Like or follow CPCE on   Facebook ,   Twitter ,   and   LinkedIn . 
Spotlight on: CPCE Pilot Grant

PolicyLab team members Doug Strane, MPH ; Leigh Wilson, MSW, LSW ; and Katherine Kellom have been awarded the spring 2018 CPCE Pilot Grant to study the employment decisions made by parents of children with medical complexity.

For parents of children with complex chronic conditions, the challenges of coordinating and providing care for their children are often at odds with maintaining employment, forcing families to make difficult choices around job stability. The project team, which also includes Deshaun Parris, will conduct semi-structured interviews with low-income parents of children with complex medical needs enrolled in the Keystone/Karabots Cares (K2C) care management program at CHOP’s Nicholas and Athena Karabots Pediatric Care Center. 

The findings from this pilot study will inform clinical assessment and targeted services provided within the K2C care coordination program, and will inform the research questions and data collection tools for a multi-state prospective mixed methods study of the effect of state paid family medical leave policies on employment decisions made by low-income parents of children with medical complexity, and how such decisions impact intergenerational health outcomes.
Upcoming Events
Emotional Intelligent Relationships, Management, and Leadership: What, Why, and How
Date: July 25, 2018
Time: 8:00 - 9:00 am
Location: Stokes Auditorium, CHOP Main Hospital
Chris Feudtner, MD, PhD, MPH, Professor of Pediatrics and Medical Ethics and Health Policy, Perelman School of Medicine at the University of Pennsylvania, Director of Research for the Pediatric Advanced Care Team at CHOP, and Steven D. Handler Endowed Chair in Medical Ethics will give the first in a series of summer Grand Rounds covering the theme of leadership in medicine.

If you have events to share, please let us know by e-mailing CPCE@email.chop.edu.
CPCE in
the News!
Recent Publications
Total anomalous pulmonary venous connection (TAPVC) is a rare form of congenital heart disease in which the pulmonary veins drain by various pathways to the right atrium instead of the left atrium. Postoperative obstruction of the pulmonary veins is a known complication. This paper describes a pattern of postoperative obstruction in a specific arrangement of mixed TAPVC, suggesting that this arrangement predisposes patients to obstruction after surgical repair. Further investigation may aid pediatric cardiologists in risk-stratifying and counseling these patients.

Approximately 50% of childhood cancer survivors will experience at least one hormonal disorder over the course of their lives. This paper provides an overview the most common endocrine late effects seen in survivors and recommends a systematic approach to screening on the basis of risk factors to help improve health outcomes.

Thirty percent of adults with fibromyalgia receive an opioid, but the prevalence of opioid prescribing in pediatric patients with chronic musculoskeletal pain was previously unknown. This study found that 20% of children with chronic musculoskeletal pain received an opioid. Furthermore, 26% of children experienced polypharmacy, with the majority receiving 2-4 medications.

Human adenoviruses (HAdVs) are associated with significant morbidity and death after hematopoietic cell transplantation (HCT). This study sought to determine the incidence of HAdV infection among pediatric HCT recipients in the polymerase chain reaction (PCR) testing era, identify risk factors for viremia among patients undergoing HAdV surveillance, and assess the effectiveness of preemptive cidofovir.

There is a critical need for measures to evaluate structural progression in the pediatric sacroiliac joint (SIJ). We aimed to evaluate the construct validity and reliability of the Spondyloarthritis Research Consortium of Canada SIJ Structural Score (SSS) in children with suspected or confirmed juvenile spondyloarthritis.

This paper reports a successful percutaneous nephrolithotomy (PCNL) in an 8-week-old, 4.12 kg infant, believed to be the youngest patient to undergo PCNL reported in the literature.

Sepsis is associated with high early and total in-hospital mortality. Despite recent revisions in the diagnostic criteria for sepsis that sought to improve predictive validity for mortality, it remains difficult to identify patients at greatest risk of death. This paper compared the utility of nine biomarkers to predict mortality in subjects with clinically suspected bacterial sepsis.

Funding Opportunities
Recognizing that primary caregivers play an essential role in supporting social, emotional, and academic outcomes for children, WPF seeks to increase opportunities to support adults in their role as their child's first teacher. To that end, the foundation's Family Literacy Initiative is designed to help organizations deepen and expand the connections between adult and child literacy programming and improve language and literacy skills and practices for adults and children in Philadelphia.

The Elton John Aids Foundation is accepting Letters of Intent from organizations working with people who are most affected by HIV in the Americas, defined as the United States, Canada, Mexico, the Caribbean, or Central or South America.

The Rheumatology Research Foundation is accepting applications for its 2018 Scientist Development Award, an annual program designed to provide support for a structured, formal, clinical, or basic science research training program for rheumatologists or health professionals in the field of rheumatology. Grants of up to $225,000 for up to three years will be awarded to individuals in the early stages of their careers or those without significant prior research experience who plan to embark on a career in biomedical and/or clinical research in arthritis and rheumatic diseases. 

The National Institute for Health Care Management Foundation is a nonprofit, nonpartisan organization dedicated to improving the effectiveness, efficiency, and quality of the U.S. healthcare system. To that end, the foundation is inviting Letters of Inquiry for its Investigator-Initiated Health Services Research Grants program. The foundation will award seven or eight grants totaling $400,000. Priority will be given to studies that address issues of broad significance for the U.S. healthcare system and that have high potential to produce timely results and reach key target audiences.

The Future Leaders in Pain Research grant program was established in 2005 to fund pain research projects of doctoral-prepared investigators who have not yet attained NIH R01 level funding. The purpose of this grant is to encourage research in pain that will add to the existing body of knowledge, and to allow investigators to develop pilot data that will aid them in securing additional major grant funding for continued pain research.

The American Legion Child Welfare Foundation supports organizations that contribute to the physical, mental, emotional, and spiritual welfare of children. The foundation awards grants for the dissemination of information about new and innovative programs designed to benefit youth or information already possessed by well-established organizations. Projects must have the potential to help American children in a large geographic area (more than one state).

Community Access to Child Health, a program of the American Academy of Pediatrics, provides support to pediatricians looking to collaborate with others in their communities so that all children have access to needed health services. Planning and Implementation Grants of up to $10,000 will be awarded to individual pediatricians and fellowship trainees in support of the planning of innovative community-based child health initiatives aimed at ensuring that all children have medical homes and access to healthcare services not otherwise available in their community. Resident Grants of up to $2,000 will be awarded to pediatric residents to support the planning and/or implementation of community-based child health initiatives.

The foundation is accepting Letters of Intent from community-based organizations working in the areas of HIV/AIDS care and direct services, education, and research. Grants will be awarded in support of developing or established programs, with emphasis on the direct benefit to clients or the target audience.
 
The Gerber Foundation is accepting concept papers for research projects focused on improving the health, nutrition, and/or development of infants and young children. In particular, the foundation is looking for practical solutions that can be rapidly implemented on a broad scale and within a predictable time frame to clinical application. Major target areas include new diagnostic tools, new treatment regimens, symptom relief, preventative measures, assessment of deficiencies or excesses (vitamins, minerals, drugs, etc.), and risk assessment tools or measures for environmental hazards, trauma, etc. Grant amounts will range up to $350,000.

The American Congress of Obstetricians and Gynecologists is accepting applications for the 2015 Warren H. Pearse Women's Health Policy Research Award. The annual program includes a single grant of $10,000 for research that explores an aspect of healthcare policy that assists, defines, or restricts the ability of a physician to deliver health care to women in either the general population or a specific area. Applicants must be a junior fellow or fellow of the college at the time of application.

Last year, the NIH received approximately $30 billion in federal support. In spite of this amount, about 42,500 grants were not funded. To address these unfunded proposals, the NIH has a new Pilot Program that is designed to match researchers with nonprofit disease Foundations or with investments from private companies. Through a new collaboration between the NIH and the private contractor Leidos, researchers can now upload their unfunded NIH Proposals into an online portal at the Online Partnership to Accelerate Research (OnPAR). Foundations and other potential funders can review the NIH scores, and decide whether they might be interested in funding the Projects. Currently, this Pilot Program allows researchers with priority scores better than the 30th percentile to submit their abstracts. Interested Foundations might ask that a researcher send their full NIH Application along with its scores. The consensus opinion is that there are a lot of worthy grants being submitted to the NIH, but there is only so much funding available. OnPAR is one way of trying to match researchers with private Foundations. 
About CPCE
We are a pediatric research center dedicated to discovering and sharing knowledge about best practices in pediatric care by facilitating, organizing and centralizing the performance of clinical effectiveness research -- research aimed at understanding the best ways to prevent, diagnose and treat diseases in children. CPCE’s multidisciplinary team conducts research on a diverse range of clinical effectiveness topics grouped within four areas of research: