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CPCE has moved! Our new location is:
Roberts Center for Pediatric Research
2716 South Street
Philadelphia, PA 19146-2305. 
Spotlight on: Sagori Mukhopadhyay
Dr. Mukhopadhyay receives new Society for Pediatric Research award

Dr. Sagori Mukhopadhyay received the inaugural Physician Scientist Award from the Society for Pediatric Research (SPR) at the Pediatric Academic Societies (PAS) 2017 meeting earlier this month. SPR created the award to give investigators an opportunity to obtain preliminary results and enable extramural funding applications.

As a neonatologist, Dr. Mukhopadhyay is interested in the effects of antibiotics commonly given to newborns to prevent sepsis. The vast majority of these infants are found to be uninfected. Moreover, there is mounting evidence that antibiotic use early in life can disrupt normal development of the microbiome and immune responses.

“Understanding early life interventions that alter later health outcomes is at the heart of neonatology research but also critical to medicine in general,” Dr. Mukhopadhyay said in a CHOP Research Institute Cornerstone blog post. She will use the SPR award and matching amount from CHOP to conduct a retrospective cohort study to determine if incidence of childhood allergic diseases and infections are related to perinatal antibiotic exposures.

Read more about CPCE's neonatology research.
Upcoming Events

University of Pennsylvania Perelman School of Medicine Seminar: Advocating for LGBT Health Equality Through an Intersectional Lens: Personal and Professional Reflections
Date: May 31, 2017
Time: 12:00 – 1:00 pm
Location: Jordan Medical Education Center, 2400 Civic Center Blvd., South Pavilion, 5th Floor, Law Auditorium
This presentation will be delivered by Henry Ng, MD, MPH, associate professor and assistant dean for admissions at Case Western University School of Medicine. Lunch will be provided. Please RSVP to dyl@mail.med.upenn.edu.

CPCE & PolicyLab Health Services Research Seminar: Value in Care of Children with Advanced Heart Failure
 Date: June 2, 2017
Time: 12:00 noon to 1:00 pm
Location: Roberts Center for Pediatric Research, 2nd floor, 2-180
Faculty speaker Joseph W. Rossano, MD, MS, is Associate Professor of Pediatrics at the University of Pennsylvania, Executive Director of The Cardiac Center and Chief of the Division of Cardiology at CHOP. More information available here. Please RSVP to CPCE@email.chop.edu.

CHOP Office of Diversity and Inclusion Seminar: Talking Diversity: What’s Race Got to Do with Medicine?
 Date: June 20, 2017
Time: 11:30 am – 1:00 pm
Location: Abramson Research Center, 1st Floor, ABC-123
Doctors often take a patient's race into account when making a diagnosis—or ruling one out. Professor Dorothy Roberts says this practice is both outdated and dangerous, and she offers some suggestions as alternatives. Join us to hear her perspective and how this simple question can raise a host of problems, and be a part of a discussion that may present some unique solutions.
Please register in Learning, found in myCareer@CHOP. 

CPCE in
the News!
Recent Publications

Post-Operative Chylothorax in Patients With Congenital Heart Disease.
Post-operative chylothorax in patients with congenital heart disease is a challenging problem with substantial morbidity and mortality. Currently, the etiology of chylothorax is poorly understood and treatment options are limited. This study aimed to report lymphatic imaging findings, determine the mechanism of chylothorax after cardiac surgery, and analyze the outcomes of lymphatic embolization.

Electronic Health Record Mid-Parental Height Auto-Calculator for Growth Assessment in Primary Care.
Primary care providers are charged with distinguishing children with an underlying growth problem from those with healthy variant short stature. Knowing the heights of the biological parents aids in making that decision. This study sought to determine the feasibility and functionality of an electronic mid-parental height (MPH) auto-calculator in the clinical assessment of child growth in a pediatric primary care setting.

Radiation Safety in Children with Congenital and Acquired Heart Disease: A Scientific Position Statement on Multimodality Dose Optimization from the Image Gently Alliance.
There is a need for consensus recommendations for ionizing radiation dose optimization during multi-modality medical imaging in children with congenital and acquired heart disease (CAHD). These children often have complex diseases and may be exposed to a relatively high cumulative burden of ionizing radiation from medical imaging procedures including cardiac computed tomography, nuclear cardiology studies and fluoroscopically guided diagnostic and interventional catheterization and electrophysiology procedures.

Factors Predicting Parent Anxiety Around Infant and Toddler Postoperative and Pain.
Understanding of parent anxiety and its effect on infant postoperative pain is limited. Dr. Feudtner and colleagues sought to identify psychological factors associated with preoperative anxiety for parents of infants and toddlers undergoing elective surgery and to determine whether parent anxiety is associated with child postoperative pain.

Lumbar Puncture for All Febrile Infants 29-56 Days Old: A Retrospective Cohort Reassessment Study.
This study looked at the incidence of bacterial meningitis (BM) among all febrile infants 29-56 days old undergoing a lumbar puncture in the emergency department of a tertiary care children's hospital and the number of low-risk febrile infants with BM to reassess the need for routine lumbar puncture in these infants.
Funding Opportunities

Gerber Foundation Pediatric Research Projects (due June 1)
The mission of the Gerber Foundation is to enhance the nutrition, care, and development of infants and young children. To that end, the foundation is accepting concept papers for health and/or nutrition-related research projects with potential to have a significant impact on issues affecting infants and young children from birth to three years of age. The total requested grant size should be no more than $350,000. Concept papers must be received no later than June 1, 2017. Upon review, selected applicants will be invited to submit a full proposals by August 15, 2017.

Children's Heart Foundation (due June 2)
Grants of up to $100,000 per year for a maximum of two years will be awarded for new research in the areas of molecular genetics/biochemistry, devices/procedural research (catheterization and surgical), and long-term care of children with congenital heart defects as they become adults.

van Ameringen Foundation, Inc. (LOI due June 9)
Within its broad focus on mental health, the Foundation is interested in encouraging and attracting innovative and practical programs in areas which: 
1. increase the accessibility of the poor and needy to mental-health services;
2. offer preventive and early-intervention strategies;
3. advocate for systemic change with local or national impact.

The Foundation generally awards up to two-year grants in the range of $25,000 to $50,000 in metropolitan New York and Philadelphia. The Foundation has in the past and may continue to increase the amount of a grant based on timely or successful efforts.

Children's Cardiomyopathy Foundation (LOI due June 14)
The Children's Cardiomyopathy Foundation (CCF) is committed to improving outcomes and quality of life for children with all forms of cardiomyopathy. CCF's research grant program aims to advance medical knowledge on the causes and mechanism of pediatric cardiomyopathy and to develop diagnostic guidelines and targeted therapies. Funding is available in the range of US$25,000 to US$50,000 for one year of total direct costs. Following the completion of the proposed study, a second year of funding may be requested by application.

Children's Leukemia Research Association (due June 30)
CLRA was founded in 1965 to support research efforts aimed at finding the causes of and a cure for leukemia. To that end, CLRA is seeking applications from investigators for promising research on childhood leukemia. Grants of up to $30,000 will be awarded for the most promising projects with the shared goal of isolating the causes of and finding a cure for childhood leukemia. Any doctor at the Ph.D. or M.D. level involved in research on the causes of and a cure for leukemia may apply.

Rheumatology Research Foundation Investigator Award (due July 3)
This award is intended to support junior investigators during the period that they are developing a project that will be competitive for NIH funding. The purpose is to provide support for basic science, translational, and clinical investigators engaged in research relevant to the rheumatic diseases for the period between the completion of post-doctorate fellowship training and establishment as an independent investigator. The award will fund up to $375,000 for up to 3 years.

North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (due July 7)
The  North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) Foundation awards grants in several categories. Awardees are typically required to be NASPGHAN members.

NIHCM Healthcare Management Research Projects (LOI due July 10)
The National Institute for Health Care Management Foundation  is inviting Letters of Inquiry for innovative research that will advance the existing knowledge base in the areas of healthcare financing, delivery, management, and/or policy. For its 2017-18 funding cycle, the foundation will award five to six grants totaling $300,000 for studies that have strong potential to yield insights that can be used to have a positive impact on the United States healthcare system by reducing spending, improving quality of care, and/or expanding access to insurance coverage and healthcare services.

New York Life Foundation Grief Reach -- Community Expansion (due August 7)
New York Life Foundation’s Grief Reach Community Expansion RFP awards nonprofits that will expand and increase access for grief support services to underserved populations in local communities.Proposals should clearly define the target population, local partners and strategy for expansion. Grants range from $15,000 to $100,000.

OnPAR Program for Unfunded NIH Proposals
Last year, the NIH received approximately $30 billion in federal support. In spite of this amount, about 42,500 grants were not funded. To address these unfunded proposals, the NIH has a new Pilot Program that is designed to match researchers with nonprofit disease Foundations or with investments from private companies. Through a new collaboration between the NIH and the private contractor Leidos, researchers can now upload their unfunded NIH Proposals into an online portal at the Online Partnership to Accelerate Research (OnPAR). Foundations and other potential funders can review the NIH scores, and decide whether they might be interested in funding the Projects. Currently, this Pilot Program allows researchers with priority scores better than the 30th percentile to submit their abstracts. Interested Foundations might ask that a researcher send their full NIH Application along with its scores. The consensus opinion is that there are a lot of worthy grants being submitted to the NIH, but there is only so much funding available. OnPAR is one way of trying to match researchers with private Foundations. 
About CPCE
We are a pediatric research center dedicated to discovering and sharing knowledge about best practices in pediatric care by facilitating, organizing and centralizing the performance of clinical effectiveness research -- research aimed at understanding the best ways to prevent, diagnose and treat diseases in children. CPCE’s multidisciplinary team conducts research on a diverse range of clinical effectiveness topics grouped within four areas of research: