attainment. Early depression intervention in young adults with SLE has the potential to improve both medical and psychosocial outcomes.

Multisite external validation of a risk prediction model for the diagnosis of blood stream infections in febrile pediatric oncology patients without severe neutropenia.
Pediatric oncology patients are at an increased risk of invasive bacterial infection due to immunosuppression. The risk of such infection in the absence of severe neutropenia is not well established and a validated prediction model for blood stream infection (BSI) risk offers clinical usefulness

The Epidemiology of Hospital Death Following Pediatric Severe Sepsis: When, Why, and How Children With Sepsis Die.
The epidemiology of in-hospital death after pediatric sepsis has not been well characterized. Dr. Fran Balamuth and colleagues investigated the timing, cause, mode, and attribution of death in children with severe sepsis, hypothesizing that refractory shock leading to early death is rare in the current era.

Risk Factors for Invasive Fungal Disease in Pediatric Cancer and Hematopoietic Stem Cell Transplantation: A Systematic Review.
Although a number of risk factors have been associated with invasive fungal disease (IFD), a systematic review of the literature to document pediatric-specific factors has not been performed. With this systematic review, Dr. Brian Fisher and colleagues have confirmed IFD risk factors that are considered routinely in daily clinical practice, and suggest that increasing age should also be considered when assessing patient risk for IFD.

A Social Media Peer Group for Mothers To Prevent Obesity from Infancy: The Grow2Gether Randomized Trial.
Few studies have addressed obesity prevention among low-income families whose infants are at increased obesity risk. The Grow2Gether study tested a Facebook peer-group intervention for low-income mothers to foster behaviors promoting healthy infant growth.

Navigating Decisional Discord: The Pediatrician's Role When Child and Parents Disagree.

From the time when children enter the preteen years onward, pediatric medical decision-making can entail a complex interaction between child, parents, and pediatrician. When the child and parents disagree regarding medical decisions, the pediatrician has the challenging task of guiding the family to a final decision.

Epidemiology of Methicillin-Resistant Staphylococcus aureus Bacteremia in Children.
Methicillin-resistant Staphylococcus aureus (MRSA) bacteremia is associated with high rates of treatment failure in adults. The epidemiology, clinical outcomes, and risk factors for treatment failure associated with MRSA bacteremia in children are still poorly understood.

Development and Application of an Antibiotic Spectrum Index for Benchmarking Antibiotic Selection Patterns Across Hospitals.
Standard metrics for antimicrobial use consider volume but not spectrum of antimicrobial prescribing. We developed an antibiotic spectrum index (ASI) to classify commonly used antibiotics based on activity against important pathogens. The application of this index to hospital antibiotic use reveals how this tool enhances current antimicrobial stewardship metrics.

Improving Recognition of Pediatric Severe Sepsis in the Emergency Department: Contributions of a Vital Sign-Based Electronic Alert and Bedside Clinician Identification.
Recognition of pediatric sepsis is a key clinical challenge. Dr. Fran Balamuth and colleagues evaluate the performance of a sepsis recognition process including an electronic sepsis alert and bedside assessment in a pediatric emergency department (ED).

See more...

Funding Opportunities

van Ameringen Foundation, Inc. (LOI due June 9)
Within its broad focus on mental health, the Foundation is interested in encouraging and attracting innovative and practical programs in areas which: 
1. increase the accessibility of the poor and needy to mental-health services;
2. offer preventive and early-intervention strategies;
3. advocate for systemic change with local or national impact.

The Foundation generally awards up to two-year grants in the range of $25,000 to $50,000 in metropolitan New York and Philadelphia. The Foundation has in the past and may continue to increase the amount of a grant based on timely or successful efforts.

Children's Cardiomyopathy Foundation (LOI due June 14)
The Children's Cardiomyopathy Foundation (CCF) is committed to improving outcomes and quality of life for children with all forms of cardiomyopathy. CCF's research grant program aims to advance medical knowledge on the causes and mechanism of pediatric cardiomyopathy and to develop diagnostic guidelines and targeted therapies. Funding is available in the range of US$25,000 to US$50,000 for one year of total direct costs. Following the completion of the proposed study, a second year of funding may be requested by application.

Children's Leukemia Research Association (due June 30)
CLRA was founded in 1965 to support research efforts aimed at finding the causes of and a cure for leukemia. To that end, CLRA is seeking applications from investigators for promising research on childhood leukemia. Grants of up to $30,000 will be awarded for the most promising projects with the shared goal of isolating the causes of and finding a cure for childhood leukemia. Any doctor at the Ph.D. or M.D. level involved in research on the causes of and a cure for leukemia may apply.

Rheumatology Research Foundation Investigator Award (due July 3)

This award is intended to support junior investigators during the period that they are developing a project that will be competitive for NIH funding. The purpose is to provide support for basic science, translational, and clinical investigators engaged in research relevant to the rheumatic diseases for the period between the completion of post-doctorate fellowship training and establishment as an independent investigator. The award will fund up to $375,000 for up to 3 years.

North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (due July 7)
The  North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) Foundation awards grants in several categories. Awardees are typically required to be NASPGHAN members.

NIHCM Healthcare Management Research Projects (LOI due July 10)
The National Institute for Health Care Management Foundation  is inviting Letters of Inquiry for innovative research that will advance the existing knowledge base in the areas of healthcare financing, delivery, management, and/or policy. For its 2017-18 funding cycle, the foundation will award five to six grants totaling $300,000 for studies that have strong potential to yield insights that can be used to have a positive impact on the United States healthcare system by reducing spending, improving quality of care, and/or expanding access to insurance coverage and healthcare services.

New York Life Foundation Grief Reach -- Community Expansion (due August 7)
New York Life Foundation’s Grief Reach Community Expansion RFP awards nonprofits that will expand and increase access for grief support services to underserved populations in local communities.Proposals should clearly define the target population, local partners and strategy for expansion. Grants range from $15,000 to $100,000.

OnPAR Program for Unfunded NIH Proposals
Last year, the NIH received approximately $30 billion in federal support. In spite of this amount, about 42,500 grants were not funded. To address these unfunded proposals, the NIH has a new Pilot Program that is designed to match researchers with nonprofit disease Foundations or with investments from private companies. Through a new collaboration between the NIH and the private contractor Leidos, researchers can now upload their unfunded NIH Proposals into an online portal at the Online Partnership to Accelerate Research (OnPAR). Foundations and other potential funders can review the NIH scores, and decide whether they might be interested in funding the Projects. Currently, this Pilot Program allows researchers with priority scores better than the 30th percentile to submit their abstracts. Interested Foundations might ask that a researcher send their full NIH Application along with its scores. The consensus opinion is that there are a lot of worthy grants being submitted to the NIH, but there is only so much funding available. OnPAR is one way of trying to match researchers with private Foundations. 
About CPCE
We are a pediatric research center dedicated to discovering and sharing knowledge about best practices in pediatric care by facilitating, organizing and centralizing the performance of clinical effectiveness research -- research aimed at understanding the best ways to prevent, diagnose and treat diseases in children. CPCE’s multidisciplinary team conducts research on a diverse range of clinical effectiveness topics grouped within four areas of research: